breast colon and melanoma tumors in the response to antitumor therapy
Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
... processes In this study we examined the role of Bcp2 in order to increase the knowledge of the enzymatic activity involved in the oxidative stress in S solfataricus To detect differences in the response ... thioredoxin) In typical 2-Cys, Sp at the N terminus and SR at the C terminus belong to different subunits and condense to form an intersubunit disulfide bond; in atypical 2-Cys, Sp at the N terminus and ... Prxs, the largest Prx class, is their second redox-active cysteine, the resolving cysteine (Cys-SR) In typical 2-Cys, Sp at the N terminus and SR at the C terminus of the protein belong to different...
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báo cáo khoa học: "Evaluation of HER2 and p53 expression in predicting response to docetaxel-based first-line chemotherapy in advanced breast cancer" docx
... in metastatic breast cancer Background Breast cancer (BC) is the leading cause of cancer and the second leading cause of cancer death in women in the USA [1] and its incidence is increasing in ... dilution, then incubated in secondary biotinylated antibody and finally counterstained with Hematoxylin Immunohistochemical analyses of c-erbB-2 expression describe the intensity and staining pattern ... countries, including Italy [2] thus representing a major health problem To date, the role of chemotherapy in BC treatment is certain and taxanes are widely used in both early and advanced setting [3,4]...
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Báo cáo khoa học: "Clinical review: Communication and logistics in the response to the 1998 terrorist bombing in Omagh, Northern Ireland" potx
... concerned were mainly medical trainees in anaesthesia (who are used to working in the ED and frequently move from one hospital to another as part of their training) and ED nurses Working within an appropriate ... Lavery and Horan Table The system’s response to bombing: strengths and weaknesses Strengths in system’s response Weaknesses in system’s response Clinical staff going to Omagh to help initial response ... Broadband access to the Internet and satellite-linked devices (which not depend on telephone landline integrity) have become valuable in receiving information in more recent major incidents [4] and...
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Báo cáo y học: "Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection" pot
... infection These results underline the fact that C elegans mounts distinct responses to bacterial and fungal infection The response of C elegans to infection by S marcescens and P aeruginosa involves ... appears to be primarily involved in the maintenance of intestinal cell integrity; abrogation of erm-1 function by RNAi provokes distortion of the intestinal lumen in the adult animal [56] In the ... KOG1339:aspartyl protease 10 Insulin_Down in Dauer_McElwee2004 Insulin_Down in daf-2 _McElwee2004 68 44 53 Insulin Down in daf-2 Murphy2003 30 Insulin_Up in Dauer_McElwee2004 Insulin_Up in daf-2 _McElwee2004...
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Báo cáo y học: "Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity" potx
... Early response Protein interaction analysis reveals a novel pathway involved in the response to cadmium In order to further define the molecular mechanisms of the cadmium defense response, the ... unknown To investigate the relationship between cadmiuminduced gene expression and resistance to cadmium toxicity, the effects of inhibiting the expression of the cadmiumresponsive genes in the presence ... confirmed the important roles of these proteins in the defense against cadmium toxicity In the present study, we utilized whole genome C elegans DNA microarrays to monitor global changes in the nematode...
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Strengthening the Education Sector Response to School Health, Nutrition and HIV/AIDS in the Caribbean Region: A Rapid Survey of 13 Countries pdf
... sector in participating countries to monitor their progress against the core set of actions to strengthen national SHN and HIV responses by the education sector, as outlined in the Port-of Spain ... central to the education sector response to the epidemic Later, in an effort to strengthen and harmonize education sector responses to HIV across the region, the Caribbean Ministers of Education and ... Nevis, St Lucia, and Trinidad and Tobago, lack an HIV section in the MoE but have a designated HIV/AIDS coordinator The HIV/AIDS coordinator in Trinidad and Tobago is attached to the Student Support...
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Báo cáo hóa học: " Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice" doc
... peripheral blood, indicating IL-10 can influence cells in the tumor microenvironment and immune response [15] Another prominent inhibitory cytokine, transforming growth factor-beta (TGF-b) can ... cancer cell line PC-3 tumors formed subcutanously in NOD.scid mice As shown in Figure 1, both the monotherapy and combination therapy by IT administration of the Ad5IL-12 vector resulted in statistical ... fat stores and breakdown of body fat supporting another indication for the inclusion of RU486 in therapy Thus, the use of RU486 in prostate cancer therapy could have effects on cachexia, androgen-dependent...
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Báo cáo hóa học: " Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice" pptx
... were cultured in a maintenance medium (containing 2% FCS) and were left for days to allow for the plaques and the cell fusion to develop Photographs of the infected cells were taken using a fluorescence ... containing 10% FCS The cultures were main- Phenotypic characterization and replication kinetics of the OncSyn and OncdSyn viruses Cells (both Vero and 4T1) were seeded into 6-well plates and infected ... embedded, sectioned, stained with hematoxylin and eosin (H&E), and evaluated by light microscopy OncdSyn, and PBS) and MOUSE within TREATMENT as main plot factors Subplot factors included PERIOD (days...
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báo cáo hóa học:" A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espírito Santo, Brazil" ppt
... platinum and cyclophosphamide or to platinum alone, therefore suggesting that the control of EOC might be conducted in an efficient but yet less toxic therapeutic regimen, and pointing to the ... the need to revisit the standard clinical protocols in a way to increase the disease treatment success in the cases of platinum-resistant EOC In conclusion, we have characterized the clinicopathological ... revisit the standard clinical protocols in a way to increase the disease treatment success in the cases of platinum-resistant EOC, which can account to as much as 80% of all treated EOC in Brazil...
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Báo cáo lâm nghiệp:"Growth and biomass partitioning of Fagus sylvatica L. and Quercus robur L. seedlings in response to shading and small changes in the R/FR-ratio of radiation" pot
... respectively)) and the dry mass of the main stem (DMshoot) at the end of the experiment, the dry mass of the main stem at the start of the experiment and after 50 days was estimated using the following ... Z2 for RHG and RGDS in the second part of the growing period as well as in the total period indicates that the difference between the control and the shade treatments in height growth and stem ... material The seeds were sown into a permeable pot of 2000 cm3 in size and the seedlings stayed there to the end of the experiment The rooting substrate consisted of a mixture of peat and agriperl...
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Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx
... through G1 into S phase requires cyclin D-CDK4/6 and cyclin E-CDK2, which phosphorylate the retinoblastoma protein [26] CDK inhibitors (CKIs) are the negative regulators and are grouped into two ... TGF1 [29-32] The aim of the present study was therefore to reveal the role of c-Myc in mitogenic response to TGF1 in nucleus pulposus cells The study was designed to (1) analyze the effect of ... proliferation and the cell cycle progression in nucleus pulposus cells, (2) determine if c-Myc transcription inhibitor obstructed the effect of TGF1, and (3) determine the role of ERK1/2 in stabilizing the...
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Báo cáo y học: " The inflammatory response seen when human omental adipose tissue explants are incubated in primary culture is not dependent upon albumin and is primarily in the nonfat cells" pps
... by increases in expression of HIF1a or NFB1 Furthermore albumin effects were primarily due to factors other than endotoxin contamination, which is in agreement with the findings of Schlesinger ... women and results in a rapid inflammatory response that can be seen within 20 minutes with respect to gene expression of inflammatory response proteins such as HIF1a and NFB as well as inflammatory ... albumin and 5.4-fold greater in the presence of 1% bovine albumin [data not shown] Clearly, the effect of albumin is not due to the presence of endotoxin The up-regulation of IL-1b, TNFa, IL-8, and...
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Báo cáo y học: " Axillary silicone lymphadenopathy presenting with a lump and altered sensation in the breast: a case report" pot
... in differing properties and products according to the variation in their chain lengths and cross-links [4, 7] Liquid silicone consists of short chains, and gels are made from long chains [4] Despite ... Malignant lesions including lymphoma and cancers of the breast and lung have arisen in those with silicone prostheses although again there has yet to be any firm proof of its carcinogenicity Indeed, some ... favourable The rationale for this is that silicone granulomata have been found as incidental findings in axillary nodes removed at mastectomy for breast cancer in the presence of intact breast prostheses...
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Báo cáo y học: " Beyond the first 25 years: The International AIDS Society and its role in the global response to AIDS" pps
... society, and the IAS is looking at ways to strategically expand its role in this area in order to strengthen the capacity of the HIV workforce The IAS has been increasingly involved in policy and ... activists and others working on the frontlines of the response The IAS encourages all professionals working in the HIV/AIDS field to become members We are convinced that in the struggle against this ... diversity, to facilitate cross-disciplinary linkages and dialogue, and to strengthen the focus on youth – began to be implemented in the planning for the XVI International AIDS Conference (AIDS 2006) in...
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Báo cáo y học: "Differences between children and adolescents in treatment response to atomoxetine and the correlation between health-related quality of life and Attention Deficit/Hyperactivity Disorder core symptoms: Meta-analysis of five atomoxetine tria
... domain and subdomains Our findings regarding the low and moderate correlations between core symptoms and HR-QoL (and the small correlations found in several instances regarding change from baseline ... core symptoms and HR-QoL at baseline and for change from baseline to endpoint were small to moderate, suggesting that next to the effect of core symptoms, other factors might play a role in the background ... of atomoxetine (p < 0.10) This interaction was due to the significant interaction found in the Threats to Achievement sub-domain (p < 0.10) Specifically, in the Risk Avoidance domain and in its...
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THE MECHANISMS REGULATING THE TRANSCRIPTION FACTOR ATF5 AND ITS FUNCTION IN THE INTEGRATED STRESS RESPONSE
... located in an insert region in the middle of the protein kinase domain (Fig 3) Heme binding inhibits HRI kinase activity, and in response to heme deficiency, heme dissociates from the heme-binding ... eIF2α In the N-terminal portion of PKR are two dsRNA-binding domains (dsRBDs), while the protein kinase domain is located at the C-terminus During virus invasion, binding of double-strand RNA to the ... transmembrane protein kinase, with its cytosolic portion containing the protein kinase domain, and the ER luminal part containing the regulatory elements for PERK The regulatory elements facilitate...
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the role of ikkalpha, ikkbeta and nf-kappab in the progression of breast cancer
... testing whether standard therapy (chemotherapy and endocrine therapy for all patients) or test-directed therapy (chemotherapy given only to patients with high risk scores, and endocrine therapy to ... identified Binding of the p65/p50 dimer results in IκBα resynthesis and IκBα is then exported back to the cytoplasm, binding NF-κB and inactivating the pathway Protein phosphatase 2A is a key regulator ... phosphorylated and processed into p52 The processing of p100 to p52 results in the loss of the ankyrin repeats in the C-terminus and allows translocation of the RelB/p52 dimers into the nucleus...
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The ancient origin of NF kb ikb and thioredoxin and their roles in immune response
... dual and opposing roles in the regulation of NF-κB in the nucleus and cytoplasm In the cytoplasm, TRX interferes with the signals to IκB kinases, and blocks the degradation of IκB, thus maintaining ... is involved in the dimerization, DNA-binding and interaction with the inhibitory IκB (inhibitor of NF-κB) proteins The difference is that RelA, RelB and c-Rel have an activation domain in their ... extracellular signaling events is the cleavage of Spätzle, which then binds to and activates the Toll receptor (Belvin and Anderson, 1996) 11 Most of the intracellular signaling components of the Toll pathway...
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