city and the corresponding crime of the founder of rome
Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins ppt
... on the presence or absence of a cytosine at position )5 in the RNA A likely explanation for the importance of the )5 cytosine mutation is offered by the observation that the amino group of the ... are located in a double-stranded region of RNA, and not interact with the protein [54], yet the disruption of the helix clearly affects the binding energy The effect of these changes in RNA conformation ... the 71 other protein–RNA complexes in our training set Figure shows the final example, a universally conserved component of the core of the signal recognition particle (SRP) The structure of the...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... Tyr These mutations may influence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the ... formation of semisynthetic b-lactam antibiotics The X-ray structure of the complex of PA with PAA shows that the acyl binding site of PA is made up of several hydrophobic residues from the a and the ... The subscripts AD and P refer to the acyl donor and product, respectively The speci city (kcat/Km) of PA for the produced antibiotic is in general 10-fold higher than the speci city for the corresponding...
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Studying the status of asthma in students at primary and secondary schools in Thai Nguyen city and the effectiveness of controlling asthma with ICS + LABA
... Of which, the rate of BA in male pupils is 10.4% and is higher than that of female pupils (8.6%) (p
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Báo cáo khoa học: Hybrid reuteransucrase enzymes reveal regions important for glucosidic linkage specificity and the transglucosylation / hydrolysis ratio pptx
... present in the glucan binding domains of GTFA and GTFO [4,5]; black and white bars, predicted locations of the a-helices and b-strands, respectively, corresponding to the relative position of these ... precisely the role of these two different regions and their amino acid residues in glucosidic linkage speci city The ratio of glucosidic linkages in the oligosaccharide and polymer products of these ... catalytic domains of the GTFA and GTFO reuteransucrases are the main determinants for glucosidic linkage speci city Within these N-termini, the A1 ⁄ A2 and O1 ⁄ O2 parts of the reuteransucrase...
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Emerging Epistemic Landscapes: Knowledge Clusters in Ho Chi Minh City and the Mekong Delta pptx
... Interestingly, the 600km waterway network links Ho Chi Minh City with Can Tho City and Ca Mau, the most southerly part of Vietnam, on the one hand, and Ho Chi Minh City with Can Tho City and Ha Tien, ... development of southern Vietnam, the importance of the emergence of knowledge clusters in these regions is evident Statistical data shows that the GDP of Ho Chi Minh City contributes one quarter of the ... City, home to the most important university in the Mekong Delta, attracts most of the students in the region, although it is the home province of only 20% of the city s university students; the...
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Tài liệu The King''''s Post Being a volume of historical facts relating to the Posts, Mail Coaches, Coach Roads, and Railway Mail Services of and connected with the Ancient City of Bristol from 1580 to the present time pdf
... farmer of the Post Office, furnished to the Secretary of State "a perfect list" of all officers in the Post Office According to this list there were eight Clerks of the Roads, viz.:—Two of the Northern ... (Extension of Head Post Office).[Pg 15] Certain lands, houses, offices, buildings and premises situate in the parish of St Werburgh, in the city and county of Bristol, in the county of Gloucester, and ... so cheap that the cost of conveyance was only a small item in the expenses of the Post Office The Mayor of Bath proposed the toast of "the Visitors," and said that they had amongst them two representatives...
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Tài liệu Báo cáo khoa học: Substrate specificity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola ppt
... 72% and 85% inhibition of BHLmL2 and BHAb, respectively, while mm 2-mer- captoethanol caused 85% and 97% inhibition of BHLmL2 and BHAb, respectively The influence of pH on the activities of the ... resulted in 55% and 51% loss of the initial activities of BHLmL2 and BHAb, respectively These results strongly suggest that Ser is involved in the catalytic activity of BHLmL2 and BHAb and are consistent ... The substrate saturation curves of both BH enzymes were determined in the presence of increasing concentrations of brassinin (Fig 4), and the corresponding kinetic parameters, calculated on the...
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Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt
... investigation of the catalytic mechanism and substrate speci city and to understand the differences therein for this class of enzymes In order to identify the subsites of the ervatamins and to understand ... [27,35] and other members of the papain family, and is made up of two domains, L and R, with a V-shaped active site cleft at the interface of the domains (Fig 1) Substrate speci city and activity of ... backbone of residues 65–64 and is partly exposed to the solvent (Fig 2B) On the other hand, the P3 moiety of E-64 in each of the of the two ervatamin-C molecules in the asymmetric unit mainly...
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Tài liệu Báo cáo khoa học: The role in the substrate specificity and catalysis of residues forming the substrate aglycone-binding site of a b-glycosidase docx
... details about the role of different residues of the aglycone-binding site in the stabilization of ESà and the interdependence between the binding of aglycone and the positioning of glycone in ... and M453 are part of the aglycone-binding site of Sfbgly and interact with the initial pentyl moiety formed by methylene groups to of the alkyl-type aglycones On the other hand, the binding of ... purposes, the glucose unit forming the non-reducing end of the aglycone was called the ‘first glucose unit’ and the other glucose units were sequentially named in the direction of the reducing end of the...
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Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... consequence of the mutagenic replacements Effects of the His120Asn and His145Asn mutations on the affinity of metal binding to arginase II To further examine the effects of the His120fiAsn and His145fiAsn ... and His145, and the corresponding His101 and His126 in arginase I, were described among the ligands for coordination of Mn2+A and Mn2+B, respectively [9,24] However, the volume of the active site ... Mn2+ for 10 at 60 °C and assay in the presence of added mm Mn2+, all of the enzymes were active and measured activities were essentially equal to the initial activity of the corresponding fully...
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Báo cáo khoa họcRe-engineering the discrimination between the oxidized coenzymes NAD+ and NADP+ in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme specificity of the wild-type enzyme docx
... of product before the steady state is reached: the presence or absence of a burst provides information on the position of the ratelimiting step along the reaction pathway, and the amplitude of ... analysis conrmed the identity of the contaminant Comparison with the spectrum of an authentic NAD+ sample revealed total similarity of the fragmentation pattern The negative portion of the spectrum ... contamination on these results Reassessment of the effects of the mutations on coenzyme specicity In view of the dramatically altered gure for the stringency of coenzyme specicity in clostridial...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... determinants of the presence of Zn(II), and therefore of the Zn- or Cu-thionein character of the polypeptides Hence, the two full-length peptides, CeMT1 and CeMT2, give rise to mixtures of complexes, ... stoichiometry and the homogeneity of their preparations These differences are a result of the different coordination capacities of the respective C-terminal moieties and are attributable to the four ... reported for the native and recombinant Cd(II)–CeMT2 isoform [16,20] The slight blueshift of the spectrum of Cd6Zn1–CeMT1 in relation to that of Cd6–CeMT2 is attributable to the influence of the Zn(II)...
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Báo cáo khoa học: Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2 potx
... transporter to the internal membrane side is the rate-limiting step and not – as proposed for most of the other electrogenic symporters – the return of the unloaded transporter to the outside of the membrane ... interpreted as the first evidence for a restricted velocity in the translocation step of the loaded transporter by the sterical conformation of the substrate The introduction of polar side groups in the ... includes not only the amino acids glycine, alanine, serine and proline but also osmolytes such as sarcosine and betaine, and the D-enantiomers of serine and alanine The apparent affinities of PAT1 substrates...
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Báo cáo khoa học: Relation between domain evolution, specificity, and taxonomy of the a-amylase family members containing a C-terminal starch-binding domain pot
... cluster of Bacillus and Thermoanaerobacter CGTases and the remaining enzymes The positions of the two CGTases from K pneumoniae and Nostoc sp PCC-9229 are, however, in agreement with the values of ... domains A and B (Fig 3B) are similar to each other and in good agreement with the complete-sequence tree (Fig 3A) In the group of CGTases produced by the genera Bacillus and Thermoanaerobacter (the ... cluster of Bacillus and Thermoanaerobacter CGTases (Fig 3B) Thus for the SBD tree there is not an obvious border between the hydrolases and transglycosidases, but rather there may be one between the...
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THE DREAMING CITY GLASGOW 2020 AND THE POWER OF MASS IMAGINATION potx
... in the triumphalist declarations of the birth of the ‘new’ and death of the ‘old’.14 THE BOOSTER CITY. Like that of many of its peers, the story of late twentiethcentury Glasgow is of a city and ... that the official future scored low on coherence and fidelity People feel that the values and beliefs of the main official institutions of the city are not the same as the values that they hold themselves ... understanding of the everyday storymaking capacity of people and cities —64— PART THE POWER OF STORY —65— THE DREAMING CITY GLASGOW 2020 AND THE POWER OF MASS IMAGINATION ‘What, Glasgow? — The city, ...
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Assessment of the Implementation of Maternal and Child Health Services of Rural Health Units in Tarlac City docx
... of the System of Implementing the MCH Services The Health workers assessed the implementation of the health services in terms of the adequacy of budget and supplies, adequacy of the workers and ... availing of the health services, the highest response was lack of medicines and health facilities This could be the wishes of the mothers who were not convinced of the adequacy of the MCH services and ... time to go to the health centers This may result to the lack of knowledge of the mothers of the potential dangers of not seeking professional health services during their pregnancy and the detrimental...
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Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf
... with the O atom of the main chain CO group of the TrpB240; Ng1 shares H bonding with O atom of the CO group of LeuB387 together with O atom of c-OH of SerB386; Ng2 is in H bonding with Od1 of AsnB241 ... COO– in the aminic part determines the position of the substrate within the S1¢-binding subsite O atoms of the main chain CO groups of LeuB387 and TrpB240, Od1 atom of AsnB241, and Oc atom of SerB386 ... presence of a single roughly conical groove, the hydrophobic part of which accommodates the phenylacetyl moiety of the ligands The more polar aminic moiety resides in the open part of the groove,...
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Báo cáo khoa học: Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7 Identification of a critical aromatic amino acid residue at position 33 doc
... experiments The film was exposed for four days in the case of UGT2B4 and UGT2B4F33Y and for one week in the case of UGT2B4Y33L (Table 1) In the case of 4-hydroxyestrone and 17-epiestriol, the Km values of ... speci city of UGTs 2B4 and 2B7 in order to better understand the molecular basis of substrate recognition and catalysis by these enzymes Attention was paid to amino acids at the N-terminal end of these ... in the substrate speci city of the isoform Importance of amino acid residue tyrosine 33 in the substrate speci city of UGT2B7 The wild-type UGT2B7 efficiently glucuronidates 17-epiestriol and...
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Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx
... demonstrated that the two hydroxyl groups of the catechol moiety bind to the catalytic iron [16–18] Despite the similarities between TH and PAH regarding the structure of the active site and the catalytic ... atom may be placed between the ring of the amino acid substrates and the active site iron, the maximal distance dTyr-Fe or dPhe-Fe between the center of the ring and ˚ the iron atom was defined ... monodentate and other binding modes to be included in further analysis Results Pterin binding to the catalytic domains of PAH and TH Docking of the native cosubstrate BH4 into the crystal structure of the...
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