abdominal obesity as a therapeutic target to manage the atherogenic dyslipidemia and related metabolic abnormalities
Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... type diabetes subjects Immunogenetics 2010, 62:101-107 36 Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Uga M, Kurihara S, Kawabata Y, et al: Genetic association ... in the spleen of Jak3-/- mice was similar to that in IL-2 -/- and IL-2b-/mice, and was reduced compared to the C57BL/6 background WT mice [48] Altogether, these findings indicate that Jak3 and ... remains to be assessed One potential limitation of the process is the identification of those antigens that are the most relevant as targets, as the human auto-antigen-specific T cell repertoire...
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Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation pot
... http://jjj.biochem.sun ac.za/database/silva/index.html free of charge Results and Discussion The potential of the glyoxalase system as a possible therapeutic target relies on its role as the main catabolic pathway ... HPLC-based assay, by derivatization with 1,2-diaminobenzene and using 2,3-dimethylquinoxaline as internal standard [36] Methylglyoxal synthase activity was assayed by measuring methylglyoxal formation ... I assays Glyoxalase II activity assay was performed using the commercially available SDL-GSH and SDL-TSH prepared from T(SH)2 and MG using yeast glyoxalase I, as previously described Concentrations...
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Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc
... the US National Institutes of Health is in the planning stage 132 Although autoantibodies in autoimmune cytopenias and some other diseases, such as pemphigus and myasthenia gravis, have a direct ... surprising because the prevailing paradigm of RA pathogenesis emphasizes the role of macrophage and fibroblast activation and the production of inflammatory mediators in the synovial tissue Therapeutic ... containing IgG rheumatoid factor can crosslink Fcγ (crystallizable fragment gamma) receptors However, in contrast to the animal model, neither for rheumatoid factor nor for any of the other autoantibodies...
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Báo cáo y học: "Th2 cytokines and asthma Interleukin-9 as a therapeutic target for asthma" ppsx
... Sasaki S, Adra CN, Kitaichi M, Inoue H, Yamauchi K, Tomichi N, Kurimoto F, Hamasaki N, Hopkin JM, Izuhara K, Shirakawa T, Deichmann KA: Genetic variants of IL-13 signalling and human asthma and ... genes, such as those for cytokines, growth factors, and receptors, that are potentially involved in airway inflammation and atopic asthma [10] Structural analyses of these candidate genes have identified ... development of the allergic asthmatic response Importantly, increased lung IL-9 expression in mice and humans is tightly and specifically associated with asthma and its risk factors; decreased IL-9...
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Polo like kinase 1 in hepatocellular carcinoma clinical significance and its potential as a therapeutic target
... HCC among other risk factors such as heavy alcohol intake and aflatoxin poisoning (Bruix and Sherman, 2005) Non-alcoholic steatohepatitis (NASH) presents another unconventional risk factor that ... undergo apoptosis without the requirement of caspase activation A cell permeable pan caspase inhibitor Z-VAD-FMK was subsequently applied to validate the requirement of capsases in apoptosis induction ... added and supernatant was subsequently transferred to a microplate that was coated with anti-caspase-3 for hour at 37oC Substrate solution was then added for hours at 37oC after a washing step Fluorescence...
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Vcd as a stimulating factor to increase the young learners’ time-on-task
... smooth And they may learn linguistic forms naturally Hence, the task-based teaching is useful in that it creates opportunities for learners to use language as a tool rather than as an object to satisfy ... for the past few decades So many approaches and methods such as Audiolingual Method, Total Physical Response, Content-based language teaching, Theme-based language teaching have been advanced, ... tasks and exercises According to Ellis (2005, p 5) the latter requires a primary focus on form rather than meaning and typically asks learners to manipulate language given to them rather than...
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Báo cáo khoa học: "NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats" ppt
... method Angiotensin I and II were measured with a rat angiotensin I and II EIA kits (Phoenix Pharmaceuticals, USA) according to the manufacturer’s instructions Urine was assayed for creatinine by a ... once per week at the same time during the day After the stabilization of the animals in o a warm box at 37 C for 15 min, the tail systolic blood pressure was measured with a non-invasive blood ... pellet diet (Purina Rodent Laboratory Chow; Ralston Purina, USA) were given ad libitum The rats were acclimatized for days prior to the start of the experiments and randomly allocated to five groups...
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Probiotics as a novel approach to modulate incretins, insulin secretion and risk factors of type 2 diabetes and complications
... according to the randomization list The appropriate package was handed to the particular participant Statistical data analysis and power calculation Statistical data analysis and the power calculation ... F_reut_IS ACC GAG AAC AAC GCG TTA TTT 21 nt R_reut_IS CAT AAC TTA ACC TAA ACA ATC AAA GAT TGT 30 nt P_reut_IS ATC GCT AAC TCA ATT AAT 18 nt Ampl Lit 159 bp (Yang et al., 2002) configured 78 bp via the ... TAC ACT TCA 24 nt tuf-S CCA TCA AGC CGC ACA CCA AGT TCG 24 nt Lacto-F2 TGG AAA CAG ATG CTA ATA CCG 21 nt Lacto-R2 CGT CCA TTG TGG TAG ATT CCC T 22 nt Lacto-S CTG AGA CAC GGC CCA WAC TCC TAC GG...
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santiago as a hemmingway code hero in the old man and the sea
... running to tell the other fishermen of the town about it, he just went home and fell asleep Landing the fish did not matter to the old man only to get it as far as the side of the boat The Old Man And ... should be an example for all to follow He fishes to be a fisherman His goal was not to catch a huge fish It was to fish and try to catch a fish of any size He did not pride himself on catching the ... offered each other the best of company While out at sea Santiago is constantlywishing the boy was there to talk to or to help with the mighty fish Santiago does not have relationships with any of the...
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Báo cáo y học: "Differential cellular FGF-2 upregulation in the rat facial nucleus following axotomy, functional electrical stimulation and corticosterone: a possible therapeutic target to Bell’s pals" doc
... of the facial nerve as described Briefly, under sodium pentobarbital (45 mgkg -1 , Cristalia, São Paulo, Brazil) anesthesia, the rat facial skin of the right side was opened near the ear and the ... neurotransmitter synthesis following cranial nerve axotomy in the neonatal and adult life has been described Cuevas and co-workers have shown that acidic fibroblast growth factor topically applied ... of the facial nucleus and the profiles were counted The cytoplasmatic and nuclear localization of the FGF-2 immunoreactivity [9] were taken into account in the discrimination of the neuronal and...
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Báo cáo khoa học: Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment pptx
... pro-inflammatory mediators is probably a result of the fact that inflammatory transcription factors such as nuclear factor-kappaB, activator protein-1 and nuclear factor of activated T-cells are positively ... neurovascular unit Astrocyte PARP-1 Neuron Inflammatory mediators AIF PARP-1 M ina am ll asa P M PARP-1 B HM G B1 M P M HM GB M P M X Endothelium X PM TR Ca2+ Inflammatory mediators X AIF Inflammatory ... from NADPH oxidase and mitochondria, sustained increase of the cytosolic Ca2+ concentration and finally nuclear translocation of mitogen-activated protein kinase kinase ⁄ extracellular regulated...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... Modulation of metal availability for treating AD P J Crouch et al research attention as potential therapeutic targets Plaques and NFTs, however, cannot be regarded as ‘upstream’ causative factors ... hyperphosphorylation Furthermore, an increase in extracellular metals can catalyse Ab oligomerization and aggregation, and the amyloid plaques that subsequently form may then exacerbate intracellular metal deficiency ... the brain The capacity for metals to facilitate this process may therefore be a critical factor in the Ab mediated pathology of the AD brain Subsequent to an early report demonstrating that the...
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Teaching English as a foreign language to large, multilevel classes ppt
... will follow the case of Jeff as he applies ALM and the Communicative Approach to one of his large classes Jeff graduated from a liberal arts college and worked as the manager of a video store for ... most important to "5" = least important - To pass the National Exam - To read magazines and books - To listen to the radio and watch TV - To talk to people in English - To get a job that requires ... classroom management and school policies with administrators, teachers, and other Volunteers? • Have you observed other teachers to see how they manage their classes • Do you have a written class...
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The Case for Controlled-Atmosphere Killing of Poultry in Transport Containers Prior to Shackling as a Humane Alternative to Electrical Stunning doc
... “[T]here are at least companies in the UK using a predominantly nitrogen based gas mixture for killing chickens and turkeys.” In Canada, the Canadian Food Inspection Agency has also approved the use ... argon is heavier and easier to contain, nitrogen’s relative cheapness has enticed producers in Europe to the point that it has become the standard in poultry slaughterhouses that use gas In the ... looking at carcasses to determine whether internal radioactivity was detected The results clearly showed that “chickens can and inhale water during electrical stunning in a waterbath and that no...
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báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx
... CXCL10 AST/Mat AST IL-12 p35 IL-12 p40 0.02 Mat Control AST/Mat AST Mat 0.00 Control AST/Mat AST Mat Control 0.05 1.0 0.8 0.015 0.01 0.010 AST/Mat AST 0.000 Mat AST/Mat AST Mat 0.00 Control AST/Mat ... keeps experimental metastasis in a dormant state [5] AST concentrations are elevated in fluids of animals harboring primary tumors [6] and other inflammatory and degenerative diseases [7,8] Following ... that a different trial design using angiostatin in cancer therapy or prevention should take into account inflammatory angiogenesis [16] Materials and methods Angiostatin Angiostatin used was...
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Báo cáo y học: "Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies" ppsx
... Intra-assay and interassay variability, (b) linearity, and (c) receiver operating characteristic analysis The intra-assay and interassay variability, expressed as coefficient of variation in percentage ... high-performance liquid chromatography Quality and purity of the peptide was assessed by mass spectrometry and analytical high-performance liquid chromatography The molecular mass was found to be 1708.1 ... based on the general protocol of the Varelisa® tests (Pharmacia Diagnostics) Assay performance characteristics To evaluate the performance of the assay, the precision, reproducibility and linearity...
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Báo cáo y học: "Interleukin-18: a therapeutic target in rheumatoid arthritis" potx
... broad anti-inflammatory effects within and beyond the synovium IL-18 overexpression has been variously reported in psoriasis, pulmonary inflammatory diseases, inflammatory bowel diseases, and various ... generation and release of other IL-1 superfamily members may also be inhibited Whether this offers therapeutic disadvantage is however unclear and need not be assumed They provide potential advantages ... (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colonystimulating factor and not via interferon-gamma to inhibit osteoclast formation J Exp Med...
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báo cáo khoa học: " The increasing chronicity of HIV in sub-Saharan Africa: Re-thinking “HIV as a long-wave event” in the era of widespread access to ART" pot
... contributed to writing the first draft and critically reviewed the final draft TB contributed to the analysis, and critically reviewed the first and final drafts All authors read and approved the final ... and address the increasing burden of chronic diseases [40] Finally, national strategic plans to address HIV also need to take into account HIVrelated disability and the diverse policy and programme ... conceive the analysis, partially wrote the first draft and wrote the final draft JHH helped conceive the analysis, and wrote portions of the first and final drafts AW helped conceive the analysis,...
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Báo cáo y học: "Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection" potx
... Kato M, Arakawa H, Sotomatsu M, Kataoka S, Asami K, Hasegawa D, Kosaka Y, Sano K, Igarashi N, Maruhashi K, Ichimi R, Kawasaki H, Maeda N, Tanizawa A, Arai K, Abe T, Hisakawa H, Miyashita H, Henter ... 38 Imashuku S, Kuriyama K, Sakai R, Nakao Y, Masuda S, Yasuda N, Kawano F, Yakushijin K, Miyagawa A, Nakao T, Teramura T, Tabata Y, Morimoto A, Hibi S: Treatment of Epstein-Barr virus-associated ... ECMO was assessed on the basis of ventilatory parameters, arterial blood gas values and chest radiograph findings The primary outcome measure was the development of VAHS and VAHS -related mortality...
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Báo cáo y học: "Using the intervention mapping protocol to develop a community-based intervention for the prevention of childhood obesity in a multi-centre European project: the IDEFICS intervention" pptx
... developing a general and standardized intervention framework However, local and cultural adaptation was necessary to make the intervention feasible and to enhance deliverability in all participating ... stages of program use, referring to the classical phasing of establishing interventions: adoption phase, implementation phase and dissemination phase [13] The adoption phase was characterized by ... structure at the community level stimulate collaboration across different agenda’s; technical assistance on action and strategic planning (module 1) Policy and media advocacy Placing the topic on the...
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