approaches for using animal models to identify loci that genetically interact with human disease causing point muta
báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... dementia with parkinsonism [115] By combining this mutation with the human APP and PS1 mutations associated with familial AD, animal models of AD have been produced in which NFTs as well as SPs are formed ... activation While animal models of human disease generally have similar pathological findings to the human disorders, distinct differences remain These models may be appropriate for studying some ... Additional animal models for studying AD-related complement activation TAPP and 3xTg-AD mice Mutations in the gene encoding for human tau protein have been linked to the development of frontotemporal...
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Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot
... appropriate to each trait and to models with equal design matrices with more than traits ESTIMATION We will consider in turn estimation for models Model The first and simplest model is of the form with ... contributions for e and e as in l , model 1, but also for Ub scaling factors, a and b for the contributions of Ub to y , i and y are introduced This model has the general form: a with It should be noted that ... log-likelihood with respect to 0and Q noting ’;1 , e are independent of and and equating to zero gives ’;1 2’ ’; that s G For , AS given T log L can be written as a function of terms of M, using and C with...
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Tài liệu Báo cáo khoa học: "Using adaptor grammars to identify synergies in the unsupervised acquisition of linguistic structure" docx
... structure needs to be “built in” to an adaptor grammar compared to a comparable PCFG For example, the adaptor grammars for syllable structure presented in sections 3.3 and 3.6 learn more information ... never expands to itself); it is currently unknown whether there are tree distributions that satisfy the adaptor grammar constraints for recursive adaptor grammars Inference for an adaptor grammar ... are likely to be learned by human learners It’s also plausible that semantics and contextual information is less important for their acquisition than, say, syntax 399 From PCFGs to Adaptor Grammars...
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human genome epidemiology 2nd edition building the evidence for using genetic information to improve health and prevent disease jan 2010
... studies for replication (11) It is this latter point that is central to the search for moderate- to high-frequency low-penetrance variants associated with human diseases and traits (12) Efforts to ... are needed to characterize the population impact of gene variants on the risk for adverse health outcomes and to identify and measure the impact of modifiable risk factors that interact with gene ... Wellcome Trust Centre for Human Genetics University of Oxford Oxford, United Kingdom and Oxford NIHR Biomedical Research Centre Churchill Hospital Oxford, United Kingdom Contributors John McLaughlin,...
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báo cáo khoa học: " Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia" pdf
... out using Gene Ontology (GO) [28] utilizing the topGO tool [29] in the Bioconductor suite along with web-based Ingenuity Pathway Analysis [30] For analysis of microarray data the Bioconductor ... lists using DAVID bioinformatics resources Nat Protoc 2009, 4:44-57 Falcon S, Gentleman R: Using GOstats to test gene lists for GO term association Bioinformatics 2007, 23:257-258 Filippatos GS, ... resemblance to the Atrogene gene expression signature [27,32] generated using gene-chips This is not due to gene-chip technology being unable to establish parallels between animal models and humans,...
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Báo cáo y học: "Patent applications for using DNA technologies to authenticate medicinal herbal material" doc
... specification Send to USPTO The Office of Initial Patent Examination of USPTO checks the format of the application If not accepted Inventor must satisfy all filing requirements If accepted USPTO assigns ... buffer are tightly bound to the chelators US Patent 7214484 was issued for a lysis buffer that does not require a high concentration of chelators, allowing proteinase K to effectively digest the ... mixed with various phosphates in a tube to form precipitate After precipitation, PCR components are added into the tube and PCR is then performed In our view, this method may not be easy to reproduce...
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Báo cáo sinh học: "Estimating variances and covariances for multivariate animal models by restricted maximum likelihood" pot
... adapted! for this case simply by reducing the vector of parameters to be estimated accordingly For the analysis under an animal model, however, it has to be borne in mind that with a record for one ... likelihoods for univariate analyses on the canonical scale together with an adjustment for the transformation with q that Noting Y1 = L 8ik Yk it follows that , k=l explicit transformation of ... were set to to account to X not of full column rank Analyses for both models were carried out for data of a general structure (strategy I: M of form (4)), and accounting for the fact that design...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... FEBS 1391 Animal models of Alzheimer’s disease O Philipson et al Transgenic animal models Models devoid of any disease- causing APP mutations Animal models expressing wild-type (wt) human APP ... platelet-derived growth factor O Philipson et al 1397 Animal models of Alzheimer’s disease O Philipson et al formed very rapidly, within 1–2 days, reaching a size that was surprisingly stable Within week, ... studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing animal models discussed,...
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Báo cáo khoa học: "Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4)" docx
... epithelium without atypia or mitotic activity In contrast to this, PMCA is characterized by peritoneal tumor composed of more abundant mucinous tumor cells with the architecture and cytological ... peritonectomy procedures in combination with intra-operative hyperthermic intra-peritoneal chemotherapy (HIPEC) Now this new combination treatment is increasingly performed as treatment for PMP ... manuscript CJH performed the initial surgery, took responsibility for the patient's postoperative care and revised the manuscript WYK assessed the histological specimens and prepared the histological...
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Báo cáo y học: " Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease" ppsx
... may be hoped that a few genes were common to all studies, or within individual studies, that might identify mediators of androgen action upon growth However, few or none appear to exhibit such ... from to mSlit2 homolog Unique hit, kb from novel transcript with homology to mScube1 Unique hit, close to novel transcript similar to mEphB3 receptor BLAST, basic local alignment search tool; ... the observation that factors such as FGF10, which are required for the formation of the prostate, are equally abundant in males and females and not appear to be regulated by testosterone [7,11]...
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Báo cáo y học: "Use of soluble MHC class II/peptide multimers to detect antigen-specific T cells in human disease." pps
... cells before and after peptide immunization in animal models of autoimmune disease, such as the NOD mouse model of type diabetes [8] Together, these animal studies have set the stage for similar ... CD4+ T cells is likely to be much lower than that of virus-specific CD8+ T cells The first use of peptide/MHC class II multimers to detect autoreactive T cells in human autoimmune disorders was ... examined blood and synovial fluid of patients with rheumatoid arthritis for T cells stainable with multimers of HLA-DRB1*0401 complexed with dominant epitopes of type II collagen and cartilage glycoprotein...
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Báo cáo sinh học: " Restricted maximum likelihood to estimate variance components for animal models with several random effects using a derivative-free algorithm" pdf
... function F=f(t) to be minimized with respect to p independent variables, and let to denot the guess for the optimum to start with The initial i simplex then comprises to and p other points t (i 1, ... attempting to minimize fill-in is to process rows with the fewest off-diagonals first Graser et al (1987) therefore suggested selection of pivots corresponding to the youngest animals first For the models ... experiment with selection within families, for example, grouping of animals according to female &dquo;founders&dquo; appears preferable to a grouping according to generation On the other hand, if animals...
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Báo cáo khoa học: "Using Non-lexical Features to Identify Effective Indexing Terms for Biomedical Illustrations" docx
... image retrieval that forms the basis of our approach Refer to Section for work related to our method in general Demner-Fushman et al (2007) developed a machine learning approach to identify images ... indicate that ineffective indexing terms can be reduced using this classification technique We conclude that ABIR approaches to biomedical image retrieval as well as hybrid CBIR/ABIR approaches, ... approach for detecting and segmenting these figures The authors rely on cues from captions to inform an image analysis algorithm that determines panel edge information We make use of this approach to...
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Báo cáo lâm nghiệp: "Using past growth to improve individual-tree diameter growth models for uneven-aged mixtures of Pinus sylvestris L. and Pinus nigra Arn. in Catalonia, north-east Spain" doc
... plot factor of the diameter growth models was predicted using the same variables (but only the significant ones) as in the plot factor models of Trasobares et al [19] The plot factor models for the ... factor models were significant at the 0.05 level The ratio estimators for the bias correction using both the fixed part and the predicted plot factors (Eqs (3–6)) were 2.6374/ 2.2689 = 1.1624 for ... measured in the field (using a hand lens); laboratory measurements using a microscope would produce more accurate data, but they would be too costly for practical forest inventories However, the...
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Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis pptx
... was established with a permutation test for each pairwise comparison to estimate the proportion of false-positive genes Hierarchical gene clustering was performed with dCHIP to characterise the ... to contribute to tolerance through maintenance of the CD4+CD25+ regulatory T cell population [35] Therefore, we have presented a strategy to identify smalleffect QTL and search for potential ... the animal facility at the University of Rostock All animal experiments were preapproved by the State Animal Care Committee CIA was induced in control and experimental animals according to established...
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Báo cáo sinh học: "Restricted maximum likelihood estimation for animal models using derivatives of the likelihood" pptx
... analysis for q traits and let y be ordered according to traits within animals Assuming that error covariances between measurements on different animals are zero, R is blockdiagonal for animals, ... space as for calculating log £ only can be required Even for analyses with one random factor (animals) only, this becomes prohibitive parameters, and very quickly, amounting to a factor of 28 forq ... components for a multivariate mixed model with equal design matrices Biometrics 41, 153-166 maximum likelihood to estimate variance components for animal models with several random effects using a...
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USING AUTHENTIC MATERIALS TO SUPPLEMENT THE COURSE BOOK ON ESP PROGRAM FOR SECOND YEAR MEDICAL STUDENTS AT HANOI MEDICAL UNIVERSITY
... Ask Ss to work individually or in pair to complete vocabulary exercise 20’25’ - Ask Ss to play role as a doctor and a patient to find out information for case history / doctor and doctor for diagnosis ... report - Play role as a doctor and a patient to find out information for case history / doctor and doctor for diagnosis report 25 -20’ - Ask Ss to exchange their notes for corrections and write ... Instruction: (Pair work) Work with your partner to create a conversation between a doctor and his/her patient Student A should start, using prompt questions to get information for diagnosis and she/he...
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Using role play to enhance english speaking skills for the 10th graders at nghi loc IV high school luận văn thạc sĩ giáo dục học
... concluded that speaking is expressing ideas, opinions, or feelings to others by using words or sounds of articulation in order to inform, to persuade, and to entertain that can be learnt by using ... provided with supportive, collaborative environments and opportunities to prepare for their informal and formal speaking experiences are more likely to have the confidence needed to "go public" with ... certain psychomotor patterns (to “loosen the tongue”) and to associate selected grammatical forms with their appropriate context From the statements above, it can be interpreted that drilling is...
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Tài liệu Báo cáo khoa học: "Using Multiple Sources to Construct a Sentiment Sensitive Thesaurus for Cross-Domain Sentiment Classification" doc
... dimensions that correspond to unigrams and bigrams wi that occur in the review d are set to di , their frequency in d The subsequent k dimensions that correspond to the top ranked based entries for ... us to select useful features for classification in a systematic way without having to preselect features using heuristic approaches The regularization parameter is set to its default value of for ... vector d ∈ RN , where the value of the j-th element dj is set to the total number of occurrences of the unigram or bigram wj in the review d To find the suitable candidates to expand a vector d for...
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Tài liệu Báo cáo khoa học: "Towards History-based Grammars: Using Richer Models for Probabilistic Parsing*" docx
... before we expand node i Hence, t~ corresponds to the sentential form a S B or equivalently to the string rlr2 In a leftmost derivation we produce the words in left-toright order Using the one -to- one ... are using n-gram models with the usual deleted interpolation for smoothing for the other four components of the model We have assigned bit strings to the syntactic and semantic categories and to ... probability to a mnemonic production, the H B G model assigns a probability to a rule template Because of this the HBG formulation allows one to handle any g r a m m a r formalism that has a derivation...
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