decreased risk of diabetes related complications associated with a 1 decrease in a1c
mechanisms of type 2 diabetes
... 3 21: 405– 412 UKPDS: decreased risk of diabetes- related complications associated with a 1% decrease in A1 C Percentage increase in relative risk corresponding to a 1% rise in HbA1C Observational analysis ... study data Any diabetesrelated endpoint Diabetesrelated death All cause Myocardial mortality infarction 14 % 21% 21% ** 14 % ** Stroke Peripheral vascular disease† Microvascular disease 12 % ** * 19 % ... 10 -14 15 + Years T2DM Harris,S et al CDA 2003; Type Diabetes and Associated Complications in Primary Care in Canada: The Impact of Duration of Disease on Morbidity Load Activity • Insulin-independent...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... that causes diabetic complications (11 -13 ) The combination of the low levels of antioxidants and raised levels of free radical play a major role in delaying wound healing in aged rate and diabetic ... and antioxidant systems in diabetic vascular disease Bratisl Lek Listy 2000 ;10 1:5 41- 51 Bruce CR, Carey AL, Hawley JA, Febbraio MA Intramuscular heat shock protein 72 and heme oxygenase -1 mRNA ... epidemiological and clinical trial data Lipids 20 01; 36: S53–S63 67 Cuzzocrea S, Riley DP, Caputi AP, Salvemini D Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion...
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Tài liệu ECCENTRIC MECHANISM OF FOUR-BAR LINKAGE pptx
... following six joint types are available: Pin Joint Cylinder Joint Planar Joint Slider Joint Ball Joint Bearing Joint PREPARE THE PARTS FOR MECHANISM Download the part files eccentric_mechanism.zip ... assembly 15 CREATE AN SUB-ASSEMBLY base_asm.asm Click , Enter the name of base_asm OK Click Then open base.prt and assemble it at default location by selecting 16 , and open bushing.prt Place ... the axis A_ 12 of the pin at arm 45 For Translation constraint, select the back face of the link, and then pick the front face of the arm Click OK to complete the pins creation Open Clip-2 and assemble...
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Tài liệu Báo cáo " Mechanism of forming the Dien Bien basin " pdf
... Late Neogene basalt erupted as a chain of olivine, pyroxene basalt stretching along the axis of the basin The sample taken from drill hole shows that the mineral composition of basalt mainly includes ... olivine basalt exposed along the main fault in Doc Lap hill, Tom village, Muong Thanh airport [2] The olivine basalt is also found in borehole at the depth of 16 0m in the central part of basin ... Bien Lai Chau fault was left-lateral and Sop Cop Lang Chanh was right-lateral one, producing an extensional field, associating secondary faults The secondary faults played a role of the channel...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... Tyr99 Pro100 1. 06 1. 10 1. 75 1. 74 1. 89 1. 32 1. 57 1. 45 1. 10 1. 02 1. 06 1. 17 1. 13 1. 41 1 .19 1. 38 1. 27 1. 07 1. 57 in the A- chain and B-chain of nPS, and in the case of His37, the v1 torsion angle changes ... of 15 N, 13 C, H labelled proteins with high sensitivity J Am Chem Soc 11 6, 11 655 11 666 Chakrabarti KS & Sarma Siddhartha P (2006) NMR assignment of 2H, 13 C and 15 N labeled amino-terminal domain ... substrate binding His106 is involved in intersubunit interactions via its side chain, and is in a similar position to Glu132 in A thaliana PS Val 111 and Gly 113 , on the other hand, are both affected...
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Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt
... conformation that is fit to activate The fact that kcat and Km for tRNAArg in the aminoacylation reaction not change in the Asn106 fi Ala, Gln 111 fi Ala and Phe109 fi Ala mutants of S cerevisiae ArgRS ... form aminoacyl-tRNA In the aminoacylation reaction of class I aaRSs with aminoacyl-AMP, the 2¢-OH group of the ribose of A7 6 tRNA attacks the carbonyl carbon atom of the –Ca–(CO)–O– moiety of aminoacyl-AMP ... the amino acid and ATP in the reaction path of aminoacyl-AMP formation on the aaRSs has not been attained yet In particular, the following detailed biochemical findings on the formation of aminoacyl-AMP...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... examination of the articular cartilage after experimentally induced OA Articular cartilage of the femoral condyles from the experimental joints was examined to assess any macroscopic damage caused ... inhibition and TRAIL play a pivotal role in canine chondrocyte death and cartilage degradation These findings indicate that the maintenance of hypoxic conditions in cartilage inhibits articular ... experimentally induced OA Cartilage damage was visualized on the tibial plateau of the experimental joints when compared with normal control joints The medial tibia plateau cartilage in the experimental...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx
... compilation ª 2007 FEBS 2249 Mechanism and kinetics of dihydroneopterin aldolase Y Wang et al 5¢-GGAATTCCATATGGATATTGTATTTATAGAGCA AC-3¢ (forward primer with a Nde I site) and 5¢-CGGGA TCCTTAATTATTTTCTTTCAGATTATTGCC-3¢ ... dihydroneopterin aldolase to a cofactor-independent oxygenase J Am Chem Soc 12 8, 13 216 13 223 19 Yaylayan VA, Harty-Majors S & Ismail AA (19 98) Investigation of the mechanism of dissociation of glycolaldehyde ... Scheme Kinetic mechanism of the DHNA-catalyzed reactions 2244 B Fig Fluorimetric titration of SaDHNA with NP (A) and of HPO with SaDHNA (B) (A) A 2-mL solution containing 15 lM SaDHNA in 10 0 mM...
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Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf
... 3.4 .11 .10 ] and M28E Aeromonas proteolytica aminopeptidase [(AAP) EC 3.4 .11 .10 ] In addition, the M28 family includes important human aminopeptidases such as M28B glutamate carboxypeptidase II (N-acetylated, ... the SGAP catalytic residue, Tyr246 [36]; (d) the binding affinities to the natural inhibitors bestatin and amastatin are approximately two-fold larger in AAP than in SGAP [10 ]; and (e) in SGAP, ... aminopeptidases that involves an acidic residue acting as a general acid ⁄ general base and a di-nuclear metal center participating in binding the substrate and stabilizing the transition state [2 ,14 ,35–37]...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... Significantly, a decrease in scattering (increase in membrane rupture) was also observed on addition of VtA3 (insert Fig 1B) The increase in leakage and decrease in scattering elicited by VtA3 demonstrate ... the mechanism of action of vis- cotoxins, by examining the interaction of VtA3 with fungal cells We describe a detailed investigation of the cellular and signalling characteristics of VtA3-induced ... increased at increasing concentrations of VtA3, indicating that VtA3 interacts with fungal membranes, increasing its rigidity at all temperatures These results provide evidence that VtA3 is incorporated...
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Tài liệu Báo cáo khoa học: Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc
... designed and synthesized at iGENE (Tsukuba, Japan) The forward sequences of the siRNAs were: #973, sense 5¢-UCAUCACACUGAUAACCAACACUGA-AG-3¢; #2578, sense 5¢-GGAUCAAAGAGAACACUGGGGUAUA-AG-3¢; and #15 13 ... growth by a delay in G1 and cyclin A associated apoptosis Oncogene 21, 14 0 14 7 14 Mutaguchi K, Yasumoto H, Mita K, Matsubara A, Shiina H, Igawa M, Dahiya R & Usui T (2003) Restoration of insulin-like ... 5¢-AGUUCACGUGCAAGAACAAG UUCUG-AG-3¢ The forward sequence of the scrambled RNA was 5¢-GAUCCAAGUAAUACAGAGAUGGGAG AG-3¢ OVISE cells were plated the day before transfection at a cell density of 50–60%...
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Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt
... 5¢-CAGTTGACAATAAGTACAGCG-3¢ (for A7 2L ⁄ F73L); 5¢-CTTTAGGTCGACTCAAATTTTCAGTTGACAATAA GTACAGCG-3¢ (for A7 2L ⁄ F73L ⁄ W78L); 5¢-CCGGCCAG TGTTCATCGATAAATAC-3¢ (for F223H); 5¢-CTTTAGG TCGACTCAAATTTTCAGTTGACAATAAGTACAGCG-3¢ ... 16 25, 2 91 295 Asawatreratanakul K, Zhang Y-W, Wititsuwannakul D, Wititsuwannakul R, Takahashi S, Rattanapittayapron A & Koyama T (2003) Molecular cloning, expression and characterization of cDNA encoding ... PAGE with Coomassie brilliant blue staining Protein concentrations were measured by the method of Bradford with BSA as standard Expressions of Srt1p and Srt1p-delta in yeasts pJR 113 3-Srt1p and...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... MH26 71 cotransformed with pFAB4 and pAN222 (approx 4–8 copies facB) yA2, pabaA1, pdhA1 yA2, pabaA1; pdhB4 yA2, pabaA1; pdhC1 biA1; veA1 yA2, pabaA1; wA3; veA1 pyrG89; DargB::trpCDB; pyroA4; veA1 ... McsA McsA McsA McsA McsA G50 G50 /A1 00 G50/P100 G50 /A1 00/P100 A1 00 G10/P100 A1 00/P100 G50 G50 /A1 00 G50/P100 G50 /A1 00/P100 A1 00 G10/P100 A1 00/P100 G50 G50 /A1 00 G50/P100 G50 /A1 00/P100 A1 00 G10/P100 ... G50 /A1 00/P100 A1 00 G10/P100 A1 00/P100 G50 G50 /A1 00 G50/P100 G50 /A1 00/P100 A1 00 G10/P100 A1 00/P100 G50 G50 /A1 00 G50/P100 G50 /A1 00/P100 A1 00 G10/P100 A1 00/P100 19 47 22 59 15 3 13 3 13 5 10 16 10 26 58 77 59 0.2...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... CTGACCTtcTGGCATAACACCGGtGAAATC AgeI CCTGGTtcCATAACACCGGtGAAATC AgeI GGTGCTgAGCTCAAGTGTGACTTtcGTCTAC SacI CCGGTGGTcGAcTTTGGTTtcACGCCC SalI ACGTACTGCTgTCCGGAAAGtACtCCATGGCCGC ScaI TCCAATCCGTtAGTCTGgCCaTAGAACGCGC ... (Glc -a- (1 4)-Glc -a- (1 6)-Glc -a- (1 4)-Glc) [1, 16], 42 -a- isomaltosylisomaltose (Glc -a- (1 6)-Glc -a- (1 4)Glc -a- (1 6)-Glc) [16 ], and 63 -a- glucosylmaltotriose (Glc -a- (1 6)-Glc -a- (1 4)-Glc -a- (1 4)-Glc) [1, 16] We measured ... MscI GGAGAATGGTgCCAGGGTACATTTcCAATCCGTCA KpnI AATACATCTTaAGGCCGTCGTtGTCGGTGTGG A II AATACATCTTaAGGCCGTtGCGTCGGTG A II W32F W240F W402F E273Q D353N E356Q D372N D373N sequencing, and the original StyI–XbaI...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... & Braunstein, A. E (19 47) Labilization of a- hydrogen of amino acids under the action of aminoferase Biokhimia 12 , 556–568 (in Russian) Ó FEBS 2004 Esaki, N., Nakayuma, T., Sawada, S., Tanaka, H ... the cofactor plane [17 ], and shows that the pattern of binding is the same for a variety of amino acids It has been established [5] that for a number of amino acid inhibitors bearing nonbranched ... substrate, when the external aldimine is formed The anchoring of a- carboxylate and a- amino group in the external aldimine defines automatically the positions of the a- proton and the side chain of any...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... evidence is: (a) the EPR spectrum of a trapped amino acid radical found by Lardinois et al [48] in at least one catalytic intermediate of MPO and (b) the high redox potential of this intermediate, which ... compared to other peroxidases (e.g horseradish and chloroperoxidase) that one may look at MPO as a catalase/peroxidase A first-order rate constant of 2.2 · 10 6 s )1 has been reported for the catalatic ... physiological role of the amino acid radical that forms only in the presence of an ÔactiveÕ form of LPO, as shown by Lardinois et al [ 51] It cannot be generated in the presence of inhibitors and has been...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... analyzed by SDS/PAGE and autoradiography Figure shows that after incubation with labelled MSSAE, membranes contained radioactive protein both monomeric and dimeric (lane 1) This indicates that ... repeats Nature 366, 7 517 56 Papageorgiou, A. , Shapiro, R & Acharya, K (19 97) Molecular recognition of human angiogenin by placental ribonuclease inhibitor an X-ray crystallographic study at 20 A ... MSSAE incubated with plasma membranes (PM) from SVT2 cells Lane 1, plasma membranes treated for 16 h with 12 5I-labelled MSSAE; lane 2, labelled proteins extracted from PM with high salt; lane...
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Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx
... k -13 [O2] k14 [Ar][NADH] Reaction 3.0 a 1. 8 ã 10 7 a 1. 5 ã 10 5 a 5.2 ã 10 3 a 2.0 ã 10 7 a 1. 7 ã 10 7 a 2.0 ã 10 7 a 4.0 ã 10 7 a 6.0 ã 10 7 a 1. 8 ã 10 6 a 1. 0 ã 10 5 a Variable 6.0 ã 10 )3 b,c 6.0 ã 10 )3 ... effect of the pH on the enzyme inactivation Figure shows a plot of the rate of enzyme inactivation against pH We note that the rate of inactivation increases with decreasing pH We were not able ... during an oscillatory state induced by melatonin The reaction was performed in 0 .1 M acetate buer, pH 5 .1 The reaction was started by infusion of NADH (ow rate 34 lLặh )1) to a solution containing 1. 2...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... arginases and agmatinase greately differ in the N terminal region, the agmatinase and rat liver arginases were stripped of the first 32 and five amino acids, respectively The location of the gaps ... wild-type agmatinase and this was interpreted as supporting the presence of a binuclear metal center in the active site of fully activated agmatinase [9] The Km for agmatine (1. 6 ± 0 .1 mM) and the ... investigation in our laboratory In any case, despite the structural differences between agmatinase and arginase, agmatine and arginine were fixed in essentially the same position in the corresponding...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25