at a glance summary of suggested antiviral agents against treatable pathogenic viruses
Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
... who cannot take efavirenz and if rifabutin not available Alternative for patients who cannot take efavirenz and if rifabutin not available Alternative for patients who cannot take efavirenz and ... saquinavir, indinavir, amprenavir, fos-amprenavir, atazanavir, tipranavir or darunavir CCR-5 receptor antagonists No change Lopinavir/ritonavir (Kaletra ™) Antiretroviral dose change Dual protease ... if rifabutin not available; preferred for young children when rifabutin not available Alternative for patients who cannot take efavirenz and if rifabutin not available Alternative for patients...
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báo cáo hóa học:" Confronting TB/HIV in the era of increasing anti-TB drug resistance" pdf
... Grabar S, Lanoy E, Allavena C, Mary-Krause M, Bentata M, Fischer P, Mahamat A, Rabaud C, Costagliola D, on behalf of the Clinical Epidemiology Group of the French Hospital Database on HIV: Causes ... hepatic reactions, although relatively uncommon, may complicate the provision of appropriate care for HIV infected TB patients leading to greater health resource utilization and a greater demand ... Jeremiah Chakaya prepared the first draft of the presentation at the XVII International AIDS conference and the first draft of this manuscript with the assistance of Haileyesus Getahun Reuben Granich...
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Báo cáo y học: "Clinical Management of Adult Patients with a History of Nonsteroidal Anti-Inflammatory Drug–Induced Urticaria/ Angioedema: Update" ppt
... cyclooxygenase; NSAID nonsteroidal anti-inflammatory drug; PAD propionic acid derivatives Asero, Clinical Management of Adult Patients with NSAID-Induced Urticaria/Angioedema an increase in cardiovascular ... Cross-Reaction/Reaction on First Exposure Asthma and rhinitis exacerbated by NSAID Urticaria/angioedema exacerbated by NSAID Urticaria/angioedema from single NSAID Acute urticaria/angioedema from ... urticaria patients with NSAID intolerance and patients with AERD are characterized by elevated baseline urinary LTE4 levels and found that such levels are markedly increased by aspirin administration.27,28...
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Báo cáo y học: " Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children" pot
... clinical manifestation of NSAID hypersensitivity at this age is facial angioedema with or without generalized urticaria A classic example of facial angioedema and urticaria provoked by ibuprofen ... adapting a weight-related challenge protocol similar to the one described in Table Almost no data are available on the natural history of the pediatric disease, the pathogenesis of angioedema/ ... during ASA or ibuprofen challenge in a small proportion of asthmatic children, the vast majority of asthmatics not show associated respiratory exacerbations with antipyretic doses of ibuprofen...
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Báo cáo y học: " ncremental cost effectiveness of proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug ulcers: a pharmacoeconomic analysis linked to a case-control study" potx
... the observational period Data for these cases was retrieved from questionnaires and hospital administrative records The typical case is an older patient, mean age at diagnosis 70.4 years (SD 16.7; ... Arthritis Research & Therapy Vol 10 No Vonkeman et al with NSAIDs) with the appropriate pharmacoeconomic information Materials and methods The pharmacoeconomic evaluation was linked to a 26-month ... estimate, indicating that with the current estimate of the risk of serious NSAID ulcer complications and the estimate of costs associated with those serious NSAID ulcer complications, no large...
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Báo cáo khoa học: "Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug" ppt
... demonstrate reduced nuclear accumulation of βcatenin [6] Oncogenic activation of the Wnt-signalling pathway by mutations in APC or β-catenin, which results in the accumulation and nuclear translocation ... initial stages of the colorectal adenoma-carcinoma sequence, suggesting a link to the APC/β-catenin/TCF pathway (Wnt-signalling pathway), and the colonic polyps of patients treated with NSAIDs ... of β-catenin and in β-catenin/TCF4-regulated transcription of TCF target genes, is mandatory for the initial neoplastic transformation of intestinal epithelium [8,9] The basic and clinical data...
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Báo cáo y học: " Maintenance treatment with esomeprazole following initial relief of non-steroidal anti-inflammatory drug-associated upper gastrointestinal symptoms: the NASA2 and SPACE2 studies'''' doc
... analysis of covariance The proportion of patients maintained free of investigator-assessed symptoms of heartburn, acid regurgitation, upper abdominal bloating, and nausea at months was assessed ... protocol) was more than 90% in all three treatment arms Patient compliance with NSAID treatment (drugs used on at least 70% of days according to diary data) was similarly high (more than 90% of patients) ... data acquisition and interpretation JN was involved in data interpretation Data analysis was provided by GL All authors read and approved the final manuscript 12 Acknowledgements 13 This research...
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Báo cáo y học: "Incremental cost effectiveness of proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug ulcers: a pharmacoeconomic analysis linked to a case-control study" pptx
... the observational period Data for these cases was retrieved from questionnaires and hospital administrative records The typical case is an older patient, mean age at diagnosis 70.4 years (SD 16.7; ... Arthritis Research & Therapy Vol 10 No Vonkeman et al with NSAIDs) with the appropriate pharmacoeconomic information Materials and methods The pharmacoeconomic evaluation was linked to a 26-month ... estimate, indicating that with the current estimate of the risk of serious NSAID ulcer complications and the estimate of costs associated with those serious NSAID ulcer complications, no large...
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Báo cáo y học: "Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation" docx
... transplantation She was discharged home on day 21st She had a mild renal impairment with the urea of 15 mmol/L and creatinine of 220 mmol/L She was treated for singles one year later She had an ... rate and increases renal vascular resistance via Endothelin-1 The net effect is ischemia and endothelial cell injury That triggers inflammation and platelet aggregation, resulting in thrombi and ... FK506associated thrombotic microangiopathy: report of two cases and review of the literature Transplantation 1999, 27;67(4):539-44 10 Pham PT, Peng A, Wilkinson AH, Gritsch HA, Lassman C, Pham PC, Danovitch...
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Báo cáo y học: "Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis" pptx
... picomoles) was automatically calculated relative to internal standards generated with known concentrations of appropriate NIR dyes For visualization and analysis purposes, the FMT 2500 system software ... Corr M, Hammaker D, Davis RJ, Flavell RA, Firestein GS: Mitogen-activated protein kinase kinase is a pivotal pathway regulating p38 activation in inflammatory arthritis Proc Natl Acad Sci USA 2006, ... imaging of CAIA, we imaged untreated and control mice at the peak of inflammatory disease (day 8) using a three-dimensional FMT imaging approach In this study, intravenous injection of a cathepsin-activatable...
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Synthesis of the Anti-influenza Drug Oseltamivir Phosphate (Tamiflu)
... Kipassa, N T.; Okamura, H.; Kina, K.; Hamada, T.; Iwagana, T Org Lett 2008, 5, 815-816 Shibasaki and Kanai synthesis First generation (1/2) Synthesis based on an asymmetric ring-opening of acyl-aziridine ... transition state mimic: Zanamivir (Relenza): low bioavailability, administered by inhalation Oseltamivir phosphate (Tamiflu): orally active prodrug active form is corresponding carboxylic acid ... pandemic? Neuraminidase inhibitors: Oseltamivir phosphate design Schematic representation of neuraminidase action Hydrolysis step of sialic acid by neuraminidase (NA) Design of neuraminidase inhibitors...
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Effects of anti malaria drug artesunate in the treatment of rhinovirus induced asthma exacerbation
... binding activity of NF-κB Artesunate attenuated the exacerbation of RV on asthma, and our findings implicated a potential value of artesunate in the treatment of rhinovirus-induced asthma exacerbation ... and transactivation 80 4.6 Artesunate treatment reduces the exacerbation of recruitment of inflammatory cells in mice with allerfic airway inflammation and inflammatory cell infiltration and ... Effect of artesnuate on rhinovirus-induced NF-κB signaling pathway 97 xii LIST OF ABBREVIATIONS AHR airway hyperresponsiveness AMV avian myeloblastosis virus AP alkaline phosphatase ARTs artesunate...
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Predicting in vivo anti hepatofibrotic drug efficacy based on in vitro high content analysis
... signaling is mediated by caspase family proteins, which include initiator caspases such as caspase 2, 8, and 10, and effector caspases such as caspase 3, and The initiator caspases are activated ... from a wide range of categories such as PPAR-gamma receptor antagonists (e.g pioglitazone), statins (e.g simvastatin and lovastatin), and anti-oxidants (e.g resveratrol and silymarin) The primary ... primary human HSC 2.2.2 Proliferation marker HSC activation is accompanied by a drastic increase in proliferation rate Controlling HSC proliferation rate can limit the population of activated...
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A study of quality and safety of herbal medicine adulteration and herb drug interactions
... LIST OF ABBREVIATIONS AND SYMBOLS ACN Acetonitrile ADP Adenosine diphosphate ANOVA Analysis of variance ATP Adenosine triphosphate AUC Area under the plasma concentration-time curve ASA Aspirin ... intraperitoneal administration of aspirin in rats nor did it change the pharmacokinetics of aspirin after a single intravenous administration of aspirin Most of the pharmacokinetic parameters of aspirin and ... plasma (n=5) 174 Table 5.5 Precision and accuracy for the determination of aspirin and salicylic acid in blank rat plasma 174 Table 5.6 Pharmacokinetic parameters of aspirin and salicylic acid...
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Pharmacokinetics pharmacodynamics driven approach for lead optimization in anti mycobacterial and anti malarial drug discovery
... compounds” AAPS-NUS, 2nd PharmSci@India, 3rd & 4th September 2011, National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad-500037, India Lakshminarayana SB “Evaluation of PharmacokineticsPharmacodynamics ... be considered as treatment against drug-resistant strains of malarial parasites The advantages of combination therapy should be balanced against the increased chance of drug interactions Cytochrome ... the majority of malaria deaths globally P vivax is the second most significant species prevalent in Southeast Asia and Latin America P vivax and P ovale cause additional complication of dormant...
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In vivo aspects of potential stereospecific drug interactions of oral warfarin and rutin in rats
... Fluconazolea Fluvastatina Ethacrynic acida Sucralfateb Miconazolea Clofibratea Metolazonea Danazola Itraconazolea Cholestyraminec Spironolactoneb Stanozalola Ketoconazolea Simvastatina Immuno- Disulfirama ... reasons, as data required are available only from animal studies But useful alternatives of target-mediated pharmacokinetic models are available Such models also allow characterization of data ... Secobarbitalb Aspirina Oral Tetracyclinsa Chloral hydratea Rofecoxiba contraceptivesb Nafcillinb Antihyperlipidaemics: Celecoxiba Sucralfateb Antifungal: Lovastatina Diuretics: Diazoxidea Fluconazolea...
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Synthesis of fluorescent anti malarial drug probes and evaluation within plasmodium falciparum
... (left) and Cancer Incidences worldwide (right) Fig 35 – Future applications for probe III LIST OF ABBREVIATIONS ACN – Acetonitrile Ar – Argon Ato – Atovaquone AtoR – Atovaquone resistant Ato-PG – Atovaquone ... ultimate of purpose of complete eradication Vaccine development18-20 has taken a great leap with certain vaccines already reaching Phase III trials of testing These vaccines are expected to create ... strain26 Artemisinin and its derivatives have a wide range of mode of action within the parasite There are still ongoing debates on the modes of action of artemisinin and its bio-activation pathways...
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Báo cáo y học: "Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence" pdf
... Risk factors for major infections in Wegener’s granulomatosis: analysis of 113 patients Ann Rheum Dis 2008, 68:658-663 Takizawa Y, Inokuma S, Tanaka Y, Saito K, Atsumi T, Hirakata M, Kameda H, ... than the maintenance phase Bacterial infections are the most frequently mentioned causes of death Types of infections are given as clinical conditions or causative agents as information was available ... N, Takei H, Nagasawa H, Tokuhira M, Tanaka T, Saito Y, Amano K, Abe T, Takeuchi T: Incidence of cytomegalovirus reactivation in patients with inflammatory connective tissue diseases who are under...
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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... protection against biological warfare threats via immunization of at- risk troops, whereas drugs are useful mainly in immediate pretreatment against certain chemical agents Introduction and in treating ... primary biological warfare threat to military personnel Weaponized anthrax, designed to propagate the most deadly inhalational form, is a primary biological warfare threat because it is relatively ... legislation by Congress Because vaccines for biological warfare threats have potential use against bioterrorist attacks on the U.S domestic civilian population, coordination of military and civilian...
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drug-nucleic acid interactions
... previously have shown that attempts to incorporate the added cooperativity parameter are statistically unwarranted and that attempts to force fits to integral values of n are futile 25 Friedman and Manning ... than the calculated function This results in nonrandom residuals, indicating an inadequate fit of the model to the data 28 The fractional values of n that are required to obtain a statistically ... support as ligand bound to the RNA The assay offers a simple, rapid, and quantitative method that facilitates the discovery and characterization of RNA binders directed at a specific complex Surface...
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