chronic inflammation and pathogenesis of gi and pancreatic cancers
Báo cáo y học: " Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively" docx
... Journal of Inflammation 2009, 6:6 Introduction The risk of death from all causes enlarges throughout the range of moderate and severe increase of body weight for both men and women in all ... without IR and young obese individuals with IR, jj) the correlation between the http://www.journal -inflammation. com/content/6/1/6 entity of VAT and SAAT deposition and the severity of HS, all of them ... assessment of IR (HOMA) cut-off (>or = 1.95 as insulin resistant) [16] Exclusion criteria were a history of infectious chronic diseases including hepatitis B and C, neoplastic and/ or haematological...
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Báo cáo y học: "T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation" pdf
... injury and in loss of self-tolerance as the biological system ages Senescent T cells: facilitators of inflammation Expansion of CD4+ and CD8+ T cells that have lost the expression of CD28, and are ... (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells Clin Exp Immunol 1998, 114:113-118 Markovic-Plese S, Cortese I, Wandinger KP, ... pressure from memory cells and a breakdown of distinct naive and memory cell compartments Also, the phenotypic distinction of naive and memory cells based on CD45 isoforms, which is relatively...
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Báo cáo y học: "The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation" pps
... 253)) 320- and 242-bp fragments of the TNFR1 and TNFR2 receptors from rat brain and monocyte cDNA, respectively (gifts from Adrian Bristow, National Institute for Biological Standards and Control, ... cells in the maintenance of chronic pain states The analgesic efficacy of anti-TNF therapies in human arthropathies attests to the importance of TNF in the pathogenesis of chronic arthritic pain ... linearised and were transcribed with DIG-UTP RNA mix (Roche, Basel, Switzerland) In situ mRNA hybridisation was performed on 10 µM sections of DRG from naive rats and days after the induction of inflammation...
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Influence of CD137L reverse signaling on myelopoiesis in acute and chronic inflammation
... 1.12 Immuneaging, inflammation and myelopoiesis 31 1.12.1 Mechanism and consequence of immuneaging 32 1.12.2 Intervention of immuneaging 33 1.13 Aim and scope 34 CHAPTER MATERIALS AND METHODS ... Illustration of bidirectional signaling of CD137 and CD137L on APC and T cells Figure 1.3: Illustration of reverse signaling of CD137L on monocytes, DCs and macropahges Figure 1.4 Illustration of the ... Illustration of bidirectional signaling of CD137 and CD137L on APC and T cells APC: Antigen Presenting Cells (Shao and Schwarz 2011) 15 1.7 Reverse signaling of CD137L on APC 1.7.1 Importance of understanding...
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Role of h2s in acute and chronic inflammation
... of H2S in inflammation most likely depends on the actual experimental conditions and the concentration of H2S at the site of inflammation [6] Apart from the H2S concentration at the site of inflammation, ... expression and reduced H2S biosynthesis in the models of high fat fed and endotoxin tolerant mice These results give us an insight into the roles of H2S during the early stages of atherosclerosis and ... of H2S……………………………………………………………….3 1.4 Biological effects and physiological functions of H2S……………………………4 1.5 Research Objectives……………………………………………………………….8 CHAPTER 2: Effects of administration of...
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Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta
... C57BL/6 and BALB/c 86 background strains could both be induced to develop robust allergic lung inflammation Induction of allergic lung inflammation Naïve mice were injected i.p at day and day ... Recruitment of CD4 T cells, B lymphocytes, and CD11c+ dendritic cells to the peribronchial space was also normal Our results show that the initiation and effector phase of allergic lung inflammation ... induction of allergic lung inflammation in LTβ and CCL21/CCL19 deficient mice We found that both kinds of mutant mice mounted normal or enhanced Th2 responses as measured by eosinophil recruitment and...
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Tài liệu Transmission and Pathogenesis of Tuberculosis docx
... details about pathogenesis of latent tuberculosis infection (LTBI) and TB disease are described in Figure 2.3 Figure 2.3 Pathogenesis of LTBI and TB Disease Area of detail for boxes 2, 4, and Droplet ... meningitis Tuberculous meningitis is often seen at the base of the brain on imaging studies Symptoms include headache, decreased level of consciousness, and neck stiffness The duration of illness ... Chapter 2: Transmission and Pathogenesis of Tuberculosis 42 References American Thoracic Society and CDC Diagnostic standards and classification of tuberculosis in adults and children Am J Respir...
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Medical and Psychosocial Aspects of Chronic Illness and Disability pptx
... OF CHRONIC ILLNESS AND DISABILITY Impact of Chronic Illness and Disability .1 Disease and Illness Impairment, Disability, and Handicap Stress in Chronic Illness and ... focus of the book is to help professionals and students understand medical and psychosocial aspects of chronic illness and disability and how they affect an individual’s functioning in all areas of ... Functional Aspects of Chronic Illness and Disability 20 Psychological Issues in Chronic Illness and Disability 20 xi XII MEDICAL AND PSYCHOSOCIAL ASPECTS OF CHRONIC ILLNESS AND DISABILITY Lifestyle...
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Báo cáo khoa học: Tumor suppressor p16INK4a ) modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells ppt
... -III, -V and -VI genes and abolishment of transcription of the b4GalT-IV gene [32] Second, comparison of DNA microarray-based expression profiles between specimens of pancreatic cancer and normal ... of p16INK4a ´ S Andre et al Fig Quantitative profiling of N-glycans Complete representation of the N-glycan profiles of mock- and p16INK4a-transfected pancreatic carcinoma cells and their molar ... Dan-G pancreatic cancer cells without and with p16INK4a expression Of note, these two cell lines give insight into the specificity of the effect as a result of their differences in the status of...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... apoptosis in the pathogenesis of RA Results GM-CSF induces the proliferation of MH7A cells and the expression of MLN51 Our recent study has shown that GM-CSF is involved in the proliferation of primary ... presence or absence of 10 lgÆmL)1 of a-amanitin for 20 h (A), 25 lgÆmL)1 of cycloheximide (CHX) for 20 h (B) and 20 lM MG-132 for h (C) The expression of MLN51 was assessed by RT-PCR and western blot ... transcriptional and post-translational control; (3) FLIP expression is induced; and (4) this results in the anti-apoptotic proliferation of FLS, contributing to the pathogenesis of RA (Fig 6) MLN51 and MLN51-induced...
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NUTRITIONAL ASPECTS and CLINICAL MANAGEMENT of CHRONIC DISORDERS and DISEASES doc
... Prevention and Treatment, Jana Parízková and Andrew Hills Alcohol and Coffee Use in the Aging, Ronald R Watson Handbook of Nutrition in the Aged, Third Edition, Ronald R Watson Vegetables, Fruits, and ... visiting professor at the Universities of Cape Town, Tel Aviv, and Lyon, and at the Pasteur and Weizmann Institutes He is a fellow of the American Association for the Advancement of Science and of the ... aspects of trauma and postsurgical care in Chapter 10 They analyze stress and the stress response in relation to surgical stress, the determinants of the host response to stress, and the role of cytokines...
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Economic Implications Of Chronic Illness And Disability In Eastern Europe And The Former Soviet Union pptx
... Characteristics of the Panel and Full Samples Incidence of No and Full Limitations by Domain of Physical Functioning Correlation of Scores for Domains of Physical Functioning Disability and Physical ... Measures of Disability and Physical Functioning Correlations of Alternative Measures of Disability to Official Disability Status Probability of Having Official Disability Status Consumption and Disability: ... Predictors of Less-than-Good Health Status Predictors of Employment Predictors of Less-than-Good Health Status of Males Predictors of Less-than-Good Health Status of Females Predictors of Employment of...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... models have shown that chronic treatment with a subset of NSAIDs (e.g ibuprofen, flurbiprofen, indomethacin) reduced brain inflammation and Aβ levels in addition to the deposition of Aβ in brain [13,14] ... M, Metter EJ: Risk of Alzheimer's disease and duration of NSAID use Neurology 1997, 48:626-632 Neuroinflammation Working Group: Inflammation and Alzheimer's disease Neurobiol Aging 2000, 21:383-421 ... Biological) Brain Aβ1-40 and Aβ1-42 levels Sequential extraction of brain samples was performed with high-salt buffer and formic acid, respectively to measure soluble and insoluble Aβ1-40 and...
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báo cáo hóa học: " Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions" pptx
... distinct regulation of pro- and secreted IL-16 in acute, subacute and chronic MS lesions, and in normal-appearing white matter, from brain and spinal cord of 39 patients with MS and 19 normal controls ... inflammation and subsequent tissue damage in MS remain largely unexplored In this study we investigated correlations between the regulation of IL-16, regulation of CD4+Th1 inflammation, and inflammation- induced ... acute to subacute and chronic lesions [5] In brain lesions, levels of T-bet were almost equally high in acute and chronic lesions, and corresponded to similarly high levels of secreted IL-16...
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Health and Quality of Life Outcomes BioMed Central Editorial Open Access Chronic fatigue and doc
... fatigue, and ultimately to chronic fatigue and chronic fatigue syndrome? Or is CFS a distinct disease entity not only quantitatively different (in degree of fatigue, functional impairment and additional ... estimations of CFS prevalence in epidemiological studies only of CFS This would mean that valid epidemiological studies of CFS in the general population without clinical evaluation of the subjects ... finding is that only one third of the CFS subjects retained the classification of CFS at one year follow-up, and only 21% at and years follow-up And, most striking, only of the 40 (8%) subjects sustained...
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INFLAMMATION, CHRONIC DISEASES AND CANCER – CELL AND MOLECULAR BIOLOGY, IMMUNOLOGY AND CLINICAL pdf
... of a wide range of diseases and many cancers, particularly in an aging body Understanding the fundamental basis of shared and interrelated features of unresolved inflammation in the genesis and ... subclinical) inflammation and longevity are known as comorbidity and co-mortality risk factors in the genesis and progression of nearly all chronic 12 Inflammation, Chronic Diseases and Cancer Cell and ... that Inflammation, Chronic Diseases and Cancer Cell and Molecular Biology, Immunology and Clinical Bases inflammation is a common denominator in the genesis and manifestation of a wide range of...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... incidence and prevalence of eosinophilic esophagitis J Allergy Clin Immunol 2008, 121(2):S71 Furuta GT, Straumann A: Review article: the pathogenesis and management of eosinophilic oesophagitis Aliment ... degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases Blood 2000, 95(6):1911-7 Rothenberg ME: Biology and treatment of eosinophilic esophagitis ... subsets and can be found in a variety of tissues, including epithelial and mesenchymal tissue [20] bFGF increases the half-life of cells and could possibly increase the overall lifetime of the...
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Báo cáo y học: "Increased expression of FcγRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus" ppsx
... design and data interpretation, and assisted in patient recruitment and preparation of the manuscript HBR conceived of the study and coordinated patient recruitment, data analysis and preparation of ... important to the pathogenesis of ICmediated nephritis in SLE Elevated production of IFNα and IFNγ in SLE may induce the expression of FcγRI/CD64 monocytes and facilitate the infiltration of these cells ... presence of the protein transport inhibitor GolgiStop™ (BD Pharmingen) In all cases, cells were incubated at 37°C in a 5% CO2 atmosphere for hours The dose of LPS and CRP and the length of incubation...
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Báo cáo y học: "β Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis" ppt
... (Geneva, Switzerland) Water and food were provided ad libitum and all experiments were approved by the Institutional Animal Care and Use Committee of Switzerland Induction and treatment of arthritis ... then embedded in paraffin and 5-µm sagittal serial sections of whole hind paws were cut and stained with hematoxylin and eosin and examined for the degree of synovitis and bone erosions by microscopic ... standard error of the mean expression of IL-6 and of TNF-α was decreased (50% and 55% respectively) in mice treated with 2.5 µg IFN-β for days in comparison with saline-treated mice (P = 0.02 and...
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báo cáo khoa học: "Concurrent insulinoma and pancreatic adenocarcinoma: report of a rare case and review of the literature" pdf
... of pancreatic adenocarcinoma and insulinoma is very rare and has never been reported before Clinical symptoms should be evaluated carefully and since imaging modalities have low sensitivity and ... acquisition and interpretation of data, and he drafted the manuscript EK performed the appropriate histological analysis of the surgical specimens and provided histological sections as figures for the ... the coexistence of insulinoma and gastrointestinal stromal tumours especially in patients with neurofibromatosis type I [10] However, the concurrence of pancreatic adenocarcinoma and insulinoma...
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