active targeting of brain tumors
EVOLUTION OF THE MOLECULAR BIOLOGY OF BRAIN TUMORS AND THE THERAPEUTIC IMPLICATIONS pdf
... properly cited 4 Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications high grade gliomas The structure and compounds of the ECM of the brain tissue have many specific ... effectiveness of oncotherapy in brain tumors remains under the expectations in comparison to anaplastic tumors of other organs Knowing the very modest survival rates enormous efforts of neuro-oncological ... (ECS) of the healthy brain tissue volume is approxi‐ matley 20% The extracellular volume fraction in the majority of primary brain tumors is sig‐ nificantly increased, representing about 48% of...
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Level set segmentation of brain tumors in magnetic resonance images
... after the injection of a contrast agent While the presence of this enhancement can be a strong indicator of tumor location, there exist a large variety of types of brain tumors, and their appearance ... use of an automatic brain masking preprocessing operation This operation removes those pixels from the analysis that are not part of the brain area Another advantage of this method is the use of ... and 3D view [30] a registered brain atlas as a model for healthy brains Then, they make use of the robust estimates of the location and dispersion of the normal brain tissue intensity clusters...
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báo cáo hóa học:" Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors" docx
... limit of pore size in the BBTB of the microvasculature of early, less mature and smaller malignant brain tumor colonies is to nanometers lower than that of the BBTB of the microvasculature of late, ... Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood -brain barrier disruption Proceedings of the National Academy of Sciences of the United States of America ... Journal of Clinical Oncology 2007, 25:2295 Nies AT: The role of membrane transporters in drug delivery to brain tumors Cancer Letters 2007, 254:11 Vick NA, Khandekar JD, Bigner DD: Chemotherapy of brain...
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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc
... genes involved in a variety of critical immunologic functions Specific to the current discussion of the immune system, Table 1: A summary of existing animal models of brain tumors Tumorigenesis Method ... tissue into mice to create brain tumors, which likely will always have some immunologic effects Gene Targeted Methods Mutational analyses of tissue from human brain tumors have revealed that various ... belonging to one of two groups: 1) Tumors created by methods which not target a specific gene, and 2) Tumors created by targeted mutation of genes known to be mutated in human tumors (i.e gene...
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Báo cáo hóa học: " Abstract Despite new additions to the standard of care therapy for high grade primary malignant brain tumors, the prognosis for patients with this disease is still poor." ppt
... IL-13Ra1 Since nearly 80% of high grade primary brain tumors express IL-13Ra2, but normal brain cells not, the effector cells target the glioma cells [11-14] Delivery of the gene-modified allogeneic ... Immunization of patients relies upon activation of endogenous immune cells and is categorized as a form of active immunotherapy In Table (upper half) we list cell-based vaccination trials Three of the ... measurements of TGF-b may be monitored over time as a measure of tumor burden Its increase systemically, after surgical resection, could offer an indication of tumor regrowth Page of 10 Conclusions...
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báo cáo hóa học:" Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor" docx
... Photoshop 7.0 software Statistics on bioluminescent signal intensity was obtained using WinView software according to the software instruction For comparison of tumor targeting of two cell populations, ... Transient expression of erbB2 in the lungs of hCAR mice was induced by iv injection of AdCMVerbB2 Expression of erbB2 exclusively in the lungs of hCAR mice were confirmed by Western Blot of organ lysates ... of cells that home to tumors or other sites The tumor homing behavior of MSCs was demonstrated by the mere presence of these cells in the sites of interest and/or lack of such cells in other...
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Báo cáo khoa học: " Experimental iodine-125 seed irradiation of intracerebral brain tumors in nude mice" ppt
... sections of mouse brain (a) Section of an non-irradiated mouse brain with a large vital glioblastoma (T) that died 4.6 weeks after sham seed implantation Normal brain tissue (B) (b) Section of the brain ... implantation of the 125I brachytherapy seed Diffuse infiltration of cells (T) is present in the brain (d) Section of the brain of an irradiated mouse euthanized at 13 weeks after implantation of a 125I ... meningioma [5] Brachytherapy with radioactive iodine-125 (125I) seeds, which is effective against brain tumors, is used mostly for re-irradiation of recurrent brain tumors [6-9] Although radiotherapy...
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Báo cáo y học: " Patient Specification Quality Assurance for Glioblastoma Multiforme Brain Tumors Treated with Intensity Modulated Radiation Therapy"
... measurements of high-energy photon beams The 2D-ARRAY chamber is calibrated using a setup of 10 cm x10 cm field size, 100 MU, 10 MV beams at a depth of 10 cm, and a dose rate of 300 cGy/MU In favor of ... Lifeline Software, Inc., Tyler, TX) to check independent monitor units (MU) for each beam Pretreatment IMRT plans for ten patients diagnosed with GBM brain tumors were selected For each of the ten ... The sensitive volume of each chamber is 0.125 cm3 These ionization chambers are uniformly arranged in a 27 × 27 matrix with an active area of 27 × 27 cm2 and dimensional area of 22 mm x 300 mm x...
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Social Phobia as a Consequence of Brain Defects
... might be the outcome of both a general absence of hypotheses to be tested as well as the types of experimental designs in use Of the two, the lack of a neurobiological theory of social phobia is ... the active process of fearing of the whole living organism in the face of threat, be it phobic or not Genetic Transmission of Social Phobia In principle, the most satisfactory demonstration of ... participants A test of the degree of specificity of the family aggregation of all types of phobia was performed by Fyer et al (1995) First-degree relatives 170 What Causes Social Phobia? of panic/agoraphobic...
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Tài liệu What You Need To Know About - Brain Tumors ppt
... sheet Tumor Grade Types of Primary Brain Tumors There are many types of primary brain tumors Primary brain tumors are named according to the type of cells or the part of the brain in which they begin ... sensitive areas of the brain and cause serious health problems —Unlike benign tumors in most other parts of the body, benign brain tumors are sometimes life threatening —Benign brain tumors may become ... buildup of extra cells often forms a mass of tissue called a growth or tumor Primary brain tumors can be benign or malignant: • Benign brain tumors not contain cancer cells: —Usually, benign tumors...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
... concentrations of active enzyme, and to ensure that all comparisons of the two forms of FVIIa were performed using the concentrations of active enzyme The enzymes were diluted to a concentration of 100 ... is a prerequisite to attain the most active conformation of FVIIa but not in order to respond to TF Results Determination of active concentrations Titrations of G372A-FVIIa and FVIIa with d-PhePhe-Arg-chloromethyl ... activity of these FVIIa variants is presumably linked to a more stable burial of the N-terminus of the protease domain in the activation pocket of the activation domain [15] This event is (part of) ...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... Role of PKA in the mitochondrial targeting of CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches The first approach involved measuring the level of ... Mitochondrial targeting of rat CYPs in yeast cells studies led us to propose the concept of chimeric protein -targeting signals that drive the bimodal targeting of the same primary translation ... the targeting to mitochondria of Su9-DHFR, in which the presequence of ATPase subunit of Neurospora crassa was fused to a passenger protein, DHFR As seen in Fig 5A, the level of mitochondrial targeting...
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Tài liệu Báo cáo khoa học: Production of biologically active forms of recombinant hepcidin, the iron-regulatory hormone docx
... of E coli in plate assay using 100 pmol of each peptide, complete disappearance of ferroportin signal at the membrane of iron treated macrophage J774 cells in the presence of 700 lM of each of ... microlitres of hepcidin (0.1 mgÆmL)1) were eluted with the following gradient at mLÆmin)1 from 90% of (H2O, 0.1% TFA) and 10% of (H2O 30%, CH3CN 70%, TFA 0.1%) to 10% of (H2O, 0.1% TFA) and 90% of (H2O ... for proteins Step1: purification of TRX-huhepc After 30 h of growth, h of induction and lysis, 8.5 g of soluble proteins were obtained; 8% of which comprised TRX-huhepc (approximately 700 mg) (Fig...
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![Tài liệu Báo cáo khoa học: Specific targeting of a DNA-alkylating reagent to mitochondria Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide doc](https://media.store123doc.com/images/document/14/br/vp/small_vpv1392870032.jpg)
Tài liệu Báo cáo khoa học: Specific targeting of a DNA-alkylating reagent to mitochondria Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide doc
... development of antigenomic therapies, such a reagent might also be useful in investigating the rate of turnover of mtDNA and in the derivation of mtDNA-free (q°) clones of the large number of cell ... addition of a TPP-moiety has been used to drive the selective uptake of a wide variety of Ó FEBS 2003 Fig Selective uptake of mitoDC-81 by mitochondria and subsequent alkylation of mtDNA The uptake of ... millimolar concentration of mitoDC-81 within mitochondria on incubation of cells with high nanomolar to micromolar concentrations of mitoDC-81 This high local concentration of mitoDC-81 within mitochondria...
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Tài liệu Báo cáo khoa học: Site-directed mutagenesis of a loop at the active site of E1 (a2b2) of the pyruvate dehydrogenase complex A possible common sequence motif docx
... regulation of, the enzyme [11] This is consistent with the finding that phosphorylation of only one of two active sites in mammalian E1p leads to complete inactivation [7] Crystal structures of the ... PLOT software Temperature-dependence of catalytic activity The dependence of the catalytic activity of E1 on temperature was investigated using the DCPIP assay over a temperature range of 15 ... be noted that Tyr281 and Arg282 are located at the mouth of the funnel-shaped active site of E1, at the bottom of which lies ˚ the ThDP cofactor some 20–25 A from the protein ÔsurfaceÕ [14] Thus...
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Tài liệu Báo cáo Y học: Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium pptx
... extended with the C-terminal 274 amino acids of Mls1p (out of a total of 554), including the terminal SKL Expression of this GFP-Mls1p was compared to that of a control GFP extended solely by SKL ... compartmentalization of the yeast glyoxylate cycle into peroxisomes has been put into question in light of chronicled observations of growth of S cerevisiae pex mutants devoid of functional peroxisomes ... signi®cance of this similarity is currently being addressed Demonstration of the cytosolic location of Mls1p in wild-type cells grown on ethanol completes the picture of the extra-peroxisomal location of...
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Báo cáo khoa học: Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity doc
... aggregation of the protein (data not shown) This instability of the protein precluded an estimate of equilibrium thermodynamic parameters, and thus also measurement of the effect of ligands on ... ATP at the active site of WT hGK The partial quenching effect of AMP-PNP on the T228M reference enzyme with disrupted ATP binding at the active site (Fig 2A,C) suggests a contribution of nonspecific ... support of binding of ATP to the ligand-free hGK, resulting in a change of protein conformation The MD simulations indicate that the binding triggers molecular motion of the flexible surface ⁄ active...
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Báo cáo khoa học: Scaffolds are ‘active’ regulators of signaling modules doc
... Dephosphorylation of 14-3-3 binding sites and degradation of IMP is needed to enable KSR1 activation (B) After the receipt of a growth signal, KSR1 and b-RAF translocate to the membrane with the help of their ... formation of an active serine ⁄ threonine protein phosphatase 2A holoenzyme on the KSR1-platform, which in turn dephosphorylates one of the 14-3-3 binding sites These processes make the C1 domain of ... Interestingly, release of 14-3-3 dimer opens the scaffold’s FXFP docking site for activated ERK [39], so all the active components of the RAF–MEK–ERK signaling module are colocalized at the site of action...
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Báo cáo khoa học: Protein transport in organelles: Dual targeting of proteins to mitochondria and chloroplasts ppt
... an outline of the future challenges in this field is provided, and the insights that may be gained from a greater understanding of the mechanism of dual targeting for the targeting of location-specific ... constraint compared to targeting of location-specific proteins to avoid loss of targeting to the ‘parental’ organelle (i.e the ambiguous dual targeting signal is a compromise and dual targeting ability ... protein has dual targeting ability Thus, acquisition of dual targeting ability may be a pre-requisite or at least facilitate the loss of organelle genes Therefore, dual targeting of proteins may...
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Báo cáo khoa học: Interactions of imidazoline ligands with the active site of purified monoamine oxidase A potx
... MAO-A, giving only 50% inhibition of the oxidation of 0.3 mm kynuramine at mm Docking of imidazolines to the structure of the MAO-A active site Using qxp ⁄ flo software [33], three imidazoline ... observed The transfer of electrons from the amine to the flavin requires a catalytic interaction, so the nitro˚ genous group of agmatine must be within A of N5 of the isoalloxazine ring of the flavin Agmatine, ... of these ligands to the flavin in MAO-A comes from the influence of the ligand on the redox properties of the flavin Like other inhibitors of MAO-A [23,30], 2-BFI strongly increased the amount of...
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