... multidimensional, and can be described or seen in various ways, including both wet (experimental) and dry (computational and theoretical), reductionist and synthetic, qualitative and quantitative, anda ... including creating it, storing it, editing it, comparing it with other stored models, nding it again ina principled way, visualizing it, sharing it, running it, analysing the results ofthe run, ... 2C, D and E highlight the basic and iterative relations between computational models and reality on one hand and between changes inthe model that are invoked and its subsequent dynamic behaviour,...
... and design, acquisition, analysis and interpretation of data and drafting ofthe manuscript EH was involved in design, interpretation of data, drafting ofthe manuscript and supervision ØE was ... was involved in conception and design, interpretation of data, drafting ofthe manuscript and supervision BL was involved in analysis and interpretation of data AMB is the guarantor for this paper ... Inventory b HADS – Hospital Anxiety and Depression Scale down in adaptation that results from the long-term imbalance of demands and resources [33] and may result in cynicism As the samples in...
... There was a particularly troubling bone pain involving his forearms, wrists and hands bilaterally The arm pain was unpredictable, episodic and intense with aching and burning qualities There were ... devise the drug regimen and conducted the initial literature search I also wish to acknowledge the assistance of Dr Mike Harlos andthe many participants on PaedPalCare for their clinical advice ... Vigano A, Romano F, Neumann C, Hanson J, Quan HK, Walker P: Safety of subcutaneous clodronate and efficacy in hypercalcemia of malignancy: a novel route of administration J Pain Symptom Manage 2003,...
... International Classification of Functioning, Disability and Health andthe position ofthe variables included inthe study by Brionez and colleagues [1] AS, ankylosing spondylitis; BASFI, Bath Ankylosing ... psychological variables and biomedical factors would help improve our understanding of, and insight into, health outcomes Identification ofa core set of psychological variables from the increasingly large ... seen as the major mechanism ofa positive reference shift, which refers to the idea that patients not rate their health in reference to an absolute standard but in reference to a relative standard...
... Staphylococcus aureus [1] The fact that 28% ofthe RNAs tested affected the process of uptake, either increasing or decreasing bacterial uptake, strongly validates the initial screening with LBPs andthe interactome ... classes of luminal proteins include hydrolases and other bacteriocidal proteins Inthe phagosome membrane are found the various subunits ofthe proton transporter H+-ATPase, other transporters and ... causing the initiation of intracellular signaling pathways, most prominently those leading to the membranedependent assembly of actin filaments andthe exocytosis of various membrane compartments These...
... non-marine, formations exist inthe northern Sacramento Valley They are the Alluvial deposits, the Tuscan Formation, units Aand B, the Tuscan Formation, unit C, andthe Tehama Formation These ... below the Tuscan Formation andthe Tehama Formation, and above the Great Valley Sequence, Neroly Formation, and Ione Formation represents the approximate contact between fresh and saline groundwater, ... groundwater The Alluvium, the Modesto and Riverbank Formations, andthe Basin deposits are identified as Qa, Qm, Qr, and Qb, respectively, in Figure The Alluvium is composed of gravel, sand and...
... characteristic ofthe TGFb superfamily type I receptors are in bold and underlined, andthe cysteine knot is boxed Also boxed are the transmembrane domain, the ATP binding site, the L45 loop and ... to interact with both BMPs and activins via its double extracellular ligand binding domains Such promiscuous behaviour has already been described for the Drosophila sax [42] and Caenohabditis ... screens in flies (mad Drosophila mutants) and worms (sma Caenorhabditis mutants) These move to the nucleus to associate with transcriptional coactivators and regulate the transcription of target...
... be a critical source for maintaining a steady Cys availability as it is continuously exported out of cells into plasma and converted to circulating cysteine by the action of c-GT and dipeptidase ... converted into CysGly and then into Cys by the combined action ofthe membrane enzymes c-glutamyl transpeptidase (cGT) and dipeptidases (DP) The activity of cGT is inhibited by acivicin Alternatively, ... previously [43] Maintenance ofan adequate plasma thiol–disulfide balance appears to be fundamental Ithas been demonstrated that even a minimal shift inthe redox state of either the Cys ⁄ CySS...
... KRDmsAF (CGGTATTGG CTGCTGAGGTGAGTAAACGTGGTTTGG) and KRD- msAR (CCAAACCACGTTTACTCACCTCAGCAGCCA ATACCG) for KR mutation; RKDmsAF (GCTGCTGAG GTGAGTCGCAAAGGTTTGGTAAAAACG) and RKDmsAR (CGTTTTTACCAAACCTTTGCGACTCACCTC ... (CGTTTTTACCAAACCTTTGCGACTCACCTC AGCAGC) for RK mutation; and KRtoKKDmsAF (GCTGAGGTGAGTAAAAAGGGTTTGGTAAAAACG ACAGCG) and KRtoKKDmsAR (CGCTGTCGTTT TTACCAAACCCTTTTTACTCACCTCAGC) for KK mutation SDS/PAGE and western ... corresponding band was present inthe same peak elution fraction inthe TatAy immunoblot, indicating the presence ofa TatAyCy complex The vast majority ofthe TatAy protein did not bind the column and...
... of marital outcomes, variously referred to as marital stability, marital adjustment, marital quality, marital satisfaction, marital dissolution, marital conflict, and many more (Karney and Bradbury, ... be a history ofthe social and institutional changes that have a ected military couples over the same period By mapping changes in rates of marriage and marital dissolution within the military ... Afghanistan and Iraq, the demands on the military have been higher than they have been at any time since the Vietnam War In particular, deployments, especially for the Army andthe Marine Corps, have...
... other races including American Indian, Alaska Native, Asian, and Hispanic White Twenty percent of youth lived ina single-parent household Nearly half (46%) lived in households with an annual ... / MARCH 2003 ventive measures (such as the adoption of filtering and blocking software) and incidents of exposure Longitudinal and qualitative research, along with the use of standardized measures, ... at the level of more than a little or all the time during the days right after the incident happened In another series of bivariate analyses, few ofthe characteristics ofthe youth, their patterns...
... selects a financial accounting standard where comments letters were used and compares the change in this financial accounting standard to an additional randomly selected financial accounting standard ... standard setting Cross Case Analysis Random Case Random Case Final financial accounting standard, including all related source documents, after FASB issued standard Final financial accounting standard, ... qualitative report Note Numeric indicators reference Linking of Data Points UA is Unit of Analysis Code comments and relate to FAS changes Compare change in standard Financial accounting standard,...
... forms of animals and plants first appeared inthe Arctic and migrated later to temperate climes They report that data from the « Eureka Sound Formation inthe Canadian high Arctic reveals profound ... between the time of appearance of fossil land plants and vertebrates inthe Arctic and mid-northern latitudes Latest Cretaceous plant fossils inthe Arctic predate mid-latitude occurrences by as much ... characters as being a consequence ofthe exposure to and sensitivity ofthe organism to ultraviolet light and/ or cosmic rays The mitigating factors affecting exposure such as latitude, aquatic...
... plexus, andthe median, radial, and ulnar nerves were each transected cm distal to where they branched off ofthe brachial plexus and loosely sutured to the anterolateral aspect ofthe normally innervated ... analysis ofthe histologic specimens; and TK and GD participated inthe design and coordination ofthe model All authors read and approved the final manuscript Competing interests The authors declare ... significant differences inthe median, radial, and ulnar neuromas in terms of myelinated axon counts at a distance of 15 mm proximally However, it is important to note that whereas Scadding and Thomas...
... indicate testing fasting blood glucose within two years and LDL within one year, measuring BP within six months, and having active prescriptions for aspirin, a statin, andan angiotensin-modifying ... measuring BP and glycosylated haemoglobin within six months, and having active prescriptions for a statin andan angiotensin-modifying agent For patients with IHD, a maximum score of would indicate ... amongst Canadian family practitioners, who manage the bulk of care for these patients [2] Unfortunately, there remains a large gap between ideal and actual care provided to such patients, making them...
... to amplify full-length cDNAs: ACR9, 5’-TGTTGTT GATTCATTGGCTC-3’ and 5’-AGTAGTAGATGAATATATTG-3’; ACR10, 5’-ATAGGAGGAACAACACAAAC-3’ and 5’-TTACTATGAAACCCACACAG-3’; ACR11, 5’-AAAAGGATCCATGGCTATGGCCTCT ... proteins, andthe Figure Amino acid sequence alignments of ACR proteins andACT domains (A) Sequence alignment of Arabidopsis ACR11 and ACR12 proteins ACT domains are indicated with solid lines above ... domains Ithas been shown that the C-terminal ACT domains of GlnD may regulate its activity through the binding of glutamine [21] TheACT domain, named after bacterial aspartate kinase, chorismate...
... data analysis and writing ofthe manuscript MK and TB contributed to the writing ofthe manuscript and edited it for important content JH conducted data analysis and contributed to the writing ... serve as consultants for UNITAID Authors' contributions BW designed and coordinated the study, participated in data cleaning and data analysis, and was the lead author on this paper ED, LS and ... person-years of volume in 2008 Trends in FDC market share across purchasers and manufacturers Analysis of market share by both purchasers andthe manufacturers that supply them reflects the dominant...
... drafting ofthe manuscript RL and AM aided inthe collection and analysis of interview data CAL participated inthe design ofthe study and all authors read and approved the final manuscript SAS ... conceived ofthe study, participated in its design and coordination, and helped with the drafting and editing ofthe manuscript PC contributed to the conception, theory, and design ofthe study, and aided ... Russia, Malaysia, Vietnam, and China [36-38,24] Bluthenthal et al [39] found a 46% increase inthe total number of California's NEPs after the passage ofan assembly bill eliminating criminal prosecution...