abdominal obesity and the endocannabinoid system cb1 blockade insulin resistance

Tài liệu Báo cáo khoa học: Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects Implications for a mechanism linking obesity and type 2 diabetes pdf

... & Heine RJ (20 01) The potential role of adenosine in the pathophysiology of the insulin resistance syndrome Atherosclerosis 155, 28 3 29 0 FEBS Journal 27 3 (20 06) 528 8–53 02 ª 20 06 The Authors Journal ... 0.090.01 4 .28 1.68 0 .25 0.07 0. 020 .08 ) 0.010.00 0.050.18 ) 1.100.18 0.160.01 ) 0. 620 .11 0. 620 .17 0 .25 0.44 0.170.08 0. 020 .38 ) 5.000.89 ) 0. 120 .01 FEBS Journal 27 3 (20 06) 528 8–53 02 ª 20 06 The Authors ... Grigiene J (20 02) Multiple effects of 2, 2,5,5-tetrachlorbiphenyl on oxidative phosphorylation in rat liver mitochondria Toxicol Sci 65, 22 0 22 7 FEBS Journal 27 3 (20 06) 528 8–53 02 ª 20 06 The Authors...

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Long-term Exposure to Traffic-related Air Pollution and Type 2 Diabetes Prevalence in a Cross-sectional Screening-study in the Netherlands pdf

Danh mục: Điện - Điện tử

... 1,795 (22 %) 110 (18%) 38 (18%) 1,685 (23 %) 60-65 1,446 (18%) 122 (20 %) 45 (21 %) 1, 324 (18%) ≥ 65 2, 024 (25 %) 29 1 (47%) 1 02 (48%) 1,733 (24 %) BMI (kg·m -2) < 18.5 51 (1%) (1%) (1%) 48 (1%) 18.5 -25 .0 ... or 25 0 m Table Characteristics of the total population and of participants with and without type diabetes Characteristic Total population Type Diabetes Screening diagnosed Type Diabetes No Type ... region of the Netherlands Methods Study area and study population The study was performed among residents of the semirural area of Westfriesland in the North-West of the Page of Netherlands (Figure...

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Báo cáo y học: " Dimensionality and scale properties of the Edinburgh Depression Scale (EDS) in patients with type 2 diabetes mellitus: the DiaDDzoB study" pot

Danh mục: Báo cáo khoa học

... 1. 92 2.74 1.46 0.81 1. 92 2.74 540 07 14 20 09 07 14 20 1.45 2. 0 b 0.71 1.88 2. 27 1.45 0.71 1.88 2. 27 08 1 Males(n = 828 ) 07 14 16 08 07 14 16 794 24 .1** 2. 3 21 .9 1.35 10 -0.73 10 0.58 09 2. 84 25 ... 0.46 12 3.34 41 048/.360 15.8* 0.1 15.7 1. 52 -0.53 0. 42 2.96 1.53 -0.48 0.70 2. 84 000/ .20 2 12 09 08 26 13 08 10 30 1. 92 -0.40 0.95 2. 36 1. 92 -0.40 0.95 2. 36 10 05 06 14 10 05 06 14 2. 08 -0. 62 1.04 ... 1.04 2. 49 2. 08 -0. 62 1.04 2. 49 11 05 06 14 11 05 06 14 11.9 0.1 11.8 1 .2 1 32 746 6.3 0.7 5.6 2. 47 13 0.01 04 0.98 05 2. 38 13 2. 47 13 0.01 04 0.98 05 2. 38 13 774 5.9 1.1 4.8 2. 68 -0.03 1.50 2. 58 2. 68...

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Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot

Danh mục: Báo cáo khoa học

... Urso B & James DE (20 00) Signalling through the insulin receptor Curr Opin Cell Biol 12, 22 2 22 8 Saltiel AR & Kahn CR (20 01) Insulin signalling and the regulation of glucose and lipid metabolism ... 0.1–0 .2 1.1–1.8 0.6–0.7 0.3–0.4 0. 02 0.03 1.1–1.8 1.8 2. 0 0.6–0.7 0.1–0 .2 1.1–1.8 1.8 2. 0 0.6–0.7 0.1–0 .2 1.1–1.8 1.8 2. 0 0.6–0.7 0.1–0 .2 1.1–1.8 1.8 2. 0 0.6–0.7 0.1–0 .2 FEBS Journal 27 2 (20 05) ... normal subjects, but that this insulin resistance could 1 42 A Danielsson et al be reversed The insulin resistance in cells from patients with type diabetes, on the other hand, was not reversible Results...

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báo cáo hóa học:" Is there a relationship between factor V Leiden and type 2 diabetes?" doc

Danh mục: Hóa học - Dầu khí

... has been published diabetes is recognised as one of the more common risk factor for atherothrombosis [2] Both type diabetes (i.e insulin dependent) and type diabetes (i.e not -insulin dependent) ... (table 2) Discussion The association between FVL and VTE is well known [11], while the association between FVL and atherothrombosis is still matter of discussion [ 12] On the other hand, the association ... Lipinska I, D'Agostino RB, Wilson PW: Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study JAMA 20 00, 28 3 (2) :22 1 -22 8 Ceriello A, Giugliano D, Dello Russo P,...

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báo cáo hóa học:" Determinants of quality of life in adults with type 1 and type 2 diabetes" pdf

Danh mục: Hóa học - Dầu khí

... (100.0) 25 4 (22 .1) 1.1 (1 .2) 1.6 (1 .2) < 0.0001 199 (40.6) 22 0 (19 .2) 138 (28 .2) 329 (28 .7) 85 (17.3) 377 ( 32. 9) 44 (9.0) 147 ( 12. 8) 20 (4.1) 62 (5.4) (0.8) BMI (kg/m2) Lifestyle factors 12 (1.0) 26 .2 ... Groenier KH, Bilo HJ: Prediction of 20 22 23 24 25 26 27 28 29 30 mortality in type diabetes from health-related quality of life (ZODIAC4) Diabetes Care 20 08, 31(5):9 32- 933 Imayama I, Plotnikoff RC, ... 21 4 (43.7) 400 (34.9) < $20 ,000 50 (10 .2) 157 (13.7) $20 ,000-39,999 1 12 (22 .9) 330 (28 .8) $40,000-59,999 $60,000-79,999 105 (21 .4) 109 (22 .2) 29 3 (25 .5) 1 72 (15.0) Marital status 0.03 0.11 No partner...

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báo cáo khoa học:" Determinants of quality of life in adults with type 1 and type 2 diabetes" ppsx

Danh mục: Báo cáo khoa học

... losses associated with diabetes in the US Diabetes Care 20 01, 24 (2) :25 7 -26 1 29 Table 1.Characteristics of type and type diabetes samples Type diabetes (N=490) Mean (SD) N (%) Type diabetes (N=1147) ... comorbidities 1.1 (1 .2) 1.6 (1 .2) < 0.0001 (range 0-5) 199 (40.6) 22 0 (19 .2) 138 (28 .2) 329 (28 .7) 85 (17.3) 377 ( 32. 9) 44 (9.0) 147 ( 12. 8) 20 (4.1) 62 (5.4) (0.8) 12 (1.0) BMI (kg/m ) 26 .2 (4.6) 29 .1 (5.7) ... degree and higher 21 4 (43.7) 400 (34.9) Annual income

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IMPAIRED CARDIOVASCULAR RESPONSES TO GLUCAGON-LIKE PEPTIDE 1 IN METABOLIC SYNDROME AND TYPE 2 DIABETES MELLITUS

Danh mục: Y khoa - Dược

... SYNDROME AND TYPE DIABETES MELLITUS Recent advancements in the management of systemic glucose regulation in obesity/ T2DM include drug therapies designed to utilize components of the incretin system ... to determine the safety and efficacy in the MetS/T2DM population Glucagon-like Peptide and Systemic Glucose Regulation Recent advancements in the treatment of T2DM include drug therapies designed ... administration and/ or species differences Furthermore, the effects of GLP-1 on coronary blood flow and vascular tone are unknown in humans and in the settings of MetS/T2DM Further studies to determine the...

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Common genetic variation in nephrin (NPHS1) and its associations with renal and type 2 diabetes mellitus related traits

Danh mục: Tổng hợp

... rs3 927 02 Exon 11 M4 rs731934 Intron 27 M 12 rs3814995 Exon M5 rs2071 327 Exon 26 M13 rs 228 5450 Exon M6 rs480 621 3 Exon 24 M14 rs401 824 Promoter M7 rs1040 929 9 Intron 23 M15 rs443186 KIRREL2 5'UTR ... SNPs with T2DM in Chinese subjects in Singapore Cases with T2DM were from both the SDCS and NHS98 (Methods 2. 1.1 and 2. 1 .2) and non-diabetic controls were from the NHS98 (Methods 2. 1 .2) 26 Chapter ... 23 1.5.5 NPHS1 variants with T2DM and T2DM-related traits 23 1.6 Summary and rationale for present work 24 1.6.1 NPHS1 and DN 24 1.6 .2 NPHS1 and T2DM 25 ...

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Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx

Danh mục: Báo cáo khoa học

... D., Mandelbaum, A., Etinger, A & Mechoulam, R (19 92) Isolation and structure of a brain con- 20 21 22 23 24 25 26 27 28 29 30 31 32 stituent that bind to the cannabinoid receptor Science 25 8, ... N-terminal and the ﬁrst transmembrane domain of the protein of the human and rat CB2 receptor The speciﬁcity of the CB1 and CB2 antibodies was described in McIntosh et al [41] and in Shire et al [ 42] , ... amount of anandamide and/ or 2- AG [21 ,23 26 ] IgE-dependent stimulation of RBL-2H3 cells also leads to the formation of anandamide and of its congener N-palmitoylethanolamine (PalEtn) [22 ], which...

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Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt

Danh mục: Báo cáo khoa học

... Ca (2+ ) inﬂux by cannabinoid and metabotropic glutamate receptors The endocannabinoid system in cerebral ischemia 22 23 24 25 26 27 28 29 30 31 32 33 34 35 FEBS Journal 27 6 (20 09) 2 12 ª 20 08 The ... cannabinoid CB1 receptors Eur J Pharmacol 423 , 20 3 21 0 81 Hillard CJ (20 00) Endocannabinoids and vascular function J Pharmacol Exp Ther 29 4, 27 – 32 82 Mathew RJ, Wilson WH & Davis R (20 03) Postural ... dissecting the role of the endocannabinoid system in physiology as well as in pathological processes The system incorporates the endocannabinoids, their synthetic and degradative enzymes, the endocannabinoid...

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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf

Danh mục: Báo cáo khoa học

... Uchimura H, Fujishima M & Hall ED (20 00) Ovariectomy exacerbates Endocannabinoid system modulation by E2 after MCAo 22 23 24 25 26 27 28 29 30 31 32 33 34 and estrogen replacement attenuates ... released into the extracellular space and interact with type and type cannabinoid (CB1 and CB2) receptors, non -CB1 ⁄ non-CB2 receptors, and noncannabinoid receptors, including the type vanilloid ... supply may further FEBS Journal 27 4 (20 07) 4464–4475 ª 20 07 The Authors Journal compilation ª 20 07 FEBS Endocannabinoid system modulation by E2 after MCAo D Amantea et al Vehicle E2 ICI + E2 Infarct...

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Waist circumference, abdominal obesity, and depression among overweight and obese U.S. adults: national health and nutrition examination survey 2005-2006" doc

Danh mục: Báo cáo khoa học

... (0.98-4 .24 ) - abdominal obesity 52 1.49 (0 .28 -7.80) 1.31 (0 .26 -6. 52) 1.19 (0 .23 -6.00) + abdominal obesity Obese - abdominal obesity + abdominal obesity 1,185 3 .28 (1.91-5.65) < 0.001 2. 79 (1. 42- 5.48) ... 30 1 ,20 2 1 ,23 7 33.0 (5.9) 67.0 (5.9) 49.1 (1.6) 50.9 (1.6) 34.0 (4.8) 66.0 (4.8) 49.6 (1.6) 50.4 (1.6) 966 20 .6 (7.0) 42. 3 (1.6) 23 .2 (4.6) 42. 8 (1.5) 621 27 .8 (9.0) 26 .8 (1.8) 23 .9 (5.3) 27 .0 ... overweight/obese and by abdominal obesity among overweight and obese adults, NHANES 20 05 -20 06 (N = 2, 439) N Odds Ratio* Model Model Model 615 587 1.00 2. 38 (1.37-4. 12) 1.00 1.77 (1.14 -2. 75) 1.00 1.67 (1. 12- 2.50)...

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Báo cáo y học: "Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa" ppt

Danh mục: Báo cáo khoa học

... haplotype diversity in CNR1 (rs2180619, rs806379, rs153 525 5, rs2 023 239 and rs1049353), FAAH (rs9 328 16, rs 324 420 , rs 324 419, rs 229 56 32 and rs873978), NAAA (rs 229 2534, rs65 320 46, rs105181 42 and rs874546) ... rs9 328 16 rs 324 420 rs 324 419 rs873978 rs 229 56 32 rs 229 2534 rs4859567 rs105181 42 Alleles3 major/minor -22 ,959A/G -6 ,27 4A/T -6 ,21 5T/G -5,489T/C 1,359G/A -27 2G/A 10,741C/A 11,966G/A 13,883G/A 19,542C/A 368A/G ... mean age of 22 .47 ± 11.67 years and a mean BMI of 14.81 ± 2. 29 kg/m2 The catamnestic individuals had a mean age of 33.60 ± 7 .22 years and a mean BMI of 20 .78 ± 2. 05 kg/m2 In total, the 20 4 (10 male)...

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Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"

Danh mục: Y học thưởng thức

... (43.6%) 20 2 (56.4%) P < 0.001 ACSb Diagnoses (N, %) 322 97 (30.1%) 22 5 (69.9%) - other diagnoses 331 99 (29 .9%) 23 2 (70.1%) Age (years) 58 (19 to 87) 59 (22 to 87) 58 (19 to 86) P = 0 .21 4 Male ... the incidence of type diabetes: a systematic review Diabetes Care 20 02, 25 :18 62- 1868 50 Ben-Haroush A, Yogev Y, Hod M: Epidemiology of gestational diabetes mellitus and its association with Type ... KE, Saydah SH, Geiss LS: Full accounting of diabetes and pre -diabetes in the U.S population in 1988-1994 and 20 05 -20 06 Diabetes Care 20 09, 32: 287 -29 4 doi: 10.1186/cc9101 Cite this article as:...

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Báo cáo y học: "The association of meat intake and the risk of type 2 diabetes may be modified by body weight"

Danh mục: Y học thưởng thức

... 1659.4 2. 8 2. 2 2. 2 2. 68 38.6 30.9 36.0 33.8 38.8 34.3 33.1 32. 3 23 .7 10.8 11.53 42. 3 30.6 15.5 36.1 34.3 21 .1 8.5 9.9 38.9 33.8 17.3 32. 7 31.8 22 .8 12. 6 18.4 38.3 29 .3 14.1 20 .2 38.8 24 .7 16.3 ... 29 .7 17.9 22 .1 41.4 23 .7 12. 8 12. 3 35.9 30.7 21 .0 23 .8 39.4 24 .1 12. 7 14.7 37.9 28 .9 18.4 14.6 9.6 15.3 60.5 9.7 0.4 2. 3 28 .6 20 .9 14.7 26 .3 38.0 4.4 0.1 1.4 16.8 11.7 9.8 17.5 61.0 8.3 0.3 2. 7 ... 2. 7 26 .2 23.6 14.0 24 .4 38.0 5.6 0.1 1.4 18.9 14.5 9.7 15.6 60 .2 9.1 0 .2 3.6 26 .1 19.8 12. 6 22 .3 45.3 6.4 0.7 1.6 21 .6 Int J Med Sci 20 06, 158 Table 2: Unprocessed meat intake and risk of type diabetes...

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báo cáo hóa học: " A comparison of EQ-5D index scores using the UK, US, and Japan preference weights in a Thai sample with type 2 diabetes" pdf

Danh mục: Hóa học - Dầu khí

... 300,000 2. 43 123 ,457 1 .23 6.94 4.40 300,000 2. 54 118,110 5.51 6.68 4 .21 300,000 2. 47 121 ,457 2. 83 6. 62 4.17 300,000 2. 45 122 ,150 2. 28 7.05 4.49 300,000 2. 56 117,096 6. 32 Decision tree represents the ... statistic 25 2 51 0.78 0.69 0.09* -2. 16 0. 82 0.76 0.06* -2. 07 0.76 0.69 0.07** -2. 68 1.04 1 .24 1 .29 Nephropathy (No) Nephropathy (Yes) Difference Z statistic 27 8 25 0.77 0.67 0.10* -2. 57 0. 82 0.75 ... (Figures 2A–C) These plots showed the differences between scores (Yaxis) and the means of scores (X-axis) The mean of the differences (d) and the limits of agreement were indicated by dotted lines The...

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báo cáo hóa học: " Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes" docx

Danh mục: Hóa học - Dầu khí

... type diabetes The scope of the problem Diabetes Care 20 05, 28 :25 43 -25 45 Meece J: Dispelling myths and removing barriers about insulin in type diabetes Diabetes Educator 20 06, 32( 1):9S-18S Brod ... 54% 73% 62% 41% 70% 47% 52% 53% 23 % 61% 19% 23 % 23 % 43% 40% 27 % 59% 55% 25 % 40% Insulin- treated (n = 136) Mean (SD) 2. 5 ± 1.4*** 2. 8 ± 1.3*** 4 .2 ± 1.0*** 2. 5 ± 1 .2* ** 2. 9 ± 1.3*** 1.4 ± 1.0*** ... 49% ( 72/ 146) 33% (48/146) 15% (22 /146) 2% (2/ 136) 52% (70/136) 32% (43/136) 15% (21 /136) 94% (137/146) 56% (76/136)*** 2% (3/136) 6.5 ± 2. 1 (n = 38) 6.9 ± 1.6 (n = 53) 4 .2 ± 1 .2 5.3 ± 0.8 21 % (30/146)...

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báo cáo hóa học:" Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes" pdf

Danh mục: Hóa học - Dầu khí

... type diabetes The scope of the problem Diabetes Care 20 05, 28 :25 43 -25 45 Meece J: Dispelling myths and removing barriers about insulin in type diabetes Diabetes Educator 20 06, 32( 1):9S-18S Brod ... 54% 73% 62% 41% 70% 47% 52% 53% 23 % 61% 19% 23 % 23 % 43% 40% 27 % 59% 55% 25 % 40% Insulin- treated (n = 136) Mean (SD) 2. 5 ± 1.4*** 2. 8 ± 1.3*** 4 .2 ± 1.0*** 2. 5 ± 1 .2* ** 2. 9 ± 1.3*** 1.4 ± 1.0*** ... 49% ( 72/ 146) 33% (48/146) 15% (22 /146) 2% (2/ 136) 52% (70/136) 32% (43/136) 15% (21 /136) 94% (137/146) 56% (76/136)*** 2% (3/136) 6.5 ± 2. 1 (n = 38) 6.9 ± 1.6 (n = 53) 4 .2 ± 1 .2 5.3 ± 0.8 21 % (30/146)...

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TOPICS IN THE PREVENTION, TREATMENT AND COMPLICATIONS OF TYPE 2 DIABETES pptx

Danh mục: Sức khỏe giới tính

... Bellazzi R., Nucci G & Cobelli C (20 01) The Subcutaneous Route to Insulin Dependent Diabetes Therapy: ... Slovenia from 20 03 to 20 52 6000 5000 20 52 number 4000 20 03 3000 20 00 1000 0 10 20 30 40 50 age [yeas] Fig 16 Number of D2 patients from 20 03 to 20 52 60 70 80 90 100 Burden of Diabetes Type Through ... structure The results have showed that the residues at positions 15 21 and 24 – 32 are involved in the beta-sheet formation and that the turn at positions 22 and 23 plays a crucial role in the aggregation...

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abdominal obesity and the endocannabinoid system cb1 blockade insulin resistance and type 2 diabetes