... made on the basis ofthe structure ofthe 5¢UTR ofthe plus-RNA, the structure ofthe 3¢-end ofthe minusstrand RNA being at that time unavailable Inthe present study we investigated the involvement ... needed to identify the role of this stem loop in NS5B binding and RNA synthesis fromthe HCV minus-strand RNA Altogether these results suggest that several domains ofthe RNA fragment comprising the ... corresponding tothe 3¢-end ofthe minusstrand RNA was synthesized by in vitro transcription of DNA obtained by PCR amplification fromthe pGEM9Zf(–) containing the 341 nucleotides ofthe 5¢UTR of HCV-H77...
... of Daily Living (Katz et al 1963), examine the extent to which individuals can maintain themselves within their living environment, for instance, their ability to bathe or dress These types of ... representative ofthe population of older adults within the six provinces that were included inthe study Individual cases were weighted by the inverse ofthe probability of being selected as part ofthe ... line corresponding tothe number of persons on the list of older persons above The person to interview is circled Count down fromthe top ofthe list of older persons to find the ‘1st’, ‘2nd’,...
... types of institutions – a testament tothe interest in this topic We are just beginning to mine the data from this second round of research and will be releasing a full white paper later inthe ... Summary Topline Findings • April 13, 2011 Overview of findings Background Slover Linett Strategies Inc and mStoner partnered with CASE for the second year in a row in order to research educational institutions ... cheryl@sloverlinett.com Thanks for your interest CASE Social Media Survey • Summary Topline Findings • April 13, 2011 Initial findings Note that questions 1–7 are for profiling purposes to ensure the...
... attachment ofthe hexahistidine, the recombinant PpTGase protein appeared to be slightly larger These results indicate that the cDNA obtained covered the entire coding region Involvement of GTP inthe ... with the PLC-interacting region has been found Whether the hydrolysing activity of GTP of PpTGase is related to certain cellular signalling inthe slime mold remains to be determined As the production ... form Initially, determination ofthe amino-terminal amino acid sequence of purified protein was attempted, but no information was obtained, probably due tothe protein modification Therefore, the...
... to its role in protecting soybeans against SDS symptom development 3.4 The level of chitinase activity in infected soybean leaves To investigate the level of chitinase activity in infected soybean ... control For the submerged growth determination, the sterile chitosan solution was added into PDB to obtain the same chitosan concentrations ofthe radial growth determination Spore suspension of F solani ... was determined for the cleared intercellular Xuid prior to their use in enzyme activity assays Total protein was determined by Coomassie Blue Protein Assay (BioRad, USA) according tothe sensitive...
... the manuscript UAL participated inthe design ofthe study and revised the manuscript TR participated inthe design ofthe study and revised the manuscript MWG participated inthe design ofthe ... For the purpose of this analysis, subjects included inthe subgroup with exacerbation of asthma were defined by the reports of regular use of asthma medication inthe three months preceding the ... range 1–12) during the 12 months preceding the SAPALDIA assessment and 55.4% of subjects denied the use of asthma medication inthe months prior tothe survey To assess the extent of potential...
... diabetes) Using the methodology of Cavrini and associates and Sitoh and colleagues [18,19], an ordinal variable for the EQ-5D index was created by categorizing the continuous variable into levels, ... varying levels of cardiometabolic risk, using data fromthe Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) This investigation will ascertain ... Determinants of health-related quality of life in institutionalized older persons in northern Sydney Internal Med J 2005, 35:131-134 Hanninen J, Takala J, Keinanen-Kiukaanniemi S: Quality of life in...
... included inthe 253-410 region, themselves very weakly interacting with Tax2, may participate in generating the correct conformation for the critical binding site ofthe strongly interacting 253-1130 ... molecules was analyzed inthe presence and inthe absence of CIITA Inthe absence of CIITA, Tax-2 localizes both and inthe cytoplasm and inthe nucleus of 293T cells often with a punctuated ... microscopy Inthe absence of CIITA, Tax-2 localized both inthe cytoplasm and the nucleus inthe great majority ofthe cells These results obtained in 293T cells are only partially similar to those...
... included inthe 253-410 region, themselves very weakly interacting with Tax2, may participate in generating the correct conformation for the critical binding site ofthe strongly interacting 253-1130 ... molecules was analyzed inthe presence and inthe absence of CIITA Inthe absence of CIITA, Tax-2 localizes both and inthe cytoplasm and inthe nucleus of 293T cells often with a punctuated ... microscopy Inthe absence of CIITA, Tax-2 localized both inthe cytoplasm and the nucleus inthe great majority ofthe cells These results obtained in 293T cells are only partially similar to those...
... individuals from a range of birth cohorts to be combined inthe analysis of age trajectories In this paper, we show how to use SAS PROC MIXED [12] to fit the individual growth models to QOL data from ... for computing the denominator degrees of freedom for tests ofthe fixed effects NOTEST prevents the printing results of type tests of fixed effects RANDOM statement contains a list ofthe random ... analyzed the data, interpreted the findings, and drafted the article Patricia Cohen supervised the data analysis and assisted with the interpretation of findings and the critical revision ofthe article...
... sampling class The stock in tC/ha was multiplied by the area ofthe plots to obtain the stock of tC inthe three components: soil, humus and vegetation The total stock, in tC, for the whole of Fougères ... part ofthe stock due to their limited area inthe forest It should also be noted that 68% ofthe carbon stocks inthe soil were located inthe upper 30 cm ofthe profile For the humus, the values ... There was some uncertainty inthe estimation ofthe stocks of carbon inthe soil which were much higher inthe hydromorphic zones than inthe other classes For the soils, the number of sampling...
... significant expression of TNF inthe entheses and peripheral joints in all the conditions [44-47] This has led tothe use of TNF antagonists inthe treatment of SpA resistant to NSAIDs and the traditional ... the event was not received within fourfold ofthe expected therapeutic interval Under this definition, treatment was discontinued in 553 of 1,388 (39.8%) AEs in RA and in 123 of 329 (37.4%) in ... Non-communication ofthe TNF antagonist discontinuation was detected in 6% of cases and non-communication of RAE in 16%; non-communication of either discontinuation or RAE was present in 18% ofthe sample...
... are indebted tothe staff in HWW's laboratory for their support References 10 11 12 13 14 Turner MW: Mannose-binding lectin: the pluripotent molecule ofthe innate immune system Immunol Today ... have a role inthe early diagnosis ofthe subgroups of JIA Competing interests 15 16 17 The authors declare that they have no competing interests 18 Authors' contributions MK prepared the manuscript, ... dysfunction ofthe complement system caused by MBL gene mutation is involved inthe immune response to infection However, the polymorphism of MBL did not seem to be associated with JIA or any of its...
... shunt fromthe COX tothe 5-LO pathway in human OA osteoblasts We also examined the implication of both 5-LO and FLAP inthe production of LTB4 in these cells and the factors that might modulate their ... expression, in contrast tothe situation observed in OA chondrocytes [56] In fact, the increase in LTB4 was either due to an upregulation of FLAP expression in high OA osteoblasts in response to inhibitors ... the expression of FLAP and thereby that of LTB4 IL-10 is not involved inthe regulation ofthe synthesis of LTs in OA osteoblasts, whereas IL-18 levels are linked with PGE2 levels Competing interests...
... between the joint ofthe anterior epiphyses ofthe first metatarsal (mt.m), the most prominent part ofthe inner side ofthe ball ofthe foot, and the joint ofthe anterior epiphyses ofthe fifth ... point on the terminal phalanx ofthe third toe Digit 4, terminal (d4.t) Most anterior point on the terminal phalanx ofthe fourth toe Digit 5, terminal (d5.t) Most anterior point on the terminal ... studies in different population groups to look into the generation of additional standards which can further be used inthe identification of individuals from human remains 13 Competing interests The...
... elements, including early administration of mitomycin-C, inclusion of cisplatin and prolonged doxifluridine administration besides the intraperitoneal therapy Thus, it remains to be proven if the survival ... neuropathy inthe OFF arm The median OS inthe OFF arm was 28 weeks, and that ofthe FF arm was 13 weeks, thereby fulfilling the study hypothesis There was also a significant prolongation of PFS inthe ... examined intermittent administration of oxaliplatin in minimizing neurotoxicity from oxaliplatin The Combined Oxaliplatin Neurotoxicity Prevention Trial (CONcePT) randomized patients receiving...
... physician investigator, the patient, and the family were blinded tothe treatment assignment (placebo versus AT III) throughout the duration ofthe clinical trial The secondary outcome was change inthe ... Thus, the investigator placed a mark along a 100 mm line that best described his or her assessment ofthe patient with the domain in question There were six domains (Table 2) The scales ranged from ... distribution for the AT III groups was similar There was a shift toward the lower risk strata of SAPS II score fromthe overall population tothe all-survivors population, whereas the risks inthe in- hospital...
... prolonging the recovery from acute FV infection, and allowing the establishment of a chronic infection The interplay of different subsets of CD4+ T cells in FV infection and the relevance to HIV infection ... synthetic peptide vaccines containing the CD4+ T cell epitopes env 121-141 or env 462-479 fromthe gp70 Env glycoprotein of F-MuLV induces protection in most ofthe vaccinated mice [78] Surprisingly, ... One ofthe epitopes lies inthe N-terminal region of F-MuLV env 122-141 (DEPLTSLTPRCNTAWNRLKL) and is presented inthe context of H-2 IAb molecules while the second epitope is inthe C-terminal...
... substained internal deletions of varying sizes Strains of Drosophila may be characterized on the basis of properties related tothe phenotypic effects of their P elements Strains are specific in their ... by dividing the number of dysgenic gonads by the total of gonads scored The rate of GD sterility in cross A provided a measure ofthe * P-activity potential ofthe strain under test; in cross ... with the ability ofthe strains fromthe coastal area to suppress P activity The presence ofthe M’ type populations in inland China and the Q type along the eastern coast is in accordance with...
... texts to understand the particular things mentioned inthe texts In other words, the meaning ofthe texts is the referential meaning, the readers need to refer to both the previous and the later ... which the clause is taking off” and “if the message is organized as a Theme-Rheme structure… the Theme should be at the beginning, rather than at the end or at some other specific points” The Theme ... the left-most constituent ofthe sentence It refers to what the speaker nominates as the subject of what he will talk about inthe Rheme The functions of a Theme are to connect back or link to...