... using the direct binding assay as described in Experimental procedures Inset: Linearized plot ofthe binding data for apoE(263–286) (symbols) shown in panel A The solid line represents the linear ... fraction inthe presence of both apoE isoforms However, a greater increase inthe ordinate maximum and area under the curve is obvious inthe presence ofthe apoE4 isoform (Fig 7C, open symbols), indicating ... particular, the binding footprint for the apoE4 isoform, corresponding to 3.0 amino acids per phospholipid, is almost twofold greater than the apoE3 isoform (Table 2), suggesting these isoforms differ in...
... their determinants The matrices Xi,t and Zi, t include the same covariates inthe regressions ofthe categories of deposit interest rates; inthe regressions ofthe categories of lending interest ... Herfindahl indexes in each country instead ofthe share ofthe largest credit institutions in total assets The results have remained the same, even if at a lower level of significance Inthe indicator ... domestic banks 36 The matrices Xi,t and Zi, t include the same covariates inthe regressions ofthe categories of deposit interest rates; inthe regressions ofthe categories of lending interest rates...
... than inthe primary forest, but the values ofthe three indices for poles and large trees did not demonstrate any significant differencesbetweenthe two forests (Table 4), indicating that the impacts ... harvesting By initially decreasing overstorey density and basal area, canopy openings created by logging triggered a rapid increase in recruitment into the seedling and sapling layers The fact ... 70% ofthe basal area ofthe primary forest two decades after harvesting There are still major differencesin species composition betweenthe primary and logged forest, with the latter having...
... clinical signs were observed in any one ofthe calves in both groups during the period As was indicated, all of them were from well-managed herds The calves in this study had very high levels of ... feeders There are various methods used in early assisted suckling, especially the amount and time of colostrum feeding after birth [6,16,17] In view ofthe results inthe present study, the method ... hrs after birth The beef calves stayed with their dams inthe calving pen throughout the experiment so that they could suckle freely all the time The Holstein calves were born between February...
... participants between 15 and 54 years of age Therefore, the study did not include the age extremities of childhood or late life The relevance of including childhood inthe developmental distribution of ... participants inthe age range of 60 to 93 years compared to the participants below 60 years of age Thus, the results showed a linear increase inthe prevalence of PTSD However, the increase in prevalence ... samples These findings are consistent with previous findings that also pointed out gender differences for the HTQ [15] The gender difference inthe mean scores ofthe HTQ is highest for the age...
... factor other than the presence of multiple basic amino acids inthe cleavage site contributed to the severity of H10 viruses in mink Neuraminidase Haemagglutinin Phylogenetic analysis ofthe HA ... haemagglutinin plays an important role for tissue tropism and the host range ofthe influenza virus [19] The amino acid composition ofthe receptor binding pocket ofthe HA protein for the H10 isolates ... influence of different genes on the virulence of these H10 avian influenza viruses in mink Of those amino acid residues previously described as virulence factors influencing the outcome ofthe avian influenza...
... distribution ofthe avian receptors varied from 40-70% in most ofthe epithelial cells of large intestine inthe bird species (Table 1) We did not observe the presence of either type of receptors inthe ... of ducks ofthe age groups was an interesting finding, especially considering the dominant presence of a2,3SA-gal receptors in epithelial cell ofthe large intestine The presence of avian type ... utilize these receptors for binding to initiate infections The presence of avian receptors inthe trachea and bronchial epithelium and their absence in other parts of lung support previous findings...
... (Figure 3) The software then calculated the area of stain within the region of interest based on previously determined stain specific colour plane settings The amount of positive stain area was then ... viewing the airway of interest, the basal border ofthe epithelium (corresponding to the basement membrane) was traced The image with clearly defined boundaries for morphometric analysis was then ... region of interest of defined band depth (5, 10, 15, 20, 25, 30, and 35 μm) is projected into the parenchyma from the sub-epithelial basement membrane trace (black lines) The stain of interest...
... are in fact under a stronger selection pressure either because ofgeneticdifferencesinthe magnitude, specificity, or potency ofthe natural immune response, or because ofdifferencesin factors ... P-values placebo and vaccinated recipients confirm that selection pressure differs between viruses infecting these three races, deciphering thegenetic determinants of these differences should become ... suggest that the rate of virus evolution is greater in this group than in other volunteers Differencesin immune response to HIV-1 infection have been pointed out by the rgp120 HIV Vaccine Study...
... found inthe GNA/Man complex (RCSB PDB code 1MSA) [17] was calculated using the forcefield of Discover3 and used to anchor the pyranose ring ofthe sugars into the binding sites ofthe lectin The ... software 2.0.2) to determine the binding kinetics These affinity and kinetic values are apparent values as the injected concentrations ofthe evaluated compounds did result in biphasic binding ... GNAmaize , in contrast to GNA, and SNA pre-binding of gp120 partially prevents the binding of GNAmaize on gp120 but does not influence the additional binding of GNA to gp120 Taking into account the...
... taken into pre-trial detention in 10 (out of 11) juvenile justice institutions inthe Netherlands between May 2006 and February 2008; data collection including interviews with the mothers of these ... with the neglectful mother-son relationship type, even when taking the educational level ofthe parents, single-parenting, and incarceration ofthe child into account In fact, the neglectful mother-son ... study Sixty-six mothers were of Moroccan origin (i.e., she or the father of her son was born in Morocco) and 63 mothers were of native Dutch origin Since incomplete participation ofthe parents may...
... relationships in causing or exacerbating some learning difficulties The wording ofthe Code of Practice acknowledges that there are limits to inclusion (Evans and Lunt 2002) and maintains the principle of ... because ofthe nature of their discipline, the way they are trained and the way they think, will tend to favour the medical model of special educational needs The medical model is one of deficit, involving ... stating inthe Green Paper on SEN (1997) that they support the Salamanca Statement However, they still maintain the principle of a continuum of provision As previously stated, the new Code of...
... cohorts. A more recent study (incident cases from 1968-2002) modeling the trends inthe ethnic groups showed that the cohort effect was present inthe Chinese and Malays but absent in Indians (144). In Chinese the age-period-cohort model had the ... between users (current and/or previous) with breast cancer. In women participating inthe Canadian National Breast Screening Study, breast cancer risk was not related to any ofthe B vitamins (folate, thiamin, riboflavin or niacin) or methionine (95) ... All 3 major ethnic groups in Singapore showed a decline in fertility. Since the 1950s, Year fertility rates in Chinese have been lower than inthe other ethnic groups. In addition, fertility rates in Chinese show fluctuations according to the Chinese lunar calendar ...
... aphidicolin for various times The rate of protein synthesis was then determined by measuring the amount of incorporation of [35S]methionine and [35S]-cysteine into cellular protein over hours The ... protein increased as the cells increased in size Thus, the rates of both synthesis and degradation of shortlived proteins increase with Schwann cell size, and the net accumulation of protein is independent ... day, independent of their size To confirm that the increase in cell volume reflected an increase in protein, we measured the amount of protein per cell, with similar results (Figure 3b) These findings...
... have indicated that the blocking of virus-induced IFN-b promoter activation is mediated by the N-terminal RNA binding domain ofthe NS1 protein [42-44] The 71 amino acid differencesbetweenthe ... binding domain and a C-terminal effector domain [19] The effector domain interacts with proteins involved inthe 3’-end cellular mRNA processing, inhibits mRNA export and pre-mRNA splicing of ... cells, indicating that the main target ofthe “mink/84” NS1 is the induction of IFN Discussion One ofthe main strategies ofthe influenza A viruses to avoid host immune responses is to inhibit IFN-a/b...
... distributed and of them displaying more pronounced local muscle pain Two of these dogs showed pain from the masseter muscles and one of them showed pain from muscles of both hind legs None ofthe dogs ... panniculitis") The remaining dogs showed unspecific crusting lesions on the bridge ofthe nose and on the ear pinnae, one ofthe dogs also had ulcers ofthe gingiva (Table 1, 2) Another Page of 10 (page ... 2) None ofthe dogs showed any signs of depression or anorexia For fourteen ofthe dogs, the duration ofthe signs before inclusion inthe study had been weeks to months, for nine ofthe dogs...
... 2000) The implication of these findings is that without the CC serving as the critical communication link betweenthe hemispheres, the behaviour of each hemisphere appears to be independent of each ... studies of sex differencesinthe CC in schizophrenia Despite the large body of literature in brain imaging inthe schizophrenia population, the number of studies that have specifically examined ... have investigated sex differencesinthe size ofthe CC by comparing a group of schizophrenia patients to healthy controls Furthermore, the investigation of sex differences was often not the 20...
... to the treatment of RA In this study, we have examined the role of a single nucleotide polymorphism inthe IL-4R inthe control of IL-17 production The results indicate that a polymorphism in ... the Th2 cytokine IL-4 and its receptor may be of particular interest inthe control of Th17-induced inflammation In mice, thegenetic absence of IL-4 leads to more severe arthritis inthe CIA model ... culture, as shown inthe top row of Figure 3A, compared to the suppression of IL-17+ cells inthe V/V genotype culture, shown inthe bottom row In these cultures, the majority of IL-17+ cells were...