and t2vo samp8 in the elevated plus maze test
Báo cáo y học: "Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats" doc
... determined according to Sinha [58] Histological examination The lungs were removed, inflated at 25 cm pressure with PBS then fixed, embedded in paraffin, sectioned and stained with hematoxylin and ... staining with hematoxylin and eosin stain, we found patches of fibrosis, which was in agreement with previous investigations [68,69]; the increase in hydroxyproline per lung agreed with another ... These enzymes include SOD, catalase and glutamate content, the rate-limiting enzyme in glutathione synthesis [85] The primary antioxidant enzymes in the extracellular matrix and alveolar lining...
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Báo cáo khoa học: "Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back" pot
... to alkylating chemotherapy both in the concomitant phase (50 mg in 78% and 75 mg in only 22%) as well as in the maintenance phase (no adjuvant treatment in 79 % and a mean of cycles in 21% of ... conflict of interest Authors’ contributions SC, SR, WW and JD treated the patients and collected the cllinical data SC and JD performed the clinical analysis of the dataset CH and AvD performed the histopathological ... analyzing different chemotherapeutic combinations, substances such as cisplatinum might inactivate or attenuate MGMT-status thus influencing the clinical outcome when combined with alkylating chemotherapies...
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Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf
... draft the manuscript LL participated in the animal instillation and in the histological and immunohistochemical experiments JC initiated the project, participated in the design of the study and in ... saline, silica in physiological saline, or silica with Lv-shCD36 or Lv-shCD36-NC in physiological saline, was instilled into the lungs using a 14-gauge needle inserted into the trachea through the ... could inhibit the expression of the collagen I and III in lung To further observe the degree of fibrosis, immunohistochemical examination of collagen I and III was performed in the lung tissue The...
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báo cáo hóa học: " Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury" pptx
... between TAI and TAI+Hx rats in the Rotarod test during the first days post-injury Although a similar deficit on the tape removal test was observed in TAI and TAI+Hx groups versus sham in the first ... Brain water content is elevated after TAI and TAI+Hx The ability of voluntary movement was determined by calculating the distance traveled during the first after the rats were placed in a testing ... concentration in the injured cortex By 2-way ANOVA, the overall increase of IL-6 (all time points within the group analysed together) was significantly more elevated in TAI+Hx brains when compared to either...
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Báo cáo khoa học: "Prophylactic effect of plaster and cataplasm contained ketoprofen in rats with adjuvant arthritis" pot
... mentioned In summary, the prophylactic effect of the CT and PT prominently suppressed swelling and bony changes in all regions of the femur, tibia and paw of the non-adjuvantinjected leg and the adjuvant-injected ... swelling in the adjuvant injected and non-injected paws than the control, but secondary paw swelling was unaffected The score of clinical arthritis in the controls rat showed increases until the end ... observed in all regions of the femur and the tibia of the nonadjuvant-injected legs as well as the adjuvant-injected legs In the femur, a significant decrease occurred on days 21 and 28 in the adjuvant-injected...
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Báo cáo khoa học: "Changes of biomarkers with oral exposure to benzo(a)pyrene, phenanthrene and pyrene in rats" ppt
... of BaP, PH and PY in muscle and fat, and their metabolites in urine; in addition, we studied the EROD activity in the liver and the DNA adducts of BaP in blood lymphocytes as well as the serum ... housed in a cage specially designed to collect the overnight urine The urine samples were kept Determination of parent compounds in muscle and fat, and their metabolites in urine For the determination ... BaP, PH and PY and their metabolites in urine The 3-OH-BaP compound, a major metabolite of BaP, was not detected in urine during treatment or after withdrawal of treatment in both the BaP and BPP...
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Báo cáo y học: "Inhibition by Natural Dietary Substances of Gastrointestinal Absorption of Starch and Sucrose in Rats and Pigs: 1. Acute Studies" pot
... starch and sucrose in the gastrointestinal tract, diminishing glucose entrance into the blood stream The actions of the bean and hibiscus extracts and L-arabinose on CHO absorption in the gastrointestinal ... one time In Table 4, it can be seen that the addition of the formula containing the enzyme inhibitors significantly lowered the appearance of glucose in the circulating blood whether the challenge ... the gastrointestinal breakdown of rice starch and sucrose The hypothesis tested was that natural starch and sucrose enzyme inhibitors (amylase and sucrase) would diminish and/ or slow the breakdown...
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Báo cáo y học: "The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway" ppt
... is involved in IL-1β-induced SYN expression Materials and methods Reagents, antibodies, and plasmids All the mitogen-activated protein kinase (MAPK) inhibitors used in this study, including the ... 6c) These findings suggest that the activation of Erk and ETS1 is involved in the overgrowth of mouse synovial fibroblasts during CIA Based on these findings, we collectively concluded that the ... cells in the rheumatoid joint and induce the production of MMPs and cytokines that participate in the rheumatoid process [33,35] The involvement of all three MAPK family members, JNK, Erk, and...
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Báo cáo khoa học: "Prognosticators and Risk Grouping in Patients with Lung Metastasis from Nasopharyngeal Carcinoma: A more accurate and appropriate assessment of prognosis" doc
... conceived of the study, and participated in its design and coordination and helped to draft the manuscript All authors read and approved the final manuscript 16 17 18 19 20 21 Competing interests The ... solitary and multiple metastases and between unilateral and bilateral pulmonary metastases The discrepancies between the findings in the literature and our study are likely the result of the different ... the manuscript and participated in the sequence alignment RZL participated in the design of the study and participated in the sequence alignment YL, LRH and WQL participated in the sequence alignment...
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Báo cáo y học: "Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile Christine Lyn Le Maitre, Judith Alison Hoyland and Anthony J Freemont" ppsx
... observed in the matrix of the IVD or in blood vessels Staining was particularly prominent in the cytoplasm of the chondrocyte-like cells of the NP and IAF, with significantly lower numbers of cells in ... Anakinra: the first interleukin-1 inhibitor in the treatment of rheumatoid arthritis Int J Clin Pract 2003, 57:231-234 33 Le Maitre CL, Freemont AJ, Hoyland JA: A preliminary in vitro study into ... the intervertebraldisc and its inhibition using IL-1Ra gene transfer Mol Therapy 2003, 5:S405 Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral...
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Báo cáo y học: " HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction" doc
... with either gp120 or Tat caused some discontinuous staining within the plasma membranes and appeared to increase the amount of punctate staining within the cytosol The magnification bar in the lower ... cells, and lung fluid (necessary for the findings in all of the figures), and wrote the initial draft of the manuscript XF determined tight junction (occludin and ZO-1) gene and protein expression ... observed in the alveolar epithelium of rats that expressed these proteins in vivo Discussion In this study we determined that HIV-1 transgene expression in rats, in which HIV-related proteins including...
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Báo cáo y học: "Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung" potx
... of Oulu and the Finnish Cancer Society The funding body had no role in study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision ... during the pseudo-glandular period, a finding which is concurrent with the results of immunohistochemistry Furthermore, the mRNAs of both claudin-3 and claudin-4 were at their highest during the ... well as in bronchial epithelium suggesting that these claudins in contrast to claudin-1 are also involved in the development of acinus and the differ- Page of 10 entiation of alveolar epithelial...
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Báo cáo y học: " Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis" ppsx
... Clinic for their contribution in collecting the clinical data and in obtaining the samples for genotype analysis The authors also thank Ms Gisela Wirz for performing the lung function tests and database ... Competing interests The author(s) declare that they have no competing interests Authors' contributions RK designed, coordinated and conceived the study DB took part in the interpretation of data and ... observed in CF remains incompletely explained and most likely reflects the influence of multiple, interrelated factors These may include differences in CFTR mutation and presence of infective...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... Lysine ⁄ fibrin binding sites of kringles modeled after the structure of kringle of prothrombin Proteins 3, 85–96 20 Thorsen S (1975) Differences in the binding to fibrin of native plasminogen and ... Ponting CP (1998) Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle and the N-terminal ... results indicate that in contrast to the selective K1-dependent binding of Glu-Pg to fibrin and cells, in Lys-Pg either the K1- or the K4-LBS can mediate initial binding for its activation These...
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Reproductive System Structure, Development and Function in Cephalopods with a New General Scale for Maturity Stages pot
... lay their eggs in rigid capsules, capsule glands and albumin glands are present in a complex of pallial glands These differ in their origin and function (Chukchin, 1984) Oviductal glands in octopus ... extruded from the testis ampullae and the edges of the testis show erosion Functional maturation and maturity The remaining stages involve expelling the mature sexual cells from the coelom and their ... situated between the entrance of the gonoduct and the coelom, the second between the gonoduct and accessory glands and the third at the exit of the sexual viae (Fig 1) In octopus and cuttlefish...
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) pptx
... forms indoxyl, isatine and indigo red, methionine is oxidised to sulphoxide and finally, to the corresponding sulphone, and tyrosine forms dopaquinone (Tan et al., 1987a) Studies of proteins (bovine ... concentrations) or disrupting their permeability (at low concentrations) (USDA, 2002a) and then penetrating into the cell and disrupting the protein synthesis At a pH of 8.5, chlorine dioxide was reported ... package and the introduction of the hazard analysis and critical control points (HACCP) principles in the entire food chain, establishments are obliged to improve their hygiene and processing procedures...
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Báo cáo khoa học: Role of extracellular signal regulated kinases 1 and 2 in neuronal survival docx
... rat spinal neurons against nitric oxide, acting partially through ERK1/2 [23] Similarly, the cAMP inducer forskolin increased the survival of cultured dopaminergic neurons by reducing the spontaneous ... mortality in rats with pilocarpine-induced seizures [35] Ó FEBS 2004 Interestingly, in several non-neuronal systems, damaging stimuli including DNA injury, oxidative stress or death receptor signaling ... against apoptosis induced by DNA damage [15,16] In these studies, DNA damage was induced by genotoxic anticancer drugs, camptothecin or cisplatin (CPDD) Interestingly, cisplatin is highly neurotoxic,...
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báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
... for ligand binding, therefore reducing apoptotic signaling Procedures All treatments including milrinone dosing was at the discretion of the patient's attending physician, with initial dosing between ... change in TnI or MYO after 24 hours of milrinone compared to baseline On the other hand, there were significant reductions in inflammatory and apoptotic signaling with milrinone infusion This is the ... randomization and placebo control was not practical Another related concern is whether standard therapy, particularly increased loop diuretic dosing, could explain the findings and confound the milrinone...
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Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot
... combined navelbine and mitoxantrone, supporting the testing of combination therapy with estramustine, mitoxantrone, and vinorelbine in patients with CRPC One study demonstrated a potential clinical ... to adding estramustine with vinorelbine as second line therapy in CRPC [13] Another study conducted by the Hellenic Cooperative Oncology Group, evaluated the safety and activity of the combination ... and other investigators have studied novel BH3 domain mimetics such as AT101 and ABT263, which modulate multiple Bcl-2 family proteins, and are being tested in early clinical studies [8-10] The...
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Báo cáo hóa học: " Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies" doc
... the experiments and participated in the design of the study AM, AP and MC carried out the experiments AP and GS participated in the design of the study and were responsible for patient care and ... (Th2) cytokine production [3] In humans, G-CSF increases interleukin (IL)-4 release and decreases interferon (IFN)-g production [4], induces immune modulatory genes in T cells, including the Th2 ... pegfilgrastim administration We were also interested in evaluating whether pegfilgrastim induced the release of immune suppressive HGF and TGF-b1 HGF is a pro-angiogenic and tumor-promoting cytokine HGF...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008