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bone marrow biopsy and its utility in the diagnosis of al amyloidosis and other plasma cell dyscrasias

Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

Báo cáo khoa học

... occured A binding isotherm was fitted to the data, expressed in terms of the heat change per mole of ligand against the ligand to macromolecule ratio From the binding isotherm values for the reaction ... experiment of titrating stefin B protein with glycine alone was performed and no binding was observed In our hands, as others [54], the most reproducible data was obtained from injections of the metal into ... solution of the protein Typically an initial injection of lL copper chelate solution was followed by a further 29 injections of lL of Cu(II) into the protein in the sample cell stirred at 300 r.p.m Injections...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx

Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx

Báo cáo khoa học

... mammalian cells and plants as a component of the docking complex and a point of convergence of the PEX5- and PEX7-dependent import pathways [15–17] The N-terminal part of PEX14 interacts with the ... membrane-spanning domains in PEX14 have been unambiguously identified and it was observed in mammalian cells and S cerevisiae that both the N-terminal and the C-terminal domain are at the cytosolic face of ... lM, and that the amino-terminal domains of the two peroxins were responsible for this interaction The role of TbPEX14 in glycosome biogenesis received further confirmation by analysing the subcellular...
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Báo cáo y học:

Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot

Báo cáo khoa học

... either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation of signal transduction molecules including motifs similar to those involved in insulin ... TH2-like cells, IL-4 blockade inhibits the biological activities of IL-4 and, equally important, reduces the primary research IL-4 is increased in the serum and bronchoalveolar lavage of allergic individuals ... the third section of the AQLQ (Asthma Quality of Life Questionnaire, showing a patient’s perception of general health and physical functioning) worsened in the placebo group and improved in the...
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CHARACTERISATION OF    GLUTAMYL TRANSPEPTIDASE AND ELUCIDATING ITS ROLES IN THE PATHOGENESIS OF HELICOBACTER PYLORI

CHARACTERISATION OF GLUTAMYL TRANSPEPTIDASE AND ELUCIDATING ITS ROLES IN THE PATHOGENESIS OF HELICOBACTER PYLORI

Y - Dược

... Assessing the ability of GGT in inducing IL-8 generation in various cell types  Analyzing GGT entry into host cells and its probable downstream effects  Examining the role of GGT in vacuolation induction ... this, the study will focus on the following objectives:  Cloning of ggt gene (full length and individual large and small subunits) from H pylori and expressing the recombinant proteins in E coli ... in E coli  Raising and characterizing specific polyclonal and monoclonal antibodies against GGT  Determining the subcellular localization of GGT in H pylori  Investigating the mechanism by...
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Development of a novel toll like receptor based two hybrid assay for detecting protein protein interactions and its application in the study of CD14 dimerization and FcyRIIA activation

Development of a novel toll like receptor based two hybrid assay for detecting protein protein interactions and its application in the study of CD14 dimerization and FcyRIIA activation

Cao đẳng - Đại học

... known protein by expressing the protein in fusion with BD domain and then screening proteins in fusion with AD It also allows the identification of specific binding sites on proteins in combination ... efficiency of the given cell type, the quality and quantity of DNA taken up by the cells, the cytotoxicity of the transfection reagent and the condition of the cells These limitations have restricted the ... domain-containing adaptors and TLR signaling MyD88 is an essential TIR domain-containing adaptor for the induction of inflammatory cytokines via all the TLRs TIRAP/Mal is a second TIR domain-containing...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt

Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt

Báo cáo khoa học

... ¯ow rate of mLámin)1 The following gradients were used: incubations containing arbutin or salicin as substrate; 100% C initial, increasing D to 20% (10 min), 50% (15 min), 100% (5 min), held ... H), genistein (R, OH); (D) hydroquinone; (E) salicyl alcohol; (F) mandelonitrile (prunasin, amygdalin) and glucosides of simple phenolics (salicin, arbutin) occurred at  10% and 1% of the average ... and measuring the release of 4NP Protein assays and protein sequencing Total protein in crude and semipuri®ed samples was estimated using the Pierce Protein Assay Reagent with BSA as standard For...
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Báo cáo lâm nghiệp:

Báo cáo lâm nghiệp: " Sweet chestnut silviculture in an ecological extreme of its range in the west of Spain (Extremadura)" potx

Báo cáo khoa học

... sample-plots within each of the five geographical clusters was proportional to their size (number of grid-cells) and randomly located The sample-plots were all chestnut-dominated stands ( 15 HF and 15 ... classes: insignifi< (classified as cant, slight and severe), (13) insolation (indicating the amount of solar radiation on the ground as determined by the slope, the aspect and the latitude of the ... latitude of the plot; Gandullo, 1974), (14) complexity of the sumoundings (indicating the degree of simplicity of the orography of the surrounding area; Blanco et al, 1989), (15) wind protection coefficient...
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Báo cáo y học:

Báo cáo y học: " the Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer"

Y học thưởng thức

... ruins protein profiles Another factor may be the differences in statistical analyses Direct analyses on linear data were used in the present study and the study by Mathelin et al (27) Li et al. , ... response rather than malignancy Another study by Mathelin et al included a total of 89 patients Bc1a and Bc1b defined by the authors corresponded to the Bc1 and Bc3a and Bc3b corresponded to Bc3 of Li ... Presence of moderate staining completely surrounding cytoplasmic membrane in at least 10% of invasive carcinoma cells or presence of membranous staining in less than 30% provided that the staining...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf

Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf

Sức khỏe phụ nữ

... the role of DWI and ADC in distinguishing between benign and malignant lymph nodes may be limited Lin et al [62] reported the combination of size and relative ADC values was useful in detecting ... molecules within the keratinoid substance results in a high signal on DWI and a low ADC value, which was first utilized in the diagnosis of intracranial epidermoid cyst [50] Detecting the keratinoid ... determine the ultimate clinical utility demonstrate the tumor focus because the signal intensity of endometrial cancer ranges from high to low and is sometimes indistinguishable from normal endometrium...
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Accuracy of Clinical Signs in the Diagnosis of Pulmonary Tuberculosis: Comparison of Three Reference Standards Using Data from a Tertiary Care Centre in Rwanda doc

Accuracy of Clinical Signs in the Diagnosis of Pulmonary Tuberculosis: Comparison of Three Reference Standards Using Data from a Tertiary Care Centre in Rwanda doc

Sức khỏe giới tính

... directly mathematically, but iterative application of algorithms can deduce the probability of each test pattern for the hypothetical disease, the prevalence of the hypothetical disease, and the diagnostic ... testing was part of routine examination For HIV testing, specific informed consent was asked and counseling offered Approval for this study was obtained from the relevant authorities of the Ministry ... period in the public wards of internal medicine of CHK, a 600-bed hospital of national referral center in Rwanda Three hundred consecutive patients who were hospitalized with a cough of at least...
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Báo cáo hóa học:

Báo cáo hóa học: " An international evaluation of ultrasound vs. computed tomography in the diagnosis of appendicitis" doc

Hóa học - Dầu khí

... as the first-line test in the case of suspected appendicitis, and its use is increasing [15,16,20] In this international study, we compared the performance of CT and US in the evaluation of suspected ... performed the statistical analysis, and participated in the drafting of the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have ... conditional CT strategy, with initial US in adult patients presenting with acute abdominal pain, including suspected Reich et al International Journal of Emergency Medicine 2011, 4:68 http://www.intjem.com/content/4/1/68...
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ADVANCES IN THE DIAGNOSIS OF CORONARY ATHEROSCLEROSIS pot

ADVANCES IN THE DIAGNOSIS OF CORONARY ATHEROSCLEROSIS pot

Sức khỏe giới tính

... Effects of TRAIL on cellular components in the arterial wall (in vitro findings) Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the principal cellular components of the normal ... signaling cascades are activated in EPCs and in endothelial cells An array of biological activities are subsequently elicited in vivo and in vitro, including angiogenesis, endothelial survival, ... KDR Kinase insert domain-containing receptor/fetal liver kinase-1, also called VEGFR2 (KDR), is expressed in a wide variety of cells such as endothelial progenitor cells (EPCs), endothelial cells,...
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Báo cáo y học:

Báo cáo y học: "Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus" potx

Báo cáo khoa học

... in the ELISA according to the instructions for use of the respective kit Statistical evaluation of results The results obtained from the comparative study were evaluated using the Analyse-it Software ... antibodies in the diagnosis of SLE Whether this modified amino acid also plays a central role in the development of the SLE-specific B -cell immune response to the Sm particles remains a matter of speculation ... ELISAexperiments and helped with data analysis FH consulted in the evaluation of the data and helped to write the manuscript All authors read and approved the final manuscript Acknowledgements The authors...
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Báo cáo y học:

Báo cáo y học: "Ultrasound in the diagnosis of a median neuropathy in the forearm: case report" doc

Báo cáo khoa học

... (A) of the proximal forearm demonstrates the normal echo-texture of the median nerve The cross-sectional ultrasound image (A) of the proximal forearm demonstrates the normal echo-texture of the ... an increase in median nerve cross-sectional area Alternatively, the initial injury could have caused a tear of the flexor digitorum profundus muscle to the index finger, with the development of ... at other sites, and this finding identified the specific site of neuropathy [5,6] There were no ultrasonographic changes to suggest the presence of a neuroma Finally, the abnormal appearance of...
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báo cáo khoa học:

báo cáo khoa học: "Contribution of magnetic resonance imaging in the diagnosis of talus skip metastases of Ewing’s sarcoma of the calcaneus in a child: a case report" pdf

Báo cáo khoa học

... especially for the investigation of tumor spread to bony structures and bone marrow MRI should always be performed in the analysis of Ewing’s sarcoma since it allows accurate evaluation of the ... essential in the determination of the true extent of the tumor It is important to bear in mind that early recognition of an unusual appearance and location of Ewing’s sarcoma is necessary for its ... lesion in the talus as a low signal mass with peripheral enhancement Cook listed 29 cases of Ewing’s sarcoma of the calcaneus in the literature since 1921 [3] These rare cases are usually misdiagnosed,...
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Báo cáo y học:

Báo cáo y học: " Pitfalls in the diagnosis of a tumefactive demyelinating lesion: A case report" potx

Báo cáo khoa học

... demyelination alternating with rings of intact myelin MRI is the method of choice for imaging demyelination lesions, tumefactive or not Although the usual appearance of MS is that of multiple, small, ... T-lymphocytes favors the diagnosis of demyelinating plaque The presence of alternating rings of myelin preservation or remyelination and myelin loss, consistent with demyelination, corresponds to the concentric ... of follow-up A serial MRI showed a lowsignal, non-enhancing lesion Discussion Diagnosis of tumefactive brain lesions is challenging to both clinicians and radiologists Clinical differential diagnosis...
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Báo cáo y học:

Báo cáo y học: "Usefulness of manufactured tomato extracts in the diagnosis of tomato sensitization: Comparison with the prick-prick method" pdf

Báo cáo khoa học

... on Skin Tests of the European Academy of Allergology and Clinical Immunology: Methods for skin testing Allergy 1989, 44(Suppl 10):22-30 The European Agency for the Evaluation of Medicinal Products ... profile of the extracts revealed several bands in a molecular weight range of and 50 kDa in the peel extract The most prominent bands had molecular weights of approximately 9, 16, 25, 28, 35 and ... the use of natural fresh foods may have disadvantages due to the variability of the source material, the low reproducibility of the test and the poor availability of the material In the present...
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Báo cáo y học:

Báo cáo y học: "Real-time reverse-transcription PCR in the diagnosis of influenza A (H1N1)v in intensive care unit adult patients" pdf

Báo cáo khoa học

... cause The antiviral treatment should be maintained until the clinical diagnosis is confirmed by a new RT-PCR sample Competing interests The authors declare that they have no competing interests ... suboptimal performance of RT-PCR for diagnosis of influenza A (H1N1)v pneumonia, which is important in the decision-making process Only 25% of our patients started antiviral treatment within 48 ... Evaluation of four real-time PCR assays for detection of influenza A(H1N1)v viruses Euro Surveill 2009, 14:pii 19230 The ANZIC Influenza Investigators: Critical care services and 2009 H1N1 influenza...
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Báo cáo y học:

Báo cáo y học: " Reconstitution of the myeloid and lymphoid compartments after the transplantation of autologous and genetically modified CD34+ bone marrow cells, following gamma irradiation in cynomolgus macaques" potx

Báo cáo khoa học

... was not detected in peripheral blood cells In the three remaining animals, vector DNA was detected in peripheral blood cells (up to 500 copies per million cells) and in the bone marrow (up to 6250 ... resulting in the formation of clusters of GFP-positive cells within a single myeloid colony In our in vivo study, autologous HSC were injected into the bone marrow, whereas intravenous injection ... with the dose of CD34+ cells infused, the speed of reconstitution increasing with the number of CD34+ cells injected (macaque 6653) Reconstitution of bone marrow clonogenic activity We determined...
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Globalization and its effects on the development of educational service in Vietnam

Globalization and its effects on the development of educational service in Vietnam

Kinh tế - Quản lý

... general education, official training and informal on -the- job training Informal on-thejob training is likely to correlate with the skill content of the job, and hence MNEs offer more of this when they ... vocational training The involvement of MNEs in firm-specific and general vocational training is another way MNEs can affect the supply of skills This goes beyond charitable giving and is in the self-interest ... supply the training program for local workers in international standards In conclusion, the increase in FDI into Vietnam not only increases the demand for quantity but also increases the demand...
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