alzheimer s disease and other dementias alexander p auchus and christopher chen
Tài liệu Alzheimer’s Disease and Other Dementias doc
... Psychological Disorders Alzheimer s Disease and Other Dementias Psychological Disorders Addiction Alzheimer s Disease and Other Dementias Anxiety Disorders Child Abuse and Stress Disorders ... 2006010414 Chelsea House books are available at special discounts when purchased in bulk quantities for businesses, associations, institutions, or sales promotions Please call our Special Sales Department ... brain and hereditary diseases like Wilson s disease Huntington s disease is an involuntary movement disorder that is often associated with dementia Parkinson s disease is a progressive brain disorder...
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The Handbook of Alzheimer’s Disease and Other Dementias doc
... dementias Vascular dementias Psychiatric disorders Important examples Prion diseases, syphilis, Lyme disease, chronic meningidites, PML, HIV, Whipple s disease, hydrocephalus Primary or metastatic ... lipofuscinosis Multiple infarct dementia “Binswanger s disease “Small vessel ischemic disease CADASIL Schizophrenia Dementia syndrome of depression Bipolar disorder Malingering Obsessive compulsive ... time (see later section) When patients have no support system, try to assist the patient in establishing support networks and relevant services (Grossberg & Desai, 2003) Alzheimer s Disease The...
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LifeOut of Focus Alzheimer’s Disease and Related Disorders ppt
... disturbances or subtle changes in personality Alzheimer s is a progressive disease; this means that the condition continues to get worse with time Usually, Alzheimer s disease gets progressively worse ... ALZHEIMER S DISEASE AND RELATED DISORDERS This woman is a resident of a home for people with Alzheimer s disease Because of patients’ memory loss, signs have been posted as reminders of which flowers ... OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS A gradual loss of memory, affecting a person s skills and behavior, characterizes Alzheimer s disease In Helen s case, she slowly lost her...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... omits articles, prepositions, conjunctions, pronouns, plurals, and past tenses) is an indication of Broca s aphasia Difficulties following simple commands indicate possible comprehension problems ... movement side effects of neuroleptics, delusions, and other types of hallucinations Single photon emission computed tomography (SPECT) demonstrates hypoperfusion,110 and PET111 demonstrates a glucose ... language assessments, patients should be referred to a speech pathologist; but the physician can assess basic elements of language comprehension and production in the office The MMSE covers simple...
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ALZHEIMER’S DISEASE AND RELATED DISORDERS ANNUAL doc
... diagnosis is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association ... disease: synapse loss is the major correlate of cognitive impairment Ann Neurol 1991;30:572–580 70 Scheff SW, Price DA, Schmitt FA, et al Stereological assessment of hippocampal synapses in people ... Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association Definite and probable AD vs OND 49 probable AD 49 controls Kapaki et al, 200324 Gold standardb 11:09 AM a Populationa...
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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
... disease from paralysis agitans (Latin for shaking palsy) to la maladie de Parkinson (French for Parkinson s disease) T-sub-type PD patients have a better prognosis and slower disease progression ... oligomerizes and aggregates, is resistant to UPS-mediated degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES TOXIN Autosomal ... the SNc in PD demonstrated a reduction in the mRNA levels of 2 0S proteasome a-subunits (PSAM2, PSMA3 and PSMA5), a non-ATPase subunit (PSMD8/Rpn12) and an ATPase subunit (PSMC4/Rpt3) of PA700...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... electron transmission microscope operated at 120 V All reagents were supplied by Electron Microscopy Sciences (Hatfield, PA, USA) Assessement of SEC-isolated peptides by HPLC and SDS-PAGE Samples (100 ... Analysis Center, University of Uppsala, Sweden Sequence analysis was performed using an Applied Biosystems Procise 492 cLC sequenator (Applied Biosystems, Framingham, MA, USA) employing standard ... Ab peptides Chemical synthesis of various Ab peptides is now routine [18,19], but is time-consuming and requires access to specialized equipment, and is relatively expensive, especially for isotope...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
... CA, Piccardo P, Petegnief V, Ghetti B, Paul SM 1999 Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer s disease Proc Natl Acad Sci USA ... 4, other risk factors, and course of Alzheimer s disease Biol Psychiatry 45(5): 633– [68] Yaffe K, Cauley J, Sands L, Browner W 1997 Apolipoprotein E phenotype and cognitive decline in a prospective ... Subtest and the repetition of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities...
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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders pot
... animals and humans with such disorders The most serious shortcoming of the aforementioned scheme of parkinsonian pathophysiology is, perhaps, that changes in the spontaneous discharge patterns, and ... movement disorders such as Parkinson s and Huntington s diseases (PD/HD) These structures classically include: 1) the striatum, which comprises the caudate nucleus (CD), putamen (PUT), and nucleus accumbens ... electrophysiological experiments showed that activation of these inputs results in very strong short latency monosynaptic excitatory postsynaptic potentials (EPSP) with multiple spikes in STN neurons,...
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Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc
... the cells expressing the Notch substrate As c-secretase cleavage resembles the cleavage of signal peptides by signal peptide peptidases (SPP), an inhibitor of SPP was also tested in our assay Both ... cells Figure 1B shows phase (panels and 3) and fluorescence microscopy (panels and 4) of COS-7 cells transfected with both constructs (panels and 4) or with an empty pCDNA3.1+ plasmid plus the reporter ... genes yielded fluorescent cells Double-transfected COS-7 cells were fixed and observed by phase (panels and 3) and fluorescence microscopy (panels and 4) Phase microscopy showed similar images of...
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Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... and autophosphorylated at serine 2481 In AD brain, high levels of phosphorylated mTOR phosphorylate p7 0S6 K and transmit a positive signal to the p7 0S6 K pathway, and phosphorylate and disassociate ... proteins with either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies ... p- 4E-BP1, and p- eEF2 We used phosphospecific antibodies to p- mTOR, p- 4EBP1, p- eEF2 and PHF-tau (PHF-1) to stain the sections of the medial temporal cortex from AD and control brains We observed...
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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf
... Monsonego A, Weiner HL: Immunotherapeutic approaches to Alzheimer s disease Science 2003, 302:834-838 Heppner FL, Gandy S, McLaurin J: Current Concepts and Future Prospects for Alzheimer Disease ... (ANOVA) and Tukey s multiple comparisons post-test (a P value of less than 0.05 was considered significant) Results Generation and characterization of chimeric viruses expressing Ab1-10 or Ab1-7 peptides ... cell epitope of Ab42 has been mapped to the N terminus of this peptide [30,34-40] and, importantly, these peptides not possess T helper epitope /s [35,41] Accordingly, Ab 1-10 (Figure 1A) and Ab...
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báo cáo hóa học: " Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer''''s disease" pdf
... transcription factors Cell cycledependent phosphorylation of pRb by CDKs inactivates pRb and inhibits pRb target binding, allowing cell cycle progression The expression of phosphorylated pRb (ppRb) ... expression of COX-2 or ppRb and the increased glial response observed during AD pathology Although suggested by in vitro studies, our evaluation of post mortem brain tissue suggests that it is ... Demographic characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary...
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báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
... image analysis, data analysis and manuscript preparation; IH performed immunohistochemistry, image analysis, data analysis and presentation and assisted with perfusions and animal care; OY performed ... MF performed immunohistochemistry, image analysis, data analysis and presentation, molecular genetic studies and manuscript preparation; RK prepared immunogens and performed immunoassays, S. W performed ... A, Schenk D, Tang P, Vasquez N, Seubert P, Yednock T: Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer' s disease- like neuropathology Proc...
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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
... clinical diagnosis of probable Alzheimer' s disease [10] All participants underwent a physical examination, blood tests and neuroimaging assessments They also underwent cognitive assessments using the ... scoreslevels in participants grouped according to Serum AOC levels in participants grouped according to MMSE scores Square and circle symbols indicate controls and Alzheimer' s disease patients, ... Similar results were obtained when the analysis was carried out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in Figure 2, high serum AOC levels predicted...
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báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx
... data, and assisted in manuscript preparation MPC performed the data analyses and assisted with manuscript preparation DAB provided the serum samples and assisted with manuscript preparation JMF provided ... KruskalWallis test (for post-mortem intervals [PMI]), and exact versions of Pearson s chi-square tests (for gender, apolipoprotein E [apoE] status, and use of anti-inflammatory medications) P- values ... P- values ≤ 0.05 were considered statistically significant All p- values were two-tailed Statistical analyses were performed using The SAS System for Windows version 9.2 Power and sample size analyses...
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báo cáo hóa học: " Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice" ppt
... GFAP+ astrocytes at the month time point (C) Eight month old APP/PS1 transgenic mice displayed low numbers of GFAP positive astrocytes, whereas (D) animals suffering from osteoarthritis presented ... role for specific polymorphisms in disease risk Exp Gerotontol 2000, 35:481-487 Cunningham C, et al: Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ... cells was significantly increased in APP/PS1; Col1-IL1b XAT mice with osteoarthritis compared to APP/PS1 mice without osteoarthritis and wild type controls (Figure 4I) mRNA analysis for several...
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ALZHEIMER’S DISEASE PATHOGENESIS-CORE CONCEPTS, SHIFTING PARADIGMS AND THERAPEUTIC TARGETS pot
... biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans: Alzheimers.Dement., v 6, no 3, p 265-273 20 Alzheimer s Disease Pathogenesis-Core Concepts, Shifting Paradigms and ... family/Phosphoinositide 3-kinase/Akt/Glycogen synthase kinase3(GSK3) pathway They reported that both disease processes contribute to overlapping pathology, thereby compounding disease symptoms and progression ... appears the oxidative stress plays an important role Oxidative stress is extensive in AD and Aβ peptides stimulate oxidative stress by both direct and indirect mechanisms Aβ peptides by themselves...
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