active demyelination associated with t lymphocyte and macrophage dominated inflammation without significant amounts of antibody or complement deposition
Báo cáo y học: "Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen" pot
... factors that are able to break tolerance via activation of Toll-like receptors The therapeutic profile of CIA in the B6 mouse was similar to that of RA, with a therapeutic action of methotrexate ... M, et al.: Infliximab and methotrexate in the treatment of rheumatoid arthritis Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group The New England Journal ... new therapeutics, especially directed against T cells, in addition to investigating mechanisms of action of current therapies such as methotrexate Competing interests The authors declare that they...
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RISK OF PULMONARY TUBERCULOSIS ASSOCIATED WITH EXOGENOUS REINFECTION AND ENDOGENOUS REACTIVATION IN A SOUTH INDIAN RURAL POPULATION-A MATHEMATICAL ESTIMATE* doc
... infection is given in Table The risk of disease associated with reinfection is 31 times that for endogenous reactivation and twice that for recent infection Table Risk of disease associated with ... (6.55% and 0.21%), these rates were applied to * Krishnamurthy et al With the information on the size of previously infected population, with or without recent reinfection, it is possible to construct ... infected with no recent reinfection * Krishnamurthy et al highest proportional contribution to the total new cases arising in the community More over, the newly infected persons together with the...
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Báo cáo khoa học: Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma pot
... initial negative 4198 roles attributed to RhoGDI, recent evidence suggests that it may also act as a positive regulator that is necessary for correct targeting and regulation of Rho activities by ... Proteins with the genesis and progression of CRC L Zhao et al evaluate the correlation between clinicopathological characteristics of CRC and expression of these target proteins, in order to better ... haematoxylin and eosin Permission for this study was obtained from the Ethics Committee of Southern Medical University The informed consent with a uniform format was designed by the Ethics Committee and...
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Pulmonary tuberculosis associated with increased number and percentage of natural killer and B cells in the peripheral blood pot
... was limited by lack of access to the patient records therefore it was not possible to correlate the laboratory data with the clinical findings Peripheral blood subset data of the patients were ... counts in patients with PTB The lymphocyte cytotoxic effect of CD8 + cells is strongly related to the host capacity to block the development of disease due to MTB (Flynn et al., 1992) The normal CD8 ... IgG1FITC Mouse IgG2 PE Target cell T lymphocytes T helper lymphocytes Cytotoxic T lymphocytes B lymphocytes Natural killer (NK) Cells Activated lymphocytes Isotype control Isotype control FITC =...
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báo cáo hóa học:" Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer" pptx
... pepsinogen or gastrin which are important markers for the intestinal type of GC but not the diffuse type [25,26] This study found that serum levels of HMGB1 were associated with depth of invasion (T stage), ... did not differ between AGC without distant metastasis and metastatic GC For metastasis to occur, tumor cells must pass through a multi-step process involving a series of sequential and selective ... levels were significantly increased in patients with GC compared to those of patients without cancer Although HMGB1 and its receptor, RAGE, are thought to be elevated in almost all types of cancer...
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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
... domain that declines first in most patients The MMSE (out of 30) is a test of global cognitive function that includes questions on orientation in time and space, attention, language, memory and ... findings suggest that AOC might be a good indicator of the general health status of the body and of its capacity to cope with inflammatory and oxidative insults The lower levels of peripheral ... associated with MMSE and LSS scores at the time of blood sampling for AOC determination, they did not predict the cognitive deficit two years later Although our study may have been Another important...
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báo cáo hóa học: " Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke" pptx
... experiments and observations made in stroke patients indicate that activation of the complement system is one of the mechanisms contributing to the extension of the cerebral infarct after ischemic stroke ... compared with the χ2 test for trend The association between the serum concentration of selected proteins and the outcome of stroke was calculated by multiple logistic regression, adjusted for the ... sex and the age of the patients All tests were two-tailed All data are presented as median values with the 25th to 75th percentiles in parentheses unless stated otherwise Results The concentrations...
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Báo cáo y học: "Vastus medialis cross-sectional area is positively associated with patella cartilage and bone volumes in a pain-free community-based population" pdf
... interests The authors declare that they have no competing interests Authors' contributions FMC and AEW participated in the design of the study and in the analysis and interpretation of data and ... measurement of knee cartilage and bone structure, participated in the analysis and interpretation of data, and reviewed the manuscript PAB and AJT performed the statistical analysis and interpretation ... http://arthritis-research.com/content/10/6/R143 have found vastus medialis, rather than vastus lateralis, to be the significant determinant of patella structures The relative importance of vastus medialis at the patellofemoral...
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Báo cáo y học: "Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study" potx
... autoantibodies was associated with the presence of IgG anti-dsDNA only in two patients at the 24th week and in four patients at the 48th week after treatment None of the patients with RA treated ... http://arthritis-research.com/content/8/1/R3 Table Antinuclear antibody detection during adalimumab treatment Treatment Week autoantibodies before methotrexate treatment and a further one became positive for anti-Ro at the end of follow-up ... patients treated with methotrexate alone (data not shown) Occurrence of ANA in patients treated with adalimumab At baseline, of 57 (7%) adalimumab-treated patients with RA, and of 55 (9%) methotrexate-treated...
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Báo cáo y học: "Vastus medialis cross-sectional area is positively associated with patella cartilage and bone volumes in a pain-free community-based population" ppt
... interests The authors declare that they have no competing interests Authors' contributions FMC and AEW participated in the design of the study and in the analysis and interpretation of data and ... measurement of knee cartilage and bone structure, participated in the analysis and interpretation of data, and reviewed the manuscript PAB and AJT performed the statistical analysis and interpretation ... http://arthritis-research.com/content/10/6/R143 have found vastus medialis, rather than vastus lateralis, to be the significant determinant of patella structures The relative importance of vastus medialis at the patellofemoral...
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Báo cáo y học: "erum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis" doc
... admitted to the hospital with CT evidence of ischemic occlusion or with carotid endarterectomy, or the subject presented with stroke/transient ischemic attack (TIA) symptoms with significant plaque ... proteins are associated not only with RA inflammation and autoantibody production, but also with the recruitment of classical vascular risk factors to end-organ damage This association with vascular ... Patients completed a questionnaire detailing CV history, risk factors, treatment, and details of RA Each patient was clinically evaluated, with chart review to confirm history, at least once The...
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Báo cáo y học: "Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level" doc
... variants were present on at least one of the genotyping arrays used in the original obesity GWASs (Table 3) but were not found associated with the trait It is important to note that our study ... independent validation of the genetic association with obesity Results and discussion Selection of samples at extremes of the BMI distribution To increase the power of our study to detect variants associated ... importance of population and study design in obesity association studies for both discovery and replication It is important to note that, in our study, we strengthen the initial genetic association...
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Báo cáo khoa hoc:" The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes" pptx
... apparent contribution of SNPs to disease manifestations, one of these reports examined a large number of patients of diverse nationality and ethnicity but could not replicate the association of the ... of the rs9399005TT genotype was lower in Ssc than in control patients, and that the T allele was associated with altered mRNA stability [15] This is an interesting finding awaiting validation ... indicated in italics above the error bars significant differences between the CC, CG and GG genotypes in terms of mortality or development of ESRD in the total population under study (Table 3)...
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báo cáo khoa học: " Resistance to Plasmopara viticola in a grapevine segregating population is associated with stilbenoid accumulation and with specific host transcriptional responses" doc
... positive correlation between the offsprings’ resistance to P viticola and the stilbenoid content of their leaves To further investigate the plants’ resistance response to P viticola, we took ... genotypes with varying degrees of resistance to the oomycete [18,19] Type of substitution and oligomerisation state appear to be of importance in determining the role of a stilbene as a phytoalexin ... segregates for resistance and stilbenoid content traits A strong negative correlation between the concentrations of stilbenoid viniferins in the leaves and the progress of infection was demonstrated...
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Báo cáo y học: "Henoch-Schönlein nephritis associated with streptococcal infection and persistent hypocomplementemia: a case report" pot
... histological examination of the kidney, and were major contributors in writing the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they ... speculate about streptococcal infection being involved in both GN, with the participation of NAPlr antigen In our case, we can speculate that streptococcal infection in a patient with abnormal ... Journal of Medical Case Reports 2010, 4:50 http://www.jmedicalcasereports.com/content/4/1/50 Consent Written informed consent was obtained from the parents of our patient for publication of this...
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Báo cáo y học: "A severe case of erythrodermic psoriasis associated with advanced nail and joint manifestations: a case report" pptx
... Authors' contributions CGT wrote most of the manuscript and aided in the final editing of the text CB retrieved most of the information relevant to the case presentation CNTE was in charge of ... condition to evolve from one type to another was short, and without any history of the triggering factors commonly described in the literature The diagnosis of erythrodermic psoriasis is based on the ... parakeratosis and hyperkeratosis, elongation of rete ridges, and neutrophil infiltration (Figure 3) The initial management of our patient's condition included systemic treatment with methotrexate,...
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Báo cáo y học: "Platypnea and orthodeoxia associated with Pneumocystis jiroveci and Cytomegalovirus pneumonia: a case report" potx
... interests The authors declare that they have no competing interests Authors' contributions KK was the main author and carried out the pulmonary investigation of the case IM carried out the nephrological ... more than half of Pneumocystis-infected patients [15] and thus the major pathogen is not easily defined As we found no other common pathogens and our patient continued to deteriorate despite the ... condition under treatment with 16 mg/day of methylprednisolone She was initially treated with empirical antibiotic treatment and underwent computed tomographic (CT) scanning which showed patchy...
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Báo cáo y học: " Self-esteem is associated with premorbid adjustment and positive psychotic symptoms in early psychosis" doc
... analyses to explore whether self-esteem acted as a mediator or moderator of the relationship between premorbid adjustment and symptoms Table Mean and standard deviations for patient characteristics and ... analysis and interpretation of data, the writing of the report or the decision to submit the paper for publication Author details Division of Mental Health and Addiction, Oslo University Hospital, ... it critically for important intellectual content IM has made substantial contributions to conception and design, drafting of the manuscript and have been revising it critically for important...
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báo cáo khoa học: " Identification of genes associated with growth cessation and bud dormancy entrance using a dormancy-incapable tree mutant" doc
... 5’-AGAAGAGGATGAGGAGGAAGACG-3’ R 5’-GTTGTTGACAGGGTCGATTCTGG-3’ ATP-binding cassette transporter MRP6 GE653330 F 5’-CTGGGATTGTGGGTAGAACTGG-3’ Unknown1 GE653303 R F 5’-CCTTCAAACATGGTTGGGTCCTG-3’ 5’-CTCTCTGTGCTTCTCTCTCCTCA-3’ ... 5’-GCATACCTCTGCGGCTCAGC-3’ Auxin-binding protein ABP20 precursor GE653207 F 5’-AGCCTCACCTCCATTGACTTGG-3’ Amino acid transporter family protein GE653321 R F 5’-TGTTGCTCAGTTTCCTGGTGTGA-3’ 5’-GGCTTCACCCATGACATCACC-3’ ... DY650410) Statistical analysis Statistical testing of quantitative expression level between WT and evg within sampling date was performed with the Mann-Whitney-Wilcoxon test (P < 0.05) Growth elongation...
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Báo cáo khoa học: "Bovine viral diarrhea virus NS4B protein is an integral membrane protein associated with Golgi markers and rearranged host membranes" ppsx
... colocalizes with NS5A and NS5B in a Golgilike compartment, we are tempted to speculate that NS4B may recruit NS5A and NS5B to form the BVDV replication complex This interpretation is in agreement with the ... Competing interests The authors declare that they have no competing interests Authors' contributions EW performed all the experiments except for the immunoEM, membrane floatation, subcellular distribution ... with EcoRI and BamHI and the purified fragment was subcloned into EcoRI- and BamHI-cleaved pEGFP-N1 vector (Clonetech, Palo Alto, CA) The resulting vector was cleaved with XhoI and NotI and the...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008