comparison of the average accuracies of svm classification systems for the prediction of inhibitors substrates of different p450 isoenzymes by using modeling testing sets and independent validation sets
Machine learning approach in pharmacokinetics and toxicity prediction
... validation sets .134 Table 6.6 Comparison of the average accuracies of SVM classification systems for the prediction of inhibitors/ substrates of different P450 isoenzymes by using modeling testing ... 4.5 SVM prediction accuracy for the substrates and non -substrates of P-gp by using independent validation sets 89 Table 4.6 SVM prediction accuracy of the substrates and non -substrates of ... using independent validation sets .133 Table 6.5 Average accuracies of 10 groups of SVM classification systems for the prediction of CYP3A4 substrates/ non -substrates by using independent validation...
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establish an anaerobic batch system by using guideline vdi 4630 and determine the biogas yield of different substrates in food processing villages
... oxygen demand) The biogas yield (per amount of substrate, per VS of inoculum, per COD of substrate) and the degradability of different substrates will be evaluated Objective The aim of this thesis ... from the interaction between the ingredients, the type of fermenter and the operation of the plant (KALTSCHMITT et al., 2009) The addition of substrates with high proportions of carbohydrates and ... increased by the storage and spreading of residues The masses of the ingredients of the digestate as phosphorus, calcium, potassium and magnesium are not reduced by the fermentation The sulfur...
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Báo cáo y học: "Revision of late periprosthetic infections of total hip endoprostheses: pros and cons of different concepts"
... position for a certain period of time before the final prosthesis is implanted [17,20,30,33,34] The function of the spacer is on the one hand to release the antibiotic into the infected bed of the ... antibiotic-loaded cement of the spacer and used for the systemic treatment is chosen on the basis of the sensitivity of the bacterium causing the infection Since the use of several antibiotics ... re-implantation The disadvantage of the cemented revision technique is related to the fact that the osseous bed of the prosthesis has not only been enlarged by the loosening of the primary prosthesis...
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Consumer acceptance of cheese,influence of different testing conditions
... groups of samples Detailed information about average ratings of cheese samples and the standard deviations together with the total averages of the standard deviation per cheese sample and per testing ... different For the central location test the overlap is the strongest, while for the in-home test the overlap is the weakest For the laboratory testing, the mid group overlaps with both the high and ... conclusion as for the full analysis, indicating no effect of the order of the testing situation Table shows data from the in-home testing The majority of the consumers (80%) tasted the cheese samples...
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Evaluation of different weather files on energy analysis of buildings
... the effect the simulation domain size and the climate data have on the accuracy of the energy demands of a rather large complex of buildings To this aim, the energy demands of the buildings of ... obviously depends on both the quality of the data and on the sophistication of the simulation Of these data, those concerning the construction of the building and of the HVAC system are well defined ... certain The influence of the internal loads uncertainty on the final result depends on the time scale of the simulation and on the size of the simulation domain, since the increase of either or...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt
... performed after analysis by bidimensional PAGE The antibody recognition of the proteins performed on the same filter was prevented by the SouthWestern treatment Therefore, identification of the ... 270) 3259 cells, the presence of two different clusters of eEF1A isoforms (cluster and cluster 2) The apparent pI of cluster ( pH 9.0), was calculated theoretically by considering the pH gradient ... recognized the more basic form of eEF1A, whereas a very weak interaction was found for the isoform of eEF1A focusing at a pH of 9.0 The recognition seemed highly specific because, under these experimental...
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Improvement of different vaccine delivery systems for cancer therapy pptx
... altering the interaction between the vaccine and different APCs at the site of injection Hence, the routes of administration and formulation of DNA clearly affect the therapeutic response by altering ... two different arms of the immune system may be enhanced by using two different modalities (i.e., CD4+ and then CD8+ T cells); and 3) some of the most effective methods of immunization, like the ... the possibility of random integration of the vector DNA into the host genome and their high cost [48,49] Non-viral or synthetic vectors have many advantages over their viral counterparts as they...
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EVALUATION OF DIFFERENT TYPES OF CHEST SYMPTOMS FOR DIAGNOSING PULMONARY TUBERCULOSIS CASES IN COMMUNITY SURVEYS pot
... two-third of the cases whereas CXR alone picked up more than three-fourth of the cases With either method the prevalence was underestimated by one-third in the former method and about one-fifth in the ... two surveys were 9.7 and 16.0%; and 14.4 and 17.3% respectively The yield of cases according to the interval between the onset of cough and the time of elicitation of cough is given in Table-3 It ... surveys The workload and the cost involved in collection of sputum from these symptomatics and processing the specimens in the laboratory can also be avoided The study emphasized the importance of...
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Báo cáo khoa học: Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane pot
... lipid-A and two phosphate moieties The ions with m ⁄ z of 1519.6 and 1541.6 are mono- and di-sodiated forms of the de-O-acylated LOS and the ion with m ⁄ z of 1479.6 is the anhydrous form of the ... consists of two GlcNAc and two 3-OH C12:0 groups Among the other ions m ⁄ z of 2654.8, 2694.8 and 2717.4 indicates the presence of the anhydro form and mono- and di-sodiated form of the molecular ion ... shown in the inset The m ⁄ z 917.4 and 797.4 are due to sodiated and dehydrated forms, respectively, of the m ⁄ z 895.4 fragment ion The de-O-acylated LOSs from the wild-type O35E and the mutant...
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Báo cáo khoa học: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-a pdf
... This is the first identification of natural substrates of FAP dipeptidyl peptidase activity NPY, BNP, substance P and PYY were the most efficient FAP substrates, and the first hormone substrates of FAP ... consistent with the loss of the N-terminal dipeptide Tyr-Ala from GRF No further breakdown of either peptide was observed up to 72 h, and neither peptide showed breakdown at 37 °C in the absence of protease ... both the fastest (NPY) and the slowest (PYY) substrates Previously reported data on the endopeptidyl substrates of FAP, a2-antiplasmin and denatured type I collagen, show a preference for the...
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Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf
... biosynthetic genes are located in a gene cluster and three of them are P450 enzymes The FUM6 protein (CYP505B1) intervenes in one of the first steps in fumonisin synthesis by hydroxylation of the ... with the peroxide shunt reaction for common P450s [34] Indeed, P450SPa lacks the critical residues compulsory for the fulfilment of the typical monooxygenation reaction; in the distal I helix the ... maltosa) Another advantage of the P450 bypass is the circumvention of H2O2 formation by the fatty alcohol oxidase However, the overoxidation cascade requires 210 three molecules of NADPH, potentially...
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Báo cáo khoa học: "Are These Documents Written from Different Perspectives? A Test of Different Perspectives Based On Statistical Distribution Divergence" ppt
... definition of different perspectives We first develop statistical models for the two document collections, A and B, and then measure the degree of contrast by calculating the “distance” between A and ... pairs of different perspectives and document collection pairs of the same perspective and others We thus evaluate the proposed test of different perspectives in the following four types of document ... Perspective (SP) A and B are written from the same perspective For example, A and B consist of the words spoken by Kerry Different Topics (DT) A and B are written on different topics For example, A...
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Báo cáo Y học: Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin Characterization of different PAI-1 mutants pdf
... used in the SPR analysis, another as yet unknown part of active PAI-1 converts to the latent form and thus cannot bind to Vn anymore Therefore, the analysis of the interaction of PAI-1 and, especially, ... but for the PAI-1 mutants a different maximum for the speci®c activity may exist Furthermore, within the time frame of determination of the amount of active PAI-1 in a given preparation to the ... 37 °C for h Then, 10 lL of chromogenic substrate were added and the thrombin activity measured monitoring the change of optical density at 405 nm The activity of thrombin in the absence of inhibitor...
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shape-controllable synthesis of ultrafine zno powders of different
... regular crystal form and high purity The EDS pattern was performed on one of the ZnO flowerlike structures, and the composition analysis of the powder showed the existence of Zn and O (from the sample), ... h, and the micro-rods of the flower-like structures grew more regular In summary, the influences of the reaction temperature, the OHÀ/Zn2þ mol ratio and the reaction time on the morphologies of the ... ratio and reaction time 10 h 3.4 XRD patterns of ZnO powders and EDS pattern of flower-like structure The XRD patterns of ZnO of flower-like particles, rods and flake, and the EDS pattern of the ZnO...
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Báo cáo sinh học: " Comparisons of the M1 genome segments and encoded µ2 proteins of different reovirus isolates" pptx
... Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates The start and stop ... plus-strand copies of each genome segment These plus-strand RNAs are used as templates for translation by the host machinery as well as for minus-strand synthesis by the viral replicase complexes The ... trees These programs were run using the Jumble option to test the trees using 50 different, randomly generated orders of adding the different sequences In addition, DNAPENNY (parsimony by brand -and- bound...
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Báo cáo sinh học: " Susceptibility of different leukocyte cell types to Vaccinia virus infection" potx
... recombinants and performed viral infections and participated in the drafting of the manuscript LS and GR performed the preparation of PBLs, carried out the flow cytometry and elaborated the data ... pathogenicity of poxviruses remains to be further investigated Comparison of the patterns obtained with the two virus strains and their TK(-) mutants indicate that both the virus strain and the TK phenotype ... influence the infection rate of PBL cells Those might include a variety of such as the accessibility and amount of receptors, ability to internalize the virus, and the metabolic state of the cell...
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báo cáo hóa học:" Effect of different cuff widths on the motor nerve conduction of the median nerve: an experimental study" doc
... before and following the application of the two cuffs was calculated by dividing the distance between the two stimulation sites by the difference in the onset latency proximal and distal to the ... following the application of the 14 cm and cm Mean Mean values of the percentage MNCV at different time durations before and following the application of the 14 cm and cm cuff A decrease in MNCV ... followed by either of the two cuffs Page of (page number not for citation purposes) Journal of Orthopaedic Surgery and Research 2008, 3:1 Discussion The primary aim of the study was to investigate the...
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báo cáo hóa học:" Comparisons of the M1 genome segments and encoded µ2 proteins of different reovirus isolates" doc
... Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates The start and stop ... plus-strand copies of each genome segment These plus-strand RNAs are used as templates for translation by the host machinery as well as for minus-strand synthesis by the viral replicase complexes The ... trees These programs were run using the Jumble option to test the trees using 50 different, randomly generated orders of adding the different sequences In addition, DNAPENNY (parsimony by brand -and- bound...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008