3rapid androgen response and pi3k crosstalk in prostate cancer
Báo cáo khoa học: "Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking" pps
... always during RT Twenty-six patients received combined androgen blockade (CAB) consisting of antiandrogen and gonadotropin releasing hormone analogue (GnRH) Three patients received antiandrogen ... Kemmerling L, Born EJ, Mini R, Greiner RH, Aebersold DM: Daily organ tracking in intensitymodulated radiotherapy of prostate cancer using an electronic portal imaging device with a dose saving acquisition ... abdomen and pelvis and a total-body bone scan When clinically indicated a chest x-ray and/ or thoracic CT was performed Based on these examinations clinical staging was defined according to the...
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The androgen receptor centric transcriptional network in prostate cancer
... Androgen Response Elements and other Motifs in ARBS Like other DNA binding transcription factors, the AR DNA binding domain is mainly responsible for determining its DNA binding specificity and ... distinct functional domains, namely, a N-terminal domain (NTD) containing transcriptional activation units (AF-1 and AF-5), a DNA binding domain (DBD) where four-cysteine zinc-binding domains ... Functional Domains of AR (Koochekpour, 2010) Structurally, AR comprise of a N-terminal domain, a DNA binding domain and a ligand binding domain Figure 1.2 A Simplified Schematic on Androgen Signaling through...
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Báo cáo khoa học: "Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study" pptx
... Longitudinal magnetic resonance imagingbased assessment of vascular changes and radiation response in androgen- sensitive prostate carcinoma xenografts under androgenexposed and androgen- deprived conditions ... training, testing and validating the network showed curve flattening after a few training epochs, this indicated that no overtraining occurred However, if such a model is to be applied on clinical ... preclinical study in prostate cancer xenografts, and suggest that the combination of functional MRI parameters, in addition to standard clinical parameters, increases the power of predicting therapeutic...
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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques" ppt
... becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1] Thus late rectal and urinary damage became a major concern in prostate cancer; ... radiotherapy-irradiation of prostate, seminal vesicles, and lymph nodes followed by a prostate boost (116 patients, 59%); and prostate- only (PO) radiotherapy-irradiation of prostate and seminal vesicles (81 ... for matching with portal images Planning target volume (PTV) of the prostate (PTV3) was the entire organ (clinical target volume of prostate- CTV3), and PTV2 was the entire prostate and seminal vesicles...
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báo cáo hóa học:" Can urinary exosomes act as treatment response markers in prostate cancer?" ppt
... produced by LNCaP -prostate cancer cell line Prostate cancer cell lines (LNCaP and DU145), as indicated, were maintained in culture as a source of positive-control prostate cancer exosomes (for ... loading Bands for prostate- derived proteins PSA or PSMA were evident in patients (p1, p7, p8, p9, p10), indicating that at least some of the exosomes present in the urine were of prostate origin ... advances are being made in understanding the biology underlying this disease, and in many respects in its treatment, there remains a need for better tools for PCa diagnosis and monitoring Disease-related...
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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx
... liver and pancreas by immunohistochemical staining In contrast, PSA was stained in both prostate cancer tissue and non-cancerous tissue (Figure 2C) These data indicated that AMACR had a mostly cancer- specific ... Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Surgically resected prostate cancer tissue ... was detected in three prostate cancer cell lines (LNCaP, DU145 and PC-3) C Expression of AMACR in cancer tissues and noncancerous tissues from surgical specimens of two prostate cancer cases...
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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
... inhibitors of the PI3K/ Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate cancer cell lines Up to now our data revealed that ErPC3 is a potent inhibitor ... perifosine and the prototypic intravenously applicable ErPC3, in preclinical and clinical investigations is based on their ability to induce apoptosis in tumor cells and their ability to increase ... Cell lines and cell culture The prostate cancer cell lines LNCaP (p53 wild type, androgen- dependent, highly differentiated), PC3 (p53-/-, androgen- independent, poorly differentiated), and DU145...
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Báo cáo khoa học: "In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol" pot
... radiosensitivity in the androgen independent PC cell line PC-3 has been demonstrated in vitro and in vivo [26,27] Our study analyzes the interactions of irradiation and genistein or estradiol incubation in androgen ... several protein tyrosine- and histidine kinases [810], and inhibits topoisomerase I and II [11] These effects result in alterations of several intracellular and extracellular pathways including cell ... anti -prostate cancer activity in vitro and in vivo Clin Cancer Res 2004, 10:5282-5292 Ouchi H, Ishiguro H, Ikeda N, Hori M, Kubota Y, Uemura H: Genistein induces cell growth inhibition in prostate...
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Báo cáo khoa học: " Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapy" docx
... 23 patients) in Table and the mean standard deviations (mean random error) in Table Then, we determined means and standard deviations from control EPIs for each patient resulting in the same error ... values10%variability, prostate line), format, Measured deviations in and Measured deviations in LR, SI and AP directions in a box plot format, showing the mean values (black squares), the median values (lines in ... issue indicate that a 3mm planning target margin is in most cases sufficient to account for intrafractional motion [39] Both uncertainties, setup error and target motion can be split into random and...
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Báo cáo y học: "Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies" ppt
... (Biochrom, Berlin, Germany) The PBMCs were then frozen in FCS containing 10% dimethyl sulfoxide (Sigma, Saint-Quentin Fallavier, France) and stored in liquid nitrogen until use Epstein-Barr virus ... (four cases in the randomized phase of the trials and six cases in the extension phase) in the treated groups (3,493 patient-years) and none in the placebo groups (1,512 patient-years) [5] Inflammatory ... normalize the variations in PBMC number or DNA extraction All standard dilutions, control samples and PBMC samples were run in parallel and in duplicate for EBV and albumin DNA quantifica- Page...
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báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx
... somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines (LNCaP, ... somatostatin indicates a promising strategy for prostate cancer therapy Materials and methods Cell lines and cell culture A human prostate epithelial cell line (RWPE-1) and prostate cancer cell lines ... in prostate cancer cell lines We found that somatostatin and Octreotide up-regulated XAF1 mRNA and protein expression in prostate cancer cell lines The enhanced XAF1 expression by somatostatin...
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Báo cáo y học: "Dynamic correlation between CTL response and viral load in primary human immunodeficiency virus-1 infected Koreans" ppt
... responses using an IFN-g enzymelinked immunosorbent spot (ELISPOT) assay Cryopreserved PBMCs were thawed and cultured in RPMI 1640 medium containing 10% fetal bovine serum (FBS) and 1% penicillin/streptomycin ... (FBS) and 1% penicillin/streptomycin (Gibco, Grand Island, NY, USA) for 24 h at 37°C Cultured PBMCs were counted using trypan blue vital staining (Gibco) at the beginning of the IFN-g ELISPOT assay ... of infection Fig shows the correlations of viral load and CTL response to each epitope in subjects divided into four groups based on their serological profile and elapsed time following HIV infection...
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Báo cáo y học: "Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selection and efficacy monitoring" doc
... LNCaP cells, an androgen- sensitive prostate cancer cell line, exhibited sensitivity to dasatinib distinct from other androgen- sensitive cell lines, including 22Rv, MDAPCa2b, VCaP and DuCaP Transcriptionally, ... model in prostate cell lines and tumors Expression pattern of a five-gene model in prostate cell lines and tumors (a) Hierarchical clustering of five genes, AR, PSA, CK5, uPA, and EphA2, in prostate ... targeted therapeutics for prostate cancer candidate predictor of efficacy in both prostate and breast cancer Finally, the observed sensitivity to dasatinib of prostate cancer cell lines with expression...
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CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF TRACE AMOUNT OF SEX HORMONE RECEPTOR ACTIVE COMPOUNDS IN PROSTATE CANCER RELATED BIOLOGICAL SAMPLES
... first transform into the androgen dependent cancer cells when there were abundant androgens After ADT, the androgen dependent cells are eliminated, leaving behind only the androgen independent malignant ... ARCCR cells Outlaw AR Androgen independent Ligand independent AR dependent Bypass AR Androgen independent AR independent Lurker Cells Androgen Independent AR independent Promiscuous ... Occurrence of Prostate Cancer (PCa) in Men 2-3 1.2 Prostate and its Importance 1.3 Signs & Symptoms and Detection of Prostate Cancers 1.4 Treatment Options for Prostate Cancer 1.4.1 Hormone or Androgen...
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EZH2 and NF KB crosstalk in breast cancer
... TSS UTR WT Xist Interleukin Interleukin Ingenuity pathway analysis NF-κB inhibitor α Jumonji D3 Lymphotoxin β Maltose-binding protein Methyl-CpG binding domain proteins Micro RNA Messenger RNA ... and growth factor signaling High in the expression of genes involved in immune processes and cell signaling High in the expression of genes involved in motility and extracellularmatrix High in ... essential roles in promoting breast cancer in general, including both BLBC and luminal breast cancer (Cleator et al., 2007; Santana-Davila and Perez, 2010) For example, PI3K/ AKT/mTOR and Ras/MEK/MAPK...
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ADVANCES IN PROSTATE CANCER docx
... of all prostate cancer cases The risk of getting prostate cancer increases nearly exponentially with increasing age This makes prostate cancer one of the most distinctive cancers in aging popu‐ ... biology of prostate cancer, including cancer stem cells, inflammatory processes, roles of androgen receptor and diverse non -androgen gene transcripts and, furthermore, cell adhesion proteins This ... Integrins in Prostate Cancer Invasion and Metastasis 619 Paulynn Chin Suyin, Joanne Louise Dickinson and Adele Frances Holloway Chapter 26 The Role of E-Cadherin-Catenin Complex in Prostate Cancer...
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Báo cáo khoa học: Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells pot
... chemopreventive agents, including resveratrol [26,27], brassinin [28,29], and deguelin [30,31] Resveratrol is present in grapes, red wine and peanuts, brassinin is from Chinese cabbage, and deguelin is from ... apoptosis in SW480 human colon cancer cells To investigate the effects of IxoA on apoptosis, we 5720 used acridine orange ⁄ ethidium bromide staining and DAPI staining and found a marked increase in ... microscope slides, fixed in formalin and methanol, and stained with DAPI Stained nuclei were visualized using a fluorescent microscope Blebbing of the membrane, chromatin aggregation, and nuclear condensation...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
... HERs are commonly activated upon binding of a ligand in their extracellular domain, resulting in dimerization of HERs and triggering the intrinsic tyrosine kinase activity of the receptors responsible ... fusion gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breast cancer cell lines (Zhao et al, 2011) Upon administration of ... organs, including mammary glands, in female goats and sheep (Glascock and Hoekstra 1959) This finding was a crucial observation to understand the role of estrogens in processes involving target...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
... SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript LG, JV, and ... Methods Lung cancer cell lines Six NSCLC cell lines consisting of three adenocarcinoma cell lines (A549, H522 and H358), two large carcinoma cell lines (H460, H661), and one squamous cell carcinoma...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25