bruxism dystonia dyskinesia and drug induced dystonic extrapyramidal reactions
Báo cáo y học: "Clinical and laboratory characteristics of drug-induced vasculitic syndromes Allan Wiik" potx
... ANAs and antihistone antibodies as well as myeloperoxidase–ANCAs in such patients, the latter being likely to be caused by drug- induced damage directed at the neutrophils that process the drug ... propylthiouracilinduced vasculitis associated with anti-neutrophil cytoplasmic antibody (ANCA); review of literature Clin Nephrol 1997, 47: 336-340 Rubin RL: Autoantibody specificity in drug- induced lupus and ... Bonaci-Nikolic BM, Nikolic MM, Andrejevic S, Zoric S, Bukilica M: Antineutrophil cytoplasmic antibodies (ANCA)-associated autoimmune diseases induced by antithyroid drugs: Comparison with idiopathic...
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Báo cáo khoa học: "Clinical review: Aggressive management and extracorporeal support for drug-induced cardiotoxicity" potx
... of sotalol and verapamil in one case, acebutolol and meprobamate in two cases, propranolol, verapamil and betaxolol in one case, and various psychotropic drugs in one case; the single drug poisoning ... beta-blocker (BB), and membrane-stabilizing agent (MSA) poisoning This algorithm is based on series and case reports HR, heart rate; SBP, systolic blood pressure contractility Many cases of drug- induced ... antidepressants and chloroquine, while it can be underestimated for labetalol poisoning Therefore, in drug- induced cardiovascular shock with apparent refractoriness to conventional treatment, it is mandatory...
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Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)
... injury and its pattern 1.2 Clinical outcomes of drug- induced liver injury 1.3 Mechanism of liver injury 1.3.1 General drug- induced liver injury mechanism 1.3.2 APAP -induced ... Ruenn Chai for his helps and inputs on the MSC-derived exosomes and also Judy Saw for her assistance in tocotrienols uptake assay The Laboratory of Liver Cancer and Drug- Induced Liver Diseases ... APAP- and H2O2 -induced in liver injury in vitro……… 112 4.3.1 Effect of T3 analogs on APAP and H2O2 -induced on cell death in TAMH cells 112 4.3.2 Effect of lower dosage of -T3 and...
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The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
... which is induced by Fas ligand (FasL), tumour necrosis factor alpha (TNFα) and TNF related apoptosis inducing ligand (TRAIL ) where these ligands bind to specific death domain receptors and induce ... from other DNA binding proteins, and a largely conserved C terminal domain which has sufficient variation to allow for ligand selectivity and possesses a ligand induced activation function called ... sumoylation, and phosphorylation have defined crucial roles in coactivator and corepressor activity and consequently on nuclear receptor function (Levine and Tjian, 2003) The concept that ligands act...
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Báo cáo y học: "A pilot study of rizatriptan and visually-induced motion sickness in migraineu"
... animal models 34-36 and tryptophan depletion has been found to increase visually -induced nausea and dizziness in migraineurs Based on our results and the known effects of rizatriptan and serotonin, ... administering the drug, the technicians performing testing, and the subject were blinded to treatment assignment The Investigational Drug Service provided the unidentifiable drug in a container ... V+ and V- groups and between groups with and without visual motion sensitivity were performed using the Wilcoxon rank sum test Results Fourteen persons were identified as possible study candidates...
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Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... United States, and Central Africa; B and C predominate in Asia; D is associated with southern Europe, the Middle East, and India; E is uniquely African; and F is found in Central and South America ... Not well standardized Can indicate and confirm emergence of antiviral resistance Wide variation in test sensitivities Direct marker and gold standard for HBV viral replication No gold standard among ... resistance) [24] Monitoring HBV Drug Resistance Several options are currently available to monitor HBV drug resistance, and can generally be divided into genotypic assays and phenotypic methods The...
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U.S. Food and Drug Administration - Juice HACCP — The Final Rule
... gloves, and outer garments, and from raw product to processed product; (4) Maintenance of handwashing, hand sanitizing, and toilet facilities; (5) Protection of food, food packaging material, and ... September and 15, 1999, November 16 and 1, 1999, and February 2, 2000 FDA, DHHS, Hazard Analysis and Critical Control Point (HACCP); Procedures for the Safe and Sanitary Processing and Importing ... juice from a country that has an active memorandum of understanding (MOU) or similar agreement with the Food and Drug Administration, that covers the food and documents the equivalency or compliance...
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Tài liệu Báo cáo " Effect of Sweet potato (Ipomoea batatas (L.) Lam) leaf extract on hypoglycaemia, blood insulin secretion, and key carbohydrate metabolic enzymes in expermentally obese and STZ-induced diabetic mice " pptx
... Reuter T.Y Diet induced models for obesity and type diabetes Drug discovery today: disease models Vol.4 (1) (2007) 124 D.N Lien et al / VNU Journal of Science, Natural Sciences and Technology ... insulin and key hepatic enzymes in experimental diabetes, Pharmaceutical Biology 40(3), (2002) 165 [8] N Brandstrup, JE Kirk, C Bruni, The hexokinase and phosphoglucoisomerase activities of aortic and ... diet (ND from NIHE), other fed with high fat diet (HFD) [4,5] and water ad libitum, for weeks 2.3 Development of HFD-fed and STZ -induced type diabetic mice After weeks of dietary manipulation,...
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Tài liệu Báo cáo khoa học: RMI1 deficiency in mice protects from diet and genetic-induced obesity pptx
... this mutant strain as described below) Body and organ weights as well as plasma parameters (Tables S2 and S3) were measured, and learning, memory and behavioral tests (Table S4) as well as histopathological ... Resistance to KK- and KK-Ay -induced genetic induced obesity in RMI1+/) mice To explore resistance to the development of obesity under other conditions, we generated KK-a ⁄ a and KK-Ay ⁄ a RMI1-deficient ... Matsushime, Masato Kobori, Jiro Hirosumi and Mr Tsutomu Higashiya at Astellas Pharma Inc., and Junko Kawano and Akemi Matsuoka at Trans Genic Inc for their helpful advice and support 12 References 13 Zhang...
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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... Chemical and Biological Defense DIA Drug Information Association DoD U.S Department of Defense E&T education and training FDA U.S Food and Drug Administration xix xx The Acquisition of Drugs and Biologics ... decentralized, and fragmented organizational system for drug and vaccine development This required us to understand the relation of different DoD organizations to CBW drug and biologics development and ... development and licensing capability Were DoD more effective in managing the drug development and licensing process, fewer candidate drugs and vaccines would be “parked” in IND status, and more...
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Tài liệu NEW INSIGHTS INTO TOXICITY AND DRUG TESTING pptx
... A prevailing issue in drug development is the attrition of new drug candidates Between 1995 and 2005, a total of 34 drugs were withdrawn from various markets (Table 1) and the reason for withdrawal ... investigational drug during drug development, Hy's Law falls short of constituting a "gold standard'" and validation of Hy's Law is much needed, chiefly with regards to its sensitivity and specificity ... hepatotoxicity Pharmacoepidemiology and Drug Safety 2006; 15: 241-243 [18] Faich GA, Moseley RH Troglitazone (Rezulin) and hepatic injury Pharmacoepidemi‐ ology and Drug Safety 2001; 10: 537-547 DOI:...
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Tài liệu Báo cáo khoa học: Guanidinium chloride- and urea-induced unfolding of FprA, a mycobacterium NADPH-ferredoxin reductase Stabilization of an apo-protein by GdmCl docx
... chromatographic profiles for FprA and on incubation with and without urea on Superdex 200 H column at pH 7.0 and 25 °C Curves and represent profiles for FprA at pH 7.0 and that on incubation with M ... have studied the effect of GdmCl- and ureainduced changes in the structural and functional properties of FprA Time-dependent changes in the structural parameters and enzymatic activity of FprA at ... curve showing two distinct transitions between and 0.8 m and 0.8 and m GdmCl were observed (Fig 4B) These observations demonstrate that during GdmCl -induced denaturation of FprA the transition observed...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... lane 6, Glu-Pg- and mAb 34D3-treated cells Bands in lanes and correspond to forms I and II of plasmin(ogen) High molecular weight bands in lanes and correspond to mAb A10.2- and mAb 34D3-plasminogen ... Lys-plasmin(ogen) binding and activation These structural–functional transitions are determinant in the initiation and development of both fibrinolysis and cell detachment -induced apoptosis and may therefore ... evaluate their respective contribution to Gluand Lys-Pg binding and activation onto fibrin and cells, as well as their effects on fibrinolysis and on plasmin -induced cell apoptosis The LBS specificity...
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Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf
... occurring mutations found as sequence polymorphisms and in drug resistance, with wild-type and five drug- resistant mutant PRs: M46L, V82A, I84V and L90M mutations that appeared together with the ... PR, and the respective S4 and S3 binding sites could accept a variety of residues [33,34,46] When compared to peptides having the same natural sequence background (peptides and 1, and 2, and ... it interacts with Arg8 and Glu21 through water molecules and makes hydrophobic interactions with Phe53, Pro81 and Val82 [26] P3 Arg could interact favorably with Asp29 and P1 Asn, which may contribute...
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Báo cáo khoa học: Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1 pot
... protein and are relayed from the NBDs to the TMDs as a consequence of nucleotide binding and drug binding, respectively, thereby enabling active drug efflux by ABCB1 However, we are yet to understand ... changes are relayed between the TMD and NBD, and how they enable drug translocation Transmembrane helix (TM6) and transmembrane helix 12 (TM12) are likely candidates to effect coupling, given ... purchased from Lonza (Wokingham, UK) and Excell 405 from SAFC Biosciences (Andover, UK) CM, FM and BM were purchased from Molecular Probes (Leiden, The Netherlands) Site-directed mutagenesis of...
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Báo cáo khoa học: Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats ppt
... protective effects of curcumin and capsaicin H Manjunatha and K Srinivasan Table Effect of dietary curcumin and capsaicin on iron(II) -induced (in vivo) and copper -induced (in vitro) LDL oxidation ... effects of curcumin and capsaicin H Manjunatha and K Srinivasan Protective effect of dietary curcumin, capsaicin and their combination on iron -induced LDL oxidation in vivo and copper -induced LDL oxidation ... suggest that dietary curcumin and capsaicin individually are protective to LDL oxidation both in vivo and in vitro, to iron -induced hepatotoxicity and to carrageenan -induced inflammation These beneficial...
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Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf
... purified enzyme resulted in the release of AA Km and Vmax values obtained for the reactions were 4.1 and lM and 948 and 193 nmolÆmin)1Æmg)1 for CTE-I and a MTE-I, respectively Next, we measured the ... and stromal cells of the ovary and Leydig cells of the testis [39] Moreover, it was demonstrated that ACS4 expression in the murine adrenocortical tumor cell line Y1 (Y1) is induced by ACTH and ... synthetase and thioesterase are, indeed, essential for AA release and adrenal cholesterol metabolism We demonstrate that recombinant MTE-I and CTE-I release AA from arachidonoyl-CoA in vitro and that...
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Báo cáo khoa học: Specific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast docx
... to mm glucose, and metabolites were extracted at and and 2, and h Within min, a large change occurred for many compounds A very fast decay of UDP-glucose, phosphorylated glucose and fructose (Fig ... h) and the cell length at the time of division decreased (10 lm versus 15 lm) in comparison with the 111, 11.1 and 4.4 mm glucose conditions Further reduction of glucose to 1.7 and 1.1 mm induced ... cultured in 111 and 4.4 mm glucose Based on the narrow doubling time distribution in the second and third divisions, the doubling time was quite uniform for 111 and 4.4 mm glucose, and the stochastic...
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Radiological Findings of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-AIDS Adults: Comparisons with Findings of Multidrug-Resistant and Drug-Sensitive Tuberculosis docx
... TB = drug- sensitive tuberculosis, MDR TB = multidrug-resistant tuberculosis, XDR TB = extensively drug- resistant tuberculosis, SD = standard deviation Numbers in parentheses are median, standard ... Numbers represent mean standard deviation of involved zones Numbers in parentheses are median, standard error and range DS TB = drug- sensitive tuberculosis, MDR TB = multidrug-resistant tuberculosis, ... Numbers represent mean standard deviation of involved lobes Numbers in parentheses are median, standard error and range DS TB = drug- sensitive tuberculosis, MDR TB = multidrug-resistant tuberculosis,...
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Guidance for Industry on Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug Administration pptx
... Department of Health and Human Services Food and Drug Administration Center for Biologics Evaluation and Research (CBER) Center for Drug Evaluation and Research (CDER) Center for Devices and Radiological ... 13 Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug ~dministration' This draft guidance, when finalized, will represent the Food and Drug Administration's ... of Policy and Planning, Office of the Commissioner, Food and Drug Administration, with assistance from the Center for Biologics Evaluation and Research, the Center for Drug Evaluation and Research,...
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