... with the conception and design of the study, helped to supervise the staff and helped to draft the manuscript OA and GHP helped with the conception and design of the study and helped draft the ... of melatonin administration on night shift workers in an actual workplace setting [26] The purpose of this study was to compare the efficacyof melatonin (5 mg) and placebo in the treatment of ... provided by staff and students at Imam and Baharloo Hospital/ Tehran University of Medical Sciences 10 11 12 13 14 15 16 References Coffey L, Skipper J, Jung F: Nurses and shift work: effects onjob...
... and significant improvement of ICU monitoring (in particular of the patient’s hydration status) and treatment (more rapid and adequate resuscitation of severe sepsis and shock and avoidance of ... Spapen et al.: Renal and neurological sideeffectsof colistin in critically ill patients Annals of Intensive Care 2011 1:14 Page of Submit your manuscript to a journal and benefit from: Convenient ... Nephrology Working Group of the European Society of Intensive Care Medicine: Prevention of acute kidney injury and protection of renal function in the intensive care unit Expert opinion of the Working...
... comparisons of groups, ipsilateral side, 72 h and day (Bonferroni Corrrection is applied and results were considered significant when p < 0.0125), b comparisons of groups, contralateral side, 72 h and ... and talc administrations and in the acute and subacute phases due to systemic distribution Moreover, morphologic changes were observed on the contralateral side Well-documented sideeffectsof ... contributions AG and BÖ conceived of the study, and participated in its design and coordination and helped to draft and performed the statistical analysis AFÇ carried out the macroscopic and microscopic...
... management of the study and GM undertook patient care and management NI, AH, SW and JD carried out laboratory work, collected and analysed the data and conducted the transfer and interpretation of the ... established mechanisms of action of rhGH, it is suggestive that some of the beneficial effects on both the developing thymocytes and thymic stroma may lead to emergence of new CD4+ and CD8+ T cells ... infection is of considerable importance [11,12], and may be critical for enabling control of viral activity and retarding disease progression in persistent HIV-1 infection in the presence of, and possibly...
... evaluation of the therapeutic response andsideeffects is often reported by the parents of the child with ADHD This may also lead to some correlation between therapeutic andsideeffects The aim of ... therapeutic andsideeffects as well as correlation in parental assessment of therapeutic andsideeffects We also postulated that if the correlation between therapeutic andsideeffects is at ... frequencies of the 17 side effects, as well as the frequencies of severe side effects, between the placebo and active conditions Repeated measures analysis of variance (ANOVA) was used to detect the effects...
... proliferation of T cells, the production of interferon-γ (IFN-γ) by NK cells, and ultimately the cytolytic activity, the magnitude, and the spectrum of stimulatory effects by IL-2 and IL-12 are ... stronger stimulator of proliferation and cytolytic activity, IL-12 is a stronger inducer of IFN-γ from NK cells and activated T cells Although the combination ofrecombinant IL-2 and IL-12 treatment ... administration of these cytokines causes toxic sideeffects Recent reports of intratumoral co-injection of adenoviral vectors expressing IL-2 and IL-12 demonstrated the regression of pre-established...
... alternative courses of action: Another source of importance of planning is that it permits managers to examine and analyze alternative course of action with a better understanding of their likely ... importance of planning function as follows: Provides Direction: Planning provides a clear sense of direction to the activities of the organization and to the job behavior of managers and others ... and tomorrow, and beyond immediate concerns It encourages them to probe and cut through complexities and uncertainties of the environment and to gain control over the elements of change 3 Minimizes...
... pregnancy and gestation Complete details of the study, including a description of reproductive effects in parents and offspring, are included in Section In the F1 offspring there were no effects ... of adverse effects Developmental Toxicity Some evidence of adverse effects Limited evidence of adverse effects Insufficient evidence for a conclusion Limited evidence of no adverse effects Reproductive ... Some evidence of no adverse effects Clear evidence of no adverse effects development and reproduction These studies reported that exposure of pregnant dams to relatively high doses of DIDP causes...
... taste and stimulant property excite and keep up a profuse discharge from the mucous follicles and salivary glands Probably to this circumstance alone, is owing the superior efficacyof this mode of ... variety of computers including obsolete, old, middle-aged and new computers It exists because of the efforts of hundreds of volunteers and donations from people in all walks of life Volunteers and ... meeting of the Medical Society of the County of Oneida, on the 5th of March, 1830, a communication was received, signed by a number of highly respectable gentlemen from this and other counties of...
... studies of the reductive half-reaction of AADH Studies of the reductive half-reaction were performed to allow comparison of kinetic parameters for native andrecombinant AADH Reduction of the TTQ cofactor ... Table Analysis of the temperature dependence of reaction rates with protiated and deuterated benzylamine provides a sensitive test for the functional equivalence of native andrecombinant AADH ... orf-4 and hemE) all putatively transcribed in the same direction [7] The second and fifth genes (aauA and aauB) encode the large and small subunits of AADH, respectively The genes aauD and aauE...
... than the developmental effects observed at “high” doses on survival and growth and the “low” dose effects on brain and behavior, mammary gland, prostate gland, and onset of puberty in females ... the incidence of a variety of other ovarian and uterine proliferative lesions and cysts were also reported Replication of these findings and further study of the linkage of early and late occurring ... in considering the biological plausibility of a number of the reported low dose effects The NTP does not necessarily consider it appropriate to consider the reported biological effectsof bisphenol...
... splicing A variety of tools are available to us for this purpose and further investigation of these sequence variants will not only further our understanding of the splicing mechanism and improve clinical ... number of examples reported to date in the literature is not as large as expected and this may be because synonymous variations have previously always been considered neutral and because of an ... sites, most of them still lack experimental approaches directed at identifying the exact mechanism involved In spite of the well-known lack of reliability of in silico approaches, many of the synonymous...
... methyl of Aib, on the opposite sideof the pyrrolidine ring of Pro A parallel can be drawn regarding the differences in biological activities between [Ala9]SP and [Gly9]SP on the one hand, and [b2-HAla9]SP ... (1998) b2- and b3-peptides with proteinaceous side chains Synthesis and solution structures of constitutional isomers, a novel helical secondary structure, and the influence of solvation and hydrophobic ... grid searches of b-amino acids were initially carried out at intervals of 30° for each torsion angle /, h, and w and were subsequently refined by varying /, w angles in intervals of 10° and setting...
... D74N and E202Q, allowing flexibility of the gorge for entrance and binding of substrates or inhibitors and exit of reaction products The carboxylic groups of E202 and E450, the hydroxyl group of ... in the active site gorges of TcAChE and HuAChE is evidence for the importance of water in the structure of AChE The structure and number of water molecules in the gorge and bound to the enzyme ... types of behavior were observed For wild-type AChE, D74N and E202Q mutants, plots were biphasic, allowing the estimation of two activation volumes, on both sides of the break The E450A and the...
... ii Abstract The Effectsof Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effectsof Care on Client Mobility: Findings from Contra ... focused on the disabled and aging populations Yet certain types of residents and residents of certain parts of Contra Costa have better access to transportation facilities and community services ... with survey design and thinking about the interaction of land use and transportation variables; Professor Paola Timiras, Department of Molecular & Cell Biology, University of California, Berkeley,...
... depositing at the feet of the chains of huge deposits of sand, gravel and clay There then followed a phase of general increased marine predominance, lasting a good part of the Miocene and all the Pliocene ... the Channel of Sicily In the Adriatic, besides the various low and sandy islands of the Po delta and Venetian lagoon, there emerges the Tremiti archipelago (3 sq km) to the north of the Gargano ... with the exceptions of the bulge of the Po delta andof the two rocky promontories of the Conero and Gargano The Ionian and Tyrrhenian shores are very different, their extensive sandy curves, corresponding...
... plot As a crude extract ofrecombinant AtNIT1 had a half-time of days at pH and °C, the in¯uence of antioxidants and protease inhibitors on enzyme stability was investigated Of the applied thiols ... volume of mL each of a solution of 3-phenylpropionitrile (181.5 mg) and 3-phenylpropionic acid (205.2 mg) in methanol (10 mL), and Tris/HCl buffer (990 mL, 70 mM, pH 8.5) were mixed, and mL from ... agreement with a reported value of mM [4] Enzyme stability Fig Puri®cation and characterization ofrecombinant AtNIT1 in E coli (A) Lysate of isopropyl b-D-thiogalactopyranoside-induced E coli-pQE10-AtNIT1...
... protein sequence with that of other species (Xenopus, Drosophila, mouse isoforms 1, 2, and 4, rat isoforms and 2, bovine isoforms 1, 2, 3, and 4, and human isoforms 1, 2, 3, and 4) is shown in Fig ... applies to Artemia mitochondria, we tested the effect of ADP and ATP in the presence and absence of the ANT inhibitory ligand cATR, andof the F0F1ATP synthase inhibitor oligomycin The results ... well-characterized, inhibitors of ANT have also been reported [37] Mindful of (a) the well-established ligand profile of ANT, (b) the modulatory role of ANT in the mammalian PTP, and (c) the absence of a Ca2+-induced...
... proof of apoptosis, cleaved caspase-3 was determined in cell extracts by western blot (G) Representative blot of n = experiments showing 17 and 19 kDa caspase-3 cleavage bands and the levels of ... pancreatic b-cells The objective of the present study was to investigate the expression and antioxidant effectsof PHB in pancreatic b-cells exposed to ethanol Effectsof prohibitin in b-cells * 80 ... J H Lee et al Results Effectsof ethanol andrecombinant PHB on b-cell mitochondrial function and apoptosis We first generated a dose–response curve of ethanol toxicity using the 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyl-tetrazolium...