copd and decreased in more severe disease
Báo cáo y học: " Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke" pot
... down-regulated in the nasal mucosa of smokers and in severe COPD in vivo Figure TLR4 mRNA expression is down-regulated in the nasal mucosa of smokers and in severe COPD in vivo Outpatients attending for ... was no significant reduction in expression of TLR2 (P = 0.28) or HBD2 (P = 0.20) Expression of TLR4 and HBD2 is upregulated in COPD, and decreased in more severe disease There were no significant ... upregulation in mild-moderate COPD compared to controls (P < 0.005), and reduced expression in severe COPD compared to mild-moderate disease (P < 0.05) HBD2 expression in severe COPD was statistically...
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Báo cáo y học: "Long acting b2-agonist and corticosteroid restore airway glandular cell function altered by bacterial supernatant" pdf
... of CFTR and actin (A) The pattern of CFTR (green staining) and actin (red staining) stainings was essentially apical in control cells as well as in cells treated with Sal/FP (B) (C) The incubation ... purpose, we examined the co-localisation of these proteins by immunofluorescence The pattern of staining of CFTR (green staining) and actin (red staining) was essentially apical in control cells ... combination of Sal and FP had a beneficial effect in downregulating inflammatory cytokines following S aureus infection Pro-inflammatory mediator levels are markedly increased in induced sputum of...
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Báo cáo y học: " Overcoming beta-agonist tolerance: high dose salbutamol and ipratropium bromide. Two randomised controlled trials" pps
... impact of increasing bronchoconstriction Eur Respir J 2003, 21:810-815 Van der Woude HJ, Winter TH, Aalbers R: Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate ... treatment In addition, not all of the subjects in these studies were taking inhaled corticosteroids, whereas current guidelines recommend that long-acting beta-agonists are used in conjunction with inhaled ... salbutamol/formoterol 40 20 30 20 15 10 m m m m in in in in e e in li n l sa in st se 5m po ba Figure Response to salbutamol and ipratropium bromide (n = 11) Response to salbutamol and ipratropium bromide (n =...
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Báo cáo y học: "Inhaled steroid/long-acting β2 agonist combination products provide 24 hours improvement in lung function in adult asthmatic patients" pps
... salmeterol and formoterol have a long-lasting clinical efficacy after a single daily dose, which maintains significance above baseline at a 12 hour monitoring time point [12,13,18-25] In the current ... adverse events The baseline characteristics of subjects in both studies, including dose of inhaled corticosteroid are shown in Table Primary endpoints Study A Both SFC and FBC increased FEV1 at 16 ... which was administered in the Clinic This dose of FBC is the actuated dose from a 6.0/200 mcg inhaler Medication was administered as one inhalation from a Diskus inhaler containing either SFC...
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Bóa cáo y học: "Reduction in airway epithelial chloride transport in septicaemia related pulmonary oedema reversible by beta agonist application" docx
... seen in lung injury due to other infectious and non-infectious etiologies then this is another potential mechanism by which beta-agonists might improve fluid clearance and thus support the findings ... Eisenhut explain the mechanism of this effect As discussed, possible mechanisms include improved respiratory mechanics, reduced inflammation and improved edema clearance If the finding of reversibly ... study [1] and the beta-agonist lung injury trial [2] Hopefully future studies will include randomized controlled trials to demonstrate if beta-agonists are an effective treatment in ALI and also...
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nghiên cứu phương pháp phân tích các chất kích thích tăng trưởng họ beta-agonist trong thịt heo, gan heo, thức ăn nuôi heo bằng phương pháp phân tích sắc ký ghép khối phổ (gc-ms)
... Clenbuterol Salbutamol Chloramphenicol Sulfamerazine Sulfadimethoxine Sulfamonomethoxine Oxolinic acid Pyrimethamine Nicarbazin 10 Furazolidone 11 Avoparcin Tại Malaysia: yêu cầu tất sản phẩm thòt, ... promotion with concomitant reduction of fat tissues in meat-producing livestock In Viet Nam, CLEN, SAL are being mainly detected by the screening ELISA method Use of GC/MS (Gas chromatographic-mass ... NH4I + DTE (1000:4:2) at 600C for 15 minutes The selected ions monitoring mode is performed at m/z 227, 300, 335, 336 and 337 for CLEN, and 207, 294, 350, 369 and 370 for SAL Recoveries of CLEN,...
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Tài liệu Báo cáo khoa học: a-Defensins increase lung fibroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc
... obtained data indicating that a-defensin-1 and a-defensins-2 induce an increase in the protein content of cyclin D and that quercetin inhibits the a-defensininduced increase in cyclin D protein ... b-catenin, total b-catenin and collagen-I, and cell proliferation were determined As shown in Figs 7A,B and 8A,B, the incubation of lung fibroblasts with a-defensin-1 and a-defensin-2 induced increases ... b-catenin, suggesting that a-defensins activate the b-catenin signaling pathway We then studied the role of the b-catenin signaling pathway in a-defensininduced increases in the proliferation and...
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Báo cáo toán học: " Measurement of beta amyloid peptides in specific cells using a photo thin-film transistor" pot
... Biologically, more evolved studies examined that Aβ peptides which are incorporated into planar lipid bilayers of neurons induce multimeric ion channels inducing excessive calcium influx into neurons and ... sensing area was placed in the middle of the well as shown in Figure 2a After washing three times with phosphate-buffered saline, laminin as an extracellular matrix was coated on the channel, and ... Kilbourn MR: In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease Neurol 1999, 52:691-699 15 Barbee KD, Hsiao AP, Roller EE, Huang X: Multiplexed protein detection...
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Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways" doc
... µg/ml aprotinin, µg/ml each of leupeptin and pepstatin, and mM dithiothreitol) Cell lysates were centrifuged at 500 g for min, and the pellets containing nuclei were retrieved and washed in ml cold ... phosphate-buffered saline (PBS), and incubated in DMEM supplemented with 1× insulin–transferrin–selenium-A (Invitrogen, Carlsbad, CA, USA) for 24 hours before the addition of cytokines and other reagents ... combined influence of other proinflammatory cytokines in addition to IL-17 In view of the fact that IL-1β, TNF-α, and IL-17 are most likely to produce a combined effect on the RA joint, investigation...
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Báo cáo y học: "Effect of short-acting beta blocker on the cardiac recovery after cardiopulmonary bypass" pot
... unclamping to weaning) was 29.6 ± 8.9 minutes in control group and 24.3 ± 7.8 minutes in esmolol group (P = 0.007) The bypass time was 69.9 ± 9.0 minutes in control group and 63.7 ± 10.9 minutes in ... benefit for the weaning process More and more physicians incline to use beta blocker to treat various arrhythmias including ventricular arrhythmia in non-surgical patients [8-11] And in accordance ... re-beat HR represents heart rate and bpm represents beat per minute The aortic-cross clamping time was 39.9 ± 9.1 minutes in control group and 39.4 ± 8.0 minutes in esmolol group (P = 0.827) The...
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Báo cáo y học: "Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-B pathways" pps
... for increasing the levels of nitric oxide (NO) and prostaglandins (PGs), the overproduction of proinflammatory cytokines (e.g TNF-a, IL-6, IL-1b) and inflammatory mediators (e.g PGE2, NO), and ... Arctiin down-regulates production of pro-inflammatory cytokines The in vitro anti-inflammatory activity of arctiin was monitored by evaluating the gene and protein expression levels of inflammation-related ... enzymes (iNOS and COX2) and several proinflammatory cytokines (IL-1b, IL-6, and TNF-a) with ELISA and western blot analysis As shown in Figure 4A, arctiin significantly suppressed the protein expression...
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Báo cáo y học: "Endotoxin-activated microglia injure brain derived endothelial cells via NF-B, JAK-STAT and JNK stress kinase pathways" docx
... (Escherichia coli, O26:B6), aminoguandine, apocynin, allopurinol, minocycline, N(omega)-hydroxy-Larginine (NOHA), indomethacin and amino-3-morpholinyl-1,2,3-oxadiazolium chloride (SIN-1) were purchased ... that NOS (aminoguanidine and LNMMA) and ROS (apocynin, allopurinol, indomethicin) inhibitors all reduced LPS-induced cell death in BV2 cells (Figure 4A) Interestingly, aminoguanidine (AG, a relatively ... with NOS inhibitors (L-NMMA and aminoguanidine) and ROS inhibitors (apocynin and allopurinol) markedly reduced endothelial disruption in this in vitro model Since we also found that SIN-1 was...
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Báo cáo y học: "Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-B pathways" potx
... for increasing the levels of nitric oxide (NO) and prostaglandins (PGs), the overproduction of proinflammatory cytokines (e.g TNF-a, IL-6, IL-1b) and inflammatory mediators (e.g PGE2, NO), and ... Arctiin down-regulates production of pro-inflammatory cytokines The in vitro anti-inflammatory activity of arctiin was monitored by evaluating the gene and protein expression levels of inflammation-related ... enzymes (iNOS and COX2) and several proinflammatory cytokines (IL-1b, IL-6, and TNF-a) with ELISA and western blot analysis As shown in Figure 4A, arctiin significantly suppressed the protein expression...
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Báo cáo hóa học: " Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized mice" pptx
... Methacholine, mg/ml RSV Sal FP FPS Figure FPS is more effective than FP or Sal alone in preventing AHR and lung inflammation FPS is more effective than FP or Sal alone in preventing AHR and lung inflammation ... production by intracellular cytokine staining (Fig 3A & B) Cells were stimulated with anti-CD3 in panel A and with OVA in panel B FP increased the number of cells producing IL-10 and Sal increased ... 7.5), 100 mM MgSO4, and 150 mM NaCl) and stored in aliquots in liquid nitrogen Viral titers were determined by standard plaque assay combined with immunostaining for RSV Mice were infected under light...
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Báo cáo khoa học: Expression level and agonist-binding affect the turnover, ubiquitination and complex formation of peroxisome proliferator activated receptor b pptx
... transfection, cells were starved for 45 in methionine ⁄ cysteine-free DMEM (Invitrogen, Karlsruhe, Germany) containing 1% glutamine and 5% dialyzed fetal bovine serum, and incubated with 430 lCi of Redivue ... mechanism impinging on PPARb that could be relevant, for example, in protecting the cell against the overexpression of PPARb in pathophysiological conditions Furthermore, our findings indicate that ... fetal bovine serum, 100 UÆmL)1 penicillin and 100 lgÆmL)1 streptomycin in a humidified incubator at 37 °C and 5% CO2 Plasmids pCMX-mPPARa [7] was kindly provided by Dr ˆ R Evans (The Salk Institute,...
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báo cáo hóa học:" Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation" doc
... after infusion if cell adhesion molecules and chemokine receptors as also upregulated in vivo as part of activation In vitro, we have observed increases in CD54 and CCR7 (10-fold and 1.4-fold increase ... activates human B cells, including classically defined memory and naïve subsets, triggering increased expression of immuno-stimulatory molecules and production of cytokines Furthermore, we found that ... example, induces increased surface expression of costimulatory and MHC molecules, production of proinflammatory cytokines, and enhanced T cell triggering [11,12] CD40 ligation on resting B cells increases...
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Báo cáo khoa học: "nhaled beta-2 agonist salbutamol and acute lung injury: an association with improvement in acute lung injury" doc
... could be beneficial in ALI, including improving respiratory mechanics, reducing inflammation and increasing edema clearance • To date there have been no published studies examining the effect of ... dobutamine and dopexamine (both β1 and β2 agonists) decreased lung IL-6 protein and mRNA expression, and attenuated neutrophil accumulation in the lung [12] We did not measure markers of inflammation in ... chemotaxis and accumulation in the lung [39] and decrease IL-1 [40], tumor necrosis factor-α [41] and IL-6 [42] production from macrophages In a murine model of endotoxin-induced lung injury, dobutamine...
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Toàn văn đánh giá hàm lượng các chất b agonist (clenbuterol và salbutamol) trong thức ăn gia súc và dư lượng trong thịt gia súc bằng kỹ thuật sắc ký lỏng ghép khối phổ
... pháp phân tích ractopamine, isoxpurine, clenbuterol thịt, gan, thận heo cách kết hợp kỹ thuật chiết mẫu SPE với cột nhồi loại polymer in dấu phân tử MIP (Molecularly imprinted polymers) kỹ thuật ... Levoalbuterol Salbutamol (Albuterol, Ventolin) Terbutaline Pirbuterol (Maxair) Procaterol Orciprenaline Metaproterenol (Alupent) Fenoterol Bitolterol mesylate Ritodrine Nhóm có tác dụng kéo dài vào thể ... pháp sàng lọc, dù chứng minh áp dụng cho đối tượng kiểm nghiệm, phải xác minh lại phương pháp có tính khẳng định có nghi ngờ kết Nhìn chung phương pháp sàng lọc ELISA có độ tin cậy không thật cao...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25