data analysis for high throughput biology and bioconductor

Báo cáo y học: "ISsaga is an ensemble of web-based methods for high throughput identification and semiautomatic annotation of insertion sequences in prokaryotic genomes" pdf

... combination for providing high quality data, especially when subject to expert human inspection and validation The numerical importance of transposases in nature [4], and presumably, therefore, the ... ways: firstly by enriching the ISfinder database by high throughput annotation of completely assembled and scaffold-based genomes; and secondly by direct analysis of the metagenomes themselves ... Perochon for extensive bioinformatics support Authors’ contributions AMV conceived and developed ISsaga, and drafted the manuscript PS carried out ISsaga tests and design, managed the ISfinder database...

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System level modeling of endothelial permeability pathway and high throughput data analysis for disease biomarker selection

Danh mục: Thạc sĩ - Cao học

... diacylglycerol and Ca2+ [29-33] The unconventional isoforms, δ, ε, η, and θ, require phosphatidylserine and diacylglycerol but not require Ca2+ The ζ and λ isoforms are called atypical and require ... Processing for microarray data and copy number variation were described Section, 2.4 2.5 present the method and strategies used for marker selection from microarray data 2.1 Methods for mathematics ... the disease biomarker selection using high throughput data, includes microarray and copy number variation datasets (Section 1.3) The motivation of this work and outline of the structure of this...

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Tài liệu technology and method developments for high throughput translational medicine doc

Danh mục: Kĩ thuật Viễn thông

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Báo cáo khoa học: 15 N-Labelled proteins by cell-free protein synthesis Strategies for high-throughput NMR studies of proteins and protein–ligand complexes doc

Danh mục: Báo cáo khoa học

... produced in high yields in vivo are also suitable for efﬁcient production by cell-free synthesis In order to compensate for the increased effort and expense required for the production and selective ... scrambling and easier sample handling compared to in vivo protein production render cell-free protein synthesis particularly attractive for high- throughput production of proteins and selective ... proteins makes it an attractive tool for preliminary studies prior to the production of uniformly [15N ⁄ 13C]labelled samples for in-depth NMR analysis Much information can be gleaned already from...

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STATISTICS AND DATA ANALYSIS FOR THE BEHAVIORAl SCIENCES docx

Danh mục: Vật lý

... information-enough data- to make a sound choice His short visits to each campus were Chapter Introduction: Statistics and Data Analysis as Tools for Researchers Statistics and data analysis highlight ... variables, and make better judgments about how and why people behave the way they Statistics and Data Analysis for the Behavioral Sciences teaches the theory behind statistics and the analysis of data ... Interquartile and the Semi-Interquartile Range 153 Variance and Standard Deviation 155 Sample Variance and Standard Deviation 157 Homogeneity and Heterogeneity: Understanding the Standard Deviations...

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Báo cáo sinh học: "Generalized Models for high-throughput analysis of uncer- tain nonlinear systems" doc

Danh mục: Hóa học - Dầu khí

... Abstract Purpose — Describe a high- throughput method for the analysis of uncertain models, e.g in biological research Methods — Generalized modeling for conceptual analysis of large classes of ... Generalized Models for high- throughput analysis of uncertain nonlinear systems Thilo Gross1,2 , Stefan Siegmund∗2 Max-Planck Technical Institute for the Physics of Complex Systems, ... valid for a class of models and robust against uncertainties in speciﬁc models positive X ∗ and F (X ∗ ) We write • avoids expensive numerical approximation of steady states and can be scaled to highdimensional...

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Báo cáo hóa học: " Generalized Models for high-throughput analysis of uncer- tain nonlinear systems" pdf

Danh mục: Hóa học - Dầu khí

... Abstract Purpose — Describe a high- throughput method for the analysis of uncertain models, e.g in biological research Methods — Generalized modeling for conceptual analysis of large classes of ... Generalized Models for high- throughput analysis of uncertain nonlinear systems Thilo Gross1,2 , Stefan Siegmund∗2 Max-Planck Technical Institute for the Physics of Complex Systems, ... valid for a class of models and robust against uncertainties in speciﬁc models positive X ∗ and F (X ∗ ) We write • avoids expensive numerical approximation of steady states and can be scaled to highdimensional...

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Báo cáo toán học: " Generalized Models for high-throughput analysis of uncer- tain nonlinear systems" ppt

Danh mục: Toán học

... Abstract Purpose — Describe a high- throughput method for the analysis of uncertain models, e.g in biological research Methods — Generalized modeling for conceptual analysis of large classes of ... Generalized Models for high- throughput analysis of uncertain nonlinear systems Thilo Gross1,2 , Stefan Siegmund∗2 Max-Planck Technical Institute for the Physics of Complex Systems, ... valid for a class of models and robust against uncertainties in speciﬁc models positive X ∗ and F (X ∗ ) We write • avoids expensive numerical approximation of steady states and can be scaled to highdimensional...

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Báo cáo y học: "Establishment of a novel CCR5 and CXCR4 expressing line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists" pdf

Danh mục: Báo cáo khoa học

... [9], and cancer [10-12] Important ligands for CCR5 are the βchemokines 'regulated on activation normal T cell expressed and secreted' (RANTES), and the 'macrophage inflammatory proteins' MIP-1α and ... cytometric analysis of(3 panels, right and in the single-transfectedand CXCR4 in the U87.CD4.CCR5.CXCR4 double -and Flow cytometric analysis of the membrane expression of CD4, CCR5 and CXCR4 in ... MOLT-4.CCR5 and Jurkat.CCR5 cells After days of infection, a strong cytopathic effect was visible microscopically for NL4.3 and HE but not for BaL in the SupT1.CCR5, MOLT-4.CCR5 and Jurkat.CCR5 cells (data...

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Báo cáo y học: "A method for high-throughput gene expression signature analysis" ppt

Danh mục: Báo cáo khoa học

... and flexibility, and at very high throughput and dramatically lower cost, represents, in our view, the next transformative technology in the gene expression field We believe that the Genome Biology ... 191 wells: 99.5% accuracy; data not shown) Taken together, these data indicate that LMF represents a highly accurate signature analysis method that is suitable for high- throughput applications reviews ... LMF data used to assess the reproducibility of the method and for comparisons between platforms (in the tab-delimited txt file format; Additional data file 5); a document containing raw LMF data...

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Chemical and pharmacological studies of ardisia elliptica antiplatelet, anticoagulant activities and multivariate data analysis for drug discovery

Danh mục: Cao đẳng - Đại học

... the leaves of the plant and fractionated HPLC and GC-MS were used for the analysis of the extract and fractions Platelet aggregation assay was performed on the extract and fractions using a platelet ... Linearity, LOD and LOQ data of α-amyrin and β-amyrin standard calibration curves 162 Table 5.3 163 Table 5.4 Absolute and analytical recovery of α-amyrin and βamyrin Stability of α-amyrin and β-amyrin ... 21.3 and 10.5 µM for α- and β-amyrin respectively These values indicated that α- and β-amyrin are three and six times more active respectively than aspirin (IC50 value= 62.7 µM) Hence, α- xi and...

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On interaction motif inference from biomolecular interactions riding the growth of the high throughput sequential and structural data

Danh mục: Cao đẳng - Đại học

... subsequent projects that I did and I am indebted to him for that I also wish to thank many friends and colleagues in the Computational Biology Lab for their interesting discussion and warm friendship Huge ... protein-protein interaction data in the recent years, we expect that D-SLIMMER and other programs in this line would be of high importance for mining more SLiMs from the PPI data We designed another ... structural data in the PDB database We characterized 452 distinct SLiMs from the Protein Data Bank (PDB), of which 155 are validated by either literature validations or over-representation in high throughput...

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Methods for DNA copy number variation analysis using high throughput sequencing

Danh mục: Cao đẳng - Đại học

... Jean, Hu Yong Li, and Aslam, for all your help in all aspects i ii Finally, and most importantly, I would like to thank my wife, Dong Fang — without your support and understanding, I must have ... Polymorphism xv List of Papers and Manuscripts Xie, C and M T Tammi (2009) CNV-seq, a new method to detect copy number variation using high- throughput sequencing BMC Bioinformatics 10, 80 (Appendix ... large and well characterized family (Singleton et al., 2003) The gene triplication doubles α-synuclein protein level in blood and brain and causes formation of Lewy bodies by the aggregated form...

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Development and application of advanced proteomic techniques for high throughput identification of proteins

Danh mục: Thạc sĩ - Cao học

... Engl 44, 1048-1053 (2005) Hu, Y., Uttamchandani, M & Yao, S.Q Microarray: a versatile platform for highthroughput functional proteomics Comb Chem High Throughput Screen 9, 203-212 (2006) x List ... endeavors have shifted towards high- throughput approaches that facilitate large-scale analysis of proteins, i.e proteomics (Pandey and Mann, 2000; Tyers and Mann, 2003) Therefore, the advancement of ... sample preparation and analysis 128 7.1.3.1 DNA extraction and polymerase chain reaction (PCR) 128 7.1.3.2 DNA cloning and sequencing 129 7.1.4 Protein sample preparation and analysis 130 7.1.4.1...

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Exergy analysis for combined regenerative Brayton and inverse Brayton cycles

Danh mục: Môi trường

... Energy and Environment (IJEE), Volume 3, Issue 5, 2012, pp.715-730 717 Figure T-s diagram for the combined cycle Exergy analysis and optimization The following assumptions are made for simplicity and ... the system efficiency for open cycle systems In this paper, the exergy analysis for combined regenerative Brayton and inverse Brayton cycles proposed in Ref [10] is performed The purposes of ... been performed in this paper The effects of the effectiveness of the regenerator and other parameters on the exergy performances of the combined cycle are analyzed, and the exergy performances...

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bioinformatics for high throughput sequencing [electronic resource]

Danh mục: Đại cương

... Computational Infrastructure and Basic Data Analysis for High- Throughput Sequencing David Sexton 55 Base-Calling for Bioinformaticians Mona A Sheikh and Yaniv Erlich 67 De Novo Short-Read ... CLIP-Seq Data Michael Q Zhang 191 209 13 Analysis of Metagenomics Data Elizabeth M Glass and Folker Meyer 219 14 High- Throughput Sequencing Data Analysis Software: Current State and ... molecular biology and biochemistry The ultra -high- throughput instruments are essentially high- tech machines and understanding the engineering principles gives the user the ability to command and troubleshoot...

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