days while in the septuagint it is contracted to three
Báo cáo y học: "Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice" pot
... mistakenly using an incorrect file to make the plot The incorrect file was an incomplete working file obtained from the same animal and experiment as shown in Fig 3Bin the main text, but with an incorrect ... through the peak in temperature that occurred in the middle of mealtime in waveform D Clearly, the peak in temperature in D is not reflected by the density of the same data in B In addition, the ... i.e., it displays a rhythm with an anticipatory phase angle To interpret these data, it is necessary to see activity and temperature during ad-lib food access PRIOR TO the feeding schedule Without...
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Báo cáo y học: "Erythropoietin in the critically ill – is it more than just blood" ppt
... activities of EPO is providing exciting new avenues for study Despite the inherent difficulties in performing these studies in the critically ill, the potential for EPO to be of benefit in the critically ... Critical Care October 2004 Vol No Corwin difficult to determine More importantly, the pathophysiology of tissue injury in the critically ill can be quite complex, involving many interacting ... in patients with anemia associated with other clinical conditions However, it remains to be seen whether any outcome benefits are associated with EPO administration, either related to transfusion...
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Bóa cáo y học: " Early apoptosis of blood monocytes in the septic host: is it a mechanism of protection in the event of septic shock" ppt
... compatible with the current theory of the pathogenesis of sepsis elaborating a connection between the production of proinflammatory cytokines by monocytes and the intensity of the inflammatory process ... shown in Figure Discussion The present study investigated the existence of apoptosis in blood monocytes over the evolution of sepsis and its correlation to the final outcome of the host The study ... by an autocrine mode eliciting apoptosis Knowledge of apoptosis of cells of the immune system in sepsis is derived mainly from animal studies Initiation of apoptosis in the field of a septic process...
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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
... longer incubation periods Interestingly, the interruption of TAG synthesis preceded the appearance of toxic effects, supporting the notion that it constitutes the initiating event in the process ... exposure of liver cells to FFAs Interruption of TAG synthesis in conditions of excess availability of SFAs is the key point in the molecular mechanism of SFA-induced lipotoxicity It is suggested that ... process of lipotoxicity Stearate has to be activated in order to be toxic The first enzyme involved in metabolism of FFAs after their uptake into liver cells is the long-chain acyl-CoA synthetase (ACS),...
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Tài liệu “Don’t spit in the well - you may need to drink from it!” -- Unknown, Russia. docx
... easier to point the finger at agricultural, industrial, and mining operations However, here are a few tips: Conserve water; the less water you use, the less will be running down the drains and into ... in increasing concentrations in lakes and rivers Scientists have discovered that many PPCPs act as hormone disrupters, which means that the synthetic hormones in the products interfere with the ... hormones in animals, especially fish that live in the water There has not been enough research to determine the effects that PPCPs can have on humans, but there is evidence to suggest that these...
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Tài liệu Báo cáo khoa học: Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension pdf
... at the exit site from ER and therefore the mutant protein remains longer in the lumen of the ER and finally is diverted to the degradation pathway Because the degradation is blocked by inhibitors ... found to be heavily ubiquitinated in the presence of the inhibitor of proteasome function Furthermore, the extent of ubiquitination of TNSALP (1559delT) was further augmented in the cells expressing ... retrotranslocated into the cytoplasm? What type of ubiquitin ligase(s) is involved in the ubiquitination of TNSALP mutant proteins prior to destruction in the proteasome? Furthermore, as both...
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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
... treated with cholera toxin, an activator of cAMP synthesis (Fig 6C) However, addition of the protein kinase C activator PMA to granulosa cells had little effect on the localization of LRH-1 into nuclear ... positive regulatory effect on LRH-1 activity In response to pituitary gonadotropins, the cAMP signaling pathway is the most important pathway in the stimulation of gonadal steroidogenesis [40] In ... sumoylation was reported to comprise another important post-translational regulatory mechanism The small ubiquitin-related modifier (SUMO) is covalently linked to lysines in target proteins through sequential...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... proximity of the mutation to the cleavage site, probably resulting in a small interference with the binding of the activator to the FXI zymogen There are some examples of inherited coagulation disorders ... occupies the position corresponding to FXI Val371 in some other serine proteases, such as vitamin-K-dependent protein C, hepatocyte growth factor activator, and neurotrypsin The Val371Ile mutation in ... b-carbon has two substitutions); nevertheless, the mutation is not isosteric, isoleucine being larger than valine, and having an additional methyl on its side chain In the structure of the FXI zymogen...
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Báo cáo hóa học: "The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer" docx
... radiotherapy before the collection of the samples The histopathologic characteristics of the colon carcinoma tissue specimens were confirmed by blinded review of the original pathology slides The ... metastasis-free survival (LMFS) was defined as the time from surgery to liver metastasis Immunohistochemistry The specimens were fixed in formaldehyde and embedded in paraffin Only blocks containing ... Evaluation of risk of liver metastasis in colorectal adenocarcinoma based on the combination of risk factors including CD10 expression: multivariate analysis of clinicopathological and immunohistochemical...
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báo cáo hóa học: " Nogo receptor is involved in the adhesion of dendritic cells to myelin" ppt
... outside the CNS, perhaps in the activation of DCs or in homing of DCs to specific tissues This is supported by the findings of the non-myelin associated proteins B cell activating factor (BAFF) ... of NgR1 in matDCs promotes their adhesion to myelin, resulting in the selective accumulation of matDCs rather than immDC in the myelin debris-containing lesion This would result in further antigen ... receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors Neuron 2005, 45:345-351 Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J,...
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it is essential to complete business assessment targets in Traffic construction enterprises under Ministry of Transport
... will include: the increasing number of new customers; the decreasing number of leaving old customers; the rate of satisfactory customers of the quality of construction; the rate of satisfactory ... between the financial and nonfinancial criteria, etc - Create the link between criteria under the causal relation, thus enable the administrators to forecast the operating results in the future ... the enterprises participating in the survey - Charter capital of the enterprises participating in the survey - Operation time of the enterprises participating in the survey Actually, the research...
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Some people think that it is important to use leisure time for activitiesthat improve the mind
... during and after the dinner party, despite their grumbling Our beliefs about what we enjoy can be inaccurate, and this is one reason why in leisure, as in life, we can find ourselves unwittingly ... whose natural inclination is to avoid social gatherings, as it is for company-loving extroverts Studies show that husbands who reluctantly attend dinner parties at the insistence of their wives ... were to spend our time doing something else What leisure activities bring us lasting joy and satisfaction? Empirical research suggests the following: socialising, doing voluntary community or...
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Tài liệu Work with Data-Bound Multi-Select List Boxes Using Windows Forms It is common to have to assign docx
... product in the Unselected Products list box and then click on the arrow button pointing to the right (>), then the item is moved to the Selected Products list box If you select items in the Selected ... Create the LoadSelectedProducts routine by entering the code in Listing 8.4 into the form you created for this tutorial This routine performs basically the same tasks that the routine listed in the ... Add the code in Listing 8.8 to the Click event of the btnUnSelect command button Again, this code is similar to the previous step, but it is used to set the CategoryID column to null if the product...
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"It is impossible to avoid all faults" doc
... dealt with in this section The normal distribution is the most widely accepted However, it is seldom used in reliability engineering The exponential distribution is often used in electrical engineering, ... seen on the percent scale for the ordinate The division of the time axis into classes and the assignment of failure times to the individual classes is called classification In this process information ... frequencies and the empirical density function f *(t) In the density function the midpoints of the beams in the histogram are connected with straight lines In this way a function between the failure...
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Báo cáo khoa học: Structure of Streptococcus agalactiae serine⁄threonine phosphatase The subdomain conformation is coupled to the binding of a third metal ion pptx
... of protonating the phosphate leaving group This is also consistent with the binding of M3 in SaSTP when a putative substrate-mimic loop binds into the active site (see below) Second, when the residues ... kcat is unsurprising There is probably no change in active site contents The WH in prokaryotic enzymes is located on the opposite side of the substrate phosphate in comparison with His62 in HsSTP ... 1C) The flap in TxSTP contains the antiparallel strands in addition to the two helices found in SaSTP and MtSTP Furthermore, the flap is in a totally different conformation In HsSTP, the flap consists...
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Báo cáo khóa học: Disruption of the interaction between the Rieske iron–sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b potx
... compensatory mutations are shown in pink, and the hinge region of the ISP is shown in white the integration or stability of the ISP within the bc1 complex In order to investigate its effect on the ... unstable under the conditions of the assay This was confirmed by monitoring the sensitivity of the activity of the bc1 complex to detergent The mutant enzyme was inactivated by a incubation with 0.025% ... position 167, may also explain the variations in the ISP content observed in different membrane preparations The integrity of the complex appears to be sensitive to the protein/lipid ratio It is...
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Báo cáo khoa học: Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) ppt
... containing a cDNA encoding the insulin signal sequence and the Protein A-IgG binding domain, was inserted into NheI-HindIII digested pcDNA3.1, producing the vector, pInsProA pDN42 was digested with ... treated recombinant GalNAc-T1 with PCMPS in the presence of either UDP-GalNAc or UDP To increase the sensitivity in this experiment, the cysteine modification was performed with the minimal PCMPS ... protein secreted into the medium was quantified by Western blotting in combination with densitometric scanning of the bands on the blotting membrane The enzymatic activities were correlated with the...
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Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx
... Also, the actin-binding site in G4 that is high affinity (30 nM) in calcium-activated gelsolin is low affinity (1 lM) in pH-activated gelsolin It is proposed [20] that calcium binding especially in ... changes in these domains that altered the interaction between domains G2 and G4–6 [22] Therefore, we investigated the possibility of a pH sensitivity in the interaction of the G4–6 domains with the ... of gelsolin-actin binding The gelsolin molecule forms a direct complex with two actin monomers (GA2), through three distinct actin binding sites The GA2 complex may not be equivalent to the geometry...
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Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt
... 1A) to the multiphasic fluorescence enhancement induced by Glc binding; (b) to identify the active site residues involved in the binding of Glc to the super-open state (Fig 1C) of this two domain ... enzyme, and thus the site of initiation of the global conformational transition; and (c) to gain some insight into how the local torsional stresses at the contact residues in the super-open state ... residues involved in the initial binding of Glc to the super-open state (Fig 1C) of this two domain hinge-bending enzyme, all the actual residues were individually mutated (supplementary Table S2) The...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu