bioinspired engineering of intelligent drug delivery systems and protein polymer conjugates

... controlled drug delivery matrices for both small molecule model drug of ibuprofen (IBU) and large protein drug of bovine serum albumin (BSA) In the preparation of controlled drug delivery system ... 161 xv List of Tables and Schemes List of Tables and Schemes Table 2.1 Major non-degradable polymers for drug delivery systems 10 Table 2.2 Environmentally sensitive hydrogels for drug delivery ... give benefits to drug companies by creating new forms of established drugs and offering improved versions of drugs It has been shown that companies developing new drug delivery systems seem to...

Ngày tải lên: 13/09/2015, 19:46

... solubility and stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ... covers some of the advances in the Chemical Aspects of Drug Delivery Systems New materials for drug delivery and targeting are reviewed and a representative range of excipients and delivery systems ... approval and clearance, and the constraints imposed by the nature of the various routes of administration available for drug delivery ROUTES OF ADMINISTRATION AND CLASSIFICATION OF DRUG DELIVERY SYSTEMS...

Ngày tải lên: 28/03/2014, 10:20

... drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM Definition: A drug ... A4: series of multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug?  Prodrug is an inactive precursor of a drug  Prodrug reconversion ... route of delivery:  Topical (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation  Systemic drug delivery systems: drugs...

Ngày tải lên: 18/04/2014, 15:37

... construction of drug delivery systems in not too long a time The functionalization of CNTs used in the construction of drug delivery systems will be discussed in later sections In vivo behavior of functionalized ... application of CNTs as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems ... mixing and heating of CNTs and urea to initiate a polymerization reaction of the isocyanic acid and/ or cyanate ion to yield modified CNTs [45] As a summary, there have been a lot of literatures and...

Ngày tải lên: 20/06/2014, 22:20

... nanocapsule delivery system to investigate the capacity of temporal release of antiangiogenetic drug and anticancer drug in vitro We found that the drug release profiles of the encapsulated drugs, ... imaging and drug delivery (94) Other integrin targeting micelle drug delivery systems with diverse compositions were also available (95, 96) Besides using RGD as integrin targeting ligand, Kim and ... modification Briefly, 0.5 g of PLGA was dissolved in 10 ml of methylene chloride and activated by the addition of 26.3 mg of p-nitrophenyl chloroformate and 18 μL of pyridine to the solution,...

Ngày tải lên: 11/09/2015, 09:58

... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... hydrolysis of the monomer structure 367 368 15 Drug Delivery Systems A further complication in predicting and understanding the kinetics of degradation of this family of polymers is the effect of device ... loading of up to 20% w/w of protein in the polymer with full retention of the protein enzymatic activity The addition of PEG to the formulation eliminated the burst release of drug and drug release...

Ngày tải lên: 25/10/2013, 08:20

... Mechanisms of action of CPEs (a) Schematic representation of the highly ordered and packed lipid bilayers and the hydrophilic and lipophilic routes of drug penetration through SC with proposed sites of ... numerous Masters and PhD students in drug delivery research areas, many of whom now have successful careers in R&D in industry She is on the editorial board of Current Drug Delivery and acts as a ... Kent) offering advice in the areas of drug development and topical and transdermal drug delivery Contributors Hugh Alsop, Acrux Ltd., West Melbourne, Australia Eva Benfeldt, Department of Environmental...

Ngày tải lên: 05/03/2014, 22:21

... http://www.molecular-cancer.com/content/10/1/3 Page of 20 Figure Live/non-live delivery systems Live or biological gene delivery systems include viral and/ or bacterial vectors Non-live or nonbiological delivery systems mainly include ... the surface of PLGA NPs [62] These polymers have been designated as feasible candidates for drug delivery systems, anti-cancer agents and vaccine immunotherapy For example, DNA vaccine delivery ... fusion of E6 and E7 (E67), addition of a tissue plasminogen activator (tpa) signal sequence, addition of CD40 ligand (CD40L) or Fms-like tyrosine kinase-3 ligand (Flt3L) When E6 (Co) and E7 (Co)...

Ngày tải lên: 06/03/2014, 02:21

... in Understanding Complex Systems series (UCS) promotes new strategies and paradigms for understanding and realizing applications of complex systems research in a wide variety of fields and endeavors ... (study of driver-to-driver effects in a group of drivers) • Braking car (study of safety effects of ADAS on a group of drivers) • Merging assistant (study of emotional effects of ADAS on a group of ... impetus for the development of the fields of ubiquitous and pervasive computing The field of AmI emerged in turn by calling for an understanding of the total integration of intelligent devices in the...

Ngày tải lên: 28/04/2014, 15:53

... define drug- delivery systems of a certain size range Reflecting this trend of size definition, Nanoparticulate Drug Delivery Systems is a worthy attempt to bring together a wide range of drug- delivery ... Poorly Soluble Drugs 71 Jan Möschwitzer and Rainer H Müller Lipid-Based Nanoparticulate Drug Delivery Systems 89 Jun Wu, Xiaobin Zhao, and Robert J Lee Nanoengineering of Drug Delivery Systems Ashwath ... nanoparticulate drug- delivery systems The first chapter covers a complete overview of the nanoparticulate drugdelivery system, covering wide applications and evaluation of the nanoparticulate drug- delivery...

Ngày tải lên: 04/06/2014, 14:47

... targeted drug delivery at the site of disease to improve the uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted ... biological responses and cell signalling, and the research needed for the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles ... attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification of drug pharmacokinetics and biological distribution Too often, chemotherapy fails to cure...

Ngày tải lên: 20/06/2014, 00:20

... advantages, the SC route of dosing is not free of problems Drug exposure via SC route of delivery can be still limited by absorption, stability, dissolution rate, and solubility of the drug In order to ... the delivery of DCU via intravenous (IV) infusion route was explored Similar to oral delivery, IV delivery of DCU was limited by the poor aqueous solubility of DCU The poor aqueous solubility of ... route of delivery of the nanosuspension of DCU was tested and was found to be suitable for future PK/PD studies The findings confirmed our previous hypothesis and strongly support the use of SC...

Ngày tải lên: 21/06/2014, 03:20

... Banker and Christopher T Rhodes 122 Surfactants and Polymers in Drug Delivery, Martin Malmsten 123 Transdermal Drug Delivery: Second Edition, Revised and Expanded, edited by Richard H Guy and Jonathan ... expanding Systems range from simple solutions to novel delivery systems such as biodegradable polymeric systems, corneal collagen shields, iontophoresis, and viral and nonviral gene delivery systems, ... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic Drug Delivery Systems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery...

Ngày tải lên: 10/08/2014, 00:20

... loss of efficacy, the development of prodrugs takes advantage of the increased corneal permeability of the prodrug and the subsequent hydrolysis of the prodrug to active compound (16, 99,100) Prodrugs ... advantages of direct topical drug administration include targeted drug delivery to the anterior segment of the eye and avoidance of systemic drug toxicity Many of the disadvantages of eyedrops, ... vitreous and retina, compliance, and the advantages of the use of drug delivery systems, are discussed in other sections of this text Intravenous and oral therapy are used in the treatment of generalized...

Ngày tải lên: 10/08/2014, 00:20

... concentration of polymer (collagen and hyaluronic acid) in the hydrogel in units of grams of polymer per gram of hydrogel Using the sum of the maximum concentration of collagen and hyaluronic ... fields of pharmacokinetics, (especially in the area of drug distribution and metabolism) and pharmacodynamics It has also been used to study the in vitro protein and melanin binding of drugs (54) ... increased utility of the microdialysis approach in the study of ocular drug delivery and disposition Unique applications of the microdialysis approach in the examination of drug ocular disposition...

Ngày tải lên: 10/08/2014, 00:20

... to promote site-specific delivery of drugs to intraocular tissues in the back of the eye (23) The increasing interest in intraocular delivery of peptide and protein drugs, drug therapy targeting ... segment eye disease, and the advent of new chemical entities and novel ophthalmic drug delivery systems necessitates a thorough understanding of the noncorneal pathway and approaches of exploiting this ... Robinson, J R., and Mlynek, G M Bioadhesive and phase-change polymers for ocular drug delivery Adv Drug Delivery Rev 16:45–50, 1995 Salminen, L., and Urtti, H Prolonged pulse-entry of pilocarpine...

Ngày tải lên: 10/08/2014, 00:20

... potential for the concept appears to be in the area of intraocular delivery of polar molecules, peptides and protein drugs, and directed drug delivery to treat posterior segment eye disease REFERENCES ... delivery: case studies (7) Ocular delivery of peptide and protein drugs, Adv Drug Delivery Rev., 8:331–339 81 Chiou, G C Y (1994) Systemic delivery of polypeptide drugs through ocular route, J Ocul Pharmacol., ... systemic delivery of peptide drugs via the ocular route with surfactants, Drug Dev Res., 27:177–183 80 Harris, D., Liaw, J H., and Robinson, J R (1992) Routes of delivery: case studies (7) Ocular delivery...

Ngày tải lên: 10/08/2014, 00:20

... OCULAR DELIVERY OF PEPTIDE AND PROTEIN DRUGS Peptides and proteins may be instilled into the eye for local/topical use Instillation of a topical dose of a drug to the eye leads to absorption of a drug ... route delivery of peptide and protein drug delivery In: Peptide and Protein Drug Delivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13 52 Harris, A S (1986) Biopharmaceutical aspects of the ... M., and Leesman, G D (1989) Absorption of difficult drug molecules: Carrier mediated transport of peptides and peptide analogues In: Novel Drug Delivery and Therapeutic Application L F Presscot and...

Ngày tải lên: 10/08/2014, 00:20

... binding of high mobility group protein (HMG-1) increase the potency of the complex and enhances nuclear targeting and stability of the DNA after delivery into the nuclear envelope The success of HVJ-liposome ... routes of delivery to the affected area Preparative amounts of neurotrophic proteins can be easily purified from recombinant expression systems, and combinations of several therapeutic proteins ... frequency of protein turnover, the intracellular environment of the cell, and the extent of longevity of ODNs after administration Gene knockdown practices are still under development and will...

Ngày tải lên: 10/08/2014, 00:20

... distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids Pharm Res., 13:1367–1372 P L Felgner (1990) Particulate systems and polymers for in vitro and in vivo delivery of ... clinical investigations and NDAs for marketing approval The terms drug and new drug are inclusive of the drug substance and the drug product It is important to understand that a new drug is not just ... nonviral gene delivery Adv Drug Deliv Rev., 38:279–289 88 M X Tang and F C Szoka (1997) The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting...

Ngày tải lên: 10/08/2014, 00:20