calculation of the permeability surface area product psat and p gp mediated efflux clearance clp gp t of the p gp substrate into mice brain and heart
Báo cáo y học: " Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination" pps
... vivo permeability values measured in rats Step III: Calculation of the permeability- surface area product (PSAt) and P- gp- mediated efflux clearance (CLP -gp, t) of the P- gp substrate into mice brain ... distribution in non-eliminating tissues expressing P- gp transporters, namely brain and heart It was also prompted by the need to improve the ability of the PBPK approach to predict the impact of P- gp ... quantifiable from human data [36, 37], were applied to mice As the estimation of permeability- surface area product (PSAt) and P- gp efflux (CLP -gp, t) clearance of a P- gp substrate through blood-tissue...
- 13
- 478
- 0
Báo cáo khoa học: Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles pdf
... active site pocket of TGase Assessment of reactivity and specificity of E51 sequence in the peptide form (pepE51) To assess the reactivity and isozyme-specificity of E51 (PPPYSFYQSRWV) in peptide ... accept pepE51 (data not shown) These results demonstrate that pepE51 acts as a good substrate, similarly to the fusion protein To further investigate whether the isozyme specificity was preserved, the ... Evaluation of the reactivities of the selected peptides as GST(QN) fusion proteins (A) Incorporation of Dansyl-Cd into the purified recombinant GST(QN) fusion proteins with peptide that were selected...
- 11
- 645
- 0
báo cáo hóa học:" Research Article Extremal Values of Half-Eigenvalues for p-Laplacian with Weights in L1 Balls" potx
... p- Laplacian associated with different types of boundary conditions see 7–10 As an elementary application of such a stronger continuity, the proof of the first step, that is, the existence of minimizers or ... indefinite weight, and applications to population dynamics,” Japan Journal of Industrial and Applied Mathematics, vol 23, no 3, pp 275–292, 2006 A Zettl, Sturm-Liouville Theory, vol 121 of Mathematical ... 2.3 ; p sin π /p m p , m ∈ Z, and sinp θ if and only if ∗ p − |sinp θ |p ≡ By setting p x −y and introducing the Prufer transformation x ¨ sinp θ, the scalar equation p x − b t p x− a t p x...
- 21
- 326
- 0
Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf
... domains of the MMP participated in the activation Both the HPX and the Cat-Hinge regions activated the promoter, whereas the prodomain and the hinge-region alone had no effect on the activation Compared ... allosteric and the other comprising an autocatalytic removal of the prodomain Peroxynitrite has also been shown to inactivate TIMP-1 [38] Thus, it appears that peroxynitrite potentiates MMP activity ... not to the 6-position (C6S) enhanced the activation in the presence of suboptimal concentrations of MT3-MMP Binding of proMMP-2 to the CS-chains without MT3-MMP did not result in activation The...
- 18
- 463
- 0
Báo cáo khoa học: Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue docx
... such as the type of buffer solution, the type and concentration of the enzymatic preparation, the temperature and the pH had any major effect on the recovery of the [3H]-PAF at the BSA pellet Ó ... bound to the BSA precipitates after the addition of trichloroacetic acid to the reaction mixture The radioactive product, co eluted with authentic PAF at either TLC or HPLC separation, was further ... of the radioactivity to the BSA pellet All the precipitated radioactivity was found in the water phase of the Bligh–Dyer extraction of the pellet indicating that it was due to the small fraction...
- 9
- 324
- 0
báo cáo hóa học: " Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD" pptx
... provided transgenic mice and contributed to the preparation of the manuscript; MPV provided transgenic mice, participated in the study design and in the manuscript preparation Acknowledgements ... "killing" phase [4-6] However, the gene profile of macrophages can change, shutting down the production of pro-inflammatory cytokines and increasing the production of factors that participate in tissue ... functional phenotypes not only protect the tissue from invaders, but orchestrate and promote tissue reconstruction resulting in resolution of the injury Repair processes mediated by alternative activation...
- 12
- 512
- 0
Báo cáo hóa học: " Research Article Power Allocation Strategies for Distributed Space-Time Codes in Amplify-and-Forward Mode" docx
... maximizing the average SNR at the destination Proposition Assume α portion of the total power is transmitted in the first phase and the remaining power is transmitted by relays at the second phase, ... repetitionbased cooperation that take both the statistical CSI and the residual energy information into account to prolong the network lifetime while meeting the BER QoS requirement of the destination ... optimum p is also proportional to ermax Using the power constraint of the transmitted power in the second phase, that is, pt p = P2 , we have p = P2 ermax This means that for each realization...
- 13
- 367
- 0
research report 'using the activity in pairs and in groups to teach writing in english'
... Ask the students to get into pairs Give out copies of one text to half of the class and the other text to the half - Ask them to list all the words in their text alphabetically - Ask the students ... When the first student has finished his part, he must fold the paper to hide what he has written, except the last line - Then he passes the paper to the second student, this student starts with the ... interesting enough to stimulate the students to start writing immediately and dictate the beginning of the story to them - After the dictation, each student adds up the story within two minutes...
- 4
- 470
- 1
Báo cáo toán học: "Asymptotics for the distributions of subtableaux in Young and up-down tableaux" pps
... deleting one cell Just as the number of standard tableaux of shape µ of size k is the multiplicity of the representation with highest weight µ in the kth tensor power of the defining representation ... limit theorem of Kuperberg [10] to relate these asymptotics to asymptotics for the random walk We expect Brownian motion to approximate a random walk for large time That is, if the steps in the ... point for the random walk to reach at step N As N goes to infinity, we expect that the probability that the random walk is in this region at step N and the probability the electronic journal of...
- 22
- 378
- 0
Báo cáo khoa học: "Surgical treatment for different forms of hernias in sheep and goats" ppt
... rehto ehT noitarepo tsrif eht retfa skeew ta noitartsac detatissecen esac sihT edis detceffa eht fo mutorcs dna sitset eht fo gnillews dna noitammalfni fo mrof eht ni snoitacilpmoc evitarepotsop ... dooG htnom retfa derruccoeR dooG dooG dooG dooG dooG emoctuO 781 tugtaC tugtaC SDP kliS tugtaC kliS SDP tugtaC kliS kliS tugtaC tugtaC kliS tugtaC SDP tugtaC kliS SDP SDP kliS SDP kliS kliS tugtaC ... lanretxe eht fo erusolc etelpmoc yb dewollof saw siht dna ,deihporta deraeppa yeht revenehw devomer erew selcitset ehT )tseuqer s’renwo eht ot gnidrocca sitset eht peek ot mar ni( sehctits tugtac...
- 7
- 330
- 0
Báo cáo lâm nghiệp: "of morphological characters and molecular markers for the analysis of hybridization in sessile and pedunculate oak" pps
... human populations (Roberts and Hiorns, 1965; Elston, 1971) study of the hybridization and morphology of the hybrid forms in oaks is imporThe tant to understand the evolution of these taxa and of their ... crown of several open-pollinated trees of the two species A map of the positions of the mother trees in the stand is given in figure The families were chosen as a function of the The 41 morphological ... in the adult populations were estimated both considering that these populations were at the Hardy-Weinberg equilibrium, and under the hypothesis that a heterozygote deficit were present in the...
- 13
- 404
- 0
Báo cáo khoa hoc:" Genetic relationship between cyclic ovarian activity in heifers and cows and beef traits in males" ppt
... surveys without quantifying, however, the genetic and environmental contributions The most important aspect of the present study was the opportunity to quantify the genetic relationship between male ... beef traits and two components of the female reproduction: age at puberty and postpartum anoestrus length In order to improve the productivity of beef cattle herds, it is necessary to reduce the ... age at first oestrus or age at first positive progesterone test These results were consistent with previously published estimates [11] The postpartum interval to first positive progesterone test was...
- 15
- 242
- 0
Báo cáo y học: "Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury" pps
... part of the manuscript TDT contributed to the ATII cell culture and drafting of part of the manuscript NBN contributed to the immunohistochemistry and drafting of part of the manuscript ABM conceived ... generated the murine model and performed the murine RT-PCR KMU and LA contributed to the ATII cell isolation and culture KMG and BZ performed the real time PCR and contributed to drafting of part of ... subjects[4] The increase in constitutional production in time would suggest active secretion The relationship of these findings at the protein level to those at the mRNA level is not clear-cut The...
- 12
- 313
- 0
Báo cáo y học: " G-CSF and IL-8 for early diagnosis of sepsis in neonates and critically ill children – safety and cost effectiveness of a new laboratory prediction model: study protocol of a randomized controlled trial [ISRCTN91123847]" pps
... from data analysis, because in these patients the decision to stop antibiotic treatment is no longer the responsibility of participating intensivists Setting The participating university hospital ... participated in the design of the study JF and TH wrote the protocol TH carried out the pilot study under supervision of JF TH implemented the project into clinical routine JF will carry out statistical ... Control strategy For patients randomized to the control arm, if the physician orders microbial cultures then they are obliged to document their best estimate of the probability that the patient has...
- 8
- 407
- 0
Multi-beneficial for mitigation of climate change in Vietnam and Indochina countries by development of biomass energy project
... t and root length of Jatropha plant cultured in vitro at day 42 Table Effect of supporting material on leaf area and increase dry weight of Jatropha plant culture in vitro on day 42 Treatment ... 0) XI E Effect of sugar types on num ber of open leaves and leaf area of Jatropha plant cultured in vitro at day 42 a IFW (mg/pit) s Root length (mm/pit) s E ffect of supporting m aterial on increased ... Overcoms of Poverty Utilization of Glycerlin Improvement of air Pnltufc: R M aw aterials far B F O Sulfur, No Arornatics ( Cultivation u f Jdlropha) Prots rton V of * iter r — PoSttbn I Protection of...
- 122
- 403
- 1
Regulation of sla2p by activity in endocytosis and actin organization by the ark1 prk1 family of kinases
... regulatory effect on the activity of the protein For instance, Pan 1p, the best studied substrate of Prk 1p, is phosphorylated at multiple sites Over-phosphorylation of Pan 1p causes it to dissociate from ... non-directional movement within the plane of the cortex The actin machinery consisting of Abp 1p, Myo 3p and Myo 5p join at this point and initiate short burst of actin polymerization that results in the ... postulated that Abp 1p acts as a competitive antagonist to these two NPFs (D’Agostino and Goode, 2005) Abp 1p appears last at the actin patch, just before the rapid movement It might function in...
- 180
- 364
- 0
Báo cáo khoa học: Function of microRNA-375 and microRNA-124a in pancreas and brain doc
... miR-124-binding sites in the 3¢-UTRs of MeCP2 and CoREST, encoding two components of the REST complex [47] Together, these data indicate that neurogenesis requires the functions of the REST ⁄ SCP1 system as ... transcription factor, within the proximal regulatory region of miR-124a, implicating the role of cAMP response element-binding protein in the positive regulation of this miRNA [47] Despite the importance ... regulate target gene expression at the post-transcriptional level [21] Biogenesis of miRNAs starts with the transcription of a long primary precursor product, pri-miRNA, synthesized by RNA polymerase...
- 13
- 251
- 0
Tài liệu Báo cáo khoa học: Experimental proof for a signal peptidase I like activity in Mycoplasma pneumoniae, but absence of a gene encoding a conserved bacterial type I SPase pdf
... degradation Therefore, we used mass spectrometric analysis of an in-gel digest of P4 0 To prove that the candidate peptide was the N-terminal peptide of P4 0, we labeled the N-terminus of P4 0 within the ... method is the tryptic digestion of the purified protein and subsequent analysis of the derived peptides by mass spectrometry If a candidate mass is detected and peptide sequencing proves, that there ... the protein complex formed by the proteins P1 , P4 0 and P9 0, it is a prerequisite to know the primary structure of the subunits To get sufficient material for the identification of the amino terminus,...
- 9
- 559
- 1
Báo cáo khoa học: A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles pdf
... fractions of different cell types using a combination of the peptide substrate, aspartic proteinase inhibitor (pepstatin A) and depletion of CatE by immunoprecipitation Activities were determined ... immunoprecipitation To determine the specificity of our immobilized CatE antibody in depleting CatE from the samples, we tested it with CatE and CatD CatE (recombinant) was completely immunoprecipitated ... proteinases and represents TAPA For the specific determination of CatE and CatD activity, CatE was specifically depleted by immunoprecipitation The remaining activity is due to CatD, and the decrease...
- 12
- 645
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008