cerebral magnetic resonance imaging and ultrasonography findings after neonatal hypoglycemia pediatrics 103 1999
mechanisms of type 2 diabetes
... 2001, it cost $22.8 billion in public and private funds to treat patients with kidney failure Minorities experience higher than average rates of nephropathy and kidney disease Diabetic Neuropathy ... Mechanisms of Action Blood glucose Muscle and adipose tissue ↓ insulin resistance ↑ glucose uptake Liver ↓ ↓ insulin resistance hepatic glucose production Pancreas ↓ demand for insulin secretion ↑ beta-cell ... Mechanism of Insulin Sensitization Inzucchi, 1999; Yale University, unpublished Thiazolidinediones: Mechanism of Insulin Sensitization Inzucchi, 1999; Yale University, unpublished Thiazolidinediones:...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance (7) The vascular and ... Popliteal and pedal pulses were absent bilaterally with poor capillary refill The left foot was red and inflamed up to and including the medial malleolus The lateral aspect of the great toe and second ... 144/67 in second, third and fourth weeks after treatment, and to 128/66 during 6th to 8th weeks post-treatment while the patient was on no medication Her blood sugar was improved and HbA1c was dropped...
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Tài liệu ECCENTRIC MECHANISM OF FOUR-BAR LINKAGE pptx
... 42 Change the view to RIGHT side view, and be sure that both gaps indicated by red circle are same distance The gaps between washer and eccentric; washer and arm Click , then open link.prt Click ... base_asm.asm Click , Enter the name of base_asm OK Click Then open base.prt and assemble it at default location by selecting 16 , and open bushing.prt Place the bushing at the most left hole in the ... assembly Edit -> Repeat etc , and open post.prt Place the post at the most left hole in the base – see Click figure below 18 Perform the Global Interference check and make sure there are NO interference...
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Tài liệu Báo cáo " Mechanism of forming the Dien Bien basin " pdf
... center of the zone and several secondary faults in the south The fault zone cuts through Proterozoic, Paleozoic and Mesozoic sedimentary and metamorphic rocks, also Paleozoic and Triassic granitoids ... of pebble, granule, sand and boulder in the low part, silt, clay mixed with some sand layers in the upper part The last one is composed of pebble, granule mixed with silt and clay Mechanism of ... steeper and dipping eastward; the second, located near the basin center, is gentler 77 and dipping westward Between these groups there is a brittle deformation zone which is subsided and covered...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... missing for Asp35, Asn101, Thr103, Glu104, Tyr108, Phe127, Thr132, Val134, Leu137, Leu140, and Phe153 These resonances were not visible even after denaturation and refolding to facilitate back-exchange ... density maps and facilitate further rebuilding and improvement of the molecular model, until no unexplained electron density remained, and the Rcryst and Rfree values converged at 18.9% and 24.4%, ... Protein–ligand and water-mediated protein–ligand hydrogen bond interactions (broken lines) that stablize the pantoate molecules in site I and site II of nPS Oxygen atoms of pantoate and water...
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Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt
... of Val82 and Tyr85 in the turn (Val82-Asn83Gly84-Tyr85) between the S3 and S4 strands and the hydrophobic side chains of Pro34 and Leu38 N1 and N6 of the base of A20 lie close to Nd2 and Od1 of ... H18 and the X-loop of P horikoshii ArgRS and T thermophilus ArgRS Asn498, Phe499 and Glu500 in P horikoshii ArgRS and Ser464, Phe465 and Glu466 in T thermophilus ArgRS are shown in ball -and- stick ... Arg and the main chain C@O of Ser127 and ˚ O of the side chain of Asn129 are set at 3.15 A and ˚ , and the distances between the guanidinium 3.04 A moiety and the side chain of Glu124 (S5) and...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... proteasome inhibition and TRAIL in osteoarthritic disease and chondrocyte apoptosis, and the hypoxic inhibition of cartilage and chondrocyte degeneration Results Macroscopic and radiographic examination ... proteasome inhibition and TRAIL treatment Fig Proteasome inhibition and TRAIL treatment significantly increased caspase-8 activation and JNK phosphorylation Whole-cell lysates were prepared and total protein ... ALLN and TRAIL increased caspase-8 activation and JNK phosphorylation However, both caspase-8 activation and JNK 7380 phosphorylation were inhibited under hypoxic conditions (Fig 6B) MTP and ROS...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx
... rate constants are similar between NP and MP and 2248 between HP and HPO in accordance with the similar shapes and sizes between NP and MP and between HP and HPO The different Kd values are proportional ... HP and 20 mM GA The reaction was initiated with 10 lM SaDHNA at 25 °C and quenched with M HCl The reverse reaction generated both DHNP and DHMP HP, DHNP, and DHMP were oxidized to HPO, NP, and ... using both DHNP and DHMP as the substrates and the reverse reaction (the formation of DHNP and DHMP) with HP and GA For the forward reaction, three concentrations each for DHNP and DHMP were used...
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Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf
... 1.70 1.29 1.59 activity for both SGAP and the catalytic mutant E131D, resulting in solvent isotope effects of 1.67 and 2.52, respectively, at pH 8; and 2.10 and 2.92, respectively, at pH 6.5 (Table ... (EÆÆS)à), and the bond-breaking ⁄ making step, ES fi (ESÆÆEP)à The measured and calculated thermodynamic parameters of the reaction (i.e free energy, enthalpy and entropy) for both SGAP and the ... catalysis and the mode of inhibition of anions such as fluoride and phosphate Experimental procedures Purification of SGAP The cloning of the SGAP gene, site-directed mutagenesis and the expression and...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... monochromator, and Glan-Thompson polarizers using quartz cuvettes with continuous stirring of the suspension, bandwidths of nm for excitation and nm for emission, and excitation and emission wavelengths ... potential and volume homeostasis of mitochondria Cell 91, 627–637 27 Haugland RP (1996) Handbook of Fluorescent Probes and Research Chemicals, 6th edn Molecular Probes, Inc, Eugene, OR 28 Chandra ... VtA3 on H2O2 production (A) and spore viability (B) after incubation for h Insert in (A) shows H2O2 production as a function of time for lM (n),1.5 lM (s), lM (n), lM (,) and 10 lM (h) of VtA3, whereas...
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Tài liệu Báo cáo khoa học: Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc
... MKN-45 and DLD-1 cells clearly showed doublet bands at approximately 75 kDa and two minor bands at 95 and 110 kDa The conditioned media of HSC-4 and HEK293 cells also showed weak immunoreactive bands ... cell conditioned medium before SDS ⁄ PAGE (lanes and 4) and ⁄ or into the reaction buffer after the SDS ⁄ PAGE and subsequent renaturation (lanes and 4) –, No addition, +, addition Ordinate indicates ... these facts, the 95- and 110-kDa bands in zymography (Figs 3A and 4) and immunoblotting (Fig 3B) are most likely to correspond to the matriptase ⁄ HAI-1 complexes The 95- and 110-kDa gelatinolytic...
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Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt
... of the highly conserved Phe73 and Ser74 in region III of M luteus B-P 26 UPP synthase into Ala resulted in 32- and 16-fold increases in Km value for IPP, and 16- and 12-fold decreases in kcat ... codon TAA, respectively The PCR product was digested with KpnI and SalI, and separated on a 1% agarose gel The desired band was eluted, and ligated into the pBluescript II SK(–) vector, then digested ... Wild-type SRT1 and the mutant Srt1p-delta were digested with KpnI and SalI, subcloned into pJR1133 vector, and digested with the same restriction enzymes to give pJR1133-Srt1p and pJR1133Srt1p-delta,...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... media and growth times: 10 mM glucose + 100 mM acetate harvest after 27 h; 10 mM glucose + 100 mM propionate harvest after 29 h; 10 mM glucose + 100 mM acetate + 100 mM propionate harvest after ... 0.1 U ACS and 50–100 lL diluted medium All components were added with the exception of MDH and citrate synthase and the resulting absorbance at 340 nm was measured (A1) MDH was added and the absorbance ... conditions Carbon and energy sources were: 50 mM glucose; 50 mM glucose and 100 mM sodium propionate; 50 mM glucose, 100 mM sodium acetate, and 100 mM sodium propionate; 100 mM sodium acetate and 100 mM...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... forward and M13 reverse, respectively, and two partial DNA fragments were amplified Subsequently, PCR was performed with these two amplified fragments as the templates and primers, M13 forward and ... the kinetic parameters of wild-type and W402F IPU for panose, mixtures consisting of lgÆmL)1 enzyme and from 43 to 216 mM substrate, and 20 lgÆmL)1 enzyme and 64 to 480 mM substrate, respectively, ... TLC The W402F enzyme liberated isopanose from pullulan, and isomaltose and glucose from panose, and the action patterns of the wildtype and the W402F enzymes were almost identical (Fig 2) The...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... conditions the concentration of L-Met and TPL being 95.23 mM and 2.64 unitsÆmL)1, respectively One-milliliter aliquots were withdrawn after 108, 250, 360, 568, and 754 and treated as above The theoretical ... transformation Values of KSH and kf(H) correspond to KD and kf for the reaction of nondeuterated substrate, and KSD, kf(D) and kr(D) are equal, respectively, to KD, kf and kr for the reaction of ... containing 33.94 mM L-Phe, 0.1 mM pyridoxal-P, and 1.27 unitsÆmL)1 TPL Aliquots (1 mL) of the reaction mixture were withdrawn after 71, 125, 265, 381 and 490 and heated at 90° for to inactivate the...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... MPO, LPO and their intermediates The absorption spectrum of MPO is characterized by an intense Soret peak at kmax ¼ 430 nm and weaker bands at 570, 620 and 690 nm, whereas at 370 nm and 496 nm, ... Montellano, P.R (1999) Spin-trapping and protein cross-linking of the lactoperoxidase protein radical J Biol Chem 274, 35441–35448 52 Goff, H.M & Chen, K (1999) Protein radicals and formation and reactivity ... (430, 572 and 625 nm bands) correspond to the real Cpd II? In such a case, the optical features of Cpd I isomer have to be defined The second hypothesis assigns the 455 and 625 nm bands to this...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... CRI [16] We tested MCA and MAE with increasing concentrations of CRI and found that they were inhibited by approximately 90% with a 24 molar excess of CRI Monomers MSSAE and MSSG could not be ... [18,19], and are completely cleaved by a 10-fold molar excess of dithiothreitol [19] This hyperreactivity is a feature also of the mixed disuldes formed by Cys31 and Cys32 with glutathione [12], and ... quantitation of the dimeric bands identied on the gel (Fig 2) shows that MSSAE undergoes dimerization into native-like BS-RNase in a time-dependent manner, and is ể FEBS 2003 Disuldes and antitumor action...
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Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx
... formation and decomposition of superoxide in the system Superoxide is formed via reaction and decomposed via reactions and The rate of formation depends on the concentration of NAD and oxygen and ... compound I, compound II and compound III are represented as coI, coII and coIII, with ArH and Ar indicating the aromatic compound (4-hydroxybenzoic acid or melatonin) and its free radical, respectively ... (dashed line) and at time 750 s (solid line) after the start of the experiment in (A) (D) Spectra at time zero (dashed line), at time 544 s (solid line), and at time 558 s (dotted line) after the...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... (AUH) and rat liver arginase (1rla) H, S, T and stands for a-helix, strand, turn and 310-helix Conserved residues are marked by an asterisk Identical behaviour was previously described, and confirmed ... ACCTATGCG-3¢) and the 3¢ complementary primer 5¢-AT TAATGGCATGCTTTACCCGT-3¢ Using the PCR products of agmatinase with the GfiA and CfiT substitutions in the coding and noncoding strands, respectively, and ... aligned with the sequences of 1CEV and 1RLA and pasted into the structural alignment The alignment was then corrected by hand Since the sequences of the two arginases and agmatinase greately differ...
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