... to clinical and MRI findings Clinical definition of arthritis mutilans Clinical digitised photographs ofthe hands and feet were obtained in 25 ofthe 28 patients These were examined by a rheumatologist ... unenhanced imaging ofthe fingers; the patient was repositioned so that the wrist was within the coil; unenhanced imaging ofthe wrist; contrast injection; enhanced imaging ofthe wrist; the patient ... pertain only to baseline findings in these patients, before administration ofthe study drug or placebo All patients gave informed consent according to the requirements ofthe New Zealand Multiregion...
... to clinical and MRI findings Clinical definition of arthritis mutilans Clinical digitised photographs ofthe hands and feet were obtained in 25 ofthe 28 patients These were examined by a rheumatologist ... unenhanced imaging ofthe fingers; the patient was repositioned so that the wrist was within the coil; unenhanced imaging ofthe wrist; contrast injection; enhanced imaging ofthe wrist; the patient ... pertain only to baseline findings in these patients, before administration ofthe study drug or placebo All patients gave informed consent according to the requirements ofthe New Zealand Multiregion...
... resulting inthe accumulation of both unmodified cholesteryl esters and glycated apoB inthe cells The rate of removal ofthe latter species is slow, with only 20–30% ofthe glycated protein being ... diagnosis of diabetes, consistent with a shared underlying pathogenesis [2] An early and persistent feature ofthe atherosclerotic lesion is the presence of lipid-laden (foam) cells inthe intima ofthe ... it may be the nature ofthe products arising from glycation, rather than purely the loss ofthe parent amino acid, which is the key factor in terms of receptor recognition [29] There are no data...
... striking peaks in synonymous site conservation were found – one within the capsid CDS (very 5' end ofthe polyprotein CDS) and one at the 5' end ofthe NS2A CDS (Figure 1A) The peak within the ... map ofthe JEV genome, indicating the position ofthe putative -1 ribosomal frameshift site, andthe putative transframe protein which may equate to NS1' (B) Zoom -in ofthe region corresponding ... occurrence of -1 frameshifting, at a level of 10–18%, into a short ORF overlapping the 6K CDS inthe Alphavirus genus [8] The combination of slippery heptanucleotide, 3' pseudoknot, and 45-codon...
... demonstrates the importance of each ofthe negatively charged residues inthe C-terminal extension in maintaining the solubility ofthe Hsp25 oligomer Similarly, the introduction of hydrophobicity into the ... residues inthe C-terminal extensions of other sHsps, notably aA- and aB-crystallin, the flexible regions of these proteins are unique and distinct from that of Hsp25 The a-crystallins contain negatively ... that the structure ofthe N-terminal domain is maintained, at least inthe vicinity ofthe tryptophan residues The increase in exposed clustered hydrophobicity observed for the mutants is therefore...
... animals are approved by the Institutional Animal Care and Use Committee at the University of Kentucky andarein strict accordance with the National Institutes of Health Guidelines for the Care and ... oxidative and inflammatory insults The positive feed back loop may continue until the additional neuronal death (~50% ofthe remaining ofthe initial death) combined with the initial loss exceed the ... important role inthe secondary activation of microglia, inthe progression ofthe inflammatory response, andinthe progressive loss ofthe dopaminergic neurons in MPTPinduced PD Therefore, COX-2...
... inthe seed orchards Proportion of hybrids Determination ofthe proportion of hybrids in different samples from LOLA with the following questions in mind: are there differences between the single ... strongest stain- ing intensity Genetic analysis The results obtained from the examination ofthe endosperms in seeds from the progenies of controlled crossings are given in tableI and show no ... frequency The other recombinants would yield the hybrid andthe self- ing phenotype, respectively The highest percentages of contamination areinthe seed samples of Jagen 1987 (6.2%) and Küchengarten...
... detected in antibody the multinuclear and mononuclear cells located inthe soft tissues and multinuclear cells on the bone surface (c, d) CD68 is also detected in multinuclear and mononuclear cells ... neither the β3 integrin nor the CTR are expressed by osteoclast precursors The expression of these genes increases during the late stages of osteoclast differentiation [42], after induction ofthe ... prosthesis Of importance, in our studies we observed that the levels of expression of both cathepsin K and TRAP were much higher inthe cells associated with the bone surface compared with the...
... mutated embryos, the polarity ofthe ommatidia ofthe compound eye andthe hairs ofthe wing and thorax are disrupted, such that rather than pointing inthe same direction, they point inmultiple directions ... to the orientation ofthecell s sides with respect to the global axis ofthe epithelium, allows the polarity ofthecell to be established within the plane ofthe epithelium and promotes the ... participated in data and information collection and part ofthe writing XH performed part of text writing andthe editing ofthe whole manuscript YH wrote the part ofthe manuscript and information...
... appearances ofthe polyp The most serious problem in PJS is an increased risk of cancer inthe gastrointestinal tract The occurrence of cancer inthe gastrointestinal tract has been reported in 20-25% of ... with a focus of well-differentiated adenocarcinoma Hematoxylin and eosin staining (objective 10 ×) Figure Pedunculated duodenal polyp measuring 15 mm in diameter inthe second part ofthe duodenum ... Figure Histological examination showed findings suggestive of a hamartoma without malignant components Hematoxylin and eosin staining (objective 10 ×) or sex ofthe patient, or the location, size...
... estimated The T/S ratio was determined by using the Dnaml.exe file inthe PHYLIP software to determine the maximum likelihood of obtaining the best tree For each alignment (pol, prot., RTs, and RT), the ... subtypes included It is therefore important that in determining the true relationships of sequences, at least the nine pure subtypes and circulating recombinants commonly found within the region ... strains in their sequences, with GHN117 having as compared to one in GHN21 [see Additional file 1] It will be impossible to make these inferences about the purity of GHN21 and GHN117, andthe other...
... BALT T cells and B cells for the expression of L-selectin, which binds to PNAd; α4 integrin, which is a subunit of α4β1 integrin (which binds mainly to VCAM-1) and α4β7 integrin (which binds to ... of T cells and almost all B cells in BALT α4 integrin, which is a subunit of α4β1 integrin that binds to VCAM-1, was expressed on 43% of T cells and almost all B cells in BALT LFA-1, which binds ... HEVs in any ofthe BALT samples Theadhesion molecule profile of HEVs in human BALT is similar to that of HEVs in mouse BALT, differing only inthe extent of VCAM-1 expression (66% of HEVs in human...
... increase inthe numbers of WBC at calving This was mainly due to an increase inthe numbers of circulating neutrophils, and to a less extent, an increase in monocytes At calving, the levels of ... calving not affect theadhesionmoleculesof lymphocytes and therefore they can migrate into the tissues Our results have shown a marked decline at calving in serum concentrations of vitamins A and ... proportions and MFI for the neutrophil adhesionmolecules were done using the General Linear Model (SAS Institute Inc., Cary, NC, USA) The effects of cow and period were included inthe model Mean...
... prior to the administration of red cells in patients receiving blood were labelled pre-transfusion haemoglobin and were used as the primary outcome inthe study Inthe prospective phase ofthe cohort, ... for their help in completing this project We are also indebted to the nursing staff and all other health professionals who contribute to the care of our patients and for actively supporting this ... from the literature examining the role of transfused red cells in immune modulation [34,35] andin microcirculatory alteration [36–38] From these studies, the liberal administration of red cells...
... confirmed by thein vitro assays Discussion Soluble forms ofadhesionmolecules including selectins and members ofthe immunoglobulin family, most of which are generated by alternative splicing, are considered ... start of treatment, and some uncertainty is added to the interpretation of our results because serum levels ofthe soluble adhesionmoleculesare not only influenced by their synthesis and shedding, ... observations in finding changed levels ofadhesion molecules, probably indicating endothelial activation as a result of reperfusion ofthe ischemic myocardium Limitation of this study is the lack of samples...
... aberrant activation of NF-κB and AP1 These findings suggest that Tax protein could induce the transcription of cytokines, chemokines andcelladhesionmoleculesin lung epithelial cells in a manner similar ... promotes the production of inflammatory cytokines and chemokines, andthe expression ofcelladhesionmolecules by the infected cells Such process may be involved inthe pathogenesis of HTLV-I-related ... protein inthe cytoplasm of epithelial cells (A and D), and infiltrated lymphocytes (B and E) and macrophages (C and F) HTLV-I can be transmitted into lung epithelial cells from infected T cells and...
... mortality), and predetermined subgroup analysis of medical, surgical, and trauma ICU patients It is interesting that the findings of this study not reflect the transfusion benefit previously demonstrated The ... 0.008) These findings, Page of however, are not entirely conclusive With further analysis, the authors showed that the increase in thrombotic events only affected patients not receiving heparin prophylaxis ... Efficacy of recombinant human erythropoietin inthe critically ill patient: A randomized, double-blind, placebo-controlled trial Critical Care Medicine 1999, 27: 2346-2350 Corwin HL, Gettinger A,...
... three-momenta ofthe in- coming and out-going mesons inthe center -of- mass frame andthe energy transfer, (v·k), is defined in Fig 3.2 Observe, since k, p and p ′ are counted of order ofthe Ei , this ... 3.2, and E2 and E4 arethe energies ofthe in- coming and out-going light mesons For the NLO contact interactions we again find the same contributions except for the different pseudoscalar and ... charge are spin– and flavor–independent and also present inthe limit mQ → ∞ The interactions via the chromomagnetic charge, which are spin-dependent, are on the other hand proportional to the chromomagnetic...
... on an understanding ofthe system of land tenure in vigor andofthe positive and negative political stakes involved in recognizing illegal settlements and providing them with certain municipal ... for the focus on the health of children under five years of age, and he was the leader inthe definition ofthe health status and determinants indicators that framed the literature search We are ... document investigates the hypothesis that the determinants of health, as well as the corresponding burden of disease and mortality among children in marginalized areas of towns and cities, are different...
... marked increases inthe future demand of all organic products This augurs well for the growth ofthe organic industry inthe Eastern Cape andin South Africa in general The findings of this study are ... maintain its identity inthe face of others, and therefore creates a feeling of "belonging" (Buruiana 2003) 17 10 Factors affecting the consumer awareness of organic products The results ofthe ... ofthe respondents inthe rural areas had considered consuming organic food, 18% inthe peri-urban areas and 22% inthe urban areas had considered consuming organic food A total of 18%, 11% and...