applications of human hepatocytes in drug metabolism
Báo cáo khoa học: Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism docx
... targeting of human CYP2D6 M Cook Sangar et al of oxidizing MAMC; however, there were significant inter-individual differences in the level of activity (Fig 2B) with the amino acid sequence of human ... localization of human CYP2D6 in a stable expression cell line To assess the role of mitochondrial CYP2D6 in drug metabolism, we generated cell lines expressing human CYP2D6 under the regulation of a doxycycline ... respectively, by the addition of 10 lm quinidine, a CYP2D6 specific inhibitor (Note that a concentration of lm quinidine is generally sufficient to inhibit CYP2D6 in a system using purified microsomes;...
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English morpheme system and some applications of learning morpheme in establishing words
... the trend in all over the world All countries, including Viet Nam have been cooperated with each other in many aspects of society in order to enhance development of economy It designated international ... single phonemic distinction /ʌ/ and /ɔ/, which is of course true on the phonemic level of analysis, but it is probable also true that the meaning distinction is carried by only a single distinctive ... Dependence -ful -ly Naming an act, state, condition full of, abounding in characteristic of -ize Denoting action Organize, nationalize -fy Naming action (make, form Beautify, Signify into) Prefixes Hopeful,...
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Applications of Random Matrices in Physics doc
... distribution of c|d| should be related to that described in (70) 5.4 Frequency of vanishing of L-functions I now turn to the question of the frequency of vanishing of L-functions at the central point In ... positive integers n we have fO (n) = 2n fSp (n − 1) (68) (This last result was also obtained independently in [5].) (I note in passing the following rather interesting relationship between the leading ... combined diagonal and off-diagonal terms add up to give the expression in (16), bearing in mind that when k = the total is just N , the number of terms in the sum over j and l 6 APPLICATIONS OF...
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MASS SPECTROMETRY IN DRUG METABOLISM AND DISPOSITION docx
... INTRODUCTION In a certain sense, the field of drug metabolism (DM) is standing still More specifically, the basic experiment of drug metabolism (i.e., administering a new drug to an animal or human ... Utilization of Chinese Herbal Medicine, Ministry of Education Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, 100050 China MINGSHE ZHU ... Chuang Lu, Xinxin Ding, and Donglu Zhang Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery 197 Takehito Yamamoto, Akihiro Hisaka, and Hiroshi Suzuki Drug Metabolism...
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kurti - strategic applications of named reactions in organic synthesis (elsevier, 2005)
... treasure trove of information and a joy to read, bringing each named reaction to life and conveying a strong sense of its utility and dynamism The inclusion of an up-to-date reference listing offers ... of graduate students in the field of organic chemistry He generously approved all of our requests for technical support thus helping us tremendously to finish the writing in a record amount of ... TABLE OF CONTENTS • SEARCH TEXT In the case of complex rearrangements, numbering of the initial carbon skeleton has been applied in addition to the colors to facilitate understanding Again, the...
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báo cáo hóa học:" Emerging applications of fluorescence spectroscopy in medical microbiology field" potx
... type of electromagnetic spectroscopy which analyzes fluorescence from a sample The sample is excited by using a beam of light which results in emission of light of a lower energy resulting in an ... present in both viruses and host bacterial protein Indole group of tryptophan residues are major source of UV absorbance and emission in proteins Tryptophan in pure water emits at 353 nm [8] Tryptophan ... Page of (page number not for citation purposes) Journal of Translational Medicine 2009, 7:99 http://www.translational-medicine.com/content/7/1/99 Figure FCS instrumentation for use in living cells...
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Báo cáo hóa học: "Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects" ppt
... treated by intravenous injection of ASCs [26-28] This immunosuppressive role of ASCs and their adjuvant effect in healing are also reflected in the encouraging results which are being achieved in various ... obtaining signed informed consent In this regard, risk-benefit assessment in this field is even more necessary in this field than in other areas because of the sometimes high underlying uncertainty ... different items, all of them necessary, including multiple surgical procedures, maintenance of strict aseptic conditions, specific training of technical staff and maintenance of overall technical...
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Báo cáo hóa học: " Infection of human cytomegalovirus in cultured human gingival tissue" docx
... http://www.virologyj.com/content/3/1/84 Results Figure ×400) fication, Hematoxylin and eosin staining of EpiGingival tissues (magniHematoxylin and eosin staining of EpiGingival tissues (magnification, ×400) Upon arrival, ... is defective in growth in the cultured tissues First, viral infection in the tissues was studied by examining hematoxylin and eosin-stained tissues and visualizing GFP expression in infected cells ... determine their potency in inhibiting HCMV growth and replication in human oral tissue To determine the feasibility of using the gingival tissue for antiviral compound screening and testing, two...
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báo cáo hóa học:" Imprisoned and imperiled: access to HIV and TB prevention and treatment, and denial of human rights, in Zambian prisons" ppt
... interviewing the officer in charge, deputy officer in charge, medical officer and female officer in charge; additional officers were invited to participate if sufficient time allowed Prison officers ... grant-making International human rights law indicates that donors should honor the principles of non-discrimination and equality in their funding of such services as health [42,43] While in the case of ... disease both into and out of prison settings Recognition of the importance of protecting human rights in addressing HIV and TB vulnerability is often Todrys et al Journal of the International...
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APPLICATIONS OF IONIC LIQUIDS IN SCIENCE AND TECHNOLOGY ppt
... and Wisniewski) Beyond these main areas of interest though, RTILs are finding their way into many other fields One of timely international interest is utilization of biomass as nonpetroleum-based ... such as microwaves and Applications of Ionic Liquids in Science and Technology Fig (a) Most common cations of ILs (b) Choline cations of ILs obtained by mixing of choline chloride based IL with ... from using these methods to extract lignin After the removal of sufficient amount of lignin, the lignin experiences degradation and often results in the loss of fermentable sugar content in the...
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Dissertation abstracts development of human resources in tourism in the south central coast and highlands
... training in tourism industry; (b) To make emphasis on practical skills training, tourism, (c) To encourage internal training (training in the tourism business), (d) The program of foreign aid in ... establishment of a new tourism training institutions and enhanced tourism infrastructure and the capacity of training units in theregions - Content: To invest in building new training facilities in tourism ... to training and fostering tourism human resource such as State, training units, businesses The third lesson is to determine vocational training, shifting to specialized training, enhancing practical...
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Báo cáo lâm nghiệp: "Carbon partitioning: fructose 2,6-bisphosphate content as an indicator of specific changes in carbohydrate metabolism in needles from class II spruce trees" pot
... sucrose visible signs of damage The determination of F26BP levels in needles could constitute an early indicator of affected carbon allocation tion partitioning of carbon into (starch decreases) ... into starch synthesis In July, in contrast, an opposite situation emerges with decreased amounts of F6P and F26BP and high levels of TP This metabolic situation should thus be indicative of increased ... 163-171 Keil R & Fink S (1989) Hampp R., Einig W., Energy status and carbon partitioning in spruce: specific changes in relation to needle age and degree of needle loss In: International Symposium...
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Báo cáo khoa học: "Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series" docx
... brought into an operating room and placed in a supine position She was then sedated with propofol mg intravenously (push) and a 20 mg/hour rate of continuous infusion After cleaning her abdominal ... her hip pain improved About a month prior to presentation, she again started having hip pain radiating to the anterior region of the right knee The pain was worse when standing up, walking, and ... meniscus of the left knee due to maceration After obtaining ADSCs and preparing PRP as described above for the first two patients, she was prepared for injection of the mixture into the joint In order...
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báo cáo khoa học: "Emerging Applications of Bacterial Spores in Nanobiotechnology" potx
... rich in serine, lysine and glutamine residues Serine residues account for over 50% of the CotB C-terminal half The lysine residues in the CotB repeats have been suggested to represent sites of intra- ... (380 amino acids) or CotB∆105 (275 amino acids) or CotC (66 amino acids) as carrier proteins (all in blue) The three 27-amino-acids repeats of full lenght CotB and the part of them remaining in CotB∆105 ... t12) of storage at room temperature were examined by dot blotting of extracted spore coat proteins Concentrations of purified TTFC (in nanograms) and of coat proteins (in micrograms) are indicated...
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báo cáo khoa học: " Current standards for the storage of human samples in biobanks" docx
... proofing the collection In this way sample biobanks should continue to provide valuable information well into the future and provide a long-term return on the initial investment in establishing ... dedicated single site bring benefits in robustness of the data trail, reduced cost and increased achievable throughput and accuracy of sample handling and picking; for example, through the use of automation ... effort should be directed into training of staff to agreed and validated operating procedures and in monitoring their performance to ensure quality standards are maintained Cross-validation between...
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Báo cáo y học: "Community-based assessment of human rights in a complex humanitarian emergency: the Emergency Assistance Teams-Burma and Cyclone Nargis" pot
... during the interview Interviews were identified by the date and location of the interview, logged in a simple string of numeric codes, a method that also ensured protection of interviewer and interviewee ... independent collection and dissemination of information, including reporting on the needs of communities[52,53] In this context, private and independent relief organizations such as EAT are in ... were identified during preliminary formative research[42,43] The selected relief workers were trained in Thailand to conduct interviews Trainings focused on case finding, interviewee confidentiality...
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Báo cáo y học: "Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy" ppsx
... transcription initiation [58], it is unlikely that drug response profiling using microarrays will be helpful to understand the mode of action of drugs in Leishmania Results using MTX as a lead drug and ... occurred at the level of the inverted repeats (as, for example, during a block in DNA replication) Indeed, we obtained a product of the expected size with these pairs of primers in L infantum MTX20.5 ... operating grants to MOu JMU is a Strategic Training Fellow of the Strategic Training Program in Microbial Resistance, a partnership of the CIHR Institute of Infection and Immunity and the Fonds de...
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THE ROLE OF HUMAN CAPTITAL IN SUSTAINABLE POVERTY REDUCTION IN VIET NAM
... professional qualification and increasing labor income in various sectors indicates the following points: The correlation of professional qualification and increase income of salary paid employees ... and technology into production is not only a measurement of knowledge, improved production skills but also of increase income According to the findings of the survey in Lai Chau province, when poor ... to poverty Two roles of human capital in the framework are below 1) The role of human capital in poverty reduction and nonreturning the poverty The role of human capital in poverty reduction...
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A study on improving the quality of human resource in Quang Ninh province customs department
... plans and training programs i fraining strategies T Training officers T Training documents F.quipment'venues 4.3.1 Defining the demands of training The plans of training designed by Provincial Customs ... the basis of' main development goals' for individuals 40 4.3 ENHANCING THE QUALITY OF TRAINING Picture 4.1 - The training process Define demands of training Assess demands of training Make plans ... the demands of training 4.3.3 Building training plans and program 4.3.4 Launching the training plans 4.3.5 Assessing and following after training 4.4 ENHANCING THE EFFICIENCY OF ORGANIZING STAFFS...
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