aspirin prostaglandins and platelet function pharmacology and thrombosis prevention
Platelet function and Isoprostane biology. Should Isoprostanes be the newest member of the Orphan-ligand family? potx
... factor-β, and platelet factor-4), the adhesion molecule, P-selectin, and clotting proteins (such as thrombospondin, fibronectin, and von Willebrand factor) [20] Dense granules contain platelet ... packing and resultant decrease in Figure Structure of arachidonic acid (the precursor for all prostaglandins) , various TPR ligands, PGF2α, and the most abundant isoprostane 8-iso-PGF2α Ting and ... well-characterized prostaglandins and thromboxanes (Figure 2) Of primary importance to platelet function is the formation of TXA2, which is generated from arachidonic acid in reaction catalyzed by the platelet...
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Báo cáo y học: "HES 130/0.4 impairs haemostasis and stimulates pro-inflammatory blood platelet function" potx
... intracellular granules and becomes translocated to the platelet surface upon platelet activation CD62P is one of the molecules that mediate the interaction between platelets and leukocytes, and platelets ... PBS/1% PFA and kept on ice until analysis Platelets were identified according to their forward and sideward light scatter characteristics and binding of the plateletspecific anti-CD42a and were ... the surface of platelets, and this is believed to be responsible for the inhibition of platelet aggregation [6,39] Boldt and colleagues [37] reported a significant inhibition of platelet aggregation...
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Báo cáo y học: " In Vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch" docx
... and thrombocyte function in vitro in human whole blood and tested the hypothesis that HyperHaes causes impaired whole blood coagulation and platelet function Page of in the study after oral and ... of native platelets (panels A and C) and platelets from blood after 40% dilution HyperHaes (panels B and D) in 5400fold (panels A and B) and 2000fold (panels C and D) magnification Representative ... solution and platelets leading to dehydrated and functionless thrombocytes Platelets treated with and without HH were examined by electron microscopy In the HH dilution deformed single platelets...
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hemostasis and thrombosis protocols
... toxic and must be handled with great care Gloves, masks and safety glasses must be worn Phenol must be handled in a fume hood Ethidium bromide is a potent carcinogen and teratogen and must be handled ... thrombospondin With the enhancement of platelet platelet interaction, platelet aggregation ensues Platelet aggregation causes activation, secretion, and release from other platelets, so leading to a self-sustaining ... platelets is not seen in resting platelets 4.4 Antigens Platelets have a number of antigens on their surface specific to platelets Many of the platelet- specific antigens are associated with platelet...
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Chapter 059. Bleeding and Thrombosis (Part 1) pdf
... blood, such as monocytes and red cells; (2) plasma proteins (the coagulation and fibrinolytic factors and inhibitors); and (3) the vessel wall itself Steps of Normal Hemostasis Platelet Plug Formation ... further promote aggregation and inhibit the naturally anticoagulant endothelial cell factors During platelet aggregation (platelet- platelet interaction), additional platelets are recruited from ... occlusive platelet thrombus The platelet plug is anchored and stabilized by the developing fibrin mesh The platelet glycoprotein (Gp) IIb/IIIa (α IIbβ3) complex is the most abundant receptor on the platelet...
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Chapter 059. Bleeding and Thrombosis (Part 2) potx
... covalently cross-links and thereby stabilizes the fibrin clot Figure 59-2 Fibrin formation and dissolution A Fibrinogen is a trinodular structure consisting of D domains and E domain Thrombin ... act to inhibit platelet binding, secretion, and aggregation Endothelial cells produce anticoagulant factors including heparan proteoglycans, antithrombin, TF pathway inhibitor, and thrombomodulin ... FXIIIa cross-links the D domains on adjacent molecules (C) Fibrin and fibrinogen (not shown) lysis by plasmin occurs at discrete sites and results in intermediary fibrin(ogen) degradation products...
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Chapter 059. Bleeding and Thrombosis (Part 3) docx
... loop" via FXI and FVIII activation by thrombin TFPI is bound to lipoprotein and can also be released by heparin from endothelial cells, where it is bound to glycosaminoglycans, and from platelets ... lysine-binding sites) and tPA possess specific affinity for fibrin and thereby bind selectively to clots The assembly of a ternary complex, consisting of fibrin, plasminogen, and tPA, promotes the ... between plasminogen and tPA and greatly accelerates the rate of plasminogen activation to plasmin Moreover, partial degradation of fibrin by plasmin exposes new plasminogen and tPA binding sites...
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Chapter 059. Bleeding and Thrombosis (Part 4) potx
... Defects of Platelet Adhesion von Willebrand disease Bernard-Soulier syndrome (absence of dysfunction of GpIb-IX-V) Defects of Platelet Aggregation Glanzmann's thrombasthenia (absence or dysfunction ... of moderate and severe factors VIII and IX deficiency and, in rare circumstances, of other clotting factor deficiencies Mucosal bleeding symptoms are more suggestive of underlying platelet disorders ... posttraumatic bleeding and a history of joint hyperextensibility Cushing's syndrome, chronic steroid use, and aging result in changes in skin and subcutaneous tissue, and subcutaneous bleeding...
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Chapter 059. Bleeding and Thrombosis (Part 5) ppt
... Prohemorrhagic Effects of Medications and Dietary Supplements Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase impair primary hemostasis and may exacerbate bleeding ... platelet activation They alter platelet biochemistry to produce more PGI3, a more potent platelet inhibitor than prostacyclin (PGI2), and more thromboxane A3, a less potent platelet activator than thromboxane ... bleeding time and abnormal platelet aggregation studies, but the actual associated bleeding risk is unclear Vitamin E appears to inhibit protein kinase C–mediated platelet aggregation and nitric...
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Chapter 059. Bleeding and Thrombosis (Part 6) doc
... sufficient History of Thrombosis The risk of thrombosis, like that of bleeding, is influenced by both genetic and environmental influences The major risk factor for arterial thrombosis is atherosclerosis, ... Factors that increase risks for venous and both venous and arterial thromboses are shown in Table 59-3 Table 59-3 Risk Factors for Thrombosis Venous Venous and Arterial Inherited Inherited Factor ... counts
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Chapter 059. Bleeding and Thrombosis (Part 7) pptx
... increase to the threshold for thrombosis and result in deep venous thrombosis (DVT) Note: The magnitude and duration of risk portrayed in the figure is meant for example only and may not precisely reflect ... with surgery and is not recommended for this indication The PFA-100, an instrument that measures platelet- dependent coagulation under flow conditions, is more sensitive and specific for platelet ... Venous thrombosis: A multicausal disease Lancet 353:1167, 1999.] Laboratory Evaluation Careful history taking and clinical examination are essential components in the assessment of bleeding and...
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Chapter 059. Bleeding and Thrombosis (Part 8) pptx
... The aPTT assesses the intrinsic and common coagulation pathways, factors XI, IX, VIII, X, V, II, fibrinogen, and also prekallikrein, high molecular weight kininogen and factor XII (Fig 59-6) The ... phospholipids derived from either animal or vegetable sources that function as a platelet substitute in the coagulation pathways and includes an activator of the intrinsic coagulation system, such ... reagents to clotting factor deficiencies and to inhibitors such as heparin and lupus anticoagulants Thus, aPTT results will vary from one laboratory to another, and the normal range in the laboratory...
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Chapter 059. Bleeding and Thrombosis (Part 9) ppsx
... testing For classic platelet aggregometry, various agonists are added to the patient's platelet- rich plasma, and platelet agglutination and aggregation are observed Tests of platelet secretion ... conditions, pregnancy, and medications affect levels of many coagulation factors and their inhibitors Antithrombin is decreased by heparin and in the setting of acute thrombosis Protein C and S levels ... surgery, and it is not recommended for use for this indication The PFA-100 and similar instruments that measure plateletdependent coagulation under flow conditions are generally more sensitive and...
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Hemostasis and Thrombosis - part 1 pot
... Hemostasis and Thrombosis 2nd Edition Thomas G DeLoughery, M.D Oregon Health Sciences University Portland, Oregon, U.S.A LANDES BIOSCIENCE GEORGETOWN, TEXAS U.S.A VADEMECUM Hemostasis and Thrombosis, ... Hemostasis and thrombosis / Thomas G DeLoughery. 2nd ed p ; cm (Vademecum) Includes bibliographical references and index ISBN 1-57059-686-7 Thrombosis Handbooks, manuals, etc Hemostasis Handbooks, ... disorders Handbooks, manuals, etc I Title II Series [DNLM: Hemostasis Handbooks Blood Coagulation Disorders therapy-Handbooks Coagulants therapeutic use Handbooks Hemostatic Techniques Handbooks Thrombosis...
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Hemostasis and Thrombosis - part 3 pps
... Thomas G DeLoughery ©2004 Landes Bioscience 44 Hemostasis and Thrombosis Table 6.1 Inherited defects of platelet function Platelet function disorders with normal platelet numbers Collagen aggregation ... Defective Platelet Function Most patients with inherited disorders of platelet function have normal platelet counts These patients present with signs of platelet- type bleeding such as nosebleeds and ... the number of platelets and the number of high molecular weight multimers Hemostasis and Thrombosis, 2nd Edition, by Thomas G DeLoughery ©2004 Landes Bioscience 38 Hemostasis and Thrombosis Fig...
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Hemostasis and Thrombosis - part 4 docx
... thrombocytopenia Platelet dysfunction is also present Platelets that have been activated and have released their contents but still circulate are known as “exhausted” platelets which can no longer function ... important As mentioned above, platelets are both low and dysfunctional in DIC Accordingly, a higher goal for platelet levels is needed to compensate 64 Hemostasis and Thrombosis Table 8.5 Therapy ... prone to minor and major bleeds leading to increased consumption of factors Hemostasis and Thrombosis, 2nd Edition, by Thomas G DeLoughery ©2004 Landes Bioscience 66 Hemostasis and Thrombosis Table...
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Hemostasis and Thrombosis - part 5 doc
... etiologies and diagnosis is delayed The platelet function is impaired due to continual platelet activation; this leads to the concept of “spent platelets” Even though a seemingly adequate number of platelets ... massive in-vivo platelet activation resulting in platelet microthrombi and vascular damage Our understanding of the role of von Willebrand factor is emerging When von Willebrand factor is first ... infusion ends Patients with von Willebrand disease should have a von Willebrand panel and bleeding time or PFA-100 performed before and after Patients with platelet dysfunction should just have bleeding...
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Hemostasis and Thrombosis - part 6 potx
... by prevention of both thrombosis and death Aspirin Studies using aspirin have not consistently shown that aspirin prevents deep venous thromboses In all the NIH/ACCP consensus statements, aspirin ... states • Thrombosis at early age • Family history of thrombosis • Thrombosis at unusual site • Multiple thromboses Hemostasis and Thrombosis, 2nd Edition, by Thomas G DeLoughery ©2004 Landes Bioscience ... Vein Thrombosis Patients with calf vein thrombosis are at risk for extension to proximal vein thrombosis and subsequent pulmonary embolism These patients should be anticoagulated with a heparin and...
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Hemostasis and Thrombosis - part 7 potx
... Hemostasis and Thrombosis, 2nd Edition, by Thomas G DeLoughery ©2004 Landes Bioscience 128 Hemostasis and Thrombosis Surgery The stress of undergoing surgery increases the risk of thrombosis ... venous thrombosis, arterial thrombosis, neurological disease, frequent miscarriages, and thrombocytopenia Venous thrombosis Venous thrombosis was the first described manifestation of APLA and is ... syndrome and cerebral vein thrombosis 18 130 Hemostasis and Thrombosis Pathogenesis is probably a combination of the underlying inflammatory disease and vasculitis The arterial thrombosis is either...
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Hemostasis and Thrombosis - part 8 pps
... All others: aspirin 160 mg/day or clopidogrel in aspirin- intolerant patients Hemostasis and Thrombosis, 2nd Edition, by Thomas G DeLoughery ©2004 Landes Bioscience 150 Hemostasis and Thrombosis ... bound to platelet factor These antibodies then bind to the platelet Fc receptor and activate the platelet Thus, the thrombocytopenia of HIT is due to platelet activation and deposition and not ... of dipyridamole and aspirin showed greater benefit in secondary stroke prevention than with aspirin alone However, the results of this isolated trial have been controversial and in this trial...
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