central nervous system distribution of the poxviral proteins after intranasal administration of proteins and titering of vaccinia virus in the brain after intracranial administration
Cancer of the Brain and Other Central Nervous System doc
... Cancer of the Brain and Nervous System Histologic Type of Tumor Classification NOS, C716 - Cerebellum, NOS, C717 - Brain Stem, C718 - Overlapping lesion of brain and C719 - Brain, NOS; SPINE: C701 ... Cancer of the Brain & Other Central Nervous System: Number of Cases and Exclusions, 12 SEER Areas, 1988-2001 Brain Other CNS Number Selected/ Remaining Number Excluded Number Selected/ Remaining ... Cancer Institute NOS, Not Otherwise Specified 210 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.7: Cancer of the Other Central Nervous System: Distributions and...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... around inflammatory foci in the spinal cord of rats with EAE, thus identifying potential determinants for trafficking of these cells to the CNS These findings are discussed in relation to therapeutic ... areas of the spinal cord displaying focal inflammation and demyelination (Fig 2E) Quantification of CCR1, CCR2 and CCR5 mRNAexpressing cells in relation to the stage of demyelinating activity The ... immunization) of EAE show extensive inflammation involving the white and grey matter (D), with marked demyelination in the inflammatory areas (F) The majority of the infiltrating inflammatory...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... with certain brain tumors, especially for the very young Because of the rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] of the adverse effects of chemotherapy ... Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy N Engl ... children treated with chemotherapy alone (methotrexate injected either intrathecally (into the cerebrospinal fluid) or intravenously and intrathecally) This study and many Journal of Biology 2006, 5:21...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... demyelinated axons, including partial or complete loss of myelin sheaths and increases in inter-laminar splitting of the myelin sheaths Analysis of transverse sections (Figure 9) provided further ... decreased levels of MBP in the CC and in the white-matter tracts of the striatum of treated animals (Figure 10) In agreement with the majority of the cell bodies in the mature CC belonging to oligodendrocytes ... Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemother apy N Engl...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine listeriosis has been reported previously, and the increased expression of iNOS ... brainstem and the staining pattern was similar to those of control brains with nonneurological diseases In the microabscesses, iNOS was recognized in inflammatory cells (mainly macrophages) in ... inflammation In summary, these results suggest that both nNOS and iNOS are constitutively expressed in brain cells, including neurons and some neuroglial cells, and that in the brains of goats with...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... central nervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis of the central nervous system Neurology ... angiitis of the central nervous system: initial and follow-up MR features Neuroradiology 2009, 51:651-659 12 Ay H, Sahin G, Saatci I, Söylemezoğlu F, Saribaş O: Primary Angiitis of the Central Nervous ... described the MRI features GL provided the pathological diagnosis TJ was the surgeon and gave the final approval of the version to be published Competing interests The authors declare that they have...
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Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... boys Again, changes in therapy protocols such as lack of co -administration of high-dose methotrexate and avoidance of radiotherapy in young patients may explain the lack of difference in IQ in our ... below The finding of similar outcomes in males and females is reassuring Initial reports of inferior outcomes in girls came from relatively small studies using combinations of methotrexate and ... effects of treatment Here, we report the results of intelligence tests for patients and controls assessed at baseline and at and year time-points after initiation of treatment Results During the...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... nAuNPs in the cockroach’s brain and to study the interactions between nAuNPs and the brain tissue: hyperspectral Page of imaging, XPS, confocal microscopy, and TEM imaging The Hyperspectral imaging ... a power of 350 W and a base pressure of 10-10 Torr The XPS system was used to verify the presence of the nanoparticles inside the brain by scanning the cryocut and fixed cockroach brain slices ... identify the organs affected by the nAuNPs The XPS was used to verify the presence of nAuNPs embedded in the brain tissue The confocal microscope and TEM were used to gain insights into the interaction...
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báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
... of MCC brain metastases will depend, as in many other types of brain metastases, on the number of metastases, systemic spread of the disease and the accessibility to surgery We believe that the ... conceived the idea of the study All authors participated in data collection KAK wrote the manuscript All authors read and contributed to the editing of the manuscript and gave their approval of the final ... but not in the surrounding edema Although the morphologic findings of the supratentorial mass on conventional MRI were consistent with meningioma, the occurrence of the extensive edema and the MR...
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Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system" docx
... miR-92b, ofbrain 11 the zebrafishbrain 10 fully zebrafish 29 28 27 26 25 24 23 22 21 20 miRNAs brain brain Additional brain brain brain brain the brain Acknowledgements This study was funded by the ... brain miR-200a data different LNA brain brain miR-183 expression zebrafishbrain brain data miR-181b nervous thezebrafish brain miR-181a providingthe the zebrafishbrain miR-153a usedfiguresinthe ... miR-138 testother inthedpf information acid miR-137 expressionininthezebrafish brain about miR-135cexpressionthespecificity brainbrain and miR-128 expression2thezebrafish of zebrafish brain expression...
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Báo cáo y học: "Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender" pdf
... The latter findings, evidence for reduced energy metabolism in the brain during normal aging [47], and our finding of significantly reduced expression of Werner in the brain during normal aging ... during aging in brain regions were upregulated in the spinal cord, including genes of the UPS, for example (Table S3 in Additional data file 1) In contrast to the spinal cord, very few genes in the ... findings concerning the numbers of genes identified as changed in the old group compared to the younger group A change in the expression of a gene during aging might contribute to a decline in...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... enhancing the activity of gamma-glutamylcysteine synthetase and up-regulating cystine transport The upregulation in gammaglutamylcysteine synthetase activity facilitates the redistribution of GSH into ... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... the production of Aβ or escalate its clearance in the brain The most common mechanisms of action of these drugs are the inhibition of the rate limiting steps of Aβ generation i.e β- and/ or γ- secretases...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... response in the brain following direct injection of “gutless” vectors in rats However, the high antigenicity of the Ad virion and toxicity of the virion penton proteins remain as potential complicating ... to achieve the optimized infection condition and enhance the virus replicating efficiency, we investigated the relationship between the amount of input virus and the yield of resulting replicated ... within the cell is reverse transcribed into double-stranded DNA which can then integrate randomly into the host cell genome The use of retrovirus vectors for gene delivery to the nervous system...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... cells in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy of ... expression in the rat brain after single injection of recombinant baculoviruses Fig 2.12 Activity of CMV E/PDGF promoter in cortical neurons after injection of baculovirus vectors into the striatum ... recurrent brain tumors, or to inject drugs with short half-life Gene therapy, on the other hand, can minimize this kind of damage Chapter Introduction to the brain by a single delivery of genetic...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... sterile-filtered HL3 containing 10 µg/ml of insulin The brains were then incubated with 200 µl solution of 0.5 mg/ml collagenase type I (Sigma) for 30 minutes After collagenase treatment, the brain fragments ... minute, and then washed with 200 µl of HL3 supplemented with insulin (10 µg/ml) The pelleting and washing steps were repeated for another times After discarding the washing solution, 10 µL of ... the brains while other parts like the fat tissues, mouth hook, and imaginary disks around the brains were removed Each brain was washed with the same medium and transferred together with 10 µl of...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... components in the brain, as this might be useful to the understanding of the control of locomotion and pain responses The identification of the receptor(s), and the identification of the specific ... i.c.v routes The specific binding sites of these proteins in mouse brain were identified using immunofluorescent detection of their N-terminal hexahistidine tags under both ex vivo and in vivo conditions ... completes the SPRY domain (Pung et al., 2006) 14 Binding Studies of Ohanin and Pro-ohanin The lack of natural abundance of ohanin (~1 mg/g of crude venom) and absence of pro-ohanin in the venom...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals and is 950 A ... (1985) The brain of the planarian as the ancestor of the human brain Can J Neurol Sci 12, 296–302 54 Sarnat HB & Netsky MG (2002) When does a ganglion become a brain? Evolutionary origin of the central ... stalks of the photoreceptor cells The structure appeared similar to that in the neuropil of the brain [57] In the stalk region of the photoreceptor cells, neuropeptides may be synthesized and work...
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Section III - Drugs Acting on the Central Nervous System docx
... levels of nervous integration The major monoamine-containing neurons of the brain (see below) are found here Together, these regions represent the points of central integration for coordination of ... within and between the regions of the brain Cellular Organization of the Brain Present understanding of the cellular organization of the CNS can be viewed simplistically according to three main ... cells of this class may be attracted to the brain during periods of inflammation following either microbial infection or other postinjury inflammatory reactions The response of the brain to inflammation...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... used in other studies The authors then examined the effects of 5-FU on adult mice They found an acute, transient increase in apoptosis in several brain regions, which subsided 56 days after injection ... hippocampus and the corpus callosum), primarily in progenitor cells and oligodendrocytes To determine whether these findings resulted in functional impairment, they investigated the auditory brainstem ... response in the mice at various times following treatment Loss of myelin is known to increase the latency between specific peaks in the auditory brainstem response, reflecting slowing of the impulse...
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Báo cáo y học: "Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection" ppt
... distinguish a regional source within the brain or indeed how much was produced within the brain and how much in the leptomeninges The lumbar CSF reflects the aggregate intrathecal activity after ... cytokines including interleukin-4 and -10 counteract the production of neopterin [21] The same is true for anti-inflammatory compounds including certain HMG-CoA reductase inhibitors (statins) and ... diffusion and intermixing CSF Neopterin Across the Spectrum of HIV Infection To provide a view of the CSF neopterin changes across the spectrum of HIV infection and HIV-related CNS injury within the...
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