a possible mechanism underlying fetal programming of the hpa axis and altered neuroendocrine immune interactions
Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx
... interpretation of data, manuscript preparation, and statistical analysis SKT participated in acquisition of data, analysis and interpretation of data, and manuscript preparation SC participated in acquisition ... preparation, and statistical analysis J-PP participated in study design, analysis and interpretation of data, and manuscript preparation JM-P participated in study design, analysis and interpretation ... acquisition of data and manuscript preparation All authors read and approved the final manuscript 13 14 15 16 Acknowledgements The authors thank Virginia Wallis for her assistance in manuscript preparation...
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Báo cáo y học: " A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis" doc
... differentiation J Immunol 2004, 173:4523-4528 Mitsuyasu H, Yanagihara Y, Mao XQ, Gao PS, Arinobu Y, Ihara K, Takabayashi A, Hara T, Enomoto T, Sasaki S, Kawai M, Hamasaki N, Shirakawa T, Hopkin ... requires validation in a prospective study of early RA patients Approaches that regulate Th17 cells or neutralize their products are under evaluation in the treatment of RA and may be particularly attractive ... H2SO4, was added to each well ELISA plates were read by a Synergy HT plate reader (Biotek, Winsooki, VT, USA) and analyzed by KC4 software (Biotek) Statistical analysis The data were analyzed...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... of sealed unit as used for 1% O2 Statistical evaluation All data are expressed as the mean ± SD, and were compared using Student’s t-test and the ANOVA Duncan test with the sas statistical package ... inhibits articular chondrocyte death A A B B Fig Evaluation of articular cartilage after experimentally induced osteoarthritis (A) Photomicrographs of articular cartilage (B) The evaluation of osteoarthritis ... pressure was applied to the medial side of the straight patellar ligament A 21-gauge spinal needle was inserted through the fat pad into the intercondylar space lateral to the straight patellar ligament...
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Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc
... on the kinetics of factor X activation in the absence of factor Xa at the initiation point of the reaction Yet this mechanism based on the hypothesis of the interaction between TFPI and Xa–VIIa–TF ... providing a significant amount of the Xa–VIIa–TF complex The mathematical model has shown that the analysis of the inhibition curves of the Scheme A development of Scheme by addition of the reaction of ... though it is clear that the apparent values of kcat and Km may have a more sophisticated interpretation than the constants in the classical scheme of Michaelis This approach was used in the present...
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Báo cáo khoa học: The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding A possible mechanism for its antiproliferative activity Manu Lopus and Dulal Panda docx
... (13-methyl-[1,3]-benzodioxolo[5,6-c]1,3-dioxolo-[4,5-i]-phenanthridinium chloride) (Fig 1), a benzophenanthridine alkaloid derived from the plant Sanguinaria canadensis, has been shown to have antimicrobial, anti-inflammatory, antioxidant, and anticancer ... signal was similar to that of the assembly of microtubule proteins in the absence of sanguinarine, indicating that at high concentrations sanguinarine either induced aggregation of tubulin or altered ... upregulation of pro-apoptotic Bax, downregulation of the antiapoptotic protein Bcl2, inhibition of mitogen-activated protein kinase phosphatase-1 and nuclear factor kappaB (NF-jB), and suppression of...
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Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk pot
... pmol/reaction) for ABCA1 (forward primer 5'-GAAGTACATCAGAACATGGGC-3' and reverse primer 5'GATCAAAGCCATGGCTGTAG-3' with 234-base pair amplified fragment) and 27-hydroxylase The cholesterol 27-hydroxylase-specific ... experimental data Statistical analysis was performed using SigmaStat version 2.03 (SPSS Inc., Chicago, IL, USA) Data was analyzed using the Kruskal-Wallis one-way analysis of variance on ranks Pairwise ... hours After isolation of total RNA, the RNA was reverse-transcribed and the cDNA amplified by quantitative realtime polymerase chain reaction as described Signals obtained from the amplification of...
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A vietnamese – english cross – cultural study of the use of hedging before giving bad news
... syntactic theory and semantics apparently explain the meaning of the spoken word 3 - The Northern Vietnamese dialect and the English spoken by Anglophone community of England, America, Australia, ... putting aside the views of conversational principle and maxims, and conversational contract, the distinction between normative and strategic politeness is rather loose and relative in that almost all ... it, and the rhetorical features that constitute it as a symbolic act” (Halliday and Hassan 1989:45, cf Vartalla 2001) Although the terms “hedge” and “hedging” have been part of linguistic vocabulary...
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A study of semantic and pragmatic features of the adjective warm and its vietnamese equivalents
... Grammartical Structures of the equivalent translation The target language is English and the source Adjective Warm language is Vietnamese The data are classified into semantic and pragmatic features ... hyponym of animal 2.2.1.7 Semantic field The semantic structure of vocabulary of a language can be studied in a precise and systematic way by means of componential analysis of which the theory of ... have studied of adjectives as well as semantic and pragmatic characteristics of the adjective Warm and its adjectives of temperature However, the adjective Warm is basically Vietnamese equivalents...
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A STUDY ON IMRPOVING SPEAKING SKILL OF THE 1ST YEAR STUDENTS OF PRE INTERMEDIATE LEVEL AT FPT UNIVESITY THROUGH GROUP WORK
... least and only spoke if necessary, meanwhile the things such as standing in front of the class and observe, stand at any place in the classroom and observe and remaining in the teacher’s seat and ... level of proficiency) and they just wanted to the practical activities that can help them a lot in the oral test The reason why all of them liked games activities is that they wanted to have an ... have an overview of the learning process in the orientation program, to be aware of the importance of learning as well as the activities The second thing is that the administrator and the faculty...
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Tài liệu Youth Safety on a Living Internet: Report of the Online Safety and Technology Working Group pptx
... technological mandates and instead enhance funding and encourage collaborative, multifaceted, and multi-stakeholder initiatives and approaches to enhance online safety via innovation and cooperation ... members and speakers and funds for meeting accommodations and staff support An unfunded mandate creates obstacles that can easily distract from the great work that such mandates can lead to by placing ... author and media professor at the University of Southern California, also cautioned us against sensationalist media coverage of digital teens He said that what he and his fellow researchers of...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx
... deprotonation and reprotonation of C2¢ Whether the epimerase reaction follows the same reaction intermediate as that of the aldolase reaction or the mechanism of deprotonation and reprotonation of C2¢ can ... dihydroneopterin aldolase Y Wang et al Fig Summary of the kinetic constants for the SaDHNA-catalyzed (top panel) and EcDHNA-catalyzed (lower panel) reactions Sa and Ec represent SaDHNA and EcDHNA, respectively ... (Fig and Table 1) These measured rate constants are also reasonable in that the association rate constants are similar between NP and MP and 2248 between HP and HPO in accordance with the similar...
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Tài liệu Báo cáo khoa học: Application of a fluorescent cobalamin analogue for analysis of the binding kinetics A study employing recombinant human transcobalamin and intrinsic factor pdf
... Expression and purication of human recombinant IF and TC The recombinant Cbl binding proteins and their fragments were isolated from plants and yeast as described earlier [9,17] Preparation of the unsaturated ... observation points to a reduced number of potential proteinligand bonds when the two domains are taken apart On the other hand, simultaneous interaction of the two fragments domains with the sandwiched ... calculation of k+ We have tested the application of the uorescent analogue CBC as a tool for investigation of the binding kinetics of nonuorescent ligands Cyano-cobalamin (CNCbl) was examined in the...
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Tài liệu Báo cáo khoa học: Spectroscopic characterization of a higher plant heme oxygenase isoform-1 from Glycine max (soybean) ) coordination structure of the heme complex and catabolism of heme docx
... oxyheme appeared at 540 and 579 nm Then, a broad band appeared at around 660 nm, and was maximal 9–12 after initiation of the reaction The spectral features of the final reaction mixture were analogous, ... band so that it almost vanished after 30 min, and instead, an absorption peak appeared at 637 nm, suggesting the formation of CO–verdoheme The 637 nm band disappeared gradually and was replaced ... absorption bands Heme catabolism by HOs of mammals, pathogenic bacteria, cyanobacteria and probably insects is considered to have a similar mechanism, because the characteristic absorption bands of verdoheme...
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Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx
... tyrosinase from Rastonia solanacearum environmental pH, may also affect the expression of the most appropriate enzyme Apart from the physiological roles and environmental advantages of having several ... structure data 266 ´ D Hernandez-Romero et al The only data so far available are for sweet potato (Ipomoea batata) catechol oxidase [26] The catalytic copper center is accommodated in a central four-helix ... A novel tyrosinase from Rastonia solanacearum ´ D Hernandez-Romero et al A B C particular catechol to o-dopaquinone is also called dopa oxidase (DO) activity On the other hand, laccases...
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Tài liệu Proposal for a DIRECTIVE OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on Alternative Investment Fund Managers and amending Directives 2004/39/EC and 2009/…/EC ppt
... characteristics of the AIF managed, the governance of the AIFM (including arrangements for the delegation of management services), arrangements for the valuation and safe-keeping of assets and the systems of ... the AIF and the value of the shares and units of the AIF OJ L 177, 30.6.2006, p 201 28 EN The valuator shall ensure that the assets, shares and units are valued at least once a year, and each time ... accordance with existing applicable valuation standards and rules, in order to reflect the net asset value of the shares or units of the AIF The rules applicable to the valuation of assets and the...
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Tài liệu Báo cáo khóa học: Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure pptx
... monitor the acetylation status of the MMTV promoter subjected to TSA treatment, we used a chromatin immunoprecipitation assay (ChIP) and evaluated the acetylation status of the so-called B- and nucleosome ... TSA-treated and nontreated oocytes Dark bars show TSA-treated cells smearing of the nucleosomal pattern both in the promoter and vector sequences (Fig 3A, both panels, compare lanes 1, and 13 and ... compare lanes 1, and 3, 4) However, TSA alone tended to induce transcription at a weak level, also in the absence of hormone (Fig 1C, compare lanes 1, and 5, and 9, 10) A further effect of TSA...
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Tài liệu Does Foreign Direct Investment Work For Sustainable Development? A case study of the Brazilian pulp and paper industry potx
... Klabin and Aracruz that present data for years 2003, 2004 and 2005 and Cenibra which data are available only for 2005 ** The companies not have this value calculated All plants, excepting Aracruz and ... lower than Cenibra in all parameters Votorantim, Suzano Bahia Sul, Ripasa and International paper are integrated producers of the writing and printing paper By calculating the average of the three ... their educational level because they feel a mental and physical fatigue Table presents the quantitative indicators of human capital efforts and the wages expenses of the companies from the sample...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25