blocking cerebral lymphatic drainage deteriorates cerebral oxidative injury in rats with subarachnoid hemorrhage
báo cáo hóa học: " Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury" pptx
... protein vs 8.26 ± 0.65 pg/mg protein; p < 0.05) 79.0 IL-1b 78.5 78.0 S 24 48 72 96 Time Post -Injury (hours) Figure Increase in brain edema does not differ in traumatic axonal injury rats with or without ... (hours) E * D Brain IL-2 (pg/mg protein) Brain TNF (pg/mg protein) B Time Post -Injury (hours) C Brain IL-4 (pg/mg protein) * Brain IL-1 (pg/mg protein) Brain IL-6 (pg/mg protein) A Page of 16 ... neuronal injury and induces BBB dysfunction by stimulating matrix metalloproteinases [90] IL-1b mRNA is upregulated within minutes after TBI, and increased protein levels are detectable within an...
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Báo cáo y học: "Asthma is a risk factor for acute chest syndrome and cerebral vascular accidents in children with sickle cell disease" ppt
... http://www.clinicalmolecularallergy.com/content/3/1/2 Vaso-occlusive pain was defined as pain that could not be explained by injury or infection requiring hospital admission and treatment with intravenous ... of asthma on individuals with sickle cell anemia In this study, we examined hospitalized children with sickle cell disease with concomitant asthma establishing whether there was an increased rate ... causes sickle hemoglobin to gel, inducing red blood cell sickling and vaso-occlusion within pulmonary blood vessels Asthma is the most common chronic disease of childhood occurring in 6% of the general...
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A potential protective effect of α-tocopherol on vascular complication in spinal cord reperfusion injury in rats pptx
... long-term administration of αTOL in spinal cord reperfusion injury against high oxidative stress induced by ischemia; and to investigate the role of α-TOL in the inhibition of COX-2 activity, with subsequent ... responses of the spinal cord in IRI but also its clinical neurological impacts [14] Interruption of aortic blood flow in IRI may not only induce spinal cord injury, but also induce injury of the heart, ... Medicine, Menoufiya University Induction of ischemic reperfusion injury of the spinal cord Spinal cord ischemia was induced, as described by Akguna et al [20] Rats were initially anesthetized with...
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Báo cáo y học: "Ipsilateral common iliac artery plus femoral artery clamping for inducing sciatic nerve ischemia/reperfusion injury in rats: a reliable and simple method" doc
... injury in peripheral nerves Competing interests The authors declare that they have no competing interests Authors' contributions MN participating in drafting the manuscript RR participating in drafting ... still-considerable induced functional defect in the limb make it rational to apply in experimental studies Briefly, our results show that common iliac artery and femoral artery clamping induces I/R injury in ... drafting the manuscript and statistical analysis GF participating in statistical analysis and study design MRR: Preparing the revised paper and drafting the manuscript SMR participating in setting...
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Báo cáo y học: "EGb761 protects motoneurons against avulsion-induced oxidative stress in rats Research article" ppsx
... avulsion-induced injury in rats The neuroprotective effect of EGb761 against avulsion injury is associated with reductions in nitric oxide production and NOS expressions in the injured spinal cord Compared ... measured with a NOS kit (Nanjing Jiancheng Institute of Biology and Engineering, Nanjing, China), which assessed activity by measuring the conversion of L-[14C]-arginine to L-[14C]citrulline [24] ... correlated with increased iNOS activity and changes in cNOS activity in the injured spinal cord, as well as nNOS expression in injured motoneurons EGb761 treatment diminished avulsioninduced motoneuron...
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Báo cáo y học: "Simvastatin protects bladder and renal functions following spinal cord injury in rats." ppsx
... overactivity by arginase inhibitor in rats with chronic spinal cord injury Urology 2008, 72:696-700 46 Kim D, Sands JM, Klein JD: Changes in renal medullary transport proteins during uncontrolled ... dorsal spine line, and a hemilaminectomy was done at the T9-T10 level to expose the dura overlying the spinal cord [29] Spinal cord contusion injury was induced by a controlled contusion injury ... Singh AK, Singh I: Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats J Neurosci Res 2005, 79:340-350 30 Bilgen M: A new device for experimental modeling...
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Báo cáo y học: "Simvastatin protects bladder and renal functions following spinal cord injury in rats" potx
... overactivity by arginase inhibitor in rats with chronic spinal cord injury Urology 2008, 72:696-700 46 Kim D, Sands JM, Klein JD: Changes in renal medullary transport proteins during uncontrolled ... dorsal spine line, and a hemilaminectomy was done at the T9-T10 level to expose the dura overlying the spinal cord [29] Spinal cord contusion injury was induced by a controlled contusion injury ... Singh AK, Singh I: Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats J Neurosci Res 2005, 79:340-350 30 Bilgen M: A new device for experimental modeling...
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Báo cáo y học: "Intratracheal dopamine attenuates pulmonary edema and improves survival after ventilator-induced lung injury in rats" potx
... after 60 minutes than after 30 minutes in animals with or without intratracheal dopamine After 60 minutes oxygen saturation was 91% in the group with dopamine versus 86% in the group without Although ... for 60 minutes In the group undergoing MV with HTV for 60 minutes (HVT60; n = 10), MV was maintained for 60 minutes with HVT (25 ml/kg) and RR of 40 breaths/minute At 10 minutes after starting MV, ... 30 minutes In the group undergoing MV with low tidal volume (LVT) for 30 minutes (LVT-30; n = 10), MV was maintained for 30 minutes with LVT (8 ml/kg) and RR of 50 breaths/minute At 10 minutes...
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Báo cáo y học: "Danaparoid sodium inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in rats" doc
... prevent LPS-induced lung injury by inhibiting cytokine and HMGB1 secretion We demonstrated that IL-10 increased following the administration of DA during endotoxin-induced systemic inflammation ... histopathology in lipopolysaccharide (LPS)-administered rats Rats were intravenously infused with either (DA) on lung histopathology in lipopolysaccharide (LPS)-administered rats saline (control ... the rats in the untreated LPS group died within 12 h, and an additional 30% died within 24 h, while all rats in the DA-treated LPS group (50 U/kg) survived (Figure 1) In addition, only 20% of rats...
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Báo cáo y học: "Aerosolised surfactant generated by a novel noninvasive apparatus reduced acute lung injury in rats" doc
... content in Inhalation of surfactant aerosol rats with acute lung injury induced by bronchoalveolar lavage fluid of rats with acute lung injury induced by oleic acid (a) Phospholipids in the bronchoalveolar ... aerosolisation The rats in the PPS-inst and saline-inst groups were intubated after tracheotomy performed before OA injection The rats in the PPS-inst group were instilled with 50 mg/ml PPS at ... diluted OA injection (using a syringe with a No 4.5 pedo-scalp needle) through a lingual vein for one minute Rats were divided into five groups: PPS aerosol (PPSaer, n = 16), saline aerosol (saline-aer,...
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báo cáo hóa học: " Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia" docx
... potent inflammatory mediators in IR injury [34] Recently, 5-LOX has been shown to be involved in ischemic-like injury in neuronal PC12 cells [35] As in human brain following stroke [7], we found increased ... dilution in blocking buffer) After washing in PBS containing 0.1% Tween-20, sections were incubated with the appropriate fluorophore tagged secondary antibody (1:100 dilution in blocking buffer) ... craniectomy in rats Stroke 1989, 20:84-91 Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I, Singh AK: N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia Brain Res 2003,...
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Báo cáo hóa học: " Oromotor variability in children with mild spastic cerebral palsy: a kinematic study of speech motor control" docx
... speech in children with mild forms of CP Conclusion Children with mild spastic CP showed greater STIs in PS tasks, but not in MS tasks, than children with TD These findings suggest that children with ... task Left vertical line is identified as the instance of peak closing velocity right before the initial opening of the lower lip marker Right vertical line is defined as the instance when the lower ... peak opening displacement, and peak opening velocity) obtained by dividing the standard deviation of kinematic data by the mean kinematic data Larger CV indicates higher variability of kinematic...
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Báo cáo hóa học: " Validity of gait parameters for hip flexor contracture in patients with cerebral palsy" pot
... key kinematic variables The kinetic data including time of crossover in the hip flexion-extension moment and the power burst of hip flexor in the late stance were obtained The hip flexor index ... distal hamstring lengthening, and tendo-Achilles lengthening as single event multilevel surgery TOC, time of cross over in hip flexion/extension moment; H3, late swing power burst in hip joint flexion/extension ... acquired hip subluxation in cerebral palsy J Pediatr Orthop 1986, 6:285-290 Zwick EB, Saraph V, Zwick G, Steinwender C, Linhart WE, Steinwender G: Medial hamstring lengthening in the presence of hip...
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báo cáo hóa học: " Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat" potx
... administered in a delayed treatment schedule in order to establish the therapeutic time window of protection of this COX-2 inhibitor in pMCAO, thus increasing predictive outcome in the clinic Interestingly, ... reaching maximal values by 24 h after the insertion of the filament (Fig 1A) These findings are in line with those published previously in this model of stroke [42,43] Although infarct size continues ... pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats Brain Res 2003, 990:1-7 Longa EZ, Weinstein PR, Carlson S, Cummins R: Reversible...
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Báo cáo y học: "Baseline cerebral oximetry values in cardiac and vascular surgery patients: a prospective observational study" doc
... oxyhemoglobin can be determined by using two infrared wavelengths, thereby providing a technique for continuous non-invasive, bed-side monitoring that reflects the balance between cerebral oxygen ... values is shown graphically in Figure In contrast to our findings in carotid surgery patients, diabetes, smoking and high cholesterol were not NS Smoking Cholesterol INVOS in cardiac surgery NS 61.54 ... diabetes are associated with lower baseline INVOS values in carotid surgery patients Right sided baseline INVOS values are strongly correlated with left sided INVOS values in both patient groups...
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báo cáo khoa học: "Reversible cerebral vasoconstriction syndrome in a patient taking citalopram and Hydroxycut: a case report" doc
... above 90mmHg, in an effort to balance maintaining adequate cerebral perfusion while continuing nimodipine treatment for RCVS Our patient tolerated this well without any clinical decline or symptomatic ... 10(4):295-298 Forman HP, Levin S, Stewart B, Patel M, Feinstein S: Cerebral vasculitis and hemorrhage in an adolescent taking diet pills containing phenylpropanolamine: case report and review ... described as “blank lines.” A repeat MRI revealed areas of restricted diffusion consistent with acute infarcts in the bilateral anterior cerebral artery territories and in her right occipital...
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Báo cáo y học: "Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage" doc
... occurred in 19 patients (79%) of the insulin treatment group, beginning 99.1 ± 54.4 hours after initiation of insulin infusion (duration 6.9 ± 11.6 hours) and in three patients in the noninsulin treatment ... indicate cellular distress following insulin-induced decrease in cerebral glucose Extracellular concentrations of glutamate decreased during insulin infusion (hours to 12; P < 0.05), indicating ... distress following insulin-induced decrease in cerebral glucose The role of insulin in the metabolic processes of the brain remains unclear, but recent studies in the human brain using 2-deoxy-2-[18F]fluoro-D-glucose...
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Báo cáo y học: "Cerebral microdialysis for detection of bacterial meningitis in aneurysmal subarachnoid hemorrhage patients: a cohort study" pptx
... Length of stay in haemorrhage care unit (ICU) in patients aneurysmal subarachnoid the intensive (SAH) Length of stay in the intensive care unit (ICU) in patients withwith aneurysmal subarachnoid ... 638 patients treated with CSF drainage [17] Infection rates appear not to be reduced by routine exchange of the drain, but only by shortening the total draining time [23,24] Cerebral extracellular ... cerebral increase in lactate and a decrease in glucose, and the authors conclude that BM leads to anaerobic glycolysis with increased lactate production within the brain [10] A trial evaluating...
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Báo cáo y học: "Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation" ppt
... additional anti-inflammatory effects on cerebral tissue 39 ± 42 ± 39 ± 0.363 Cerebral inflammatory response following resuscitation 4.5 ± 1.9 4.6 ± 1.0 0.982 Mechanisms of brain injury following cerebral ... maintained at 38.0°C with a heating blanket, since the physiological rectal temperature of pigs is supposed to be about 38°C [15] Hypothermia was induced by 1,000 mL saline (4°C) and maintained ... carbon dioxide (suction rate, 200 mL/min; M-PRESTN; Datex-Ohmeda Inc., Helsinki, Finland) Total intravenous anesthesia (TIVA) was maintained by continuous infusion of to mg/kg/h propofol and 0.3...
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