check if the chosen core size in step 1 is not too high
Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc
... hydrophobic core (M88V) and the other in the protein–RNA interaction (T45S), decrease the stability of the capsid Our findings illuminate the role of packing in the icosahedral lattice of the virus ... of the residue (% 59 A2) and in the interactions occurring there (Fig 8) Met88 resides in the 14 2 S M B Lima et al (Eur J Biochem 2 71) Fig Binding of bis-8-anilinonaphthalene -1- sulfonate (bis-ANS) ... leaving any hydrophobic cleft for bis-ANS binding High pressure is well known to denature proteins to partially folded states [15 ,17 ,38,48–50] The large increase in bis-ANS binding when the T45S...
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Báo cáo khoa học: Structural diversity in lipopolysaccharide expression in nontypeable Haemophilus influenzae Identification of L-glycero -D-manno-heptose in the outer-core region in three clinical isolates potx
... 960.9 12 48.8 14 10.6 15 72.6 17 34.8 19 38.4 14 38.0 15 99.6 17 61. 8 19 23.8 12 49.0 14 11. 2 15 73.3 17 35.4 19 38.6 14 38.2 16 00.4 17 62.5 19 24.6 Tracea 70 Trace ND Trace 16 ND 80 11 ND ND 5 30 ND 47 PCho•Hex1•Hep3•PEtn1•AnKdo-ol ... 2,6,7-Me3–Hep 3,4,7-Me3–Hep 1. 04 1. 16 1. 17 1. 19 1. 20 1. 34 1. 41 1.42 1. 48 1. 53 27 37 2 Trace 17 42 28 Trace Trace 17 Trace 17 22 13 5 19 14 D-Galp- (1 a 2,3,4,6-Me4-Glc represents 1, 5-di-O-acetyl-2,3,4,6-tetra-O-methyl-D-glucitol -1- d1, ... fi4)-b-D-Galp- (1 GalIII a-D-Galp- (1 99.2–99.5a 4.99 10 0.3 4. 51 103.9 4.96 10 0.0 4. 51 104.8 4.54 10 3 .1 4.46 10 3.7 4.52 10 3.7 4.96 10 1.0 4 .13 62.7 79.6 4 .16 79.9 3.40 74.3 4 .10 70.5 3.62 71. 7 3. 41 73 .1 3.54...
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Báo cáo khoa học: The chloroplast ClpP complex in Chlamydomonas reinhardtii contains an unusual high molecular mass subunit with a large apical domain doc
... a ClpR6 19 .13 4.4 .11 ClpR4 12 .4.2 .11 ClpR2 56.23 .1. 51 ClpR3 10 5 .11 .2 .11 ClpP5 16 2 .16 .2 .11 ClpR1 24.46 .1. 0 ClpP2 16 .56.2. 51 ClpP4 37 .11 .2 .11 ClpP1 – Best contig in Additional Gene Protein EST assemblya ... loop) This extension has been hypothesized to in uence access to the substrate binding pocket [18 ] Another interesting feature of these proteins is the mutation into a bulkier residue of the second ... folding protein domains capable of selfexcision, and are present in many essential proteins throughout the three kingdoms of life In contrast, the other insertion sequence, IS1 , which is found in...
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Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated doc
... the full-length protein, this modification occurs in the extreme C-terminal tail (residues 670– 711 ) and not in the DNA-binding domain (Fig 6) These results provide another convincing example highlighting ... salient differences in their DNA-binding properties, demonstrating that the glycosylation is neither directly nor indirectly involved in the DNAbinding activity In these experiments, complexes of high ... full-length HIC1 proteins is predominantly localized in the DNA-binding domain (A) Diagram of the HIC1 deletion mutants used in the study The top lane shows the full-length HIC1 protein Zinc fingers...
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Báo cáo hóa học: " Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 binding" pot
... CD 81 binding r egion CD 81 binding r egion Y 618 A L 615 A R 614 A Y 613 A F550A D533A D481A Y474A VSV-G HCV WT 1. E+00 EnvA 1. E+ 01 CD 81 binding r egion Figure substitutions within putative CD 81 binding ... 1. E+07 10 0 1. E+08 76.5 2297 A 1. E+03 1. E+02 CD 81 binding r egion CD 81 binding r egion L 615 A F550A D533A W529A D481A Y474A VSV-G HCV WT 1. E+00 EnvA 1. E+ 01 CD 81 binding r egion 0.2 H 617 A 0.5 0.2 W 616 A ... Putative CD 81 BINDING REGION _ 612 613 614 615 616 617 618 * P * * * * * Y R L W H Y 619 P C Figure Conserved residues within the putative CD 81 binding domains of E2 Conserved residues within the putative...
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Báo cáo hóa học: " A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: Potential impact on CTL epitopes" doc
... 9, 10 , 11 , 12 , 13 , 14 , 15 The analysis of subtype B involves a total of 275 Vpr alleles As expected, the extent of polymorphisms in subtype B is less in comparison to the total polymorphisms noted ... QLLFVHFRV 1. 599 1. 599 458.437 10 6. 613 1. 599 1. 599 15 9.920 1, 492.586 10 11 α Accession No.: A1.TZ. 01. A3 41_ AY253 314 β Estimate of Half Time of Disassociation of a Molecule Containing This Epitope ... 39.353 19 6.763 19 6.763 WLHELGQFI WLHELGQHI WLHELGQLI WLHELGQWI WLHELGQYI 10 82 .19 4 19 6.763 19 6.763 10 82 .19 4 10 82 .19 4 WLHELGQQD WLHELGQQV 0.2 81 1 311 .7 51 α Accession No.: A1.TZ. 01. A3 41_ AY253 314 of Half...
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Báo cáo hóa học: " The synergistic effect of IFN-α and IFN-γ against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin" pptx
... 1x104 IFN 1x103 -16 12 24 36 48 24 36 48 24 36 48 Time (h) (b) 7x104 6x104 Viable Cells 5x104 4x104 3x104 2x104 IFN 1x 1x104 -16 MS 12 Time (h) (c) 7x104 6x104 Viable Cells 5x104 4x104 1x 3x104 ... (10 0)+IFN-γ (10 0) IFN-α (200) IFN-γ (200) Vehicle IFN-α (10 0) IFN-γ (10 0) IFN-α (10 0) + IFN-γ (10 0) IFN-α (200) IFN-γ (200) Vehicle IFN-α (10 0) IFN-γ (10 0) IFN-α (10 0) + IFN-γ (10 0) IFN-α (200) IFN-γ ... ± 11 .5 ± 2.4 52 ± 5 .1 35 ± 4.2 13 3 ± 8.2 68.5 ± 5.9 74.5 ± 6 .1 ± 1. 4 54.5 ± 5.2 84.5 ± 6.5 10 0 ± 7 .1 82.5 ± 6.4 84.5 ± 6.5 19 ± 3 .1 51. 5 ± 5 .1 53 ± 5 .1 1.7 1. 6 3.8 1. 9 1. 2 8.6 1. 9 2.8 1. 9 1. 8...
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Báo cáo y học: " The inflammatory response seen when human omental adipose tissue explants are incubated in primary culture is not dependent upon albumin and is primarily in the nonfat cells" pps
... that of 11 b HSD1 was 0.25 indicating that there is 4-fold more 11 b HSD1 in fat cells than in nonfat cells Interestingly over the 48 h incubation there was a marked increase in 11 b HSD -1 gene expression ... diabetes J Clin Invest 2005, 11 5 :11 11- 111 9 Trayhurn P, Wood IS: Adipokines: inflammation and the pleiotropic roles of white adipose tissue Br J Nutr 2004, 92:347-355 Arner P: Introduction: the inflammation ... additional increases in the mRNAs for IL-8, HIF1a, and 11 b HSD1 in the nonfat cells over the 48 h incubation There was also a significant increase in IL-8 gene expression in isolated fat cells...
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Báo cáo y học: "The anti-cyclic citrullinated peptide response in tuberculosis patients is not citrulline-dependent and sensitive to treatment" ppsx
... synthesized with a C-terminal spacer and biotin tag The 04 01 peptides consist of 18 amino acids with the Cit/Arg at the sixth position, whereas the 0722 peptides consist of 13 amino acids with the ... One of these, 0401Cit and 0401Arg, corresponds to the cfc1-cyc peptide used in the first generation CCP test (CCP1) and its arginine-containing equivalent cf0-cyc [11 ]; the sequence of the second ... one epitope in the citrullinated peptides, for which the citrulline residue is not critically important Instead, the presence of an arginine at the position of the citrulline in these peptides...
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Báo cáo y học: "Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication" doc
... integration step IN is a 32 kDa protein with three distinct structural domains, the N-terminal zinc-binding domain, the central catalytic core domain and the C-terminal domain The catalytic core ... motif(s) in IN important in the induction of the lethal phenotype, various IN mutants, including F1A, K136A, K159P, V165A, A179P, KR186,7AA, KK 215 ,9AA and RK263,4AA, were introduced into HP16 ... could induce the lethal phenotype in the S cerevisiae strain HP16 (MATa ura3-52; his3 1; leu2; trp1Δ63; prb1 -11 22; pep4-3 prc1-407) A yeast expression plasmid encoding the HIV -1 IN cDNA under the...
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Báo cáo y học: " Compartmentalization of the gut viral reservoir in HIV-1 infected patients" ppt
... with the highest frequency in the rectum [23,24] The distribution of the type of T-cells in the GALT is different than the periphery, as 70% of the intraepithial lymphocytes in the small intestine ... pathogenesis in the different tissues This may explain why we did not find any clear differences in sequence motifs in the Nef protein that could be linked to viral pathogenesis or altered protein function ... did not find direct links to pathogenesis in our analyses, the clustering and differing viral diversity of the Nef protein encoding sequences is of interest The Nef protein plays many roles in...
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Báo cáo khoa học: A new sulfurtransferase from the hyperthermophilic bacterium Aquifex aeolicus Being single is not so simple when temperature gets high potx
... Thiosulfate 10 mM Lifetime (ns) Long rotational correlation time (ns) 1. 66 + 1. 41 11 1. 8 14 40 + 1. 57 21 1. 11 20 + 1. 16 25 monomeric The equilibrium was shifted to the dimeric form (14 ns) then to ... underlined Conserved residues involved in substrate binding are in bold The arrow indicates the active-site cysteine constitute the structural core of the protein In b2, the sequence XDXR (X being ... of these peaks as containing the same protein A search for this sequence in the Aquifex proteins database reveals one protein, Aq-477 This protein, encoded by aq477, was annotated as a protein...
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Báo cáo khoa học: "Optimization in Coreference Resolution Is Not Needed: A Nearly-Optimal Algorithm with Intensional Constraints" ppt
... constraints are applied in the linear variant as well, so the only difference is the ordering Linear ordering over pairs is established by sorting according to the index of the first pair element (the ... just within in the window Transitivity without further constraints is pointless.6 What we really can gain from transitivity is consistency at the linguistic level, namely (globally) adhering to ... of IDs There is also no need to explicitly maintain constraint (2), either, which states that a pair is either coreferent or not In the case that a pair cannot be set to (representing coreference),...
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Báo cáo y học: "Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor" docx
... 5 .1 6. 71 0 .1 0.8 3.2 13 .2 6.34 0 2.5 0.4 1. 5 3.4 6.00 0 1. 2 0.3 12 .6 4.43 1 0.9 7.3 0.3 15 .1 7. 91 0 0.4 0 .1 2 .1 5. 41 0 1. 2 0 .1 0 .1 0.6 4.94 2 .1 33 .1 4.6 7 .1 4. 41 1 0 .1 0.6 11 .3 3.6 5.95 1 2 .1 1.2 ... are stained with 2C8 than with mAb1 and mAb 11, indicating that staining with 2C8 is more sensitive than staining with mAb1 and mAb 11, used previously by our group [13 -15 ] The specificity of the ... (0 17 .4) Ns IFN-γa (0–2) (0–2) Ns IL -1 b 0.9 (0 .1 4.9) 1. 2 (0 .1 3.7) Ns IL -1 b 0.6 (0 .1 7.3) 0.8 (0–33 .1) Ns IL -15 neutralizingb 2.7 (0 .1 11 .3) 2.8 (0–6.6) Ns 3.6 (0.4 16 .7) 7.5 (0 15 .1) Ns IL -15 ...
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schechter - the crime of our time; why wall street is not too big to jail (2010)
... Published by: The Disinformation Company Ltd 11 1 East 14 th Street, Suite 10 8 New York, NY 10 003 Tel.: +1. 212 .6 91. 1605 Fax: +1. 212 .6 91. 1606 www.disinfo.com All rights reserved No part of this book may ... notably, the higher the income and the better the credit rating of a black borrower, the more likely the discrimination … Yet, not a peep from the Obama administration about ending this Ku Klux lending ... Complicity 13 1 cHaPtER 12 : Count Three: The Insurers 13 8 cHaPtER 13 : Co-Conspirators: The Role of The Media 14 9 cHaPtER 14 : Warnings Ignored 15 9 cHaPtER 15 : The Bear Stearns “Bleed-Out” 16 6 cHaPtER 16 :...
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The first use of cheese as food is not known
... pH 6.4 The curd is then cut with cheese knives into small pieces and heated to 10 0°F (38°C) The heating step helps to separate the whey from the curd Drain whey The whey is drained from the vat ... plants NY in 18 51 and was started by Jesse Williams who began the mass production due to demand for his • desirable cheese.From this beginning the cheese industry began to flourish In 2003, the top ... starting their production Training in production should then be obtained from an experienced cheese-maker Cheese is preserved by a number of different mechanisms: the raw milk is pasteurised...
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Check Your English Vocabulary for Living in the UK.pdf
... receive housing b t (30 ij) This is money which is paid by the local authority to cover all or part of the rent 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 28 27 29 30 31 32 33 34 35 ... television and radio programmes Unlike other broadcasters, its programmes not have amcmerlosci You cannot go into a betting shop or aignblgm club if you are under 18 10 11 12 13 14 15 16 17 18 19 ... meeting with the Prime Minister 14 Following advice from the Prime Minister, the monarch can popinat people to high positions in the mogternevn, the uhrChc of nndlEag and the mdrae esrocf 15 The...
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Tài liệu In this lab, 2 ISDN routers are required. If ISDN routers are not available, review the lab to become familiar with the process. An Adtran Atlas550 ISDN emulator is used to simulate the switch/ISDN cloud. pdf
... 0.0.0.0 19 2 .16 8.254 .1 Tokyo#configure terminal Tokyo(config)#ip route 19 2 .16 8.2.0 255.255.255.0 19 2 .16 8.253.2 Tokyo(config)#ip route 19 2 .16 8.3.0 255.255.255.0 19 2 .16 8.254.2 Step Specifying interesting ... fastethernet Tokyo(config -if) #ip address 19 2 .16 8 .1. 1 255.255.255.0 Tokyo(config -if) #no shutdown Tokyo(config -if) #exit Tokyo(config)#interface bri Tokyo(config -if) #isdn spid1 510 55 510 0000 01 55 510 00 ... to the chart at the end of the lab to correctly identify the interface identifiers to be used based on the equipment in the lab The configuration output used in this lab is produced from 17 21...
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