akt mtor and ampk in cancer and metabolic disorders
báo cáo khoa học: "Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy" ppsx
... The results of ongoing clinical trials with mTOR inhibitors, as single agents and in combination, will better define their activity in cancer Competing interests RY, AK, WJB, and DL are employed ... phase I and II trials evaluating everolimus in combination with TKIs and other agents are ongoing, including a phase II trial of the combination of everolimus and the EGFR tyrosine kinase inhibitor ... prevents mTOR activity [4] These inhibitors are similar to rapamycin in that they affect only mTORC1, but not mTORC2 The function of mTORC2 and its role in normal and cancerous cells remains relatively...
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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
... ATP binding site serves as a docking site for specific binding of cytoplasmic signaling proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains These proteins in turn ... tyrosine kinase inhibitors Inhibiting the activity of tyrosine kinases by low molecular weight compounds capable of interfering with either ligand binding (in the case of receptor tyrosine kinases) ... carcinoma Bladder cancer Glioblastoma multiforme Autocrine-paracrine loop Glioma Autocrine-paracrine loop PDGFR and PDGF IGFR and IGF I and II Breast cancer Table Protein kinase inhibitors in clinical...
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Tài liệu Area Socioeconomic Variations in Cancer Incidence and Stage at Diagnosis in New Jersey, 1996-2002 pdf
... the skin, non-Hodgkin lymphoma, oral (oral cavity and pharynx) cancer, ovarian cancer, pancreas cancer, prostate cancer, stomach cancer, thyroid cancer, and urinary bladder cancer To compare incidence ... Trends in Cancer Incidence and Mortality in New Jersey, 1979-2002; • Cancer Survival in New Jersey 1979-1997; • Cancer Prevalence in New Jersey on January 1, 2003; and • Childhood Cancer in New ... inactivity, and a diet high in saturated fat and/ or red meat and low in fruits and vegetables • The lower incidence for whites and blacks in the areas with low poverty may be due in part to increased...
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Tài liệu Psychotherapy and Survival in Cancer: The Conflict Between Hope and Evidence pptx
... needed for conducting, reporting, and interpreting randomized clinical trials This knowledge cannot be inferred from an understanding of conventional experimental design in the social and behavioral ... randomization, introducing bias Forty patients were each initially randomized to intervention and control conditions In the intervention group, patient was excluded owing to death, owing to incomplete ... emphasized reducing denial while preserving hope, completing unfinished business, and taking an active role in treatment decisions, but “above all else, simply listening, understanding, and sometimes...
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Tài liệu Nanotechnology in Cancer Treatment and Detection doc
... smaller than most human cells Cancer Nanotechnology research is interdisciplinary and incorporates Biology, Chemistry, Engineering, Medicine, and Physics Properties of Cancer Cells • Epidermal Growth ... trials reveal that a single intravenous nanoparticle injection eradicated 100 percent of tumors in mice when exposed to near-infrared light Most work is being done with near-infrared light, which ... affinity to Cancer cells than healthy cells (EGFR binding) White light and simple, inexpensive microscope is all that’s necessary for powerful ex vivo Cancer detection The scattering is so strong...
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Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf
... formed in metabolically radiolabelled cells The main radioactive oligosaccharides formed in BxPC3 cells (j in lower part, and A, B, and C of upper part) and T5AS clone (h in lower part, and A, B, and ... cultured in Dulbecco’s modified Eagle’s medium containing 10% foetal bovine serum, 100 UÆmL)1 penicillin, 1.0 mgÆmL)1 streptomycin and mM L-Glu For treating BxPC3 cells and clones with drugs affecting ... elevated in the serum of patients with various abdominal illnesses [32] including cancers of the digestive tract [33–35] Moreover, it is an E-selectin ligand [36] and may be involved in the metastatic...
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The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment potx
... 1-6 main chains and 1-4 branchings, and the more common 1-3 main chains and 1-6 branchings.18 This fraction also is highly active in vitro and in animal models of cancer, although activity in these ... predict anticancer efficacy in humans Maitake D-Fraction has been used in a few exploratory studies in cancer patients.17 In 1994, a group from China published in abstract form their findings from ... hospitals in Shanghai, Beijing, and other areas in China, with a total 189 patients The double-blind study used the same doses and test materials as the previous study, and examined PSP against the...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... gastrointestinal tract, skin, lymph node, spleen, liver and lung, as well as in pancreatic acinar cells, adrenal gland, spermatogonia and spermatids of testis, and in Purkinje cells and in the ... cell line have revealed roles for DP9 in cell adhesion, in in vitro wound healing, in cell migration, and in proliferation and apoptosis, and roles for DP8 have been found in wound healing, in cell ... Cell-surface CD26 ⁄ DPIV interacts with adenosine deaminase, CARMA-1 and caveolin-1 Stimulation of CD26 causes IRAK-1 and Toll-interacting protein to disengage from caveolin-1, resulting in the phosphorylation...
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Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
... Insulin is a polypeptide hormone that regulates glucose, lipid and protein metabolism and promotes cell growth and differentiation On ligand binding, the insulin receptor tyrosine kinase initiates ... was sensitive to PI3K ⁄ Akt inhibition and Nrf2 gene silencing The fold-increase in both HO-1 protein and mRNA in response to insulin was consistent, as well as being time and concentration dependent ... (CHX) was administered to establish the role of protein synthesis in insulin-induced HO-1 expression (Fig 2B,C) CHX abrogated HO-1 protein induction following insulin treatment but, in agreement...
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Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines potx
... recombinant full-length Cdt1 and geminin (HisT7-geminin and His-geminin, amount of recombinant protein run in each lane in ng is indicated) and immunoblotted with anti-Cdt1 and anti-geminin Ig ... differences in relative amounts of Cdt1 and its inhibitor in different cell lines It would be interesting to investigate whether geminin and/ or Cdt1 levels or the ratio of Cdt1 to its inhibitor geminin ... gastrointestinal tract, localizing mainly in the proliferating zone of the gut epithelium Cdt1 and geminin are over-expressed in cancer cells Given the correlation we observed between Cdt1 and geminin...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... their main roles focus on ectodomain shedding and nonproteolytic functions, such as binding to adhesion molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and ... such as angiostatin, tumstatin, endostatin and endorepellin MMPs also modulate the cell–cell and cell–ECM interactions by processing E-cadherin and integrins, respectively, affecting both cell phenotype ... [20] During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming growth factor (TGF)-a and amphiregulin, was observed...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... lymphomagenesis in mice [44] The miRNA miR-21 is overexpressed in many solid tumors, including breast, colon, lung, prostate and stomach, and in endocrine pancreas tumors, glioblastomas and uterine leiomyomas ... examined to date [8,52], a feature that could be particularly useful in diagnosing incident cancers in otherwise normal tissues Indeed, this approach discriminates normal and neoplastic tissues in ... neoplastic tissues in various cancer types, including CLL, breast cancer, glioblastoma, thyroid papillary carcinoma, hepatocellular carcinoma, lung cancer, colon cancer and endocrine pancreatic tumors...
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Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... Gingras AC, Sonenberg N & Thomas G (1997) The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein phosphorylation bifurcates at a rapamycin sensitive point ... sectors, and the entorhinal and temporal cortice (Fig 4D), but weak staining in the granule layers of the dentate gyrus (not shown) In contrast, in control brain slices there was weak stainings in ... pathways in AD brain mTOR is phosphorylated at serine 2448 via the PI3 kinase ⁄ Akt signalling pathway and autophosphorylated at serine 2481 In AD brain, high levels of phosphorylated mTOR phosphorylate...
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Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx
... previously [17] Supercoiling assay DNA supercoiling was assessed in terms of the linking number of intracellular plasmid pBR322 [18] DNA supercoiling was expressed as the active linking number, aLk, ... the difference in linking number of pBR322 in the respective sample and of pBR322 isolated from cells incubated for 30 with 0.1 mgámL)1 of coumermycin and 0.2 mgámL)1 rifampicin Topoisomerase ... containing the N-terminal part of topA was inserted This resulted in the plasmid pTOPA2A5TS, in which the pA1lacO-1 promoter and the lacIq1 gene are surrounded by a DNA fragment originating from...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer ppt
... tumours and are now being tested in combination therapies [47] Tyrosine kinase inhibitors are widely and successfully used in the treatment of cancer, and in the context of this review, may inhibit ... (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells Clin Cancer Res 11, ... death-associated protein kinase in lung cancers Clin Cancer Res 9, 3034–3041 Dansranjavin T, Mobius C, Tannapfel A, Bartels M, ¨ Wittekind C, Hauss J & Witzigmann H (2006) E-cadherin and DAP kinase in pancreatic...
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Báo cáo khoa học: Collective behavior in gene regulation: Metabolic clocks and cross-talking doc
... Interestingly, yeast growing in a colony undergoes cyclic changes in metabolism, from acidic to alkaline [46] Furthermore, alkali-producing colonies can entrain colonies in the acidic phase and ... of pH in the medium, are also present during the exponential growth phase, suggesting the possibility of a metabolic cycle involving the entire population, even at low cell density, and linked ... function and is obtained by a hierarchical cascade of signals Many different signaling pathways might finally be involved in the entrainment of the individual oscillator of peripheral cells to the main...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
... Wnt/βcatenin and cadherin pathway genes including N-cadherin and P-cadherin but low E-cadherin protein expression This finding demonstrated the highgrade serous ovarian cancer contained messenchymal ... colorectal cancer, which will be discussed in details below a Chromosomal instability (CIN) Chromosomal instability lead to increase rate of losing or gaining chromosomes during cell division and accounts ... targets in cancer are also included Chapters in “Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer present comprehensive and expert...
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Báo cáo khoa học: Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells potx
... K Rathinasamy and D Panda [10] The binding site of benomyl in tubulin is yet to be determined However, it has been suggested that benomyl binds to tubulin at a site that is distinct from ... the motor proteins and spindle checkpoint proteins [19] This reduction of checkpoint proteins is required for inactivating the spindle checkpoint signal and progression in the cell cycle [20] The ... beneficial in chemotherapy Similar to taxol and vinblastine, benomyl also induces apoptosis in HeLa cells, indicating that benomyl may be useful in combination with other potent anticancer drugs...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... propagates inflammatory responses and is a significant RAGE ligand in the setting of sepsis and acute inflammation HMGB1 is an apparent autocrine/paracrine regulator of monocyte invasion, involving ... upregulation of inflammation in this setting [181] Another RAGE ligand, AGE-CML, is present in endoneurial and epineurial mononuclear cells in chronic inflammatory demyelinating polyneuropathy and vasculitic ... has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells but usually undetectable in adult...
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