adult stem cells and their role in endogenous tissue repair ý pdf
Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... opaque with age and contain many inclusion bodies reactive with antibody to aB-crystallin, but not to b- and c-crystallin, suggesting an important role for aA-crystallin in maintaining lens transparency ... disorganized and aggresome-like inclusions develop in cultured nonmuscle cells deficient in desmin, again demonstrating inclusion body construction independent of intermediate fialments [62] Interestingly, ... formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing abnormal polyQ...
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Aggregate bankruptcy probabilities and their role in explaining banks’ loan losses doc
... and 20 and in Recycling (code 370) over 1996-2000 in county 19 For the corresponding years, there are no enterprises registered in the corresponding industries and counties, and submitting financial ... 20 Fernandez , Martinez and Saurina (2000) study cyclical behaviour of bank loans, loan losses and loan loss provisions in Spain and show that housing prices, asset prices and lending margins have ... are found in the following industries: Agriculture and forestry (code 111) in 1990-1992, Raising of fish (code 051) in 1988-1993, Fishery (code 052) in 1988-1993, Publishing, printing and reproduction...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... also contain a carboxy-terminal extension containing T-box and A-box motifs [124] In each zinc finger, four invariant cysteine residues coordinate tetrahedrically to a zinc ion, and both zinc fingers ... ligand-binding affinity of ecdysteroids had been measured in tissues and cells [243,244] The in vitro binding activity of representative ecdysteroids and nonsteroidal compounds evaluated in intact cells ... for retaining the ligand-binding activity They found two high-affinity binding sites (Kd1 = 0.24 nm and Kd2 = 3.9 nm) The removal of GST had no effect on PonA binding, but altered DNA binding The...
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Tế bào gốc và ứng dụng trong y sinh học (Stem cells and the application in biomedicine) potx
... from a human pancreatic cell line in vitro and in vivo Mol Endocrinol 15, 476 - 483 Dzierzak, E et al (1998); Embryonic beginnings of definitive hematopoietic stem cells Ann N Y Acad Sci 872, 256 ... circulating human embryonic blood stem cells Blood 96, 1740 - 1747 IItskovitz - Eldor, J and et al (2000).; Differentiation of human embryonic stem cells into embryoid bodies comprising the three ... 88 - 95 Itkin - ansari, P., et al (2001); PDX - and cell - cell contact act in synergy to promote d - cell development in a human pancreatic endocrine precursor cell line Mol Endocrinol 14, 814...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... SUMOylated and ADPribosylated Nucleus but has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells ... upregulation of inflammation in this setting [181] Another RAGE ligand, AGE-CML, is present in endoneurial and epineurial mononuclear cells in chronic inflammatory demyelinating polyneuropathy and vasculitic ... muscle cells, monocytes and T cells via RAGE, resulting in the generation of cytokines and proinflammatory adhesion molecules [24,67,68] Conclusion RAGE and its ligands play essential roles in inflammation,...
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báo cáo khoa học: "A Review of Metallothionein Isoforms and their Role in Pathophysiology" ppsx
... laboratory animals and in humans The above findings indicate that differences in the cellular availability of zinc in both insulin producing b -cells and in insulin target cells are associated with ... functions in the central nervous system and brain because MT-1 and MT-2 protect the central nervous system from damage induced by interleukin, 6-aminonicotinamide, kainic acid, and physical injury ... replace insulin in mammalian cells cultured in serum-free media [18] The actions of zinc are intracellular because zinc increases the phosphorylation state of the insulin receptor, and hence, protein...
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báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis" pps
... different roles in angiogenesis: Ang-1 and Ang-4 are agonist ligands for Tie2 and induce tyrosin phosphorylation of Tie2, while Ang-2 and Ang-3 are antagonist ligands They bind to Tie2 without inducing ... been fully investigated in ovarian cancer In the present study, we examined the relationship between the expression of Ets-1 and its targets Ang-2 and maspin in ovarian cancer and their clinical ... papillary cystadenocarcinoma; D: Ang-2 expression in ovarian borderline mucinous cystadenoma; E: Maspin expression in mucinous cystadenocarcinoma; F: Maspin expression in mucinous cystadenoma The...
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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
... hyroxymethyl cytosine or that they glycosylate their DNA In addition all of the r genes in T4 that are known to be involved in superinfection and lysis inhibition [45] are missing in cyanophage genomes, ... in S-PM2, P-SSM4 and S-RMS4 speD encodes S-adenosylmethionine decarboxylase a key enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising ... factor in T4 and is involved in the transcription of structural proteins [45] Homologues of the T4-genes g33 and g45 which are also involved in late transcription in T4 are all found in Clokie...
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Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx
... HIF-1 Hexokinase-1 HIF-1 Hexokinase-2 HIF-1 Insulin-like growth factor-2 (IGF-2) HIF-1 IGF-binding protein-1 HIF-1 IGF-binding protein-2 HIF-1 IGF-binding protein-3 HIF-1 Interleukin-6 NF-IL6 ... subunits in pulmonary artery smooth muscle cells J Clin Invest 1997, 100:2347–2353 Author’s affiliation: Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins ... sensing Cell 1999, 98: 281–284 Yan SF, Tritto I, Pinsky D, Liao H, Huang J, Fuller G, Brett J, May L, Stern D: Induction of interleukin (IL-6) by hypoxia in vascular cells: central role of the binding...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... This expanding IL-1R1-like family includes murine and human proteins, Drosophila (fruit fly) proteins, and a plant (tobacco) protein [7,8] In Drosophila, Toll is involved in the rapid and transient ... (see Fig 3) Further evidence for the role of TRAF6 and NF-κB-inducing kinase in TLR4 signaling came from the study of TRAF6 and NF-κB-inducing kinase dominant-negative (DN) variants, which could ... proteins are being defined, there is great interest in discovering their organization and interactions in response to microbial infection One hypothesis is that each TLR recognizes a distinct...
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Báo cáo y học: "Psychosocial factors and their role in chronic pain: A brief review of development and current stat" ppsx
... respondent pain may eventually evolve into operant and persisting pain if the environment offers pain contingent reinforcement Pain behaviour may also be learned by observing "pain models" i.e., individuals ... the on-going evolution of the understanding of the non-physical aspects of pain has been applied to the areas of screening for, intervening in and predicting those at risk of developing into a ... central and dominant influencing psychological factors in the assessment for identification and intervention strategies Competing interests The author(s) declare that they have no competing interests...
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Bees and their role in forest livelihoods A guide to the services provided by bees and the sustainable harvesting, processing and marketing of their products
... Nectar-producing species in highland forests 10 Nectar-producing species in wooded grassland (savannah) 11 Nectar-producing species in arid and semi-arid land 12 Nectar-producing species in coastal plains ... trees In spite of this, the bees perhaps play a minor role as pollinators in the rain forest compared to their role in temperate forests, monsoon forests and savannah woodland In tropical rain forests, ... national and international networks, to find out about sources of training, markets, research findings, and raises their awareness of the industry and available opportunities Concerning financial...
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HCV functional genomic protein interactions with NS3 and their role in viral replication
... protein containing the RNA-binding motif reduces the strength of the interaction The NS3-NS3 interaction was also confirmed by co-expressing myc-tagged and flag-tagged NS3 in COS-7 cells and showing ... identify both viral and host interacting partners to NS3, a pivotal player in HCV replication, in the hope of providing new insights into understanding function and effect of these interactions Yeast-two ... activities of host proteins in the long-term The understanding of the interplay between viral and host 10 proteins will shed light on the mechanism involved in HCV pathogenesis and help in the formulation...
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Effect of muscarinic agents on sclera fibroblast and their role in myopia 1
... display a remarkable affinity to heparin and are also called heparin binding growth factors (HBGF) FGF-2 is an 18Kd protein consisting of 155 amino acids, and an isoelectric point of 9.6, without ... into mesodermal tissues FGF-2 retards senescence of cells thus allowing maintenance of cells in vitro which would normally lose their differentiated phenotype in long-term cultures An FGF-2 influence ... cells, endothelial cells, fibroblasts, neuronal cells, lymphoid cells and other hematopoietic cell types, hepatocytes and keratinocytes (Miyazono and Heldin 1992, Pfeilschifter 1990, Robers and...
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Effect of muscarinic agents on sclera fibroblast and their role in myopia
... produced dark brown stain in apoptic nuclei) B Atropine 0.1 µM C Atropine µM D Atropine 10 µM E Atropine 100 µM Fig10A Immumocytochemistry of mAchR subtypes in human SF in culture Subtype selective ... corresponding to mAchR subtypes m1,m2,m4, and m5 identified in mouse sclera by immunoblotting Subtype selective antibodies bound to specific protein bands in mouse sclera extract Sepcific bands did ... Fig 8A Effect of atropine inhibiting SF cell proliferation in culture Chick SF were incubated with atropine Phase contrast photomicrographs were taken after 24...
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Generation of porcine induced pluripotent stem cells and their differentiation into cardiac lineages
... of 79 amino acids and are involved in DNA recognition and Goodfellow, 1994) binding (Harley, Lovell-Badge, & Sox proteins play important roles in the differentiation and development of cells( Pevny ... expression in porcine fibroblast cells that have been successfully infected with lentiviruses The infected cells were able to attach onto a feeder layer and they maintained their spindle shape ... generate porcine induced pluripotent stem cells (IPSCs) from porcine fibroblast cells and differentiate such cells into cardiac lineages to provide a model to study the development of cardiac cells...
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Role of sonic hedgehog signalling in human embryonic stem cells and its neural derivatives
... Immunoflourescent staining of neural stem cell marker Nestin in SHH-CM and Control-CM treated EB Middle panel shows corresponding DAPI nuclear staining in blue and right panel shows corresponding merged ... forebrain, midbrain, hindbrain and the spinal cord This figure was reproduced from Epstein et al., 1999 2.4 SHH and neural development During the initial phase of neural induction, the ectoderm is induced ... that organize the neural tube into the forebrain, midbrain, hindbrain and spinal cord The Shh and bone morphogenetic proteins (BMP) play important roles in patterning the dorsal-ventral aspect...
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Báo cáo hóa học: "Early combined treatment with sildenafil and adipose-derived mesenchymal stem cells preserves heart function in rat dilated cardiomyopathy" doc
... lower in group than in groups 3, 4, and 5, significantly lower in group than in groups and 5, and also notably lower in group than in Page 10 of 16 group This finding indicates that early combined ... stained cells in LV myocardium were significantly higher in group than in other groups, significantly higher in groups and than in groups and 5, and also notably higher in group than in group Lin ... groups and These findings indicate that the expression of cytochrome C, an index of energy supply and storage in mitochondria, was notably lower in group than in groups and The increase in cytosolic...
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báo cáo hóa học:" Preparation of TiO2 nanotube/nanoparticle composite particles and their applications in dye-sensitized solar cells" doc
... sensitized dye, and enhance incident light harvest, the use of TNTs in DSSCs has been explored [14-15] In the present work, the effect of combining TiO2 nanoparticles with TNTs and the resulting effect ... were calcined in air at 450°C for h using a programmable furnace to obtain the desired TiO2 stoichiometry and crystallinity TNTs were prepared using a hydrothermal process described in the authors' ... The pastes were finished by grinding in a three-roller mill [17] An optically transparent conducting glass (FTO, sheet resistance /sq) was washed in ethanol and deionized water in an ultrasonic...
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PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH potx
... important alkaloids of plant origin include the addictive stimulants caffeine, nicotine, codeine, atropine, morphine, ergotamine, cocaine, nicotine and ephedrine (Fig 1) Amino acids act as precursors ... of saponins and these include: steroid saponins and triterpene saponins Saponins are soluble in water and insoluble in ether, and like glycosides on hydrolysis, they give aglycones Saponins are ... DNA-degradation in cancer Isothiocyanates and the indole-3-carbinols interfere categorically in the metabolism of carcinogens thus causing inhibition of procarcinogen activation, and thereby inducing the...
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