and antioxidant enzyme gene polymorphisms in acute kidney injury
Báo cáo y học: " Clinical review: Timing and dose of continuous renal replacement therapy in acute kidney injury" ppsx
... AKI and randomized in a paired fashion [29] Patients were enrolled when the serum creatinine reached approximately mg/dl and were dialyzed to maintain a predialysis BUN of < 60 mg/dl in the intensive ... arm and approximately 100 mg/dl in the non-intensive arm The average time to initiation of dialysis was ± days in the intensive arm and ± days in the non-intensive arm Mortality was higher in ... A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure Kidney Int 2001, 60:1154-1163 Augustine JJ, Sandy D, Seifert TH, Paganini EP: A randomized controlled...
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Báo cáo y học: "Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury" potx
... kidney injury Cisplatin-induced kidney injury 2C11 ↓ Uranyl nitrate induced kidney injury 2D2 ↔ ↔ ↔ ↔ Nephrectomy Bilateral ureteral ligation Glycerol-induced kidney injury Cisplatin-induced kidney ... injury 2E1 ↑ Uranyl nitrate induced kidney injury 3A1 (3A23) ↑ Uranyl nitrate induced kidney injury 3A2 ↓ ↔ ↓ ↔ Nephrectomy Bilateral ureteral ligation Glycerol-induced kidney injury Cisplatin-induced ... nonrenal clearance in acute kidney injury in clinical studies Drug Normal renal function Acute kidney injury End-stage renal disease 130 ml/minute [55-58] 90 to 95 ml/minute [8,59] 50 ml/minute [8,60,61]...
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Báo cáo y học: " Science review: Searching for gene candidates in acute lung injury" pot
... Candidate genes in acute lung injury Gene Ontology Encoded protein Gene symbol NR IM Interleukin-1β IL1B × × Interleukin-6 IL6 × Tissue factor precursor TF Plasminogen activator inhibitor-1 IN ... receptor-5 genes were reported to be involved in several lung inflammatory disorders [38] and in amplifying inflammation in lung [39], respectively The gene encoding CXC chemokine ligand (CXCL)2 ... permeability during combined burn and smoke inhalation injury in a sheep model [49] There is evidence of epithelial involvement in ALI, such as upregulation of the CCAAT enhancer binding protein gene (C/EBP),...
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Báo cáo khoa học: "Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury" doc
... Sensitive and specific markers for kidney injury are not currently available in clinical practice Several groups are working on developing and validating biomarkers of kidney injury and GFR which ... Table Diagnostic criteria for acute kidney injury An abrupt (within 48 hours) reduction in kidney function currently defined as an absolute increase in serum creatinine of more than or equal to ... expertise and their sponsoring organization AKIN is intended to facilitate international, interdisciplinary, and intersocietal collaborations to ensure progress in the field of AKI and obtain the...
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Báo cáo y học: "Dialysis dose in acute kidney injury: no time for therapeutic nihilism – a critical appraisal of the Acute Renal Failure Trial Network study" ppt
... Therapy for the Kidney (B.E.S.T Kidney) Investigators Writing Committee: Patient and kidney survival by dialysis modality in critically ill patients with acute kidney injury Int J Artif Organs ... comparisons of intermittent and continuous therapies in acute kidney injury: what they mean? Int J Artif Organs 2008, 31: 213-220 23 Clark WR, Letteri JJ, Uchino S, Bellomo R, Ronco C: Recent clinical ... Gibney N, Tolwani A, Ronco C; Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Acute renal failure in critically ill patients: a multinational, multicenter study...
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Báo cáo y học: " Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study" ppt
... been validated in clinical practice, particularly in the acute setting [18] In designing the protocol, we recognized that combining continuous and intermittent modalities into a single treatment ... Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T Kidney) Investigators Writing Committee: Patient and kidney survival by dialysis modality in critically ill patients with acute kidney ... conference on continuous renal replacement therapy Kidney Int 2002, 62:1855-1863 Palevsky PM: Clinical review: timing and dose of continuous renal replacement therapy in acute kidney injury Crit Care...
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Báo cáo y học: "Late initiation of renal replacement therapy is associated with worse outcomes in acute kidney injury after major abdominal surgery" potx
... classification [24] for acute kidney injury GFR criteria Urine output criteria Risk Increase plasma creatinine ×1.5 or GFR decrease > 25% < 0.5 ml/kg/h × h Injury Increase plasma creatinine ×2 or GFR decrease ... sustained and uncontrolled intra-abdominal hypertension and may result in AKI or mortality, is being increasingly observed in the general surgical population [7] Thus it was assumed that abdominal ... Physicians India 1997, 45:850-852 36 Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury...
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Báo cáo y học: " Recently published papers: Renal support in acute kidney injury is low dose the new high dose" doc
... Competing interests The authors declare that they have no competing interests References Thakar CV, Christianson A, Freyberg R, Almenoff P, Render ML: Incidence and outcomes of acute kidney injury ... (Beginning and Ending Supportive Therapy for the Kidney) has examined the clinical Page of (page number not for citation purposes) parameters associated with successful cessation of continuous ... renal function, an increase in the number of filters employed and, more worryingly, an increase in hypophosphataemia Perhaps one of the most remarkable statistics was the similarity in fluid balance...
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Báo cáo hóa học: " FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study" potx
... http://www.annalsofintensivecare.com/content/1/1/21 Page of Table Baseline characteristics of patients with and without acute kidney injury No acute kidney injury Number Acute kidney injury p value ... baseline serum creatinine of 67 ± 15 μmol/L with a peak inpatient serum creatinine of 217 ± 86 μmol/L compared with a baseline serum creatinine of 69 ± 20 μmol/L and a peak serum creatinine of ... during acute kidney injury from causes other than PO4 (mmol/L) 2000 4000 6000 FGF−23 (RU/mL) Figure Correlation of serum phosphorus (PO4) and FGF-23 levels in patients with and without acute kidney...
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Báo cáo y học: "CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjögren syndrome" docx
... with pSS and 156 controls [3] The aim of our study was to investigate in a large case-control study whether CTLA-4 CT60 and/ or +49A/G SNPs were involved in genetic predisposition to pSS in French ... +49A/G polymorphisms in a replication study The geographical origin and the clinico-biological characteristics of the patients in this second cohort were the same as those in the first In this ... different origin or different clinico-biological characteristics of the patients from the two cohorts and could only be the result of a sampling bias Indeed, the findings observed in our first...
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Báo cáo y học: "Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG" pdf
... lipoproteins ApoE is also the main protein component of the very low density lipoproteins (VLDL) and high density lipoproteins (HDL) ApoE polymorphisms generate more than 10 percent of the interindividual ... for genetic analyses Reoperation for CAD, reintervention (PTCA and/ or stenting and/ or hospital admission for myocardial infarction), angina at the time of follow-up, and a combined endpoint of ... [%] 24 Genetic analyses Polymorphisms in genes coding for factors involved in lipid metabolism: apolipoprotein E (APOE) [4,8], hepatic lipase (LIPC) [7], and cholesteryl ester transfer protein (CETP)...
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Báo cáo thú y: "The effect of the combination of acids and tannin in diet on the performance and selected biochemical, haematological and antioxidant enzyme parameters in grower pig" docx
... still remained below the lower value of reference range In all animals, there is a general increase in total serum protein, a decrease in albumin, and an increase in globulins with advancing age ... effect of the combination of acids and tannin in diet on the performance and selected biochemical, haematological and antioxidant enzyme parameters in grower pigs Acta Veterinaria Scandinavica 2010 ... parameters in individual groups The minimum level of significance was defined at p < 0.05 Results At the beginning of the feeding trial one pig died during blood sampling in Group I No clinical health...
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Báo cáo khoa học: "Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units" docx
... acute kidney injury and incidence from the Australia New Zealand Intensive Care Society Adult Patient Database, 1996–2005 acute kidney injury and incidence from the Australia New Zealand Intensive ... making it possible to assess changes in incidence and outcome over a significant timespan We therefore interrogated the ANZICS APD to obtain information on the incidence and outcome of AKI in ... examining for trends in incidence over time is unfortunate when taking into account the poor clinical outcome and high cost of care for critically ill patients with AKI [10,13,32] The key findings...
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Báo cáo y học: "Acute kidney injury in the intensive care unit: current trends in incidence and outcome" potx
... disease) and AKIN (Acute Kidney Injury Network) criteria provides us a framework for identifying and staging AKI This will not only aid us in recruiting patients, but also serve as clinical endpoints ... Changes in the incidence and outcome for early acute injury in a cohort of Australian intensive care units Crit Care 2007, 11:R68 Ympa YP, Sakr Y, Reinhart K, Vincent JL: Has mortality from acute ... JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury Crit Care 2007, 11:R31 ...
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Báo cáo y học: "Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications" potx
... Mortality according to acute kidney injury stratified by the Risk, Injury, Failure, Loss of Kidney Function, End-stage Kidney Disease (RIFLE) and the Acute Kidney Injury Network (AKIN) definition/classification ... (creatinine + urine output) AKIN criteria (creatinine + urine output) 0.750 RIFLE criteria (creatinine) 0.729 AKIN criteria (creatinine) 0.745 RIFLE criteria (urine output) 0.619 AKIN criteria (urine ... Molitoris BA, Ronco C, Warnock DG, Levin A, Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury Crit Care 2007, 11:R31 14 Manjunath...
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Báo cáo y học: "Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study" ppsx
... was exposed on day in parallel with increasing plasma creatinine concentration, and patients classified as Risk were exposed and 19 days, Table Early and late acute kidney injury: characteristics, ... Data are mean (95% confidence interval) or number of patients Acute kidney injury is classified by RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease) Multiple organ ... creatinine was within the reference range during the first day after injury in all cases but one, whose plasma creatinine was 126 μmol/L All four had multiple organ failure before dialysis, and...
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Báo cáo y học: "Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury" pps
... Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T Kidney) Investigators Writing Committee Patient and kidney survival by dialysis modality in critically ill patients with acute kidney ... assessment (SOFA) and serum creatinine at CRRT initiation and CRRT downtime (hours); for IRRT the covariates included were age (10-years increments), sex and RIFLE class at IRRT initiation In addition ... Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI) Investigators North East Italian Prospective Hospital Renal Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI): targeting the problem with...
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Báo cáo y học: " Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study" pps
... is a known risk factor for AKI, Table Baseline characteristics of patients with and without acute kidney injury No acute kidney injury Acute kidney injury P value Number 21 18 Age (years)* 2.1 ... other urine and plasma biomarkers of AKI that have been measured in this cohort, including urinary IL-18, serum/urinary neutrophil-gelatinase-associated lipocalin (NGAL), urinary kidney injury ... demonstrated that inflammatory cytokines increase early after AKI as serum interleukin-6 (IL-6) and keratinocyte-derived cytokine (KC, the murine analogue of interleukin-8) were increased by hours...
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Báo cáo y học: "Correlation between parameters at initiation of renal replacement therapy and outcome in patients with acute kidney injury" ppsx
... Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney ... Maximum organ failure during ICU* Median (range) Mean (SD) Mechanical ventilation Mortality * excluding acute kidney injury AKI = acute kidney injury; APACHE = acute physiology and chronic health evaluation ... Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A: Acute Kidney Injury Network (AKIN): report of an initiative to improve outcomes in acute kidney injury Critical Care 2007, 11:R31 Knaus WA, Draper...
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Báo cáo y học: "Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients" doc
... a more accurate determination of AKI severity in critically-ill patients Page of Abbreviations AKI: acute kidney injury; AKIN: Acute Kidney Injury Network; CKD: chronic kidney disease; GFR: glomerular ... creatinine Authors' contributions EM, JB, GMC, and RLM were involved in the conception, design, analysis and interpretation of data, drafting the article and revising it critically for important intellectual ... Ascertainment and epidemiology of acute kidney injury varies with definition interpretation Clin J Am Soc Nephrol 2008, 3:948-954 Bagshaw SM, George C, Bellomo R: A comparison of the RIFLE and AKIN...
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