principles of clinical pharmacology 2nd edition
PRINCIPLES OF CLINICAL PHARMACOLOGY Second Edition potx
Ngày tải lên :
22/03/2014, 23:20
... effective use of
medicine can be traced back at least to Rudolph
Bucheim (1820–1879), who has been credited with
1
PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION
20 Principles of Clinical Pharmacology
Therefore, ... basic principles of clinical phar-
macology currently are being applied in the process of drug
development.
Journals
Clinical Pharmacology and Therapeutics
British Journal of Clinical Pharmacology
Journal ... 6 Principles of Clinical Pharmacology
TABLE 1.1 Status of Renal Function in 44 Patients with
Digoxin Toxicity
a
Serum creatinine
(mg/dL)
No. of patients with CL
CR
of
Percentage of
group
50...
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CRC Desk Reference of Clinical Pharmacology SECOND EDITION doc
Ngày tải lên :
06/03/2014, 14:20
... designation of Chester Fritz Distinguished
Professor of Pharmacology and of Clinical Neuroscience, the
highest honor bestowed by the University of North Dakota.
8 DESK REFERENCE OF CLINICAL PHARMACOLOGY
For ... July of 1999, he was appointed professor
and chairman of the Department of Pharmacology and Tox-
icology at the University of North Dakota School of Med-
icine and Health Sciences. In September of ... infringe.
Library of Congress Cataloging-in-Publication Data
Ebadi, Manuchair S.
Desk reference of clinical pharmacology / author, Manuchair Ebadi. 2nd ed.
p. ; cm.
Rev. ed. of: CRC desk reference of clinical...
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Encyclopedia of Molecular Pharmacology (2nd edition) pptx
Ngày tải lên :
29/03/2014, 13:20
... MÄNNISTÖ
Division of Pharmacology and Toxicology, Faculty of
Pharmacy
University of Helsinki
Helsinki
Finland
Pekka.Mannisto@helsinki.fi
C
HRISTIAN MARTIN
Institute of Experimental and Clinical Pharmacology ... level of a number of these factors
as well as of other inflammatory markers such as
C-reactive protein (CRP). The increased production of
inflammatory adipokines (and decreased production
of adiponectin ... consisting of a cortex (outer wall) that
Adrenal Gland 41
A
individual components of a pathway. These complexes
promote propagation, and often amplification, of the
signal. Examples of this are...
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Chapter 005. Principles of Clinical Pharmacology (Part 1) pps
Ngày tải lên :
06/07/2014, 08:20
... Chapter 005. Principles of Clinical
Pharmacology
(Part 1)
Harrison's Internal Medicine > Chapter 5. Principles of Clinical
Pharmacology
Principles of Clinical Pharmacology: Introduction ... accompaniment of drug
therapy, this is not the case. The goal of this chapter is to describe the principles of
clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context
in which the drug-target interaction occurs to achieve drug effects.
Two important goals of the discipline of clinical...
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Chapter 005. Principles of Clinical Pharmacology (Part 2) ppt
Ngày tải lên :
06/07/2014, 08:20
... P-glycoprotein, the product of the
normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical
aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5-
2). The extent of absorption may be reduced because a drug is incompletely
released from its dosage form, undergoes destruction at its site of administration, ...
a
Inhibitors affect the molecular pathway, and thus may affect substrate.
b
Clinically important genetics variants described.
A listing of CYP substrates, inhibitors, and inducers is maintained at
http://medicine.iupui.edu/flockhart/table.htm....
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Chapter 005. Principles of Clinical Pharmacology (Part 3) docx
Ngày tải lên :
06/07/2014, 08:20
... intravenous infusion, plasma concentrations at steady
Chapter 005. Principles of Clinical
Pharmacology
(Part 3)
Clinical Implications of Altered Bioavailability
Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared
to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can
result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than
any physiologic space. For example, the volume of distribution of digoxin and
tricyclic antidepressants is hundreds of liters, obviously...
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Chapter 005. Principles of Clinical Pharmacology (Part 4) ppsx
Ngày tải lên :
06/07/2014, 08:20
...
Chapter 005. Principles of Clinical
Pharmacology
(Part 4)
Clinical Implications of Drug Distribution
Digoxin accesses its cardiac site of action slowly, over a distribution phase
of several ... volume of distribution of lidocaine is reduced. Therefore, lower-than-
normal loading regimens are required to achieve equivalent plasma drug
concentrations and to avoid toxicity.
Rate of Intravenous ... prevent elimination by
very rapid (t
1/2
of seconds) uptake into erythrocytes and endothelial cells before
the drug can reach its clinical site of action, the atrioventricular node.
Plasma...
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Chapter 005. Principles of Clinical Pharmacology (Part 5) doc
Ngày tải lên :
06/07/2014, 08:20
... effect of the drugs, it may produce
severe agonist–mediated effects (such as hypertension or tachycardia) if the
blocking drug is abruptly withdrawn.
Chapter 005. Principles of Clinical
Pharmacology ... site of action, it alters the function of that
molecular target, with the ultimate result of a drug effect that the patient or
physician can perceive. For drugs used in the urgent treatment of ... accumulation of
active metabolites. Commonly, the clinical effect develops as a downstream
consequence of the initial molecular effect the drug produces. Thus, administration
of a proton-pump...
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Tài liệu McGraw.Hill - Brealey & Myers - Principles of Corporate Finance, 6th Edition Slides docx
Ngày tải lên :
17/01/2014, 02:20
... Cost of Capital
Principles of Corporate Finance
Brealey and Myers Sixth Edition
Chapter 2
41
Short Cuts
w Sometimes there are shortcuts that make it
very easy to calculate the present value of ... Financial Officer
Comptroller
Treasurer
22
Opportunity Cost of Capital
Example
You may invest $100,000 today. Depending on the
state of the economy, you may get one of three
possible cash payoffs:
140,000110,000$80,000Payoff
BoomNormalSlumpEconomy
000,110$
3
000,140000,100000,80
C ... Years
FV of $1
10% Simple
10% Compound
20
Rate of Return Rule
w Accept investments that offer rates of return
in excess of their opportunity cost of capital.
Example
In the project listed below,...
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Tài liệu Principles of Engineering Mechanics Second EditionH. R. Harrison B S ~PhD, MRAeS ,Formerly doc
Ngày tải lên :
13/02/2014, 23:20
... study of the motion of material
bodies and of the associated forces.
The study of motion is called kinematics and
involves the use of geometry and the concept of
time, whereas the study of the ... Kinematics
of
mechanisms. Kine-
tics of a rigid body. Moment
of
force and rate of
change
of
moment
of
momentum. Rotation about
a fixed axis. Euler’s angles. Rotation about a fixed
point
of ... basic principles
of
the
Part
1,
Part 2 and much
of
the Part
3
Engineering
Mechanics syllabuses
of
degree courses in
engineering. The emphasis of the book is on the
principles
of
mechanics...
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