bending moments reactions and thrust due to a single force p tables a 19 a 21
Báo cáo y học: " Femoral vein thrombophlebitis and septic pulmonary embolism due to a mixed anaerobic infection including Solobacterium moorei: a case report" ppt
... injection sites and an erythematous right groin, with bilateral groin sinuses and some lymphadenopathy on palpation Cardiovascular, respiratory and abdominal examination was unremarkable Analysis of ... became apyrexial and his clinical condition and inflammatory markers improved dramatically – by day 17 of admission his C-reactive protein had decreased to mg L-1 He was discharged on oral antibiotics ... his inferior vena cava A computed tomography examination revealed numerous small opacities in both lungs, some of which had low attenuating centres and appeared to represent small abscesses [see...
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Báo cáo y học: "Misdiagnosis and undiagnosis due to pattern similarity in Chinese medicine: a stochastic simulation study using pattern differentiation algorithm" pdf
... differentiation Abbreviations Ip: inspection; AO: auscultation and olfaction; Iq: inquiry; P: palpation; ZFSP: Zang-fu single pattern; PDA: pattern differentiation algorithm; MPSA: manifestation profile ... Monte Carlo method [34,35] was implemented for patient simulation from ZFSP in a dataset In sequence, simulated manifestation profiles were applied to PDA for automatic pattern differentiation Pattern ... the dataset, for each manifestation there was at least one possible pattern and there was no pattern without manifestations according to the Four Examinations The complete dataset is available...
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Báo cáo khoa học: Binding of the volatile general anesthetics halothane and isoflurane to a mammalian b-barrel protein doc
... lysine, with the remaining two composed of aliphatic and somewhat polar residues such as serine, phenylalanine, and asparagine The crystallographic results are in accord with earlier solution studies ... the porcine odorant binding protein cavity The competition curve was treated as a two parameter Table Dissociation constants and thermodynamic data for the binding of halothane and isoflurane to ... from Torpedo nobiliana with an average Kd value of 0.36 ± 0.03 mm using 19 F-NMR spectroscopy and gas chromatography [32] Finally, isoflurane was shown to bind to the foura-helix bundle (Aa2-L38M)2...
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The NCI Strategic Plan for Leading the Nation To Eliminate the Suffering and Death Due to Cancer pdf
... medical and nutritional approaches, and training and education for research and health professionals We will support and conduct studies to increase our understanding of and ability to measure ... screening, and excessive alcohol use stomach and prostate cancer risk Research is needed to understand and address these factors for patients across all age groups, racial and ethnic populations, ... will: > Facilitate development of standardized methodologies and robust, validated approaches for analyzing and reporting data > Support the development of standards for evaluating the performance...
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Health Education to Villages: An integrated approach to reduce childhood mortality and morbidity due to diarrhoea and dehydration; Maharashtra, India 2005 – 2010 pptx
... Villages: an integrated approach to reduce childhood mortality and morbidity due to diarrhoea and dehydration; Maharashtra, India 2005 – 2010 Region and Country: Maharashtra, India Name of Local Partners: ... educate the people of Maharashtra, especially health-care providers, mothers, and children, about basic health practice, sanitation, and child care, with a primary focus on diarrhoeal diseases and the ... it and root it into the good health landscape of Maharashtra We hope it can serve as a learning experience for other parts of India At present, the people of Maharashtra lack much of the basic...
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Báo cáo khoa học: Cytochrome P460 of Nitrosomonas europaea Formation of the heme-lysine cross-link in a heterologous host and mutagenic conversion to a non-cross-linked cytochrome c ¢ pot
... 5¢-GGTAACTGTATATGAA CTGGTCAG-3¢ (Lys70 to Tyr) The resulting plasmids, pUCYPKR, pUCYPKA, and pUCYPKY, were transformed into cells [20] The plasmids pUCYP2, pUCYPKR, pUCYPKA, and pUCYPKY were each ... Growth of cells and purification of cytochrome P4 60 Cells of P aeruginosa PAO lacI-containing plasmids pUCYP2, pUCYPKR, pUCYPKA, or pUCYPKY were grown and periplasmic extracts prepared as described ... P4 60 from N europaea in P aeruginosa was a cytochrome with catalytic and ligand-binding capabilities and UV-visible spectroscopic properties identical to cytochrome p4 60 expressed in N europaea...
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Báo cáo Y học: Human bile salt-stimulated lipase has a high frequency of size variation due to a hypervariable region in exon 11 pot
... DNA was digested with appropriate restriction enzyme(s) Digested DNA was separated on an agarose gel, transferred to a Hybond-N ®lter (Amersham) and hybridized to a [3 2P] dATP-labelled probe as ... et al [32] Approximately 20 lg of each RNA preparation was separated on 1% agarose gels, blotted onto Hybond-N ®lters (Amersham International plc., Buckinghamshire, UK) and hybridized to a [3 2P] dATP-labelled ... human embryonic and fetal pancreas and in pancreatic tumoral cell lines [35,36] FAPP and BSSL are structurally closely related, but are distinguished by a monoclonal antibody directed towards a...
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comparative phototoxicity of nanoparticulate and bulk zno to a free-living
... generation of the nanoparticles; (ii) nano-ZnO will have greater phototoxicity than bulk-ZnO, as smaller particles have a greater surface area per unit mass than larger particles and thus may be ... Dusenbery, 199 0) 2.4 Photocatalytic activity measurement Materials and methods Powdered nanoparticulate ZnO (NanoGardÒ zinc oxide) was purchased from Alfa Aesar (Ward Hill, MA, USA) with a stated size ... under ambient laboratory light (Applerot et al., 2009; Jones et al., 2008) or natural sunlight (Adams et al., 2006) as compared to dark conditions, presumably due to photoactivation of the nanoparticles...
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báo cáo hóa học:" Validity of instruments to measure physical activity may be questionable due to a lack of conceptual frameworks: a systematic review" pot
... the importance of physical activity, it is challenging to define what physical activity actually means and how to capture the important aspects of physical activity Thus, a conceptual framework ... and extracted the relevant data EGS, MP and JGA drafted the manuscript All authors contributed to revising the manuscript and approved the final version PROactive consortium approved the final ... treatment After analysis (a posteriori): - Physical activities - Physical symptoms - Psychological and - Social dimension Author, year Population Instrument Article includes a conceptual framework A priori...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 1) pptx
... is appropriate to consider what they have in common Table 101-1 Classification of Hemolytic Anemiasa Intracorpuscular Defects Hereditary Hemoglobinopathies Extracorpuscular Factors Familial hemolytic ... complement activation, with bouts of production of membrane attack complex capable of severely damaging normal cells General Clinical and Laboratory Features The clinical presentation of a patient ... a patient with mild hereditary spherocytosis or with cold agglutinin disease may be diagnosed after years This is due in large measure to the remarkable ability of the body to adapt to anemia...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 2) docx
... hemolysis regularly produces an increased unconjugated bilirubin, increased lactate dehydrogenase (LDH), increased aspartate transaminase, and reduced haptoglobin Urobilinogen will be increased in both ... is also polychromasia and sometimes nucleated red cells In most cases a bone marrow aspirate is not necessary in the diagnostic workup; if it is done, it will show erythroid hyperplasia In practice, ... places the cell's limited metabolic apparatus at risk because if any protein component deteriorates, it cannot be replaced as in most other cells; and in fact the activity of most enzymes gradually...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 3) pptx
... an inherited one, may present without anemia It is also important from the point of view of management because compensated hemolysis may become "decompensated"—i.e., anemia may suddenly appear—in ... cirrhosis, and to the heart muscle, eventually causing heart failure The increased activity of the bone marrow also entails an increased requirement for erythropoietic factors, particularly folic acid ... metabolism The Embden-Meyerhof pathway (glycolysis) generates ATP for energy and membrane maintenance The generation of NADPH maintains hemoglobin in a reduced state The hexose monophosphate...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 5) ppt
... extracellular domains of many of these proteins are heavily glycosylated, and they carry antigenic determinants that correspond to blood groups Underneath the membrane, and tangential to it, is a ... other proteins that make up the cytoskeleton The main cytoskeletal protein is spectrin, the basic unit of which is a dimer of α-spectrin and β-spectrin The membrane is physically linked to the cytoskeleton ... changes that alter the normal biconcave disc shape Thus, the majority of the diseases in this group have been known for over a century as hereditary spherocytosis (HS) and hereditary elliptocytosis...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 6) doc
... clinically asymptomatic; protective against Plasmodium falciparum EPB41 1p3 3 -p3 4.2 Band 4.1 HE (dominant) Mutations of this gene account for about 5% of mostly HE, with prominent morphology but ... SLC 4A 17q21 Band HS (anion (dominant) channel) Mutations of this gene may account for ~25% of HS Southea st Polymorp Asian hic mutation ovalocytosis (deletion of (dominant) amino acids); clinically ... homozygotes EPB42 15q15-q21 Band 4.2 HS (recessive) Mutations of this gene account for about 3% of HS RHAG 6p2 1.1 -p1 1 Rhesu Chronic Very rare; s antigen nonspherocytic associated with hemolytic total loss...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 7) docx
... However, an asymptomatic form, referred to as Southeast Asian ovalocytosis, has a frequency of up to 7% in certain populations, presumably as a result of malaria selection Stomatocytosis This rare ... evidence-based) are as follows Avoid splenectomy in mild cases Delay splenectomy until at least years of age, after the risk of severe sepsis has peaked imperative, Antipneumococcal whereas vaccination ... (1) The patient may have a de novo mutation, i.e., a mutation that has taken place in a germ cell of one of his parents or early after zygote formation; and (2) the patient may have a recessive...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 8) pdf
... young adults—for instance, in a woman during her first pregnancy, when the anemia may get worse In part the delay in diagnosis is due to the fact that the anemia is remarkably welltolerated because ... Triose Ver y rare 1 2p1 3 phosphate Ver y rare CN S isomerase (TPI) (severe), NM Glycerald 1 2p1 3 Ver My ehyde 3- 31 p1 3.1 y rare opathy phosphate dehydrogenase (GAPD) Diphosph oglycerate 7q31q34 ... y rare tosis rather than mutase (DPGM) Phosphog lycerate hemolysis Xq13 kinase Ver y rare CN S, NM May benefit (PGK) from splenectomy Pyruvate 1q21 kinase (PK) Rar May e (2) benefit from splenectomy...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 9) ppsx
... stress G6PD deficiency is a prime example of an HA due to interaction between an intracorpuscular and an extracorpuscular cause, because in the majority of cases hemolysis is triggered by an exogenous ... protein, and thus the physiologic decrease in G6PD activity that takes place with red cell ageing is greatly accelerated In some cases an amino acid replacement can also affect the catalytic function ... NADP, nicotinamide adenine dinucleotide phosphate; NADPH, reduced nicotinamide adenine dinucleotide phosphate Genetic Considerations The G6PD gene is X-linked, and this has important implications...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 10) pps
... more widespread variants are G6PD Mediterranean on the shores of the Mediterranean Sea, in the Middle East, and in India; G6PD A in Africa and in Southern Europe; G6PD Vianchan and G6PD Mahidol ... drugs (Table 101-5) Typically, a hemolytic attack starts with malaise, weakness, and abdominal or lumbar pain After an interval of several hours to 2–3 days, the patient develops jaundice and often ... normochromic, and due partly to intravascular hemolysis; hence, it is associated with hemoglobinemia, hemoglobinuria, and low or absent plasma haptoglobin The blood film shows anisocytosis, polychromasia,...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 11) doc
... Sulfadim idine Sulfadiazi ne Dapsone Antibacterial/anti Cotrimoxazole biotics Ciproflo xacin Nalidixic acid Chloramp henicol Norfloxa cin pAminosalicylic acid Nitrofurantoin Niridazole Antipyretic/analg ... Antipyretic/analg esics Acetanilide Acetylsa Acetylsali licylic acid high cylic acid 3 g/d) Phenazopyridin Acetamino e (Pyridium) phen Phenacetin Other Naphthalene Vitamin K analogues ... nts Procedure Mismatche d Abrupt blood Nearly always transfusion Repeat ABO cross match incompatibility Paroxysmal Chronic Comple nocturnal with acute ment hemoglobinuria exacerbations mediated...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 12) doc
... are also vulnerable to acute oxidative damage, and therefore the same agents (see Table 101-5) that can cause acute HA in people with the ordinary type of G6PD deficiency will cause severe exacerbations ... Peripheral blood smear from a 5-year-old G6PD-deficient boy with acute favism A very small minority of subjects with G6PD deficiency have CNSHA of variable severity The patient is always a male, ... from that of NNJ due to other causes In cases with CNSHA, if the anemia is not severe, regular folic acid supplements and regular hematologic surveillance will suffice It will be important to avoid...
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