basic principles of clinical pharmacology ppt

... P-glycoprotein, the product of the normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5- 2). The extent of absorption may be reduced because a drug is incompletely released from its dosage form, undergoes destruction at its site of administration, ... a Inhibitors affect the molecular pathway, and thus may affect substrate. b Clinically important genetics variants described. A listing of CYP substrates, inhibitors, and inducers is maintained at http://medicine.iupui.edu/flockhart/table.htm....

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

... the basic principles of clinical phar- macology currently are being applied in the process of drug development. Journals Clinical Pharmacology and Therapeutics British Journal of Clinical Pharmacology Journal ... (1) BACKGROUND Clinical pharmacology can be defined as the study of drugs in humans. Clinical pharmacology often is contrasted with basic pharmacology. Yet applied is a more appropriate antonym for basic ... effective use of medicine can be traced back at least to Rudolph Bucheim (1820–1879), who has been credited with 1 PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION 20 Principles of Clinical Pharmacology Therefore,...

Ngày tải lên: 22/03/2014, 23:20

... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of the discipline of clinical...

Ngày tải lên: 06/07/2014, 08:20

... intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology (Part 3) Clinical Implications of Altered Bioavailability Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than any physiologic space. For example, the volume of distribution of digoxin and tricyclic antidepressants is hundreds of liters, obviously...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of several ... volume of distribution of lidocaine is reduced. Therefore, lower-than- normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid toxicity. Rate of Intravenous ... prevent elimination by very rapid (t 1/2 of seconds) uptake into erythrocytes and endothelial cells before the drug can reach its clinical site of action, the atrioventricular node. Plasma...

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

... [48]. 4.2 Receptors of Innate Immunity The cells of the innate immune system rely on a series of germ line-encoded receptors to accomplish the tasks of rapid response to and eradication of invading ... the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other ... way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version,...

Ngày tải lên: 22/03/2014, 21:20

... The rate of absorption is determined by the site of administration and the drug formulation. Both the rate of absorption and the extent of input can influence the clinical effectiveness of a drug. ... metabolism of more than 50% of the clinically prescribed drugs metabolized by the liver. The involvement of individual P450s in the metabolism of a given drug may be screened in vitro by means of selective ... extrapolations must be considered tentative. Chapter 5. Basic & Clinical Evaluation of New Drugs Basic & Clinical Evaluation of New Drugs: Introduction * Acknowledgment: I thank Wallace...

Ngày tải lên: 29/03/2014, 13:20

... 30-Jan Interviews, a preparation for Speech of Introduction A, J 2-Feb SPEECH OF INTRODUCTION S, F 4-Feb SPEECH OF INTRODUCTION S, F 6-Feb SPEECH OF INTRODUCTION S, F, J 9-Feb Organizing the ... incorporate each of the previous speaking purposes, with the additional task of cooperating in a team of approximately 4 to craft an extended presentation (no more than 45 minutes) on a topic of your ... outside of our class and write a thoughtful critique of the speaker. In 2-3 pages, you should discuss topics such as the strengths and limitations of the speaker’s style, organization of content,...

Ngày tải lên: 20/12/2013, 23:15

... Part Two Annotations to the OECD Principles of Corporate Governance 9 © OECD 2004 OECD Principles of Corporate Governance The OECD Principles of Corporate Governance were originally ... board, subject to the approval of the shareholders. Some companies issue preferred (or preference) shares which have a preference in respect of receipt of the profits of the firm but which normally ... the possibility of market manipulation. OECD PRINCIPLES OF CORPORATE GOVERNANCE – 33 © OECD 2004 A. Basic shareholder rights should include the right to: 1) secure methods of ownership...

Ngày tải lên: 16/01/2014, 16:33