cellular membranes are fluid mosaics of lipids and proteins
Báo cáo y học: "The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors" doc
... of 10 basis of our studies, the OA profile of biomarkers could be described as elevated concentrations of IL-11 and OP-1 and low concentrations of LIF To move forward in the field of biomarkers, ... activation of SF biomarkers in OA and RA might be dependent on the mechanism that drives each disease and that OA and RA might be characterized by a distinct panel of catabolic and anabolic markers of ... COMP and OP-1) for the RA cohort are expressed as Spearman’s r and P values A total of 22 RA patients were sampled, five male and seventeen female correlations between IL-6 and IL-1, IL-6 and...
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Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation body
... cells of the dentate gyrus, project to the dendrites of the pyramidal cells in the CA3 through their axons which are called mossy fibers (MFs) In turn, the pyramidal cells of CA3 are the source of ... in the hilus and CA3 area, comprise the second synapse of the hippocampal circuit In this trisynaptic model of the hippocampus, based on the observations of the MFs presynapses and their locations, ... synapses with excitatory and inhibitory cells of the hilus and area CA3 It has been shown that the MFs form synapses on large thorny excrescences of CA3 pyramidal neurons (Amaral and Dent, 1981) Besides,...
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Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation
... xi List of Tables Table 4.1 Average concentrations and standard errors of Fe Cu and Zn in different layers and background levels, based on seven sections from seven rats 100 List of Figures ... targets of PKA and PKC … 18 1.2.4 Long-term depression………………………………………… 18 1.3 Mossy fibers in learning and memory……………………………………… 19 1.3.1 Role of mossy fibers plasticity in learning and memory ... …………………50 Figure 3.3 Segmentation of MRI images .…… 51 Figure 3.4 Coronal MEMRI of rat brain at 20 h, days, and days post intravenous infusion of MnCl2 at the dose of 80 mg/kg …………………………………...
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hplc of peptides and proteins, methods and protocols
... sacrificed and the final separation conditions are often likely to be a tradeoff between rate of analysis and quality of separation An enormous range of different separation techniques are available ... basis of the effect of ligand structure is not fully understood, a number of factors including the relative hydrophobicity and ligand chain length, flexibility, and the degree of exposure of surface ... elution of peptides and proteins can rarely be achieved as the experimental window of solvent concentration required for their elution is very narrow Mixtures of peptides and proteins are therefore...
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Báo cáo khoa học: "HIV-1 CRF 02 AG polymerase genes in Southern Ghana are mosaics of different 02 AG strains and the protease gene cannot infer subtypes" doc
... purity of GHN21 and GHN117, and the other GHN strains [see Additional file 1], without the RIP analysis Thus, the polymerase genes of HIV-1 strains from Ghana are made up of recombinants of several ... authors are grateful to Dr Charles Brown of the School of Allied Health Sciences, College of Health Sciences, University of Ghana, for his useful comments References The authors declare that ... the T/S values are different for different lengths of sequences and should be considered when building trees with fragments of the pol gene The similarity in topology between RTs and RT shows that...
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Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 1
... charge of lipids, there are also other factors which influence the peptide-lipid interaction, such as fluidity of membrane, flexibility of membrane and membrane curvature117 Most 25 of phospholipids ... partly determine pore formation124-126 Biological membranes are very complex and composed of a large diversity of lipids and proteins which are related to specific biological functions Molecular ... layer of gram-positive bacteria, both of which are negatively charged In addition, the cytoplasmic membrane of bacteria also consists of a high percentage of negatively charged phospholipids Compared...
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Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 3
... π12, π1 and π2 are the surface pressure of mixed monolayer, pure lipid monolayer and pure V4 monolayer at the molecular area of A, respectively X1 and X2 imply the percentage of lipid and V4 respectively ... pressure of 45.6 mN/m and 44.5 mN/m for POPG and POPC, respectively The shape of isotherms of POPG and POPC monolayer was similar especially at low molecular area, which indicated that the packing of ... interaction between the alkyl chains of lipids and charge nearly has no effect Compared with some saturated lipids, POPG and POPC both have high lift-off molecular areas at which the surface pressure...
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Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 2
... exhibited an F2 of 4.2 % and an increase in the fluorescence yield compared to TMR of Q2/Q1 of 3.21 90 Fig 5.5 Comparison of ACFs of V4-TMR and the complexes of V4-TMR with LPS, lipid A and PC The ... mixed lipids SUVs complex was similar to that of pure lipids SUVs, between 0.6 and ms Fig 5.7 Binding of V4-TMR to SUVs of mixed lipid composition Shown are ACFs of V4-TMR bound to SUVs made of ... number of particle was N = 0.064 and Q was determined to be 84 59.5 kHz Because of the similar τD and Q of V4-TMR and of free TMR, it is likely that the measured particles correspond to free TMR and...
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Following are some pictures of StudyLink International and the staff.
... HoaSen University TA081 ABSTRACT There are thousands of graduates from hundreds of universities and colleges every year Therefore, the amount of students who are ready to apply for a job is so much ... Auckland and Singapore, who assist students with arrival orientation and ongoing welfare support In addition to the Study Abroad business, the company offers Training Solutions to corporate and ... international standard training programs to upgrade their soft and hard skills for working and studying Courses currently run by StudyLink include: Health Safety and Environment (HSE), Project and Process...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... apoptosis and induces the synthesis of antioxidants [22] Alterations in mitochondrial proteins, on the other hand, are specifically linked to one of the major pathogenetic mechanisms of PD [5] Worthy of ... Nagano, Japan) and analyzed with imagemaster 2d platinum software, version 5.0 (GE Healthcare) Spots were detected automatically by the software and manually refined; gels were then matched and the resulting ... each sample and data were processed using CellQuest software (Becton-Dickinson) Fluorescent emission of propidium iodide and Annexin V-FITC were collected through a 575 and a 530 ⁄ 30 bandpass filter,...
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Tài liệu 2012 Marketing Trends Survey: Email Marketing and Social Media are Top Beneficiaries of Healthy 2012 Marketing Budgets doc
... to forge meaningful, profitable and long-lasting connections with their customers through email marketing and social media Featuring a unique combination of technology and services, StrongMail ... survey was conducted online by Zoomerang on behalf of StrongMail The poll, which gathered feedback from 939 business leaders across a wide range of industries, was conducted from November 16 - 29, ... that provides you with easy access to customer data, superior performance, low total cost of ownership and award-winning agency services Learn more at www.strongmail.com or call us at (800) 971-0380...
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Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc
... procedures Software Numerical integration, solving of implicit algebraic equations and bifurcation analysis were performed using dbsolve software (http://www.biokinetics.ru) [58] This software is ... waves of kinase activity arise from bistability in kinase/phosphatase cascades [52] Emerging evidence shows that SFKs are nonrandomly distributed on the plasma and intracellular membranes, often ... simulation and analysis of cellular metabolism and regulation Bioinformatics 15, 749–758 59 Khibnik AI, Kuznetsov YA, Levitin VV & Nikolaev EV (1993) Continuation techniques and interactive software...
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Tài liệu Báo cáo khoa học: Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide pptx
... Heterotrimeric G proteins are localized on the inner surface of cell membranes They comprise a superfamily of at least 17 distinct Ga, Gb and Gc isoforms [13] Furthermore the a subunits are divided ... release of different inflammatory mediators Stimulation of TLR leads to activation of a series of signalling proteins, and to the expression of pro- and inflammatory cytokines There is evidence that ... constructs [11] G proteins are located downstream of G-protein-coupled receptors (GPCR) [12] GPCR represent a large family of cell-surface proteins mediating the effects of a broad spectrum of biological...
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Tài liệu Báo cáo khoa học: Binding of N- and C-terminal anti-prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse doc
... banding patterns and different glycoforms of PrPC In this study, we have analyzed the glycoform patterns of PrPC of human, sheep, cattle and mice and compared them Variable immunoreactivity of ... ratios are detectable The findings are important for studies of PrPC function, regulation and expression, as full-length and truncated isoforms of di-, mono- and nonglycosylated proteins are only ... prion proteins of humans, sheep, cattle and mice Recognition sites of the antibodies SAF34, P4, 8G8, SAF60 and SAF70 are indicated Sequences of the species are recognizable by the antibodies are...
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Tài liệu Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2 ppt
... Chimera 1C2 encoded residues 1–505 and 653–725 of TAP1 and residues 494–639 of TAP2 and chimera 2C1 encoded residues 1–493 and 640–703 of TAP2 and residues 506–652 of TAP1 The exchange was performed ... EcoRI site of pHbApr1neo [22] and sequenced fully in both directions Chimera 1V2 encoded residues 1–652 of TAP1 and residues 640–703 of TAP2 and chimera 2V1 encoded residues 1–639 of TAP2 and residues ... 5.6 mL of 2.5 M sucrose gradient buffer was added and the suspension overlaid carefully with 2.9 mL of M and 2.9 mL of 1.3 M sucrose buffer About 800 lL of 0.25 M sucrose buffer was carefully...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... values) of Ni(II) and Cu(II) complexes of peptides at I = 0.1 M (KNO3) and 25 C Standard deviations on the last digits are given in parentheses EPR The X-band EPR spectra of Cu(II) complexes of VIHN ... the a carbon of the His residue is the sole source of chirality [10] However, while positions of the component dd bands and of CT transitions are relatively constant, their absolute and relative ... Stock solutions of NiCl2 and CuCl2 were standardized gravimetrically with dimethylglyoxime and complexometrically with EDTA, respectively Concentrations of stock solutions of HSA and BSA were estimated...
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Effectiveness of PRECEDE model for health education on changes and level of control of HbA1c, blood pressure, lipids, and body mass index in patients with type 2 diabetes mellitus docx
... 24 months of follow-up Sample size For an alpha of 0.05, a power of 80%, and in order to detect an reduction of HbA1c of 0.3 percentage units, with a common standard deviation (SD) of 1.15, in ... the study in either of the two models analyzed, and the adjusted effect of PRECEDE was close to zero (Table 2) In both models, the level of exercise decreased Page of slightly and was not significant ... reduction of 7% in the risk of mortality owing to cardiovascular disease, and 10% in the risk of mortality owing to ictus with every mmHg decrease in SBP The slight decrease in the lipid profile of...
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Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx
... distortion and ⁄ or damage to cellular membranes, which are composed mostly of complex lipids [49] This could result in the release of FFAs, which then would be available for esterification and the ... hazardous and are the prime candidates for LD induction The majority of in vitro tests designed for the assessment of NP safety are based on viability assays, the peroxidation of membrane lipids, ... Cd2+ and are able to induce intracellular formation of ROS in PC12 and MCF cells [4,6], they make good candidates for hypoxia mimetics [27] Thus, we used the known hypoxia mimetic, CoCl2, and...
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Báo cáo khoa học: Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast ppt
... higher proportion of the mutant proteins are bound to the U4 ⁄ U6 di-snRNP, than to the U6 snRNP, compared with wild-type A Effects of Lsm8 mutant and hybrid proteins on levels of U4 and U6 snRNAs ... The Lsm1 and Lsm8 polypeptides are most similar in the regions of the Sm1 and Sm2 motifs These motifs form the Sm-fold, the hallmark of the Sm-like proteins, consisting of a five-stranded anti-parallel ... for different domains of the Lsm1 and Lsm8 proteins in their function and localization, we created a series of mutant and hybrid proteins We deleted or exchanged their N- and ⁄ or C-terminal domains,...
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Báo cáo khoa học: Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding pptx
... chromatography and chromatofocusing, as described previously [21] Results Expression and secretion of truncated variants of GCPII To analyze the contribution of individual domains of human GCPII ... transfected with 274/587 and 274/750 The presence of recombinant proteins in cell lysates was analyzed at 0, 4, and 12 h following the addition of inhibitors No immunoreactive bands of expected molecular ... turnover of the substrate did not exceed 25% Km and kcat values were determined by a nonlinear least-squares fit of the initial velocity vs substrate concentration using a GRAFIT software package...
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