... (3) and II I1, 111 and 1V II,111 and 1V AJCC stage (4) 1,11 and III IV Resection Margin R0 R1 Perineural invasion + Lymphatic invasion - Vascular invasion - + + Tumor margin Pushing Infiltrating ... from the West; 2.8% inthe United States [9], 3% in France [9] and 5.5% in New Zealand [6,15] The high percentage reported in developing countries may be due, in part, to the higher population of ... drafts ofthe paper RID Helped in data collection and tabulation and provision of data forsurvival analysis RW - Collection of data, wrote the manuscript in draft SKK -Contributed to drafts of the...
... weakly, and is mainly expressed in lining cells and macrophages [29,30] The CS-1 isoform of fibronectin is expressed on the luminal surface ofthe endothelium and by lining layer cells in RA synovia, ... angiopoietins and their receptors Tie-1 and Tie-2 play a key role inthe development ofthe vasculature Angiopoietin-1 in adults localises to the endothelium, the lining cells andthe macrophages inthe ... another study, staining for CRH receptor andthe CRH ligand urocortin was demonstrated in RA endothelial cells andin a variety of other cell types [114] Kinin levels are raised in RA and have been...
... sequence of nine random amino acids, followed by a His6-tag inthe C-terminus of capsid protein 10 Thereby, the phages display a random nonamer on their surface, and by interactions ofthe His6-tag the ... by HC The names and sequences ofthe different substrates are indicated above the pictures ofthe gels The times of cleavage in minutes are also indicated above the corresponding lanes ofthe different ... In these substrates, two thioredoxin molecules are positioned in tandem, andthe proteins have His6-tags positioned in their C-termini The different cleavable sequences are inserted inthe linker...
... appearing in person at the institution for harvesting the substance containing the reproductive cells When donating the cells for a reproduction procedure, the donor’s declaration shall contain the ... bodies acting inthe field of donation/storage of egg cells and sperm SI Article 10 ofthe Law governing the status of reproductive cell donation stipulates that the: “Giving and receiving remuneration ... responsible for any use that might be made ofthe following information Online information about the European Union in 20 languages is available at: http://europa.eu.int Further information on the Health...
... in their in vivo therapeutic efficacy, spanning from the differentiation ofthe Th1 subset, the generation of CTL andthe promotion of T cellin vivo proliferation andsurvival [reviewed in ref ... Consistency of IFNa signature in different in vivo andin vitro settings Heatmap ofthe 74 cDNA consistently up-regulated by IFNa in any ofthein vivo andin vitro settings analyzed The lists of IFNa-up-regulated ... excluding dead cells and including cells falling inthe expected morphological gate The band pass filter used for cytofluorimetric analysis was 525 nanometers for FITC, 575 nanometers for PE and...
... important role inthe secondary activation of microglia, inthe progression ofthe inflammatory response, andinthe progressive loss ofthe dopaminergic neurons in MPTPinduced PD Therefore, COX-2 ... oxidative and inflammatory insults The positive feed back loop may continue until the additional neuronal death (~50% ofthe remaining ofthe initial death) combined with the initial loss exceed the ... which reduces the progression ofthe inflammatory response and reduces the perpetuation ofthe vicious circle instead of inhibiting microglial activation at the early stage when initial injury occurs...
... amount of virus in breast milk, andthe quality and duration of breastfeeding [23,24] Susceptibility factors, including innate and acquired immune responses inthe child, inthe mother andin breast ... education and training materials for PMTCT programmes Thus the information that is provided is out of date and fuels the fear of women and counsellors (and often policy makers) about breastfeeding There ... despite the formidable opponent of HIV, we should not give up hope Making sense ofthe numbers: denominators matter Inthe absence of any interventions, about a third of infants born to HIV-infected...
... existence of cells that contain both mucin and secretary granules within their cytoplasm Therefore we agree with the hypothesis ofthe dual entodermal and neuroendocrine origin of goblet cell carcinoid ... study the hormonal nature of goblet cell carcinoids, the location of hormones andthe phenotype of endocrine cells Another useful method for simultaneous revealing of mucin secretion and endocrine ... immunohistochemistry Dispersed endocrine cells or endocrine cells in nests containing 3–4 goblet cells were observed inthe submucous and muscle layer ofthe appendix The endocrine cells in appendiceal tumour...
... contributions All ofthe authors have been involved in drafting this paper and have read and approved the final manuscript KG conceived the idea ofthe paper, reported the case, performed the literature ... concerning radiotherapy and followed up the patient at his out-patient clinic AK was the radiologist performing the preoperative and postoperative CT and MRI scans and wrote the part ofthe paper ... S-100-protein and p75 Tumors cells were strongly immunopositive for vimentin and variable immunoreative for CD99 and Figure Kaplan-Meier survival curves showing the influence of, A) degree of resection,...
... [33,34] Therefore, the 9-amino acid motif that contains YYPGE is required forthe formation of portalcontaining capsids in HSV-1-infected cells, and it is essential forthe production of infectious ... Formation ofthe herpesvirus capsid is the first step in viral morphogenesis The capsid of HSV-1 is found inthe mature virions andinthe nuclei of infected cells from which they originate There ... three distinct types of capsid, A-, B- and C-capsids, in infected cells [6] The B-capsids of HSV-1 contain a large amount ofthe scaffolding protein (the product ofthe UL26.5 gene), and smaller...
... determined by assuming that the initial position ofthecell is (x, z) = (d, e)) and substituting r = rc and θ = θc, we obtain the final equation forthe trajectory ofthe cell: ⎛ 2R3 rc2 sin2 θ c ⎜ + ... Typically, these models simulate the interaction of cells with each other and ignore the physical environment in which the movement is occurring, e.g non-chemotactic cells and foreign debris inthe ... to the experiment introduced inthe previ- C ous section The cells passing the closest to the obstacle are the ones initially close to the z-axis, i.e d is small For such cells the distance of...
... Kenneth, Kris and Charissa for their support during the trying times of my study I also thank my Toh Yi Caregroup for being understanding and supportive while I was busy with the writing of my thesis ... Throughout the development of an organism, the intricate balance between the maintenance Introduction of stem cells andthe supply of fully differentiated cells is achieved by regulating the number and ... function in promoting and inhibiting stem cell self-renewal, loss of Pins function causes a reduction in neuroblast numbers inthe larval brain due to occurrence of GMC/GMC siblings andin turn...
... Madam Ng Geok Choo and Mr Rama for their tireless efforts in maintaining the smooth functioning ofthe lab I am greatly indebted to Mrs Josephine Howe for her time and help in teaching me transmission ... homologs of mammalian molecules involved incell death signaling are missing inthe protozoa andthe molecular architecture of PCD in protozoan parasites therefore remains puzzling The kinetoplastid ... vacuolar forms inthe large intestines Inthe human intestine, vacuolar forms divide by binary fission and may develop into amoeboid or granular forms Encystations of vacuolar forms may occur in host...
... Identification of C8-modified deoxyinosine and N2- and C8-modified deoxyguanosine as major products ofthein vivo reaction of N-hydroxy-6-aminochrysene with DNA andthe formation ofthe adducts in isolated ... recommend the Ames test using these sensitive strains (especially YG1041 and/ or YG1042) in combination with the standard tester strains (TA98 and TA100 series), in order to detect the mutagenicity of ... mutagenic inthe Ames test using YG1041, YG1042, YG3003 and/ or YG7108 strain, and 21 chemicals (8.2%) formed 8-OH-Gua inthe rat hepatocytes oxidized DNA as shown in Fig These sensitive strains could...
... role inthe development of Mechanical Engineering The thesis studies the English – Vietnamese translation of terms inthe materials for Mechanical Engineering First, the thesis collects and groups ... Engineering terms and Vietnamese ones Next, the thesis works out and compares the English terms with the Vietnamese ones to finds out appropriate Vietnamese equivalents forthe English terms The ... The thesis aims to draw out common translation strategies which can be applied inthe English-Vietnamese translation of terms in materials for mechanical engineering Hopefully, the result of the...
... Protection in Areas ofthe Far North and Marine Areas Adjacent to the Northern Coast ofthe USSR22 (Environmental Edict) in its Article specified: Inthe marine areas adjacent to the northern coast ofthe ... Navigation and pollution inthe Northern Sea Route 231 For Russia, ships must satisfy special crewing and training requirements for navigating in ice.56 Forthe USA, requirements as to manning, training, ... adjoining the USSR northern coast and that it includes seaways suitable for guiding vessels in ice Due to the vagueness concerning leading in Article 7(4) ofthe NSR Regulations, not only in the...
... address There is a relative power ofthe hearer andthe speaker; the social distance between the hearer andthe speaker, andthe ranking ofthe imposition involve in doing the face threatening act In ... collecting books and finding information from Websites containing the theories of Speech acts and politeness Then, we use analysis method to analyze the collected data Designs ofthe study The thesis ... maintain someones face, (3) Overcoming Channel noise, (4) Task oriented and (5) Doing the FTA is inthe interest ofthe hearer As seen inthe chart, the strategies (3)Overcoming Channel noise and...
... engineering More and more inventions as well as products of mechanical engineering are made inthe world More and more new information and valuable experience inthe field of mechanical engineering ... principles and methods governing the study of concepts and their designations (terms, names, symbols) in any subject field, andthe job of collecting, processing, and managing relevant data and ... the precise contextual meaning ofthe original within the constraints ofthe TL grammatical structures” and “it attempts to be completely faithful to the intentions andthe text-realization of...
... cells from their environment During integrin outside in signaling, the binding of integrins to their extracellular ligands changes the integrin conformation and promotes integrin clustering The unidirectional ... signalings, in fact, are often closely linked, as ligand binding associated with outside in signaling stimulates integrins and, conversely, integrin activation increases ligand binding for inside–out ... on the one hand, surface signaling, signaling during endocytosis into the receiving celland receptor recycling for further delayed signaling are crucial steps ofcell signaling In polarized cells,...