and or checklist for you to obtain preliminary guidance advices and recommendations on business strategies and organization designs for an internationalizing firm
Role of poly (ADP ribose) polymerase 1 and copper homeostasis factor, antioxidant protein 1 in the maintenance of genomic integrity
... Kalpana Gopalakrishnan for their help in experiments Thanks also due to friends from the ROS and Tumour laboratory, Cancer and Metastasis laboratory, Cytokine Biology laboratory, Molecular and ... also like to thank Mr J Manikandan for all his invaluable help with microarray analysis Heartfelt thanks to Mr Ganesan Arasapam for his efforts in PCRarray and Ms Cynthia and Mr Ghee Chong from ... Immunology laboratory, Dr Taneja’s laboratory and Dr Martin Lee’s laboratory for the many occasions they have enabled my research with equipment, reagents, scientific suggestions and words of support I...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... interactions [27,28] and that conformational changes in Glu-Pg are induced by ligand binding A conformational shift to the more expanded form, roughly similar to that of 3394 the U-shaped open form ... Glu-Pg- and mAb 34D3-treated cells Bands in lanes and correspond to forms I and II of plasmin(ogen) High molecular weight bands in lanes and correspond to mAb A10.2- and mAb 34D3-plasminogen complexes ... open conformation Thus, Lys-Pg has an open conformation similar to that of 6-Ahx-liganded Glu-Pg [33] The compact spiral-type conformation of Glu-Pg is resistant to activation, whereas a shift to...
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Tài liệu Báo cáo Y học: Binding of gelsolin domain 2 to actin An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin pptx
... The excitation was fixed at 340 nm and the fluorescence emission monitored between 460 and 480 nm The fluorescence was corrected for the contribution of the FITC-labelled peptide alone In this experiment, ... nÞ ð1Þ where C and E are total concentrations of peptide and actin, respectively, and X is the relative fluorescence change A/Amax (corresponding to the fraction of peptide bound to actin) A plot ... coated to plastic and increasing concentrations of gelsolin peptide were added to a fixed concentration of cofilin (0.8 mM ) The binding of the ligand used at a fixed concentration was monitored using...
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An Equilibrium Model of Rare-Event Premia and Its Implication for Option Smirks potx
... precision for rare events is much lower than that for normal shocks As a result, in addition to balancing between risk and return according to the estimated probability law, the investor factors into ... that of Anderson, Hansen, and Sargent (2000) in one important dimension.7 Specifically, our investor is worried By introducing a crash aversion component to the standard power-utility framework, ... Proposition Applying the equilibrium condition u ¼ to the first-order conditions (16) and (17), we immediately obtain Equations (20) and (21) for the optimal aà and bà Next, the equilibrium conditions...
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Báo cáo Y học: Structural and serological relatedness of the O-antigens of Proteus penneri 1 and 4 from a novel Proteus serogroup O72 pptx
... lower-®eld positions of the signals for H2 (d 4.07 and 4.02, as compared to d 3.76, respectively) and by their correlation to the corresponding nitrogen-bearing carbons at d 52.5 and 54.1 The values ... four anomeric protons at d 4.59±4.96 and two N-acetyl groups at d 2.05 and 2.06 Therefore, the polysaccharide has a tetrasaccharide repeating unit containing one residue each of D-Glc and D-Gal and ... Attached proton test for carbon-13 NMR J Magn Reson 46, 535±539 18 Altona, C & Haasnoot, C.A.G (1980) Prediction of anti and gauche vicinal proton-proton coupling constants in carbohydrates:...
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Báo cáo khoa học: Inhibitors of protein phosphatase 1 and 2A decrease the level of tubulin carboxypeptidase activity associated with microtubules pptx
... with OA for h longer; d, control (nontreated) cells (B) Cells were treated with lM OA for h, and then with 10 lM taxol for 10 Cytoskeletons were isolated and incubated for the stated times to determine ... similar to (A) and (B) were obtained for OA- and nor-okadaone-treated cells (not shown) (C–H) Cytoskeletons incubated in vitro for h (C,D) Control cells (E,F) OA-treated cells (G,H) Nor-okadaone-treated ... Studies to resolve this point are underway Acknowledgements ´ We thank C.A Argarana and C.R Mas for critical reading of the ˜ manuscript; S.N Deza and M.G Schachner for technical assistance, and S Anderson...
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báo cáo hóa học:" Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a" pot
... expression data and 100 for microRNA array data in both fluorescence channels Spots flagged by the analysis software and spots with diameters
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Báo cáo toán học: "Graphs Associated with Codes of Covering Radius 1 and Minimum Distance 2" ppsx
... author would like to thank Brendan McKay for several useful conversations and the anonymous referee for valuable suggestions References [1] A Blokhuis, S Enger, H.D.L Hollmann, and J.H van Lint On ... 1/12/2007 [12] R.G Stanton, J.D Horton, and J.G Kalbfleisch Covering theorems for vectors with special reference to the case of four and five components Journal of the London Mathematical Society, ... combinatorial significance Information and Control, 23:407–438, 1973 [5] W Haas and J Quistorff On mixed codes with covering radius and minimum distance The Electronic Journal of Combinatorics, 14:R51,...
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Báo cáo khoa học: "Consequences of an excess Al and a deficiency in Ca and Mg for stomatal functioning and net carbon assimilation of beech leaves" ppt
... The autors thank H.J Van Praag and F Weissen for supplying beech seedlings, and F Toussaint and A.M Defrenne for the maintenance of plant culture They thank also M Burlett and F Willm for help ... remained constant and similar to the value recorded in control dark-adapted leaves, i.e 0.9 3.3 Stomatal response to ABA Stomatal responses to an application of exogenous ABA via the transpiration stream ... reduced to one half of the control: 0.5 µmol gChl-1 s-1 DISCUSSION Stomata allow water loss by transpiration and the entry of CO2 into the leaf for photosynthetic carbon fixation Fine control of stomatal...
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Báo cáo y học: "Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden" potx
... fixed and stabilized [Q-prep Beckman, Coulter] then stored at +4°C prior to transportation on ice to the base laboratory for analysis CD4+ and CD8+ cell selection and Triazol treatment PBMCs were ... infection season versus those born in the harvest/low infection season For normally distributed data, the Student’s t test was used, and for skewed data, log transformation was applied and the Man ... Flanagan KL, Aveika AA, Zaman A, RowlandJones S, McConkey SJ, Whittle HC, Marchant A: Risk factors for and clinical outcome of congenital cytomegalovirus infection in a peri-urban WestAfrican...
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báo cáo khoa học: " FCR (Fludarabine, Cyclophosphamide, Rituximab) regimen followed by 90yttrium ibritumomab tiuxetan consolidation for the treatment of relapsed grades 1 and 2 follicular lymphoma: a report of 9 cases" pot
... mitoxantrone plus rituximab) and after one year, at the second relapse, he received cyclophosphamide plus dexamethasone and rituximab, remaining in CR for 48 months He died at 73 years of age for ... retrospective analysis, nine patients with relapsed grade and FL, responding to FCR regimen and consolidated with 90 Y-RIT obtained a significant high rate of response with 100% of CR and acceptable toxicity ... neutropenia and thrombocytopenia but hematologic toxicities grade or did not require transfusion but growth factor support was utilized in the majority of patients during FCR treatment, and in all...
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Báo cáo y học: "An exploration of how clinician attitudes and beliefs influence the implementation of lifestyle risk factor management in primary healthcare: a grounded theory study" pot
... intervention for three or more risk factors and/ or high intensity intervention (across risk factors), low intensity intervener = low frequency of intervention for three or more risk factors and/ or low ... I was a drug and alcohol worker it'd be a different story, but I'm not.' (Clinician 15) Expectations Informer and educator Ensure client has sufficient information to make an informed choice ... motivation and satisfaction Drugs: Education, Prevention and Policy 2005, 12:449-463 Ajzen I: The theory of planned behaviour Organizational Behaviour and Human Decision Processes 1991, 50:179-211 Bandura...
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Báo cáo y học: " Molecular characterization of genome segments 1 and 3 encoding two capsid proteins of Antheraea mylitta cytoplasmic polyhedrosis virus" pps
... incubation with Taq DNA polymerase (Bioline) at 72°C for 20 and cloned into pCR-XL-TOPO vector (Invitrogen) to make plasmid pCR-XL-TOPO/AmCPVS1 and pCR-XL-TOPO/AmCPVS3 After transforming in E coli TOP ... S3 AmCPV S1 and S3 RNA were isolated, converted to cDNA and cloned into pCR-XL-TOPO and the total nucleotide sequences were determined in both forward and reverse directions S1 consisted of 3852 ... immunoblot analysis was done with the midgut of uninfected and virus-infected larvae, polyhedra and virion particles using purified polyclonal anti-p141 and anti-p137 antibodies Major immunoreactive bands...
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Báo cáo y học: "Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts" docx
... (Invitrogen Corporation), and μg was reverse-transcribed using random primers and Superscript II (Invitrogen Corporation) Real-time polymerase chain reaction (PCR) was performed with an ABI PRISM ... provided Bor, bortezomib; B/T, bortezomib/transforming growth factor-beta; COL1A2, collagen 1A2; TGF-β, transforming growth factor-beta; UT, untreated To confirm the involvement of c-Jun in bortezomibmediated ... primary antibodies, and anti-goat (The Binding Site, Birmingham, UK) or anti-rabbit or anti-mouse (DakoCytomation, Baar, Switzerland) IgG antibodies coupled to horseradish peroxidase For DNA pull-down...
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Báo cáo y học: "Heliox improves pulmonary mechanics in a pediatric porcine model of induced severe bronchospasm and independent lung mechanical ventilation" pdf
... inspiratory to expiratory ratio (I/E) 1:1, fractional inspiratory oxygen concentration (FiO2) 30%] Central arterial and venous catheters were placed by femoral cutdown for continuous monitoring ... Vol No and anti-inflammatory agents have become the standard of care for reactive airway disease and asthma However, some patients fail to respond to aggressive therapy and require mechanical ... not obtained simultaneously Therefore, the order for each lung to be tested was determined randomly and data were compared by pulmonary function assessment number Results of PFTs obtained at and...
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Báo cáo y học: " A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread" ppt
... [18] As an extension to this general formulation of an exponential relation between exposure and the risk of infection, we extrapolate the actual exposure from information about the duration and ... that one outlier lies outside the displayed range The corresponding person day had 28 reported contacts and amounts SC = 14.15 for subfigure a, SC = 24.00 for b, and SC = 27.76 for c The rationale ... However, for reasons of manageability and measurability, we concentrate on conversational and physical contacts The actual amount of infectious organisms ingested by an individual follows a Poisson...
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Báo cáo y học: "A continuum mathematical model of endothelial layer maintenance and senescence" ppsx
... Ti = For h = 0.1 (see Results and Discussion), λi h YW performed the numerical simulations BDA and AF formulated the model equations, wrote the manuscript, and jointly supervised YW's work All ... average cell replication rate constants for the entire cell population, ranging from zero (λN = for senescent cells) to a maximum of λ (= × 10-5 s-1 for progenitor cells), and with intermediate ... days for a 40year old, and about a week for a 60-year-old Note that a 60-year-old person requires more than one month to achieve 90% recovery (θ = 0.1), and healing times increase very rapidly for...
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The roles of histone deacetylases 1 and 2 in hepatocellular carcinoma
... scientist Thank you for your inspiration and understanding as a mentor and a boss I would also like to thank Mei Yee and Tan Jing from Dr Yu Qiang’s lab at the Genome Institute of Singapore for the ... tails is not a random event HATs can have preference for one site over another Also, HATs can interact with other HATs and transcription co-repressors and co-activators to form a functional protein ... where many hepatocytes die and there is invasion by inflammatory cells and fibrosis (Thorgeirsson and Grisham, 2002) 1.2 1.2.1 Risk Factors for HCC Hepatitis B and Hepatitis C viruses The dominant...
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Báo cáo y học: "Patients'''' recollections of experiences in the intensive care unit may affect their quality of life" doc
... previously admitted to an ICU? Once for the same reason 33 (8) Twice or more for the same reason 12 (3) Once for a different reason 38 (9) Never been admitted to an ICU before 320 (80) If you are not ... between respondents and nonrespondents in background and ICU variables, except for admission diagnostic category, for which non-scheduled surgery and multiple trauma survivors answered significantly ... related either to environmental factors (characteristic of the ICU, which can lead to an overwhelming of sensory stimuli) or factors related to memory problems (namely delusional memories and amnesia)...
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