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3 types of pitfalls in conducting a meta analysis

Lung ultra for the diagnosis of pneumonia in children a meta analysis

Lung ultra for the diagnosis of pneumonia in children a meta analysis

Sức khỏe trẻ em

... cooperation, cost Other disadvantages: availability & portability, a considerable time delay & a final reading Advances in ultrasound technology have made lung ultrasound (LUS) an attractive ... based on a combination of clinical data, laboratory results, and chest imaging by CR or chest CT scan 2.2.Data Extraction: -Sample size, -gender proportion, -mean age, -LUS technique, -areas of the ... LUS sonographers were not blinded to clinical data Furthermore, (63%) studies used clinical criteria and CR as a diagnosis standard and included laboratory results as additional diagnostic tools...
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Báo cáo y học:

Báo cáo y học: "Bench-to-bedside review: Avoiding pitfalls in critical care meta-analysis — funnel plots, risk estimates, types of heterogeneity, baseline risk and the ecologic fallacy" ppsx

Báo cáo khoa học

... these factors means a greater proportion of the unexplained variation can be accounted for – increasing the power of the meta- analysis Other advantages of individual patient data meta- analyses ... patient data Individual patient data meta- analysis Analysing data at an individual patient level is the most powerful meta- analytic technique available Statistical significance is crudely determined ... Competing interests The authors declare that they have no competing interests A simulation study comparing aggregate data meta- regression and individual patient data meta- analysis found the individual...
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báo cáo hóa học:

báo cáo hóa học:" Effects of low power laser irradiation on bone healing in animals: a meta-analysis" pptx

Hóa học - Dầu khí

... point of fracture was the most common biomechanical variable in all eligible studies and was used to calculate effect size of each article in this meta analysis A total of 234 Table Study Characteristics ... fracture area, 10 minutes on the area above the point of fracture, and 10 minutes on the area below the fracture *** Meta analysis authors calculated amount of irradiated energy based on the articles ... of animal studies The QATRS is a 20-point scale evaluation chart that is designed based on randomization, blinding, similarity of animal/tissue model with human application, standardization and...
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Báo cáo khoa học:

Báo cáo khoa học: " Breast-conserving surgery with or without radiotherapy in women with ductal carcinoma in situ: a meta-analysis of randomized trials" ppt

Báo cáo khoa học

... http://www.ro-journal.com/content/2/1/28 Figure rence Meta- analysis examining adjuvant radiotherapy in DCIS for patients with breast cancer: ipsilateral DCIS breast cancer recurMeta -analysis examining adjuvant ... breast cancer: distant metastases Meta- analysis examining adjuvant radiotherapy in DCIS for patients with breast cancer: distant metastases Page of 12 (page number not for citation purposes) Radiation ... ipsilateral invasive breast cancer recurMeta -analysis examining adjuvant radiotherapy in DCIS for patients with breast cancer: ipsilateral invasive breast cancer recurrence scopic tumor size was...
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Báo cáo khoa học:

Báo cáo khoa học: "Administration of antibiotics via the respiratory tract for the prevention of ICU-acquired pneumonia: a meta-analysis of comparative trials" ppsx

Báo cáo khoa học

... DerSimonian R, Laird N: Meta- analysis in clinical trials Control Clin Trials 1986, 7:177-188 Mantel N, Mocarelli P, Marocchi A, Brambilla P, Baretta R: Stratified analysis of multivariate clinical data: ... performing a meta- analysis of comparative trials studying the effect of the administration of antibiotics via the respiratory tract on the colonization of the respiratory tract by bacteria and development ... meta- analysis that has examined the effectiveness of prophylactic antibiotics administered via the respiratory tract against the development of ICU-acquired pneumonia Some data from animal and...
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Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf

Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf

Báo cáo khoa học

... kit (Amersham Biosciences, Piscataway, NJ, USA) Expression of a- tubulin was examined as an internal control using a- tubulin monoclonal antibody (NeoMarkers, Fremont, CA, USA) Assay for HO catalytic ... R, Takahashi K, Takeda K, Furuyama K, Kaneko K, Takahashi S, Tamai M & Shibahara S (2004) Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal ... et al naya OA, Kolpakov FA et al (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL Nucleic Acids Res 26, 362–367 47 Takahashi S, Takahashi Y, Ito K, Nagano T, Shibahara...
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A meta analysis and risk assessment of heavy metal uptake in common garden vegestable

A meta analysis and risk assessment of heavy metal uptake in common garden vegestable

Môi trường

... assessment Meta- Analysis The technique of quantitatively combining, synthesizing, and summarizing data and results from different studies is known as meta- analysis (Putzrath and Ginevan 1991; Hasselblad ... determine background intakes of each plant-metal combination The model includes a consumption database (Continuing Survey of Food Intake by Individuals, 1994-1996) and a residue database (Food and ... concentration of Cd 43% in the roots of oats Trace metal deficiencies in plants have been associated with increases in heavy metal uptake (Khan and Frankland 1983) Soil pH significantly influences heavy metal...
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Báo cáo sinh học:

Báo cáo sinh học: "Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review" pdf

Hóa học - Dầu khí

... Katsuramaki T, Yasoshima T, Sasaki K, Mizushima Y, Minamida H, Kimura H, Akiyama M, Hirohashi Y, Asanuma H, Tamura Y, Shimozawa K, Sato N, Hirata K: Phase I clinical study of anti-apoptosis protein, ... 7:2277-2284 Sato Y, Maeda Y, Shomura H, Sasatomi T, Takahashi M, Une Y, Kondo M, Shinohara T, Hida N, Katagiri K, Sato K, Sato M, Yamada A, Yamana H, Harada M, Itoh K, Todo S: A phase I trial of cytotoxic ... D, Arani RB, Schlom J, LoBuglio AF: Phase I trial of a recombinant vaccinia virus encoding carcinoembryonic antigen in metastatic adenocarcinoma: comparison of intradermal versus subcutaneous administration...
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Báo cáo y học:

Báo cáo y học: "Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis" pps

Báo cáo khoa học

... CN138-134 Mania Mania Mania Mania Mania Depression Depression Maintenance Mania Overall side effects Anxiety Agitation Acathisia Constipation Headache Hyperprolactinaemia Insomnia Nausea Sedation ... combination are approved for the treatment of acute bipolar depression, and olanzapine, quetiapine and aripiprazole are approved for maintenance phase treatment http://www.annals-general-psychiatry.com/content/8/1/27 ... control of agitation through sedation, but no data on psychotic symptoms are analysed Additionally, there is a concern regarding aripiprazole and olanzapine maintenance data because the relevant...
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báo cáo khoa học:

báo cáo khoa học: "Influence of viral hepatitis status on prognosis in patients undergoing hepatic resection for hepatocellular carcinoma: a meta-analysis of observational studies" ppt

Báo cáo khoa học

... C-related hepatocellular carcinoma; NBNC-HCC = no infection of HBV or HCV related hepatocellular carcinoma; AFP = alpha fetoprotein; ALT = alanine aminotransferase; AST = aspartate aminotransferase; ... hepatocellular carcinoma: a local experience and a systematic review World J Surg Oncol 2010, 8:55 Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, Sugawara Y, Minagawa M, Takayama ... Sumida Y, Takeshita H, Hidaka S, Furukawa K, Sawai T, Yasutake T, Masuda J, Morisaki T, Nagayasu T: Clinicopathological characteristics of patients with hepatocellular carcinoma after hepatectomy:...
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Báo cáo y học:

Báo cáo y học: "A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis" doc

Báo cáo khoa học

... exception, an SIR of 1.68, was in a Japanese population and the authors state that they observed a generally higher risk of malignancies in Japanese women with RA than that reported in comparable Caucasian ... analysis evaluated malignancy risk in an identified early RA population [4,5,8,9] Askling and colleagues [4,5] found an increased risk of lymphoma and lung cancer and a decreased risk of breast ... colorectal cancer; a recent meta- analysis of all randomized controlled trials and observational studies concluded that COX-2 inhibitors and NSAIDs reduce the incidence of colonic adenomas and that NSAIDs...
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Báo cáo y học:

Báo cáo y học: "Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis" docx

Báo cáo khoa học

... A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S: An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis ... 53:42-47 Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y, Tsunoda T, Notoya K, Nakamura Y, Ikegawa S: A functional single nucleotide ... Examination All individuals included in the study were Han Chinese living in and around Nanjing None dropped out during the study In addition, a population of 750 Japanese individuals were included;...
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báo cáo khoa học:

báo cáo khoa học: "R-CHOP versus R-CVP in the treatment of follicular lymphoma: a meta-analysis and critical appraisal of current literature" ppt

Báo cáo khoa học

... FL of stages and but did not show data from each stage separately Czuczman et al [4] and Marcus et al [7] did not include patients of stage To make the data accurate and comparable across all ... rituximab may provide important data in the field of the best induction in patients with follicular lymphoma An unavoidable weakness of any meta- analysis is its inability to perform multivariate analyses ... Matthaiou DK, Bliziotis IA: The role of aminoglycosides in combination with a B-lactam for the treatment of bacterial endocarditis: a meta- analysis of comparative trials J Antimicrob Chemother 2006,...
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Báo cáo y học:

Báo cáo y học: " Psychological treatment of depressive symptoms in Chinese elderly inpatients with significant medical comorbidity: A meta-analysis" pps

Báo cáo khoa học

... Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China 2Graduate School, Chinese Academy of Sciences, Beijing, China 3Department of Clinical Psychology and the EMGO Institute ... of Statistics of China: China Statistical Yearbook Beijing 2003 18 Pan A, Franco OH, Wang YF, Yu Z, Ye X, Lin X: Prevalence and geographic disparity of depressive symptoms among middle-aged and ... the analyses, and wrote the paper JL supervised the data collection, statistical analysis and paper writing PC helped with the analyses and reviewed the texts critically All authors have read and...
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Báo cáo y học:

Báo cáo y học: " Comparative efficacy and acceptability of methylphenidate and atomoxetine in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis" pdf

Báo cáo khoa học

... methylphenidate The findings of the meta- analysis have implications for clinical practice The results from the meta- analysis show that in general atomoxetine and methylphenidate have comparable efficacy ... methylphenidate and atomoxetine Two previous meta- analysis comparing atomoxetine and methylphenidate have included a smaller number of studies Meta- analysis by Gibson et al included five head to head ... scale, all were included in the meta- analysis Data extraction Data was extracted independently by two authors using a predesigned data extraction form Title, year of publication, total number of participants,...
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Báo cáo y học:

Báo cáo y học: " Improved outcomes in patients with chronic obstructive pulmonary disease treated with salmeterol compared with placebo/usual therapy: results of a meta-analysis" ppsx

Báo cáo khoa học

... duration of COPD, smoking history and use of regular inhaled and oral corticosteroids at baseline Analysis of data on FEV1 and health status included the actual data recorded at each time point (Observed), ... planning of the meta analysis and in writing and editing the manuscript; PW and MW were involved in the writing and editing of the manuscript and responsible for the searches of the databases and ... diagram of the trial selection process Information on a number of covariates was also extracted to facilitate subgroup analysis, including age of subjects, baseline FEV1, body mass index, duration...
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Báo cáo khoa học:

Báo cáo khoa học: " The use of prophylactic fluconazole in immunocompetent high-risk surgical patients: a meta-analysis." doc

Báo cáo khoa học

... Critical Care Vol No Ho et al Figure Flow chart showing study inclusion and exclusion in this meta- analysis meta- analysis renal failure, total parenteral nutrition, gastrointestinal perforation, and ... The candidaemia rate of 4.5% in the placebo arm of this metaanalysis is consistent with the estimated risk of candidaemia in patients with at least one risk factor for candidaemia The risk factors ... pharmacoeconomic or cost-effectiveness analysis was not performed in the studies included in this meta- analysis Based on the baseline risk of candidaemia of 4.5% in the placebo arm of this meta- analysis, ...
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Báo cáo y học:

Báo cáo y học: "A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: a meta-analysis" potx

Báo cáo khoa học

... The grading of allocation concealment was based on the Cochrane approach (i.e adequate or uncertain or clearly inadequate) Blinding of the attending physician who decided when to initiate invasive ... was not improving satisfactorily 71 patients, mean APACHE II score not available, mean age 74 years, mean PaCO2 at presentation not available Variable CPAP (5–20 cmH2O), variable BiPAP (starting ... Significance of the findings The present meta- analysis indicates that BiPAP has no significant clinical advantage over CPAP in terms of reducing hospital mortality, requirement for invasive ventilation,...
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Báo cáo y học:

Báo cáo y học: "Effect of histamine-2-receptor antagonists versus sucralfate on stress ulcer prophylaxis in mechanically ventilated patients: a meta-analysis of 10 randomized controlled trials" pot

Báo cáo khoa học

... African and Latin American studies of H2RA and sucralfate are warranted and may have a positive impact on overall estimates 10 Abbreviations APACHE II: Acute Physiology and Chronic Health Evaluation ... incidence of overt bleeding was associated with H RA in comparison with sucralfate From our analysis, with all available articles, we confirmed the finding of single trials that sucralfate was associated ... 354:1896-1900 Prakash S, Rai A, Gogia AR, Prakash S: Nosocomial pneumonia in mechanically ventilated patients receiving ranitidine or sucralfate as stress ulcer prophylaxis Indian Journal of Anaesthesia 2008,...
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