... name indicating whether this person was known to the participant and another box to indicate whether this person was involved in professional contacts so far Knowing each other was defined inthe ... embedded inthe network, most notably with respect to their prominence and influence inthe network The aim of this study was to examine the connectedness in a newly established regional ParkinsonNet ... ParkinsonNet therapists by neurologists, enabling each therapist to attract a sufficient number of patients to maintain and increase expertise; optimal communication within the network via the internet,...
... on mapping the EQ-5D index in another disease area, disease specific measures for thediseasein question may also be important The mapping exercise was initially performed withthe EQ-5D index ... mapping clinical measures on to the EQ-5D index explained 37% of the variability inthe EQ-5D index and also performed poorly in individuals with EQ-5D index values of about 0.4 or less [15] Other ... from the estimation dataset are described in Tables and There were 1106 records inthe estimation data with non-missing covariates inthe final model The variables inthe base model - age, sex and...
... gabapentin inpatientswith HCV [55] These findings suggest that valproate can be used for some patientswith HCV without adversely affecting ALT levels Obtaining pretreatment baseline ALT levels in ... shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution inpatientswith ... influencing obesity in bipolar patients include nutrient intake and physical activity In assessing the nutrient intake of persons with bipolar disorder, Elmslie and colleagues found that they had increased...
... participated inthe design of the study and assisted inthe drafting of the manuscript VL participated inthe design of the study and assisted inthe drafting of the manuscript CM participated inthe ... detection utility and accuracy [16] The present study was designed to examine the underlying factor structure of the Chinese version of the HADS in a mainland Mandarin-speaking population of patients ... artifactual of the original translation process, which may also explain inconsistencies between the underlying factor structure of the instrument between Mandarin-speaking Chinese CHD patientsinthe current...
... to reduce the number of missing scores inthe SF-6D; imputing a value for missing items in a SF-36 domain using the mean value for that domain This way, the amount of missing scores inthe SF-6D ... contributions to the total score This is the case for the domains pain and mood/mental health However, the content and weights of the other domains show considerable differences, withthe EQ-5D giving more ... [18] The ceiling effect of each domain was assessed by computing the percentage of patients reporting no problems To reduce the number of missing scores inthe SF6D, we imputed missing items in the...
... zygapophyseal joints inpatientswith AS [10] Inthe present study, we first examined whether inflammation inthe spine of patientswith AS, as detected by histopathology, can be correlated with bone ... illustration of the anatomy and detection of inflammation inthe bone marrow The entire lumbar spine including the zygapophyseal joints and, if available, the thoracic spine was analyzed for increased ... joints were cut into thin slices (3 to mm) with a saw and fixed in 4% buffered formalin After decalcification with EDTA, sections to µm thick were prepared and stained with hematoxylin and eosin...
... this is sustained The findings further indicate that the use of US imaging of the foot would be more beneficial than clinical examination alone inthe refinement of diagnosis andthe implementation ... secondary care inthe UK In addition, a sample of patientswith RA at the same stage of treatment was investigated Furthermore, patient reported clinical outcomes including disease activity and foot ... regress within the forefeet In previous work, within the MCP joints of the hands a reduction in sonographically detectable synovial hypertrophy was noted at eighteen weeks following infliximab therapy,...
... working within the existing structure of the network as we conducted the intervention Our original intent was to use a lagged design, introducing the intervention to the comparison half of the ... measure their perceptions of organizational readiness to change, and discussed the aggregate findings inthe context of preparing system change They were trained inthe installation and use of reminders ... only inthe intervention hospitals The reminders were installed inthe intervention hospitals within a month after the kickoff meeting, although there was considerable variation among the intervention...
... working within the existing structure of the network as we conducted the intervention Our original intent was to use a lagged design, introducing the intervention to the comparison half of the ... measure their perceptions of organizational readiness to change, and discussed the aggregate findings inthe context of preparing system change They were trained inthe installation and use of reminders ... only inthe intervention hospitals The reminders were installed inthe intervention hospitals within a month after the kickoff meeting, although there was considerable variation among the intervention...
... determined from the kinetic rate constants (ka and kd) The binding curves were processed by double referencing and were globally fitted to a 1:1 binding model The stoichiometry of binding was ... withclinicaldisease activity in SLE [39] and RA [25] Levels of BLyS have been shown to increase during anti-CD20 mAb-mediated B-cell depletion inpatientswith both SLE and RA, and to decline ... role in regulating diverse aspects of immune function, including mediating inflammatory responses and facilitating adaptive immunity [9-11] The binding of BLyS and APRIL to TACI, BCMA, and BAFF-R...
... from the repositioned diaphragm and heart; theheart compresses the dorsal lung when supine and rests on the sternum when prone [1] Thirdly, the supine position predisposes to airway closure inthe ... improves gas exchange to a clinically meaningful extent in most patientswith ARDS when they are turned to the prone position [3,4] Obese patientsand those with congestive heart failure also benefit ... protects better against ventilator-induced lung injury [8] Clinical experience Prone positioning has improved arterial oxygenation in all studies inpatientswith ARDS that have examined the question,...
... of septic shock Katherine G Craig and Keith R Walley The debate surrounding the use of corticosteroids in septic patients has continued for over 30 years Two metaanalyses inthe mid-1990s seemed ... powered, randomized, controlled trials is confined to the most severely ill [12–15] This does not fit withthe patient described inthe aforementioned scenario Clinical case In view of conflicting ... beneficial) and newer, yet preliminary, The patient described inthe present scenario is improving in all aspects of organ failure, but remains catecholamine dependent A thorough examination and review...
... used intravenous and enteral antibiotics (including amphotericin) to achieve decontamination of the gastrointestinal tract for the purpose of possibly decreasing bacterial inoculation of the necrotic ... there is no definitive, level one, data supporting the use of intravenous antibiotics inthe treatment of patientswith severe pancreatitis, even inthe setting of pancreatic necrosis The few prospective ... [12] Among 92 patientswith infected pancreatic necrosis, 22 had Candida infections and this subgroup had a major increase in mortality (64%) compared with those patients without Candida (19%,...
... encountered in real-world settings Furthermore, the findings reported here should also be interpreted within the context of the open-label study design Additional limitations include the lack of ... enrolled inthe study, 106 patients (69.2%) were compliant with treatment During the 12-week switching period, no patients received diphenhydramine and five patients received lorazepam for the treatment ... aripiprazole to their previous medication(s), as assessed using the preference of medication scale scores during the switching treatment phase This finding, coupled withthe improvement in QOL ratings,...
... is the principal investigator who assisted in designing the ATLAS study WPM is the principal investigator and assisted in designing the Canadian M03-606 study RW and HK assisted in designing the ... radiographs of the lateral cervical and lumbar spine inpatientsinthe OASIS andthe adalimumab cohorts were scored using the mSASSS scoring method [17,18] Radiographs from the OASIS cohort andthe adalimumab ... withclinical measures of disease activity at baseline or changes from baseline inclinical measures of disease activity Changes in mSASSS were correlated with baseline scores on several clinical...
... demonstrated the involvement of the Notch pathway inthe development of glomerular disease [15] In summary our finding that ADAM10 is expressed in podocytes and found in elevated levels inthe urine of patients ... not only in tubular cells but also in immortalized human podocyte cell line andin primary podocytes isolated from urine of patientswith glomerular diseaseInthe urine of patientswith acute ... for the discovery of biomarkers useful for the early detection of kidney diseases and for the monitoring of treatment We did not find significant differences inthe amount of L1 in urine and urinary...
... cure for all bleeding Sandro Scarpelini and Sandro Rizoli We understand theclinical scenario and debate question as whether one should administer a drug outside its licensed indications (off-label) ... erosions, withthe arguable exception of a sketchy report [17] In other gastrointestinal bleeds, there are two RCTs (discussed above and found no clinical benefit) and case reports/series in Crohn’s disease, ... Particularly in gastrointestinal bleeding, RCTs have contradicted many initial expectations and demonstrated no clinical benefit of rFVIIa In 2004 RomeroCastro and coworkers [15] reported that all 10 patients...
... Without remaining findings (complete correction) 1.2 With minimal findings 1.3 With clinically significant findings 1.4 After palliative interventions: 1.4a 1.4b Group With seperation of the circulations ... expected in this setting Recommended types of exercise include interval training at moderate intensity, e.g., ball games and running games, or moderate stamina training Their afterload reducing effect ... the pacemaker pocket damaged in contact sports Extreme stretching of the arms, as for example in hanging from and swinging on the still rings, may, in an unfavorable scenario – such as when the...
... reduced inthe circulation and enriched inthe inflamed joints of patientswith chronic rheumatic diseases In total, 192 patientswith different chronic rheumatic diseases were included in this ... between the different diseases Also, a relative increase of this population inthe joint in comparison with R342 the circulation was observed in all patient groups These are interesting findings with ... represented inthe inflamed joint, thus providing a possible way for the immune cells of the joint to avoid being regulated In addition, low levels of IL-2 inthe joint could influence the function of the...