4 pharmacological use of the human placenta
Báo cáo khoa học: The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin pot
... the proteins are difficult to align because identity between the two proteins is low Nevertheless, the alignment in Fig shows that the overall similarity of the protein encoded by YBL046w to human ... subunit of Pph3p required for the binding of Psy2p, we examined the sensitivity of the YBL046w ⁄ Psy4p deletion strain to cisplatin The comparable increased sensitivities to cisplatin of the homozygous ... identical to those of the wild-type cells Examination of the phenotype of S cerevisiae carrying deletions for both the YBL046w gene and the TUB2 gene Since decreased expression of Ppp4c in D melanogaster...
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Báo cáo y học: "The use of 3D surface scanning for the measurement and assessment of the human foot" doc
... density foam box The foam collapses under their weight and when they step out of the box there is a fairly close negative of the shape of their foot left in the foam The box can then either be filled ... manufacture the orthotics, this approach reduces the number of steps in the process as well as removing many of the sources of human error There are alternative methods of obtaining the shape of the ... directly on the 3D representations of the foot obtained by surface scanning The software, as well as matching the shape of the foot sole, allows the user to alter the shape and thickness of the orthotic...
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Báo cáo y học: "Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain" docx
... Respiratory Research Vol No Kruse et al ing the unique effects of IL-13 on activated STAT3 The functions of IL-4 and IL-13 are further influenced by some of the IL-4Rα variants These findings may also ... The aim of this study was to prove this hypothesis Additionally, the role of the functional IL-4Rα variant Q551R has been studied Materials and methods Typing of IL-4Rα polymorphisms Typing of ... of the IL-13 receptor were investigated in cytoplasmatic extracts, and in the case of STAT3 also in nuclear extracts SHP-2 binding was assayed using synthetic peptides of IL-4Rα Examples of the...
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Báo cáo y học: "Increased bleeding risk associated with the use of recombinant human activated protein C in patients with advanced liver diseas" potx
... hospital, seven of whom were not evaluable because of death soon after initiation of APC Of the 34 remaining patients, nine had major bleeding episodes The clinical characteristics of these 34 patients ... associated with the risk of a bleeding event (P = 0.02, odds ratio = 23.5, 95% confidence interval = 1.75–315) Of the five patients with ALD who had bleeding episodes, four died within 28 days of drug ... and for bleeding These data suggest that they may be at greatly increased risk for bleeding while receiving APC Because such patients were excluded from the major clinical trials of APC, it may...
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Báo cáo y học: " siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptak" docx
... for the nucleotide sequences of the primers used) The probability that off-target effects were observed for such matching pairs of d-siRNAs is predicted to decrease with the square of the off-target ... value to the noise distribution observed in the screen The distribution of To reduce the number of false positive caused by systematic sources of noise occurring during the screening process, the ... quality of the diced siRNA pools (aspect on gel) and the length of their coding sequence (>900 base-pairs (bp) to allow the synthesis of a second independent batch of d-siRNA; see below)) and further...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 4
... re-confirmed by mapping the flanking sequences used in the design of the SNP assays back to the human genome assembly This resulted in the remapping of SNPs within the MHC The SNP “rs2308655” was ... perfect proxy (r2=1) The positions of the tag SNPs are also indicated in Figure 3.17 in the previous section The distribution of the tag SNPs identified in each of the sub-regions of the MHC is detailed ... D′ of 0.32 However, there is a noticeable difference in the rate of decay of LD across the different sub-regions of the MHC The class I, class III and extended class II segments show a level of...
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NMR study of the human NCK2 SH3 domains structure determination, binding diversity, folding and amyloidogenesis 4
... role in the first transition, i.e., the formation of the helical state, because its mutation still allows the correct formation of the helical conformation, highly similar to that of the wild ... Leu25Trp26-Leu27-Leu28, on the second β-strand (Figure4.1A) Three of these residues were highly conserved in the majority of sequences Further prediction of secondary structures of a variety of SH3 sequences ... 4AlaMut at pH 6.5, the T2 values for the residues around the mutation region were larger than those of the corresponding residues in the wild type at pH 2.0 On the other hand, for both the wild type...
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1997 the use and training of the human voice 3rd edition (WITH BOOKMARKS)
... and the Call 133 136 THE ORIGIN OF THE CALL 137 THE CONTROL OF THE CALL 139 DEVELOPING THE CALL AND THE MAGIC OF THE YAWN 141 THE PITCH OF THE CALL 143 131 xiii xiv Contents The Dynamics of Structural ... front of the tongue gently touches the upper gum ridge and the front palate; for the NG sound, the back of the tongue gently touches the soft palate This gentle contact of the tongue to the palate, ... voiee to the farthest row of the theatre Nevertheless, that image and instruction demands of the body something it should not be asked to dci The voice cannot be thrown out of the body The voice...
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3294 asking for directions there be prepositions directions map boardgame 4 tasks 24 cards 4 suggestions for the use of the ws 4 pages editable
... part of the sentence: Where’s the fire station? The stadium is (in front of / two blocks away from) the park It’s on Washington Street, next to the library The church is (next to / in front of) the ... Where’s the school? The library is (in front of / behind) the restaurant The bar is (in the same block of / two blocks away from) the zoo The ice ... Is there a game today? Any other places to visit? Yes, there is To get to the stadium _ If you like movies, you can go to the movie theater and to arrive there...
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Báo cáo y học: "Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study"
... asked how they would rate their general feeling of well-being over the last days on a scale of to 6, with being as bad as it could be Profile P Equals the mean of the scores recorded mental) of a ... latter setting, the W-BQ12 was not found to be responsive The authors of this latter study attributed the lack of responsiveness of the W-QB12 to two possible causes: either the socioeconomically ... prior to this being given to the patient to score Therefore, the patient was aware of the symptoms they had previously nominated, but not the previous score Each of the four items is rated on a...
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Báo cáo y học: "Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus"
... almost all of the OLP epithelium The count was performed by two investigators without knowledge of whether the samples were control or experimental The total number of basal and suprabasal epithelial ... PermountTM Negative controls consisted of omission of the primary or the secondary antibody or primary incubation in the presence of non-immunized rabbit serum instead of the primary antibody Cell quantification ... of hMSH2 Therefore, the reduced expression of hMSH2 protein could make the epithelium of OLP more susceptible to DNA mutation, making it prone to oral squamous cell carcinoma development Further...
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Contrastive analysis on english and vietnames proverbs referring to parts of the human body
... referring to parts of the human body The position of proverbs referring to part of the human body Parts of the human body 21 21 21 The classification of parts of the human body according ... diversified (multiple form) The classification of parts of the human body according to the position In the system of the proverbs, the system of words referring to parts of the human body is divided ... functions: the function of comprehension, the aesthetic function, the function of education, the words about parts of human body are used to form the meaning of proverbs, therefore, they become...
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The transference of meaning through class of words denoting parts of the human body in english and vietnames
... earth The hand of a child - The hand of a lock The heart of a man - The heart of a matter 37 The tongue of a man - The tongue of a shoe The tooth of a person - The tooth of a comb The head of a ... hands of a farm 13 The heel of a person - The heel of the hand 14 One's leg - The leg of a trip 15 One's brain - The brains of a family 16 The bosom of a person - The bosom of the church 17 The ... associations in the following groups of meanings for the same words Define the type of transference which has taken place The eye of a man - The eye of a potato The bowel of a person - The bowel of the earth...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
... product of PRPP from the crystallization solution ing 81 compounds of substrates, products and regulators of other enzymes in the human nucleotide metabolism (Table S1) The library can then be ... conformation change, then allowing the purine base to bind in accordance with the mechanism of human HPRT [19,25] This conclusion can be made based on the lack of thermal shifts when only the bases were ... spectrophotometric methods Because the enzymatic activity of PRTFDC1 towards hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... monomer of poly(dT), showing that the changes were mainly due to the binding of the first DNA, while the binding of the second DNA had less influence (Fig 5A) To ensure that the estimation of the protein:poly(dT) ... in these eukaryotic and archaeal proteins (Fig 1A) Like the case of bacterial RecA, the L1 and L2 loops of the eukaryotic Rad51 proteins face A Roles of the HsRad51 L1 and L2 loops inside of their ... precision of 3% The changes occurring upon the addition of the element are noted in parentheses ND, not determined Y Matsuo et al ciation, like the case of Tyr188 of Xenopus laevis Rad51 [28] These...
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Tài liệu Báo cáo khoa học: Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11⁄hippostasin ppt
... the isoform of translation products through the determination of the first exon in KLK11 mRNA (summarized in Fig 2A) Detection of the first exon in each KLK11 mRNA reflects the promoter use in the ... both isoforms were secreted from cells Hence, the promoter use of the KLK11 gene appears to link to the splicing pathway of KLK11 mRNAs and to regulate the trafficking of KLK11 isoforms in the trans-Golgi ... isoform 1, although the primary transcript contained exons 1b and 1c Transcript encoded another type of KLK11, isoform 2, despite the presence of exon 1c The secretory pathways of KLK11 isoforms...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
... functionality and phylogeny However, the nature of the connections between these factors needs to be understood at the level of the protein domain The global properties of the HTFN topology are partially ... estimated that there are 2000–3000 [21,23] Such an increase in the number of TFs is associated with higher control of gene regulation [24] Interestingly, such an increase is based on the use of the same ... graph of N ¼ 230 interacting human TFs was obtained (Fig 1) This can be understood as the architecture of the regulatory backbone It provides a topological view of the interaction patterns among the...
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Tài liệu Ownership of Mutual Funds, Shareholder Sentiment, and Use of the Internet, 2011 pdf
... funds The number of households owning mutual funds decreased slightly in 2011 The percentage of U.S households owning mutual funds has stayed about the same since 2002 The current estimate of the ... Households owning mutual funds in 1980 through 1986 were estimated by dividing the total number of household accounts by the number of accounts per household Beginning in 1987, the incidence of ... 55 to 64 65 or older Age of head of household 1 Age is based on the age of the sole or co-decisionmaker for household saving and investing For the complete time series of data from 1994 through...
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Tài liệu Ownership of Mutual Funds, Shareholder Sentiment, and Use of the Internet, 2012 pdf
... Households owning mutual funds in 1980 through 1986 were estimated by dividing the total number of household accounts by the number of accounts per household Beginning in 1987, the incidence of ... 55 to 64 65 or older Age of head of household1 Age is based on the age of the sole or co-decisionmaker for household saving and investing For the complete time series of data from 1994 through ... Indeed, much of the growth in the number of households owning mutual funds through tax-deferred accounts has occurred among those for whom this is their only form of fund ownership Of the 49.3 million...
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Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx
... cells The positions of the molecular size markers (kDa) are indicated to the left and right of the (C) and (D), respectively, whilst the position of the Oct-1 (98 kDa approximately) and the two ... in Fig In order to gain further insights into the modes of regulation of TPb, the aim of the current study was to map the minimal transcriptional unit and to identify the key regulatory elements ... regions of Prm3 The following lists the identities of the Prm3 gene fragments and corresponding plasmids generated in either pGL3Basic (pGL3b) or pGL3Enhancer (pGL3e) vectors and the identity of the...
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