7 regional chemotherapy dose intensification with reduced systemic exposure
Báo cáo khoa học: " The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients" potx
... clinical and dosimetric factors associated with treatment-related pneumonitis (TRP) in patients with non-small-cell lung cancer(NSCLC) treated with concurrent chemotherapy and three-dimensional conformal ... lung dose (MLD), V5, V10, V20 and V30 (the percentages of the irradiated lung volume receiving a radiation dose exceeding Gy, 10 Gy, 20 Gy and 30 Gy, respectively) were calculated from the lung Dose ... Abbreviations: RP, radiation pneumonitis; DVH, dose volume histogram; MLD, mean lung dose; V5, the percentage of the irradiated lung volume receiving a radiation dose exceeding Gy; V10, the percentage...
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Báo cáo khoa học: "Improved survival following surgery and radiation therapy for olfactory neuroblastoma: analysis of the SEER database" pdf
... model The Role of Chemotherapy The SEER database did not include information for those treated with chemotherapy, however recent reports of outcomes for ONB patients have included chemotherapy [11-15] ... benefit compared with surgery alone or surgery with radiotherapy is likely an artifact of these small numbers Based on five year survival stratified by treatment and consistent with one meta-analysis, ... of ages with most cases between the ages of 40 and 70 years old (mean age was 53 years, SD of 18) The majority of cases were treated with both surgery and radiotherapy (61%), were white with 55%...
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Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx
... patients were simulated with conventional simulator The postmastectomy chest wall received a dose of 50 Gy through two tangential fields with MV foton The mid-axilla received a dose of 50 Gy through ... The question whether with current standards of surgery and systemic adjuvant chemotherapy in this particular subset of intermediate risk patients (N1-3 positive and pT2) with additional risk ... T1-T2 and 1-3 positive axillary lymph nodes, all but one of whom received adjuvant systemic therapy with (n = 66) or without (n = 24) PMRT were analysed Fifteen of 90 patients were previously treated...
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Frontiers of Radiation Therapy and Oncology Vol. 34 doc
... in some countries surgery and adjuvant chemotherapy are more intensive In a retrospective analysis of 4,144 patients treated with radical surgery without chemotherapy for breast cancer at the ... escalation of dose to the tumor enabled by improved radiation devices With 200 kV, it was possible to deliver 40 Gy to a deep-seated tumor in 1930; in 1960, with the use of cobalt, the dose could ... in 1980, with the linear accelerator that provided an x-ray beam of 10 or more megavolts, doses of 70 Gy were achieved With conformal therapy, it seems possible to deliver 75 or 80 Gy with acceptable...
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Báo cáo khoa học: "SemiIntensity-modulated radiation therapy (IMRT) vs. 3D conformal radiotherapy (3DCRT) in locally advanced rectal cancer (LARC): dosimetric comparison and clinical implications" pptx
... shaped to the PTV with 1-cm leaves A 45 Gy dose delivered with 15 MV photons was prescribed to the PTV95 (the minimal dose received by 95% of the PTV) for the 3DCRT plans Photon dose calculation ... the dose received by 5% of the SB (SB D ) was ≤ 50 Gy, the PTV (minimal dose to the PTV) was ≥ 35 Gy, and maximal SB dose (SBmax) was 55 Gy Dose constraints for the bladder included a maximal dose ... revealed that when isodoses are less than 8.4 Gy(95 CI: 6.2-10.6), the volumes of the isodoses from IMRT plans are larger than the isodoses volumes from c3DCRT plans and when isodoses are more than...
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Báo cáo khoa học: "Use of kilovoltage X-ray volume imaging in patient dose calculation for head-and-neck and partial brain radiation therapy" pptx
... 0.70% 1Left-eye: mean dose 10.54 10.58 0.37% 1Spinal cord: max dose 47.65 1.07% 59.18 59.44 -0.43% 2GTV: mean dose 67.8 67.78 -0.03% 2CTV: mean dose 64.9 64.89 -0.02% 2PTV: mean dose NPC (patient2) ... 1Whole body: max dose 63.76 63.78 0.03% 2Brain Stem: max dose 53.83 54.36 0.98% 2Spinal cord: max dose 32.85 32.73 -0.34% 2L-parotid: mean dose 34.92 34.11 -2.37% 2R-parotid: mean dose 33.38 32.91 ... -1.41% 2Whole body: max dose 70.73 70.12 0.87% 3CTV: mean dose 61.85 61.84 -0.02% 3PTV: mean dose 60.64 60.57 -0.11% 3Brain: max dose 50.13 50.02 -0.22% 3Left-eye: mean dose Brain Tumor (patient3)...
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Báo cáo khoa học: "Comparison of coplanar and noncoplanar intensity-modulated radiation therapy and helical tomotherapy for hepatocellular carcinom" pot
... choice for HCC patients with PVT as compared with coplanar IMRT because they can achieve similar dose to the tumor with comparable UI and CI but a relatively low mean dose and V30 to the normal ... investigated for a comparison For OARs, mean dose to stomach, spleen, kidneys and maximum dose to spinal cord were assessed The maximum doses were specified as maximum dose to 1% volume, denoted as D1% ... surface, and TVPV is the portion of the PTV within the prescribed isodose volume The CI approximates unity means lesser dose to normal tissues and higher dose to target volume The uniformity index...
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Báo cáo khoa học: "An investigation of intensity-modulated radiation therapy versus conventional two-dimensional and 3D-conformal radiation therapy for early stage larynx cancer" ppt
... vertebral body (labeled the loose clinical plan) Dose was calculated without inhomogeneity corrections and a dose of 100% was assigned to the isocenter The isodose line which covered the larynx and had ... dose (Dmax), mean carotid artery dose, mean arytenoid dose, and maximum spinal cord dose Results Table 1a depicts tumor coverage averaged over all three patients with a 1.0 cm margin in the tight ... dose was lowest in the 2D tight clinical plan, at 2483 cGy, and second lowest in the IMRT plan, at 4049 cGy The spinal cord doses were all well below tolerance, with the maximum spinal cord dose...
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Báo cáo khoa học: "Plan comparison of volumetric-modulated arc therapy (RapidArc) and conventional intensitymodulated radiation therapy (IMRT) in anal canal cancer" doc
... Conformity Index, D mean: Dose mean The plans for the bladder were also equivalent The volume of bladder irradiated at low and medium doses was reduced with RA2 compared to IMRT with a trend towards ... with ≥ 95% of the prescribed dose We also checked that 95% of the PTV1 received 95% of the prescribed dose No more than 2% of the PTV was allowed to receive more than 107% of the prescribed dose ... observed for skin and genitalia with a decrease of the irradiated volume to the low and medium doses (V30: IMRT: 21.7 ± 22.4 Gy vs RA2: ± 15.1 Gy, p = 0.08) The mean dose reduced by 5.6 Gy (IMRT: 24.5...
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Báo cáo khoa học: "Whole abdomen radiation therapy in ovarian cancers: a comparison between fixed beam and volumetric arc based intensity modulation" ppt
... minus the PTVs), the integral dose, “DoseInt” was defined as the integral of the absorbed dose extended to over all voxels excluding those within the target volume (DoseInt dimensions are Gy*cm ... 95% of the prescribed dose and the volume of the total PTV_Pelvis, measured the conformity of the high dose levels For OARs, the analysis included the mean dose, the maximum dose expressed as D2% ... wide dose range is mostly due to the absence of a well defined dose response relationship and of an established consensus till date However, doses higher than 30 Gy to whole abdomen and pelvic doses...
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Báo cáo khoa học: "Comparison of conformal and intensity modulated radiation therapy techniques for treatment of pelvic tumors. Analysis of acute toxicity" pdf
... (Table 1) No patient with endometrium cancer was treated with CT, patients with cervix cancer, when treated with concomitant CT and RT, received weekly Cisplatin (40 mg/m2) Those with rectal cancer ... Adjuvant
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Báo cáo khoa học: " Stereotactic body radiation therapy for melanoma and renal cell carcinoma: impact of single fraction equivalent dose on local control" ppt
... with aggressive local therapy with possible systemic therapy Otherwise, patients were classified as having extensive metastatic disease Patients with extensive disease had relatively stable systemic ... cases, the follow-up CT was fused with the planning CT to define in-field LC If a patient with suspicious failure was subsequently treated for that lesion with chemotherapy, the lesion was considered ... from 36 to 83, with median age of 59 There were 17 males and 13 females treated with SBRT Seventeen patients had oligometastatic disease at time of treatment with all sites treated with SBRT, and...
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Báo cáo khoa học: "Intensity modulated radiation therapy (IMRT): differences in target volumes and improvement in clinically relevant doses to small bowel in rectal carcinoma" pps
... [1], with further improvement achieved with its concurrent administration with chemotherapy [2,3] Moreover, Sauer and colleagues, demonstrated that preoperative chemoradiation was superior with ... http://www.ro-journal.com/content/6/1/63 receiving at least a dose of X Gy Maximum dose was expressed as D1%, minimum dose as D99%, mean dose as Dmean, and maximum point dose as Dmax The homogeneity index (HI) and ... inferior compared with IMRT (p = 0.02) Mean doses were similar between the 3DCRT and IMRT plans (p = 0.46) With respect to target coverage, the minimum dose to the PTV, D99%, was higher with IMRT compared...
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Báo cáo khoa học: "Reirradiation of head and neck cancer focusing on hypofractionated stereotactic body radiation therapy" pdf
... difference in the rate of carotid blowout between patients treated with or without concurrent chemotherapy, or between patients treated with or without salvage surgery before reirradiation Brachytherapy ... (Table 2: additional file 2) With precise dose delivery, SRS/SRT has a physical advantage that allows highly conformal dose distribution and highly accurate dose- delivery to within a few mm for extracranial ... imagine that smaller doses than used in the original irradiation treatment will be curative Actually, despite aggressive therapy with high doses of reirradiation concomitant with chemotherapy, the...
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Báo cáo khoa học: "Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients" doc
... The postoperative increase in s-TATI was higher in patients with Stage III-IV (Z = -2.994, P = 0.003) disease than in with patients with Stage I-II disease (Z = -2.556, P 0.011) (Figure 2E-F) ... patient with ovarian cancer J Biol Chem 1982, 257:13713-13716 Turpeinen U, Koivunen E, Stenman UH: Reaction of a tumour-associated trypsin inhibitor with serine proteinases associated with coagulation ... (ref 144/2004 with amendment 597/2006) and written consent was obtained from the patients Tissue microarrays Two tissue microarray (TMA) series were constructed; one biopsy TMA with × mm cores...
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Báo cáo khoa học: "Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking" pps
... the 95% isodose and the maximum dose was limited to 105% To limit the dose to the organs at risk (OAR), a template was used with a set of dose constraints Daily treatment was intended with a full ... found with a CM >1 mm limit in any direction Following this sequential setup procedure, the patient was treated with the multi-field IMRT plan Optimization of the IMRT plan included a dose limit within ... (percentage of PTV receiving at least 95% of dose, corresponding to 76 Gy) and the Dmax and Dmin (maximum and minimum dose within the PTV) were calculated from the dose volume histograms Follow-up protocol...
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Báo cáo khoa học: "Target splitting in radiation therapy for lung cancer: further developments and exemplary treatment plans" pps
... technique However, patients with preexisting lung fibrosis should be excluded from accelerated, high dose therapies [4] With regard to the esophagus we limited the maximum dose in accelerated schedules ... whole upper volume is treated only with an elective dose (45 Gy), significant esophageal side effects have not been observed, and the beam angles were optimized with regard to sparing of lung tissues ... Regarding pulmonary doses, when we started to implement target splitting and to raise the dose, we set the constraints as recommended for safe 3D-treatments some years ago: a dose of ≥ 20 Gy should...
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Báo cáo khoa học: " Comparison of CT and integrated PET-CT based radiation therapy planning in patients with malignant pleural mesothelioma" pot
... tomography-computed tomography escalate RT dose because of significant toxicity concerns Linden et al treated 47 MPM patients with a dose of 40 Gy in 20 fractions with and without chemotherapy and they informed ... treated with an palliative approach whether they were suitable for higher RT doses in the range of curative 54 Gy, as these patients theoratically still bear a chance for cure with higher RT doses ... Johnston MR: Trimodality therapy with inductin chemotherapy followed by extrapleural pnemonectomy and adjuvant high -dose extrapleural pneumonectomy and adjuvant high -dose hemithoracic radiation for...
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Báo cáo khoa học: " Whole brain radiation therapy in management of brain metastasis: results and prognostic factors" ppsx
... data, patients with good prognosis (RPA class I) who are likely to survive more than six months, such as those with single metastasis with controlled systemic disease, should be treated with prolonged ... gender, chemotherapy, dose and fractionation schedule) analyzed were not associated with any effect in survival RPA class in this study showed similar results to RTOG protocols [5], with the ... necessary The total dose was 30–40 Gy, with a median of 35 Gy, in daily fractions of 2.0–3.0 Gy During the study period two fractionation schemes were used: conventional fractionation with daily fractions...
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Báo cáo khoa học: " Radiation therapy planning with photons and protons for early and advanced breast cancer: an overview" ppt
... tissue (within the planning target volume) will be treated with a high fractional dose Parenthetically, administering a higher fractional boost dose with protons can be achieved with or without ... volume and doses administered to OARs for 17 breast cancer patients planned with protons and photons, with or without IMRT On the average, 97% of the PTV receives 95% of the prescribed dose with protons ... compared to only 89% with conventional photon techniques With protons, the mean dose to the heart is reduced by a factor of two to three when compared to photon planning, with or without IMRT In these...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25