... set the treatment in the context ofthe family Following from Freeman et al.'s [19] work, we wish to examine whether the developmental issues described above necessarily preclude the use of child-focused ... either pharmacotherapy or concomitant psychotherapy for TTM Written informed consent was obtained from all participants for publication of this manuscript and accompanying images A copy ofthe ... were offered open BT at week on ethical grounds, no data on MAC are available through the maintenance phase ofthe study Only data from the acute phase ofthe study will be presented in the current...
... small fraction ofthe mass ofthe visible matter in the universe So, the origin of 99 percent ofthe mass ofthe visible matter in the universe can be traced back to the energy of moving quarks ... questions about the inner workings ofthe atomic nucleus, the formation ofthe elements in our universe, and the evolution ofthe cosmos Recommendation: The Department of Energy’s Office of Science, ... determination ofthe average neutrino mass and the source ofthe mass ofthe neutrinos and the determination of whether neutrinos are their own antiparticles Concerted efforts to answer these and other...
... system the precession ofthe orbit of Mercury and the bending of light by the Sun Over the ensuing decades theoretical analyses deepened the understanding ofthe theory and exhibited the richness ... PHYSICS: EXPLORINGTHE STRUCTURE OF SPACE AND TIME of space and time The application of this new theory to predict the outcome of black hole evaporation and the nature ofthe big bang singularity • The ... from the councils ofthe National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members ofthe committee responsible for the report were chosen for their...
... during the implementation phase ofthe project 11 EXPLORINGTHE CHALLENGES OF HIV/AIDS Progress in SADC countries The Healthy Relationships intervention component Over the past two years each ofthe ... Society Initiative for Southern Africa (OSISA) is very much appreciated About the editors Bridgette Prince is the Head of International Liaison in the office ofthe CEO at the Human Sciences Research ... Senior Researcher in the office ofthe CEO at the Human Sciences Research Council in Cape Town At the time of writing, Kristin Roe was a CIDA-funded intern with the Social Aspects of HIV/AIDS Research...
... interchanging the axes of space and time We have also seen how the slanting ofthe frame (the intraframe offset) along the spatial axis can be used to indicate the speed of camera movement What, then, ... happens if the slanting occurs on the temporal axis? The result of such a temporal intraframe offset is temporal motion distortion, in which the angle ofthe slant indicates the timing ofthe exposure ... On the far left side ofthe frame, which is the narrowest, the exposure time is the shortest and the bar is sharpest and has the least amount of motion blur As we move across the frame to the...
... v e c t o r s : Another lesson of Tab is that the effect ofthe composition ofthe feature vectors can vary depending both on the task and on the size ofthe feature vector The dramatic fall in ... grave for the LPE experiments because ofthe ceiling effect and the small size ofthe complete data set, therefore, we did not rerun the corresponding experiments Furthermore, the number of codebook ... CL We then determined the relevance of each of these lemmata for a given classification task by their gain ratio (Yang and Pedersen, 1997) From this ranked list of lemmata, we constructed the final...
... Ala219 ofthe catalytic site and His135 ofthe Mg2+ binding site The most striking result was the loss ofthe psychrophilic character of mutant W260K/A219N (as reflected by a threefold increase ofthe ... considerably lowered On the basis ofthe model, the behavior ofthe G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The presence ofthe additional Gly at ... validity ofthe above interpretation was further reinforced by the construction ofthe double mutant G261A/Y269A The additional substitution of Tyr269 fi Ala was designed with the aim of reducing the...
... system the precession ofthe orbit of Mercury and the bending of light by the Sun Over the ensuing decades theoretical analyses deepened the understanding ofthe theory and exhibited the richness ... PHYSICS: EXPLORINGTHE STRUCTURE OF SPACE AND TIME of space and time The application of this new theory to predict the outcome of black hole evaporation and the nature ofthe big bang singularity • The ... from the councils ofthe National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members ofthe committee responsible for the report were chosen for their...
... conserved tyrosines, the binding ofthe conserved His to the O2 ofthe adenine ribose and the carbonyl oxygen of Y54 and the binding ofthe conserved catalytic glutamate to the O2 ofthe nicotinamide ... view ofthe NAD binding cleft ofthe cholera-like class of toxins showing the intramolecular interactions around the active site and the key features [4] The binding of R7 to the oxygens ofthe ... view ofthe active site cleft ofthe DT class of toxins highlighting the key catalytic residues and mode of NAD binding [1] This illustrates the stacking ofthe nicotinamide ring between the conserved...
... with the following parameters L consisted of three labeling schemes: the set L wd of word labels, the set Lpt of preterminal labels, and the set Lnt of nonterminal labels The order < ofthe model ... guarantees The central question driving this paper is whether we can jettison these guarantees and still obtain good performance in practice For the decoding ofthe probabilistic model ofthe previous ... and test sets with an off -the- shelf tagger, namely the Brill tagger (Brill, 1994) Thus the object of our computation was HLPD ECODE(H, n, w), where n was the length ofthe sentence, and partial...
... customers They relate various characteristics of their dialogue data such as the number of utterances, the types of information exchanges and patterns of initiative taking to the stages or phases of ... examine whether there are differences ofthe number of characters and turns between speakers The results indicates that there are statistically no differences at 05 level to the number of characters ... dialogues? For example, are there any possibilities if in multi-party dialogues the role of chairpersons emerges from the nature ofthe dialogues? These are not only problems in exploring multi-party...
... gene delivery to the nucleus In the context of gene therapy, the delivery of therapeutic genes by liposomes can also result in the inhibition of angiogenesis and the observation of an enhanced ... would bind the oncogene The target ofthe 246 GENE THERAPY IN THE TREATMENT OF CANCER FIGURE 10.4 Diagram of an antisense oligonucleotide, specifically generated based on the sense sequence of an oncogene, ... is the establishment ofthe relevance ofthe genetic basis of carcinogenesis Second is the determination ofthe specific oncogene to target Third is the determination ofthe specific sequence to...
... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... anti-CD52 therapy was initiated one week after the injection of tumor cells Anti-CD52 immunotoxin therapy lead to a delay in the accumulation of tumor-associated ascites and an improvement in the median ... therapy twice-weekly for three weeks Therapy was then discontinued and tumor growth was monitored for several weeks Therapy significantly restricted solid tumor growth throughout the course of...
... participated in the design ofthe study and performed the statistical analysis and interpretation of data, and drafted the manuscript; ML participated in the design ofthe study and the statistical ... for the purpose of estimating the average utility of a cohort [8] The use of mapping techniques has been described as second-best compared to primary collection of data [9], but remain one ofthe ... imputation of utility values, rather than a single imputation as performed here Furthermore, the ability to predict the SF-6D and EQ5D from the HAQ is complicated by the weighting of items in the EQ-5D...
... ambivalence then relief surrounding disclosure, participants used this process of truth-telling to ultimately determine the extent and value of their friendship with the recipient ofthe information They ... to a new realization that others' acceptance or rejection of their information was not a reflection ofthe ill adolescent's 'problem', but rather an indication ofthe other person's virtue as a ... to talk to them and make them feel as if they are needed, and to address their problems When you have an illness in the family it takes away from a lot ofthe other siblings, and they also need...
... cytokines, the recruitment of leukocytes, the induction of protective and antiapoptotic gene expression, and the activation of T cells The resulting innate and adaptive immune responses might explain the ... CNTs penetrate the stratum corneum cells and become lodged into the viable epidermal cell layers ofthe skin, they may enter the keratinocytes directly or trigger the production of proinflammatory ... hypothesis, the lowest level of oxidative stress is associated with the induction of antioxidant and detoxification enzymes (Table 1) [41] The genes that encode the phase II enzymes are under the...
... brachytherapy is performed at relatively few centers in the U.S Balloon-based APBI methods were developed to simplify the brachytherapy procedure The MammoSite™ (MS) brachytherapy applicator was the ... over the operative field, so that the radiation therapy could be delivered without Results The radiation oncologist then broke scrub, attached the XB controller to the catheter, and inserted the ... cc was found to be the proper size, a × cm XB balloon catheter kit was then opened by the OR staff The CED was then deflated and removed and a XB was then inserted in place ofthe CED If a 40 cc...