principles of clinical pharmacology ebook

... basic principles of clinical phar- macology currently are being applied in the process of drug development. Journals Clinical Pharmacology and Therapeutics British Journal of Clinical Pharmacology Journal ... effective use of medicine can be traced back at least to Rudolph Bucheim (1820–1879), who has been credited with 1 PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION 20 Principles of Clinical Pharmacology Therefore, ... 6 Principles of Clinical Pharmacology TABLE 1.1 Status of Renal Function in 44 Patients with Digoxin Toxicity a Serum creatinine (mg/dL) No. of patients with CL CR of Percentage of group 50...

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... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of the discipline of clinical...

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... P-glycoprotein, the product of the normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5- 2). The extent of absorption may be reduced because a drug is incompletely released from its dosage form, undergoes destruction at its site of administration, ... a Inhibitors affect the molecular pathway, and thus may affect substrate. b Clinically important genetics variants described. A listing of CYP substrates, inhibitors, and inducers is maintained at http://medicine.iupui.edu/flockhart/table.htm....

Ngày tải lên: 06/07/2014, 08:20

... intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology (Part 3) Clinical Implications of Altered Bioavailability Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than any physiologic space. For example, the volume of distribution of digoxin and tricyclic antidepressants is hundreds of liters, obviously...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of several ... volume of distribution of lidocaine is reduced. Therefore, lower-than- normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid toxicity. Rate of Intravenous ... prevent elimination by very rapid (t 1/2 of seconds) uptake into erythrocytes and endothelial cells before the drug can reach its clinical site of action, the atrioventricular node. Plasma...

Ngày tải lên: 06/07/2014, 08:20

... effect of the drugs, it may produce severe agonist–mediated effects (such as hypertension or tachycardia) if the blocking drug is abruptly withdrawn. Chapter 005. Principles of Clinical Pharmacology ... site of action, it alters the function of that molecular target, with the ultimate result of a drug effect that the patient or physician can perceive. For drugs used in the urgent treatment of ... accumulation of active metabolites. Commonly, the clinical effect develops as a downstream consequence of the initial molecular effect the drug produces. Thus, administration of a proton-pump...

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... designation of Chester Fritz Distinguished Professor of Pharmacology and of Clinical Neuroscience, the highest honor bestowed by the University of North Dakota. 8 DESK REFERENCE OF CLINICAL PHARMACOLOGY For ... July of 1999, he was appointed professor and chairman of the Department of Pharmacology and Tox- icology at the University of North Dakota School of Med- icine and Health Sciences. In September of ... infringe. Library of Congress Cataloging-in-Publication Data Ebadi, Manuchair S. Desk reference of clinical pharmacology / author, Manuchair Ebadi. 2nd ed. p. ; cm. Rev. ed. of: CRC desk reference of clinical...

Ngày tải lên: 06/03/2014, 14:20