animal models of depression and neuroplasticity assessing drug action in relation to behavior and neurogenesis
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... proliferates to a normal number of cells, but instead of building into concentric layers to form the walls of the heart, the myocardial cells form into a single layer, resulting in a dilated, thin-walled ... brain barrier of a CCM [19] or if in ammatory action is part of the mechanism of pathogenesis leading to formation of aberrant blood vessels It is intriguing that the mitogen-activated protein ... STK25 and MST4 belong to a family of kinases that are thought to act upstream of the mitogen-activated protein kinases (see the accompanying minireview [11] on the biochemical interactions of the...
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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... processing of other cytokines and cytokine receptors [32-35] Interestingly, PTPH1 is known to inhibit TACE expression and activity in vitro [36] We therefore analyzed cytokines plasma levels in carrageenan-treated ... results in the activation of TRAF6 (TNF Receptor Associated Factor 6) and in the immediate activation of NFκ B, MAPK and JNK pathways, leading to the early production of pro-inflammatory cytokines ... Differential induction of the toll-like receptor 4-MyD88-dependent and independent signaling pathways by endotoxins Infect Immun 2005, 73:2940-2950 Grutz G: New insights into the molecular mechanism of interleukin-10mediated...
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Báo cáo khoa học: "Tree-ring characteristics of subalpine fir (Abies lasiocarpa (Hook.) Nutt.) in relation to elevation and climatic fluctuations" docx
... subalpine fir were developed [9], relationships between subalpine fir site index and primary site factors were examined [4], and the decline in subalpine fir site index with increased elevation and ... known about the variation in radial growth and tree-ring properties of subalpine fir in relation to site factors In the central region of interior British Columbia, subalpine fir grows from the ... positive response of RW to July temperature of the current year (corresponding to the spring season) and of LW, LW%, and MXD to August temperature of the current year (corresponding to the summer...
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Báo cáo y học: " Dimensional and hierarchical models of depression using the Beck Depression Inventory-II in an Arab college student sample" pot
... objectives of the study were: (i) using the responses of a sample of Arab college students to the Beck Depression Inventory (BDI-II) in CFA, to compare the “goodness of fit” indices of the original ... higher order models of each of these lower - order factor models (Fig 4); (vii) the bifactor model of each of the lower-order factor models (Fig 5); and (viii) the one-factor general depression ... that, in exploratory factor analysis by principal axis factoring and oblique rotation for our data, four factors emerged, accounting for 41.8% of variance explained, and that these factors were...
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Báo cáo khoa học: "Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group" doc
... limitations, animal models remain fundamental to improving our understanding of human ARF [28-30] There are three basic types of animal models in use for study of ARF: ischemia; toxins and sepsis models; ... planning, conducting and critically evaluating studies utilizing animal models Table summarizes these principles and other guidelines for the use of animal models in the study of ARF Despite their ... problems include the definition of ARF [3]; the choice, validity and relevance of animal models of ARF [4]; and the choice regarding appropriate physiological and clinical end-points for trials of...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining stable phenotypes We would argue that a single ... is now a renewed interest in studying APP processing in sporadic AD brain, and in understanding the mechanisms of Ab truncation and modification Most transgenic models produce mainly full-length ... the N-terminus of the Ab domain in APP It was identified in 1992 [47] and shown to increase Ab levels by six- to eightfold [4] These discoveries created intense interest in APP processing and paved...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... behaviour is indicative of a higher binding constant, making phosphate competition negligible The kinetics of Ni(II) binding to model peptides and albumins at pH 7.4 was also monitored by CD spectroscopy ... Ni(II) binding to DAHKam and HSA at pH 7.4 in 100 mM phosphate buer Left panel, kinetic plots (d, experimental points constructed by adding intensities at extremes of dd bands, 475 and 410 nm, lines ... albumins On the other hand, the direct thermodynamic and kinetic characterization of Ni(II) binding at site I in HSA and BSA was obtained These data can be very useful in further studies of the toxicologically...
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Báo cáo khoa học: "Corpus-Based Induction of Syntactic Structure: Models of Dependency and Constituency" pdf
... testing multiple models, it is easier to start them all off in a common way by beginning with an M-step, and, second, it allowed us to point the model in the vague general direction of what linguistic ... Finch 1993 Finding Structure in Language Ph.D thesis, University of Edinburgh Dan Klein and Christopher D Manning 2002 A generative constituent-context model for improved grammar induction In ... then recurse to the subtree under in (generating September to the right, a right STOP, and a left STOP) Since there are no more right arguments after in, its right STOP is generated, and the process...
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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc
... while many of these models involve implantation of cells into animals derived from the cell-line originating strain, these cells still represent a graft, and unfortunately too often behave immunologically ... is a suppressor of inflammatory response in mice FASEB J 2005 Morand EF: New therapeutic target in inflammatory disease: macrophage migration inhibitory factor Internal Medicine Journal 2005, ... to induce less of an immune response [4] Thus, variability in immune response occurs in a number of these models, and this should be taken into consideration when evaluating immunotherapies in...
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báo cáo hóa học:" General anxiety, depression, and physical health in relation to symptoms of heart-focused anxietya cross sectional study among patients living with the risk of serious arrhythmias and sudden cardiac death" doc
... preparation and conduct of the study and the editing of the article BR contributed to shaping of the article and the editing of the article GEE contributed to the statistical analyses and the editing of ... motive of helping the patients to manage avoidance behavior to minimize cardiac symptoms or complications, increased levels of heart-focused attention and monitoring of cardiac related stimuli, and ... correlation between the independent variables (avoidance, attention, and fear) was not too high to include them as independent determinants in the regression models To investigate the ability of...
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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... rheumatoid arthritis are thus possible An alternative mode of imaging is the use of single photon imaging of γ-emitting isotopes like 11 1In or 99Tc Imaging of γ-emitting isotopes is referred to ... ability to enter into cells through the plasma membrane in an energy-independent process and to bring along large cargo [17], linked to superparamagnetic iron [18] In vitro MRI imaging of bone ... vessels is fast and much data can be collected in a couple of minutes of recording, the migration of leukocytes in tissues is relatively slow and requires many minutes of recording to track cells...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... animal models of RA, as summarized in Figs and Restoring the cytokine balance 184 In animal models of arthritis it has long been recognized that proinflammatory cytokines, particularly TNF-α and ... discriminate cytokine targeting and cell targeting as the two main gene therapeutic approaches to arthritis In cytokine targeting, the objective is to restore the (local) cytokine balance in arthritis ... arthritis in order to silence the inflammatory process and/ or to stop the destruction of cartilage and bone Cell targeting is the elimination of cells from the inflamed joint in order to silence...
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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... splicing of loop III of FGFR1 to FGFR3 leads to distinct functional variants (IIIb and IIIc) that have different ligand-binding specificities and affinities FGF8 can bind to three receptors – ... FGF8 induced joint destruction in vivo Injection of FGF8 into the rat knee joints promoted the release of S-GAG from cartilage into the synovial fluid Following injection of FGF8, the weight of ... concentration of mg/ml, and was administered by intraperitoneal injection (20 mg/kg) hour before the injection of MIA For the vehicle group, sterile saline was administered intraperitoneally instead of...
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Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis" pps
... proteoglycan-induced spondylitis and to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c Although induction of disease ... No Robinson same inbred strain of mouse, the universally studied BALB/c, which is the most susceptible to PGIA The goal of the research was to compare the incidence and severity of PGIA and proteoglycan-induced ... any differences in incidence and severity, the sub-lines of BALB/c mice showed modest but significant differences in immune parameters such as cytokine and antibody responses and clinical scores...
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Báo cáo y học: "Lessons from animal models of arthritis over the past decade" pot
... mediator in the early stages of joint inflammation in every experimental arthritis model Although IL-1 is not a dominant early inflammatory cytokine in all models, it is the pivotal cytokine in inhibition ... Role of cytokines Findings on the involvement of TNF, IL-1, IL-6 and IL-17 in arthritis and concomitant joint destruction will be discussed below in more detail In general, TNF is a major mediator ... be linked to the need for T cells to sustain antibody production, and the greater potential of T cell macrophage interaction to sustain joint pathology Minute amounts of antigen suffice to stimulate...
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Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot
... that the range of maximization of o, bi is from minus infinity to infinity rather than to infinity in order to allow negative environmental variances This only needs minor changes to the algorithm ... !2, and so a scaled vector of x can be found to satisfy [Al] function of x and Aj z Hence vectors S can be calculated to satisfy [11] Each vector can be i substituted into !11! in order to find ... on the structure of the data and the correlation of the parameters and deserves further investigation If, after fitting this underlying model, there is interest in getting some information on covariances...
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Báo cáo y học: " General and Specific Components of Depression and Anxiety in an Adolescent Population" pdf
... Depressive and anxiety symptoms often co-occur resulting in a debate about common and distinct features of depression and anxiety Methods An exploratory factor analysis (EFA) and a bifactor modelling ... social-cognitive symptoms of depression, a worrying factor, as well as a somatic/information processing factor including psychomotor disturbance, irritability, and thinking/decision-making difficulties ... three-factor confirmatory factor analysis is reported which identified a) mood and socialcognitive symptoms of depression, b) worrying symptoms, and c) somatic and informationprocessing symptoms...
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Báo cáo y học: " The development of a knowledge test of depression and its treatment for patients suffering from non-psychotic depression: a psychometric assessment" ppt
... following are recognized symptoms of depression EXCEPT: 73 Which of the following is true about the age of onset of depression? 69 All of the following are typical of patients suffering from clinical ... performance was poor in both the high and the low groups and to increase the difficulty of some of the very easy items (items #4 and #5), thus increasing the variance and leading to improve internal consistency ... cause of depression to family or partnership difficulties [15] Our present findings are in contrast to published findings that patients and members of the public failed to recognize depression in...
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báo cáo khoa học: " Psychosocial and contextual correlates of opioid overdose risk among drug users in St. Petersburg, Russia" pot
... their awareness of and concern about overdose risk Drug users noted their lack of confidence in being able to respond to overdose situations and were interested in receiving training on overdose ... among drug injectors in eastern Europe: patterns, trends and determinants Journal of Drug Issues 1999, 29:729-776 Heimer R, Booth RE, Irwin KS, Merson MH: HIV and drug use in Eurasia In HIV/AIDS in ... population in Russia are increasing according to the State Drug Control Committee which reported 70,000 drugrelated deaths in 2004 and 100,000 in 2005 Data from a St Petersburg study of 520 injectors...
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Báo cáo y học: " First Siena International Conference on Animal Models of " pptx
... inhibition in an ozone-induced model of COPD with the p38 kinase inhibitor SB 239063; inhibition of neutrophilia in an lipopolysaccharide-driven model with GW 311616, an elastase inhibitor; and, ... necessary to develop drugs for the treatment of COPD Mechanistic models that mimic certain aspects of the disease are widely used in drug development to identify and optimize candidate compounds Models ... some species) and the importance of the choice of animal and strain Of people who smoke 15–20% develop COPD, and the lesions produced in these models are similar to those observed in humans Dr...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25