development migration and recognition strategies of y δ t cells
Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... population of T cells that are thymically derived and suppress autoreactive CD4+ T cells This is supported by the finding that thymectomy of mice at day of life leads to a lack of TR cells and produces ... The fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they persist in the body as TR cells, or whether they return to their ... limiting at the site of inflammation, the production of cytokines that lead to inhibition of T- cell responses, or the development of Tr1 or Th3 cells These regulatory phenomena are very important...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... 7b) The migration behaviour of CD4+CD25+ Treg cells does reflect their more activated phenotype, and their ability to enter inflamed joints makes it possible that they act directly at the site of ... prevent autoimmunity but also to control the extent of inflammatory reactions in order to prevent tissue damage to the host Further support for the influence of CD4+CD25+ Treg cells on arthritis development ... immunity with transfer of Treg cells Pre-activated CD4+CD25+ cells (1 × 106) were transferred at the time of antigen-induced arthritis (AIA) induction (a) Delayed-type hypersensitivity (DTH) reactivity...
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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... treatment decreases the infiltrate in joints Furthermore, RA patients relapse shortly after withdrawal of anti-TNF-α [19] and thus, despite the dampening of joint inflammation and the reinstatement of ... with active RA before treatment with anti-TNF-α were unable to suppress proinflammatory cytokine secretion from activated T cells and monocytes After anti-TNF-α treatment the ‘hibernated’ peripheral ... anti-tumour necrosis factor (TNF)-α, a benchmark therapy for RA, drastically influences the function of CD4+CD25+ Treg [18] The crucial point of that study was that Treg isolated from patients with...
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Báo cáo y học: "Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells" pps
... contributes to our understanding of recruitment of T cells to the joint in inflammatory arthritis and suggests that in the microenvironment of the joint, dysregulation of functional patterns of ... from the joints of patients with JIA by flow cytometric analysis CCL5 protein was detected within T lymphocytes from both blood and synovial fluid without any stimulation, and these were shown to ... synovial T cells, and that this can be rapidly released without new protein synthesis on stimulation We have also demonstrated that several of the features of this inflammatory T cell population within...
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Báo cáo y học: "Japanese Encephalitis Virus wild strain infection suppresses dendritic cells maturation and function, and causes the expansion of regulatory T cells" doc
... present antigen to and activate T lymphocytes through up-regulating the expression of costimulatory and antigen presentation-associtated molecules at the mature stage [17] To examine whether the characteristics ... IFN-a and TNF-a was independent on viral replication DCs infected with P3 attenuated allostimulatory activities to T cells To test whether P3 infection will impair the ability of DCs to activate ... needed to be investigated[20,21] Thus, we analyzed the capacity of the infected DCs for activating allogeneic T cells by MLR and ELISPOT assay It was observed that the T cell activating ability of...
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Báo cáo y học: "Defective response of CD4+ T cells to retinoic acid and TGFb in systemic lupus erythematosus" ppt
... to either activated T cells or to “ex-Treg” that have lost their suppressive activity Further analyses, including the methylation status of the FOXP3 locus, will be necessary to distinguish these ... defective, either because there are too many memory T cells or they are refractory to RA inhibition Interestingly, the CD25 Tregs were also expanded by the combination of RA and TGBb, and these cells ... USA Authors’ contributions ES and LM had full access to all of the data in the study and took responsibility for the integrity of the data as well as for the preparation of the manuscript They designed...
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Báo cáo y học: "Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)" pps
... suggests that the CTLs in HAM/TSP cannot control the number of infected cells One explanation for this is that the CTLs in HAM/TSP patients show less efficient cytolytic activity toward infected cells, ... HTLV-I-infected cells Nevertheless, these data suggest that potentiation of the immune response against viral proteins such as Tax may be an attractive way to treat ATL patients [94] Such strategies ... between HTLV-II infections and cancers Regardless of the homology of their tax sequences, the oncogenic potential of Tax1 (HTLV-I Tax) is more prominent than that of Tax2 (HTLVII Tax) The most striking...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... respectively The proximity to one of the intercepts between the theoretical and fitting curves reflects the relative contribution of each component Lorentzian function to the specific spectral density of ... along the correlation line is directly related to the distribution of the energy between the overall tumbling and the internal mobility, and is indicative of the degree of internal restraint of ... direct evidence supporting a structural interruption of the geometry of the recognition helix for either Antp or the TTF-1 HD, the anomalous amide exchange pattern and the NOE connectivity data of...
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Báo cáo Y học: Repression of FasL expression by retinoic acid involves a novel mechanism of inhibition of transactivation function of the nuclear factors of activated T-cells pptx
... further studies are required to establish whether RA modulates the activities of the enzymes that affect nuclear translocation and transcriptional activity of NFAT The NFAT proteins regulate the expression ... competition for CBP/p300 between these transcriptional factors might result in the inhibition of the NFAT activity Similarly, the cross-talk between retinoid receptors and NFAT might take place at the ... binding activity of NFAT To understand the molecular mechanism of RA-induced inhibition of NFAT activity, we investigated whether the DNA-binding activity of NFAT was changed by RA treatment When PBMCs...
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Cognitive moral development theory and moral maturity of accounting and finance professionals
... on the how the DIT scores were tabulated and how they were used to test the hypotheses 7 Purpose of the Study The aims of this study are to reveal the role of cognitive moral development on ethical ... to so Ethical behaviors of the contributory level employee are the focus of this study A recent study documented in the Treadway Commission Report stated that “creating an ethical climate may ... 21 maturity and moral behavior Chapter has provided an introduction to the study, background of the problem, purpose of the study, nature of the study, assumptions, limitations of the study, significance...
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báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot
... shows that both class II epitopes of hTERT (p766 and p672) used in the study were promiscuous Ex Vivo Cytotoxicity of In Vivo Generated T Cells T2 -cytotoxicity Cumulative cytotoxicity results for ... populations Cytotoxicity assays were done in triplicates, with T2 cells either peptide-pulsed or not SCC-4 Cytotoxicity Assays Cytotoxicity assays were carried out using a MHC peptide+ (hTERT naturally ... present TAAgs, potency in stimulating T cell responses, stability of the phenotype following in vivo administration, the ability to migrate to sites of T cell activation and generation of CTLs Activated...
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Báo cáo sinh học: " Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneratio" potx
... represents a typical flow cytometry scatter plot The percentages of lymphocyte and monocyte gates increased after C5a treatment (from 41% to 52.8% and 5.96% to 17.0% respectively) Further apoptosis ... whether systemic observations reflects pathological events in the eye and how systemic activation may ultimately be manifest in the eye remain to be defined To date there is no effective treatments ... unknown factors may also contribute to this T cell activation seen in AMD patients Interestingly, the findings that C5a specifically promoted the Th17 family cytokine production, but not IFN nor...
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Collaboration for Agriculture & Rural Development: Technical and economic feasibility of applying the Better Management Practices (BMP) to household aquaculture in Vietnam " MS6 pot
... advantage of water that heat holding capacity is quite high leading to more stable water temperature than embient temperature Familiar tool to check water temperature is themometer 2.3 Water transparency ... bottom that required to remove in the and of production cycle + Liming will lead to precipitation down to pond bottom 10 3.1 METHODS AND ENVIRONMENTAL STANDARDS Methods of water quality analysis ... environment Water sourse + Availability of water sourse + Annual variation of salinity + Depth and transparency + External effects: transportation, human life activities, factory Is that cause any water...
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Collaboration for Agriculture & Rural Development: Technical and economic feasibility of applying the Better Management Practices (BMP) to household aquaculture in Vietnam - MS 8 " doc
... University of Western Australia Research Institute for Aquaculture No & The University of West Australia Environmental Quality of Shrimp Aquaculture Systems This section presents data collected by Extension ... phytoplankton growth They also constitute the major buffering system to reduce fluctuations in pH Alkalinity levels in outlets and inlets at all times during the trial was unlikely to have any ... at the end of the season, the culture pond stayed at a stable 5.5 mg/l As shrimp spend most of their time on the pond bottom, the mud/water interface and its oxygen content is very important Almost...
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Collaboration for Agriculture & Rural Development:: " Technical and economic feasibility of applying the Better Management Practices (BMP) to household aquaculture in Vietnam - MS 9 " pot
... 2.2.1 The current status situation at the start of the project At the start of this BMP project, many staff and experts at RIA1 had a significant understanding of Better Management Practice theory ... 2.2.4.1 The short trip of project team to University of Western Australia 13 2.2.4.2 Attendant of the international workshop in aquaculture at Cantho University 14 2.2.4.3 Attendant of ... Aquaculture Number 2.2 The key officers and experts of RIA1 participating project 2.2.1 The current status situation at the start of the project 2.2.2 Selection of project staff and...
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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx
... applicability that will have persistent clinical effectiveness that can be built within a short duration of therapy time.1 107 Early and Late Effects of SIT on Mast Cells, Basophils, and Eosinophils SIT ... Ozdemir et al, Regulatory T Cells in the Context of Allergic Disease The mechanisms by which SIT has its effects include the very early desensitization effect The regulation of Tcell responses by generation ... Further studies are required to elucidate the in vivo role of these cells and their subsets Effects of SIT on Dendritic Cells To understand the mechanisms of action of SIT, some cardinal steps...
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Báo cáo khoa học: " Vegetative development, primary and secondary growth of the shoot system of young Terminalia superba tropical trees, in a natural environment. I. Spatial variation" pot
... spacing of tangential parenchyma bands is related to the rate of rainfall (Hill, 1982) At any rate, the outer structural discontinuity in the trunk wood of the trees studied could be related to a ... suggested to be alternately more and less dense The changes were generally gradual and apparently bore no relation to the development of the units of extension Thus, there were no rhythmic growth ... periodicity It appears that the trunk displays an alternation of long and short internode series, obvious at 27 °C and under 14- or 16-h daylengths This paper reports a study on the spatial aspects of...
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Báo cáo khoa học: "Vegetative development, primary and secondary growth of the shoot system of young Terminalia superba tropical trees, in a natural environment. II. Terminal growth, lateral growth and main stem-branch growth correlations" ppsx
... stem was a priority in the first stage of the development of T superba Study of the temporal organization in both primary and secondary, terminal and lateral growth phenomena in the shoot system ... interesting to support the view of the regulatory role played by particular branches on the shoot system development Without any other data on this subject, but in view of the number of branches the ... rosette of leaves In one of the trees studied, the accidental death of the main apex just after the initiation of a new tier proved that this main apex contributed to limiting the vertical growth...
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Báo cáo y học: "Decreased response to IL-12 and IL-18 of peripheral blood cells in rheumatoid arthritis" doc
... cell-mediated immune defect is present, as demonstrated by a defect in IFN-γ production It is noteworthy that tuberculosis developed in RA patients shortly after the beginning of anti-TNF treatment Our ... cytokine that plays an important role in the Th1-type immune response through the induction of IFN-γ synthesis in T cells and NK cells, T- cell proliferation, and cytokine production [15] Significant ... greater amounts of IFN-γ after successful anti-TNF treatment This result, if it proves to be correct, would further indicate that the defective IFN-γ production by RA-PBMCs might be related to...
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